CN102077925B - Preparation for promoting synthesis and dendritic dispersion of skin melanin of fishes - Google Patents

Preparation for promoting synthesis and dendritic dispersion of skin melanin of fishes Download PDF

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Publication number
CN102077925B
CN102077925B CN201010581667A CN201010581667A CN102077925B CN 102077925 B CN102077925 B CN 102077925B CN 201010581667 A CN201010581667 A CN 201010581667A CN 201010581667 A CN201010581667 A CN 201010581667A CN 102077925 B CN102077925 B CN 102077925B
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percent
preparation
vitamin
cobastab
fish
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CN102077925A (en
Inventor
许国焕
张丽
梁建庆
吴月嫦
江永明
郭慧青
董小林
王珺
郭莹姿
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Guangdong Bide Biotechnology Co Ltd
Guangdong Institute of Microbiology
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Guangdong Bide Biotechnology Co Ltd
Guangdong Institute of Microbiology
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81Aquaculture, e.g. of fish
    • Y02A40/818Alternative feeds for fish, e.g. in aquacultures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

Abstract

The invention discloses a preparation for promoting synthesis and dendritic dispersion of skin melanin of fishes, which comprises the following components in percent by mass in the terms of total mass percent of 100 percent: 0.15-0.4 percent of vitamin A, 0.05-0.3 percent of vitamin B1, 0.05-0.3 percent of vitamin B2, 0.05-0.35 percent of vitamin B6, 0.05-0.3 percent of adenosine, 0.01-0.1 percent of methylbenactyzine bromide and the balance of carrier. By applying the preparation for promoting synthesis and dendritic dispersion of skin melanin of fishes, the fish color can be remarkably prevented and improved, body color abnormalities (piebald, sand skin, banana, white and the like) are avoided, the commercial fish price is raised, and the comprehensive benefit of the aquaculture culture is increased. The preparation has the advantages of simpleness of formula constitution, easiness of purchasing and processing of raw materials, low cost, no residue and environment protection, and completely accords with the food sanitation requirement for feeding fishes.

Description

A kind of synthetic preparation that disperses with the dendron shape of fish epidermal melanin that promotes
Technical field:
The invention belongs to aquaculture field, be specifically related to a kind of synthetic preparation that disperses with the dendron shape of fish epidermal melanin that promotes.
Background technology:
The body colour of fish mainly depends on chromatophorous existence in the skin, and receives the control of neurotransmitter, acceptor and internal system.Factor such as nutrition, breeding environment also is to change the fish body colour through the mediator that affects the nerves, acceptor and internal system.Continuous deterioration owing to the present stage cultivation water environment; Nutrient imbalance; The unreasonable management of throwing something and feeding causes some special aquatic products kind at present, phenomenon that like Pelteobagrus fulvidraco, catfish, channel catfish etc., that body colour occurs is unusual (piebald, husky skin, banana yellow, turn white etc.); Have a strong impact on the commercial value of product, bring serious economy loss to the culturist.
Summary of the invention:
The purpose of this invention is to provide a kind of synthetic preparation that disperses with the dendron shape of fish epidermal melanin that promotes; Said preparation can and improve fish body body colour through the prevention of comprehensive regulations such as manual intervention fish melanocyte surface receptor and internal system mechanism; Thereby improve the price of marketable fish, increase the comprehensive benefit of aquaculture.
The synthetic preparation that disperses with the dendron shape of promotion fish epidermal melanin of the present invention by gross mass mark 100%, is made up of following component: vitamin A 0.15~0.4%, Cobastab 10.05 Cobastab~0.3%, 20.05 Cobastab~0.3%, 60.05~0.35%, adenosine 0.05~0.3%, benactyzine methobromide 0.01~0.1%, surplus is a carrier.
Described carrier can be wheat bran, maize cob meal; Be preferably defatted rice bran; This be because: 1) defatted rice bran is a kind of organic carrier; The unit weight of its unit weight and vitamin and receptor modulators is approaching, can guarantee that active component is evenly distributed in mixed process, reduces the classification phenomenon in the course of conveying; 2) defatted rice bran has coarse surface and surperficial aperture, helps its surface of trace active composition absorption or gets in its aperture; 3) cost of defatted rice bran is low, is prone to buying.
Vitamin A of the present invention, Cobastab 1, Cobastab 2, Cobastab 6, adenosine and benactyzine methobromide all belong to material of the prior art, can buy from market.
The synthetic preparation that disperses with the dendron shape of promotion fish epidermal melanin of the present invention is preparation like this; According to the content of each composition in the preparation, accurately weighing evenly mixes various single vitamin raw materials with a spot of carrier; Form B B-complex; Then with receptor modulators: adenosine and benactyzine methobromide, evenly mix with a spot of carrier, form the receptor modulators pre-mixing agent; B B-complex and receptor modulators pre-mixing agent are added in the remaining carrier, mixing and stirring promptly obtains the synthetic preparation that disperses with the dendron shape of promotion fish epidermal melanin of the present invention again.
The synthetic preparation that disperses with the dendron shape of promotion fish epidermal melanin of the present invention comprises vitamin: vitamin A, Cobastab 1, Cobastab 2And Cobastab 6Receptor modulators: adenosine and benactyzine methobromide; Also has carrier.As shown in Figure 1, the receptor modulators of this preparation activates the tyrosinase system through the regulation and control of melanocyte surface receptor, promotes melanic synthesizing, and strengthens body colour.Therefore preparation of the present invention carries out fortification through rational compatibility; Promote melanic propagation and the diffusion of dendron shape through the regulation and control of melanocyte surface receptor again; Reach the even distribution of melanin, make fish present the cinerous or the black of nature at the fish body surface.
The synthetic preparation that disperses with the dendron shape of promotion fish epidermal melanin of the present invention can obviously prevent and improve fish body body colour; Avoid occurring body colour unusual (piebald, husky skin, banana yellow, turn white etc.); Thereby improve the price of marketable fish, increase the comprehensive benefit of aquaculture.And the said preparation prescription is formed simple, and it is low that raw material is easy to buying, processing, cost, noresidue, and environmentally friendly, the fish of feeding meet the food hygiene requirement fully.
Description of drawings:
Fig. 1 is the mechanism of action sketch map that promotion fish epidermal melanin of the present invention synthesizes the preparation that disperses with the dendron shape.
The specific embodiment:
Below be to further specify to of the present invention, rather than limitation of the present invention.
Embodiment 1:
Weighing: vitamin A 1.5 grams, Cobastab 11.0 gram, Cobastab 21.0 gram, Cobastab 61.5 gram, receptor modulators: adenosine 0.6 gram and benactyzine methobromide 0.2 gram, the defatted rice bran 994.2g that 60 orders are dry.With vitamin A, Cobastab 1, Cobastab 2, Cobastab 6Form B B-complex with a spot of defatted rice bran mixing and stirring; And then with adenosine, benactyzine methobromide and a spot of defatted rice bran mixing and stirring formation receptor modulators pre-mixing agent; Again B B-complex and receptor modulators pre-mixing agent are added in the remaining defatted rice bran; Mixing and stirring, the promotion fish epidermal melanin that forms present embodiment therefrom synthesizes the preparation that disperses with the dendron shape.
Test group is with the synthetic preparation that disperses with the dendron shape of the promotion fish epidermal melanin of above-mentioned gained, adds in the tilapia feed unusual (turning white) Tilapia mossambica of body colour about raising counterpoise 50 grams 10 days in the ratio of mass ratio 1%.The feed of control group does not add the synthetic preparation that disperses with the dendron shape of promotion fish epidermal melanin of present embodiment, handles after the same method.The result shows: test group Tilapia mossambica dorsal fin base portion scale melanocyte adds up to 68, melanocyte aggregation extent 0.30, and body colour brightness is 99.84; And control group Tilapia mossambica dorsal fin base portion scale melanocyte adds up to 35, melanocyte aggregation extent 0.71, and body colour brightness is 108.76.This shows that test group is compared and control group, its Tilapia mossambica dorsal fin base portion scale melanocyte sum increases, and the melanocyte aggregation extent reduces, and explains that said preparation has promoted the synthetic and melanocyte dendron shape dispersion of Tilapia mossambica epidermal melanin.
Embodiment 2:
Weighing: vitamin A 2 grams, Cobastab 11.5 gram, Cobastab 21.5 gram, Cobastab 61.6 gram, receptor modulators: adenosine 2.5 grams and benactyzine methobromide 0.4 gram, the defatted rice bran 990.5g that 60 orders are dry.With vitamin A, Cobastab 1, Cobastab 2, Cobastab 6Form B B-complex with a spot of defatted rice bran mixing and stirring; And then with adenosine, benactyzine methobromide and a spot of defatted rice bran mixing and stirring formation receptor modulators pre-mixing agent; Again B B-complex and receptor modulators pre-mixing agent are added in the remaining defatted rice bran; Mixing and stirring, the promotion fish epidermal melanin that forms present embodiment therefrom synthesizes the preparation that disperses with the dendron shape.
With the synthetic preparation that disperses with the dendron shape of the promotion fish epidermal melanin of above-mentioned gained; Add in the yellow-head catfish feed in the ratio of mass ratio 1%; The body colour of feeding is the Pelteobagrus fulvidraco of (banana is yellow) unusually, establishes blank group (promptly adding the unusual Pelteobagrus fulvidraco of body colour that promotes that fish epidermal melanin the feed synthetic and preparation that the dendron shape disperses is fed) simultaneously.Through nearly 10 days throwing something and feeding, to add the Pelteobagrus fulvidraco body colour of said preparation group more than 90% and return to normal condition basically, full recovery in 10~15 days is to normal condition.And blank group fish body body colour does not improve.
Embodiment 3:
Weighing: vitamin A 4 grams, Cobastab 10.5 gram, Cobastab 23 grams, Cobastab 60.5 gram, receptor modulators: adenosine 3 grams and benactyzine methobromide 1 gram, the defatted rice bran 988g that 60 orders are dry.With vitamin A, Cobastab 1, Cobastab 2, Cobastab 6Form B B-complex with a spot of defatted rice bran mixing and stirring; And then with adenosine, benactyzine methobromide and a spot of defatted rice bran mixing and stirring formation receptor modulators pre-mixing agent; Again B B-complex and receptor modulators pre-mixing agent are added in the remaining defatted rice bran; Mixing and stirring, the promotion fish epidermal melanin that forms present embodiment therefrom synthesizes the preparation that disperses with the dendron shape.
With the synthetic preparation that disperses with the dendron shape of the promotion fish epidermal melanin of above-mentioned gained; Add in beard Nian (the being commonly called as hito) feed in the ratio of mass ratio 1%; The body colour of feeding is unusual, and (husky skinization shows as fish body parachroia, the fish back of the body, the equal entire body golden yellow of belly; And be covered with the black choice refreshments; Antenna has a little little red, is commonly called as " husky skin fish " in the production) beard Nian, establish blank group (promptly add promoting the unusual beard Nian of body colour that the feed of the synthetic preparation that disperses with the dendron shape of fish epidermal melanin is fed) simultaneously.Through nearly 10 days throwing something and feeding, to add the beard Nian body colour of preparation group more than 92% and return to normal condition basically, full recovery in 10~12 days is to normal condition.And blank group fish body body colour does not improve.
Embodiment 4:
Weighing: vitamin A 3 grams, Cobastab 13 grams, Cobastab 20.5 gram, Cobastab 63.5 gram, receptor modulators: adenosine 0.5 gram and benactyzine methobromide 0.1 gram, the defatted rice bran 989.4g that 60 orders are dry.With vitamin A, Cobastab 1, Cobastab 2, Cobastab 6Form B B-complex with a spot of defatted rice bran mixing and stirring; And then with adenosine, benactyzine methobromide and a spot of defatted rice bran mixing and stirring formation receptor modulators pre-mixing agent; Again B B-complex and receptor modulators pre-mixing agent are added in the remaining defatted rice bran; Mixing and stirring, the promotion fish epidermal melanin that forms present embodiment therefrom synthesizes the preparation that disperses with the dendron shape.
With the synthetic preparation that disperses with the dendron shape of the promotion fish epidermal melanin of above-mentioned gained; Add in the channel catfish feed in the ratio of mass ratio 1%; The channel catfish that the body colour of feeding is turned white; Through nearly 10 days throwing something and feeding, the channel catfish body colour more than 95% returns to normal condition basically, and full recovery in 10~15 days is to normal condition.And the channel catfish that the body colour that the feed that add to promote the synthetic preparation that disperses with the dendron shape of fish epidermal melanin is fed is turned white, its body colour is still turned white.

Claims (1)

1. one kind promotes the synthetic preparation that disperses with the dendron shape of fish epidermal melanin, it is characterized in that, by gross mass mark 100%, is made up of following component: vitamin A 0.15~0.4%, Cobastab 10.05 Cobastab~0.3%, 20.05 Cobastab~0.3%, 60.05~0.35%, adenosine 0.05~0.3%, benactyzine methobromide 0.01~0.1%, surplus is a defatted rice bran.
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* Cited by examiner, † Cited by third party
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CN102396653B (en) * 2011-11-09 2012-12-12 广东碧德生物科技有限公司 Granulated feed for procypris rabaudi

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1217028A (en) * 1996-03-28 1999-05-19 波士顿大学托管委员会 Method of modulating melanin synthesis
CN1411508A (en) * 2000-02-11 2003-04-16 Lvmh研究公司 Oligonucleotides modulating expression of enzymes involved in synthesis of melanic pigments
CN1827631A (en) * 2006-04-13 2006-09-06 暨南大学 Novel tyrosinase inhibitor and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1217028A (en) * 1996-03-28 1999-05-19 波士顿大学托管委员会 Method of modulating melanin synthesis
CN1411508A (en) * 2000-02-11 2003-04-16 Lvmh研究公司 Oligonucleotides modulating expression of enzymes involved in synthesis of melanic pigments
CN1827631A (en) * 2006-04-13 2006-09-06 暨南大学 Novel tyrosinase inhibitor and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李娜等.酪氨酸酶抑制剂的研究进展.《食品工业科技》.2010,第31卷(第7期),406-409. *

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