CN102068648B - Health-care capsules with auxiliary treatment effect on alcoholic liver injury and preparation method thereof - Google Patents
Health-care capsules with auxiliary treatment effect on alcoholic liver injury and preparation method thereof Download PDFInfo
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- CN102068648B CN102068648B CN200910112812.4A CN200910112812A CN102068648B CN 102068648 B CN102068648 B CN 102068648B CN 200910112812 A CN200910112812 A CN 200910112812A CN 102068648 B CN102068648 B CN 102068648B
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Abstract
The invention discloses health-care capsules with auxiliary treatment effect on alcoholic liver injury and a preparation method thereof. The health-care capsules contain medicinal-edible Chinese medicaments with auxiliary protection function on the alcoholic liver injury and medicinal auxiliary materials, wherein the Chinese medicaments with the auxiliary protection function on the alcoholic liver injury comprise kudzuvine root, root of red-rooted salvia, schisandra and amomum villosum; and the optimal weight ratio of the main medicaments to the medicinal auxiliary materials in the medicament is 80-90%:20-10%. The health-care capsules have good pharmacological effect on the alcoholic liver injury, and the extraction and preparation process accords with the requirements of functional food.
Description
Technical field
The present invention relates to Chinese prescription, pharmaceutical preparation and Chinese drug preparation field, especially relate to a kind of novel composing prescription capsule that alcoholic liver injury is had to auxiliary therapeutic action and preparation method thereof.
Technical background
Ethanol (ethanol) is referred to, for the first in the world public hazards, cause multiple serious disease by WHO: as alcoholic liver disease, the atrophy of nerve-cortex, chronic atrophic gastritis and cardiomyopathy etc.Along with the development of Chinese national economy, acute poisoning and alcoholic liver disease that excessive consumption of alcohol causes are also more and more serious.90% ethanol, at liver metabolism, reduces fat consumption; And ethanol promotion hepatocyte synthetic glycerine three esters (TG), cause triglyceride (being commonly called as fat) in hepatocyte to be accumulated.Excessive fat is built up in liver, and surpasses more than 5%, so form fatty liver.Ethanol can also excited oxygen molecule, produces oxygen and freely by base, causes reduced glutathion in the lipid peroxidation of liver plasma membrane and body and exhaust, transaminase raises, liver function damage.And further cause to the trend development of hepatic fibrosis, liver cirrhosis.But, to the crowd who often drinks and be harmful to the health, at present not one new, quality controllable, the chemical liver injury that ethanol is caused safe, effective, traditional, that have unique advantage has the health product of auxiliary therapeutic action.
Summary of the invention
The object of the present invention is to provide a kind of health-caring capsule that alcoholic liver injury is had to auxiliary therapeutic action, this capsule is good to alcoholic liver injury pharmacological effect, and formula is simple, is convenient to eat.
Technical scheme of the present invention is: a kind of health-caring capsule that alcoholic liver injury is had to auxiliary therapeutic action, what wherein contain has principal agent, drug solvent, the binding agent of auxiliary therapeutic action to alcoholic liver injury, it is characterized in that principal agent is the Chinese medicine of medicine-food two-purpose, comprise Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Fructus Amomi, coordinate and form with binding agent.
The extraction solvent using is monohydric alcohol.
The drug solvent using is from second alcohol and water, and the solubility of ethanol is 60%～100%.
The binding agent using is a kind in dextrin and starch or 2 kinds.
The optimum weight proportioning of each composition, principal agent is: Radix Puerariae 9: Radix Salviae Miltiorrhizae 4: Fructus Schisandrae Chinensis 1: Fructus Amomi 1; Principal agent and binding agent=80 ‰～90%: 20%～10%.
A formula that alcoholic liver injury is had to the health-caring capsule of auxiliary therapeutic action, the scheme of proportioning raw materials is:
The health-caring capsule of one bottle of 24 dress is that Radix Puerariae 36g, Radix Salviae Miltiorrhizae 16g, Fructus Schisandrae Chinensis 4g, Fructus Amomi 4g, lake essence are appropriate;
The health-caring capsule of one bottle of 36 dress is that Radix Puerariae 54g, Radix Salviae Miltiorrhizae 24g, Fructus Schisandrae Chinensis 6g, Fructus Amomi 6g, lake essence are appropriate;
The health-caring capsule of one bottle of 60 dress is that Radix Puerariae 90g, Radix Salviae Miltiorrhizae 40g, Fructus Schisandrae Chinensis 10g, Fructus Amomi 10g, lake essence are appropriate;
The present invention also aims to provide the preparation method of above-mentioned health-caring capsule:
(1) get Radix Puerariae 54g, Radix Salviae Miltiorrhizae 24g, Fructus Schisandrae Chinensis 6g, Fructus Amomi 6g, with the soak with ethanol 12～24h of 8 times of amounts 80%;
(2) in compound extraction is filled with, extract 2h, collect ethanol medicinal liquid;
(3) in the medicinal residues in compound extraction is filled with, add the ethanol of 5 times of amounts 80%; Extract 2h, merge ethanol medicinal liquid;
(4) on Rotary Evaporators, reclaim ethanol, add lake essence, granule processed, 80 ℃ of dry 24h in steaming empty drying baker; Or spraying is dry, subpackage.
Beneficial effect of the present invention.This health-caring capsule:
(1) adopt the Chinese medicine of medicine-food two-purpose, and formula is simple;
(2) be not subject to the impact of gastrointestinal tract various factors, yet can gastrointestinal tract do not caused and be stimulated or other adverse effect;
(4) extremely easy to use, only need oral;
(5) after testing, puerarin content is not less than 5mg/g, and salvianolic acid B is not less than 1mg/g or tanshinone ⅡA is not less than 2ug/g after testing.So safety, almost non-toxic property reaction.
This capsule can adopt the general method adopting in capsule preparing technical field to prepare, and method is simple, is convenient to produce.
The specific embodiment
Take and fill a prescription as follows as example:
Radix Puerariae 54g
Radix Salviae Miltiorrhizae 24g
Fructus Schisandrae Chinensis 6g
Fructus Amomi 6g
Lake essence is appropriate
36/bottle
If necessary, can also suitably add and can be used for capsule or operable additive, as PH regulators such as malic acid, citric acid, lactic acid; As binding agents such as starch, dextrin, magnesium stearate.
What take every bottle of 36 dresses is example, and preparation method is:
(1) get Radix Puerariae 54g, Radix Salviae Miltiorrhizae 24g, Fructus Schisandrae Chinensis 6g, Fructus Amomi 6g, with the soak with ethanol 12～24h of 8 times of amounts 80%;
(2) in compound extraction is filled with, extract 2h, collect ethanol medicinal liquid;
(3) in the medicinal residues in compound extraction is filled with, add the ethanol of 5 times of amounts 80%; Extract 2h, merge ethanol medicinal liquid;
(4) on Rotary Evaporators, reclaim ethanol, add lake essence, granule processed, 80 ℃ of dry 24h in steaming empty drying baker, or spraying is dry; Subpackage.
In the present invention, the container of encapsulated dose of use is had to special regulation, be generally carton or edible plastic bottle, general loading amount is 24,36, and 60.
Test example: by Ministry of Public Health version < < health food check in 2003 and assessment technique standard > > requirement, select ICR mice, male, 10/group, establish basic, normal, high 3 dosage groups (be equivalent to respectively quantity 10 times, 20 times, 30 times) and Normal group and sick mould matched group.Each is organized gavage capacity and is 0.4ml/10g.bw.After administration 37 days, with 50% dehydrated alcohol (AR, the distilled water diluting of take) gavage 14ml/kg.bw (dosage of amounting to ethanol is 7000mg/kg bw), cause liver injury model, fasting is put to death animal in 16 hours, carries out the detection of indices.
Zoopery proves, compares with sick mould matched group, and administration group can significantly reduce the rising of the liver TG being caused by alcoholic liver injury, the liver reduced form GSH that raises and be lowered.Illustrate that product of the present invention has protective effect for alcoholic liver injury, prompting can the liver protecting, and prevention alcoholism, fatty liver and the caused hepatopathy of insobriety, reduce the injury of excessive consumption of alcohol.Through branch center, the Fujian update search of Chinese traditional Chinese medicine literature retrieval center, prove that prescription of the present invention has novelty, be new health product that alcoholic liver injury had to assistant protection function.
Claims (1)
1. pair alcoholic liver injury has the health-caring capsule of auxiliary therapeutic action, it is characterized in that: the Chinese medicine that principal agent is medicine-food two-purpose, comprise Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Fructus Amomi, and coordinate and form with binding agent;
Described binding agent is a kind or 2 kinds in dextrin and starch;
The optimum weight proportioning of each constituent, principal agent is: Radix Puerariae: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis: Fructus Amomi=9:4:1:1, principal agent: binding agent=80% ~ 90%:20% ~ 10%;
The concrete preparation method of described health-caring capsule comprises the following steps:
1) get in proportion Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Fructus Amomi, with the soak with ethanol 12 ~ 24h of 8 times of amounts 80%;
2) in compound extraction pot, extract 2h, collect ethanol medicinal liquid;
3) in the medicinal residues in compound extraction pot, add the ethanol of 5 times of amounts 80%, extract 2h, merge ethanol medicinal liquid;
4) on Rotary Evaporators, reclaim ethanol, spraying is dry, adds dextrin, granule processed, and 80 ℃ of dry 24h in vacuum drying oven, subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910112812.4A CN102068648B (en) | 2009-11-20 | 2009-11-20 | Health-care capsules with auxiliary treatment effect on alcoholic liver injury and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910112812.4A CN102068648B (en) | 2009-11-20 | 2009-11-20 | Health-care capsules with auxiliary treatment effect on alcoholic liver injury and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102068648A CN102068648A (en) | 2011-05-25 |
| CN102068648B true CN102068648B (en) | 2014-04-30 |
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| KR101952648B1 (en) * | 2017-08-03 | 2019-02-27 | 국가식품클러스터지원센터 | The Inhibitory Effects of Amomum vilosum Loureiro Extracts and Composition Containing the Extract as Effective Ingredient |
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Non-Patent Citations (2)
| Title |
|---|
| 中成药处方与保健食品配方的设计;季绍良;《中国南宁泛中医论坛思考中医2006论文集》;20061231;33-37 * |
| 季绍良.中成药处方与保健食品配方的设计.《中国南宁泛中医论坛思考中医2006论文集》.2006,33-37. |
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