CN102066394B - 用作免疫佐剂的糖脂的类似物 - Google Patents

用作免疫佐剂的糖脂的类似物 Download PDF

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Publication number
CN102066394B
CN102066394B CN200880119643.0A CN200880119643A CN102066394B CN 102066394 B CN102066394 B CN 102066394B CN 200880119643 A CN200880119643 A CN 200880119643A CN 102066394 B CN102066394 B CN 102066394B
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CN
China
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group
alkyl
compound
antigen
benzyl
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Expired - Fee Related
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CN200880119643.0A
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English (en)
Chinese (zh)
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CN102066394A (zh
Inventor
路易吉·潘扎
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN200880119643.0A 2007-10-12 2008-10-10 用作免疫佐剂的糖脂的类似物 Expired - Fee Related CN102066394B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97978507P 2007-10-12 2007-10-12
US60/979,785 2007-10-12
PCT/IB2008/003263 WO2009060305A2 (en) 2007-10-12 2008-10-10 Analogues of glycolipids useful as immunoadjuvants

Publications (2)

Publication Number Publication Date
CN102066394A CN102066394A (zh) 2011-05-18
CN102066394B true CN102066394B (zh) 2015-04-01

Family

ID=40626266

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880119643.0A Expired - Fee Related CN102066394B (zh) 2007-10-12 2008-10-10 用作免疫佐剂的糖脂的类似物

Country Status (8)

Country Link
US (1) US8697659B2 (enExample)
EP (1) EP2483287B1 (enExample)
JP (1) JP5416125B2 (enExample)
CN (1) CN102066394B (enExample)
AU (1) AU2008326138B2 (enExample)
CA (1) CA2702344C (enExample)
ES (1) ES2574825T3 (enExample)
WO (1) WO2009060305A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5640079B2 (ja) 2009-05-18 2014-12-10 シグモイド・ファーマ・リミテッドＳｉｇｍｏｉｄ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ 油滴含有組成物
CN102573802A (zh) * 2009-08-12 2012-07-11 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
AU2013237497B2 (en) * 2012-03-19 2016-05-12 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Carbohydrate-glycolipid conjugate vaccines
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
PT3215127T (pt) 2014-11-07 2021-02-10 Sublimity Therapeutics Ltd Composições que compreendem ciclosporina
WO2022256467A1 (en) * 2021-06-02 2022-12-08 The Charlotte Mecklenburg Hospital Authority D/B/A Atrium Health Compositions and methods comprising deoxy-pentitols

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000348A2 (en) * 2003-06-24 2005-01-06 Isis Innovation Limited Vaccines inducing nkt-cell and toll-like-receptor activation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW261533B (enExample) * 1992-07-16 1995-11-01 Kirin Brewery
EP1437358B1 (en) 2001-08-16 2006-10-18 Daiichi Asubio Pharma Co., Ltd. Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
EP1784196B1 (en) 2004-08-27 2016-12-21 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US7923013B2 (en) * 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
EP1776963A1 (en) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramides as adjuvants and their uses in pharmaceutical compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000348A2 (en) * 2003-06-24 2005-01-06 Isis Innovation Limited Vaccines inducing nkt-cell and toll-like-receptor activation

Also Published As

Publication number Publication date
CN102066394A (zh) 2011-05-18
JP5416125B2 (ja) 2014-02-12
US8697659B2 (en) 2014-04-15
EP2483287B1 (en) 2016-03-16
WO2009060305A2 (en) 2009-05-14
US20110033485A1 (en) 2011-02-10
CA2702344C (en) 2016-09-27
CA2702344A1 (en) 2009-05-14
AU2008326138B2 (en) 2013-10-17
ES2574825T3 (es) 2016-06-22
WO2009060305A3 (en) 2013-05-23
EP2483287A2 (en) 2012-08-08
AU2008326138A1 (en) 2009-05-14
JP2011510910A (ja) 2011-04-07

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150401

CF01 Termination of patent right due to non-payment of annual fee