CN102065859B - 用于神经纤维瘤病的取代的苯并咪唑类 - Google Patents

用于神经纤维瘤病的取代的苯并咪唑类 Download PDF

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Publication number
CN102065859B
CN102065859B CN2009801221827A CN200980122182A CN102065859B CN 102065859 B CN102065859 B CN 102065859B CN 2009801221827 A CN2009801221827 A CN 2009801221827A CN 200980122182 A CN200980122182 A CN 200980122182A CN 102065859 B CN102065859 B CN 102065859B
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China
Prior art keywords
compounds
neurofibromatosis
purposes
causes
alkyl
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Expired - Fee Related
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CN2009801221827A
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English (en)
Chinese (zh)
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CN102065859A (zh
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D·斯图尔特
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2009801221827A 2008-06-13 2009-06-11 用于神经纤维瘤病的取代的苯并咪唑类 Expired - Fee Related CN102065859B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6115608P 2008-06-13 2008-06-13
US61/061,156 2008-06-13
PCT/US2009/046971 WO2009152288A1 (en) 2008-06-13 2009-06-11 Substituted benzimidazoles for neurofibromatosis

Publications (2)

Publication Number Publication Date
CN102065859A CN102065859A (zh) 2011-05-18
CN102065859B true CN102065859B (zh) 2012-10-03

Family

ID=40956523

Family Applications (1)

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CN2009801221827A Expired - Fee Related CN102065859B (zh) 2008-06-13 2009-06-11 用于神经纤维瘤病的取代的苯并咪唑类

Country Status (12)

Country Link
US (1) US20110092546A1 (enExample)
EP (1) EP2288354A1 (enExample)
JP (1) JP2011524362A (enExample)
KR (1) KR20110025827A (enExample)
CN (1) CN102065859B (enExample)
AU (1) AU2009257487B2 (enExample)
BR (1) BRPI0915106A2 (enExample)
CA (1) CA2726376A1 (enExample)
MX (1) MX2010013683A (enExample)
RU (1) RU2011100106A (enExample)
TW (1) TW201004621A (enExample)
WO (1) WO2009152288A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2668210T3 (da) 2011-01-26 2020-08-24 Celldex Therapeutics Inc Anti-kit antistoffer og anvendelser deraf
RU2681730C2 (ru) 2012-07-25 2019-03-12 Селлдекс Терапьютикс Инк. Антитела против kit и их применения
CN113975386A (zh) * 2014-05-23 2022-01-28 塞尔德克斯医疗公司 嗜酸性粒细胞或肥大细胞相关病症的治疗
KR101880015B1 (ko) 2017-12-08 2018-07-19 아주대학교산학협력단 인터페론 감마를 유효성분으로 함유하는 신경섬유육종 예방 또는 치료용 조성물
CN113784713A (zh) 2019-01-11 2021-12-10 纳吉斯制药股份有限公司 白三烯合成抑制剂
CN117460509B (zh) * 2021-06-23 2025-03-28 正大天晴药业集团股份有限公司 作为c-Met激酶抑制剂的化合物治疗I型神经纤维瘤病的用途
JP2024534693A (ja) * 2021-10-08 2024-09-20 ウニベルシテ クロード ベルナール リヨン １ 組織球症若しくは頭蓋咽頭腫の治療又は予防における使用のためのベンズイミダゾール誘導体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049622A1 (en) * 2005-08-30 2007-03-01 Novartis Ag Substituted benzimidazoles and methods of preparation
WO2007131689A2 (en) * 2006-05-11 2007-11-22 Novartis Ag Pharmaceutical combinations comprising a mtor inhibitor and a raf kinase inhibitor
WO2008027523A2 (en) * 2006-08-30 2008-03-06 Novartis Ag Salts of benzimidazolyl pyridyl ethers and formulations thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007987B1 (ru) * 2002-03-29 2007-02-27 Чирон Корпорейшн Замещённые бензазолы и их применение в качестве ингибиторов киназы raf
WO2008070616A2 (en) * 2006-12-01 2008-06-12 University Of Utah Research Foundation METHODS AND COMPOSITIONS RELATED TO HIF-1α
EP2175885B1 (en) * 2007-07-30 2016-10-12 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
WO2009114703A2 (en) * 2008-03-12 2009-09-17 Fox Chase Cancer Center Combination therapy for the treatment of cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049622A1 (en) * 2005-08-30 2007-03-01 Novartis Ag Substituted benzimidazoles and methods of preparation
WO2007131689A2 (en) * 2006-05-11 2007-11-22 Novartis Ag Pharmaceutical combinations comprising a mtor inhibitor and a raf kinase inhibitor
WO2008027523A2 (en) * 2006-08-30 2008-03-06 Novartis Ag Salts of benzimidazolyl pyridyl ethers and formulations thereof

Also Published As

Publication number Publication date
BRPI0915106A2 (pt) 2016-02-10
KR20110025827A (ko) 2011-03-11
AU2009257487B2 (en) 2013-01-31
EP2288354A1 (en) 2011-03-02
TW201004621A (en) 2010-02-01
CN102065859A (zh) 2011-05-18
AU2009257487A1 (en) 2009-12-17
RU2011100106A (ru) 2012-10-27
WO2009152288A1 (en) 2009-12-17
CA2726376A1 (en) 2009-12-17
US20110092546A1 (en) 2011-04-21
MX2010013683A (es) 2011-04-26
JP2011524362A (ja) 2011-09-01

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