CN102058809A - Chinese medicine composition for clearing lung, eliminating phlegm and relieving cough and asthma and preparation method thereof - Google Patents
Chinese medicine composition for clearing lung, eliminating phlegm and relieving cough and asthma and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicine composition for clearing lung, eliminating phlegm and relieving cough and asthma and a preparation method thereof, which belong to the modernization field of Chinese medicines. The Chinese medicine composition for clearing lung, eliminating phlegm and relieving cough and asthma is prepared from the following raw materials in parts by weight: 120 parts of rhizoma anemarrhenae, 120 parts of figwort, 240 parts of poppy capsule, 120 parts of ophiopogon root, 360 parts of tussilago, 120 parts of aster, 120 parts of bitter almond, 120 parts of radix stemonae and 60 parts of thunberg fritillary bulb. The invention has the advantages that: the traditional Chinese medicine composition is obtained by analyzing medical prescription with traditional Chinese medicine theory and a preparation method of reasonable and stable active ingredients is obtained by researching according to the researching result of physicochemical property and pharmacological action of the ingredients contained in each Chinese medicinal herb. By adopting the technical scheme, the prepared pharmaceutical preparation which has stable and controllable quality, and remarkable economic and social benefits compared with the marketing dosage form and reduced dosage taken by the patient is prepared.
Description
Technical field
The present invention relates to Chinese medicine composition that a kind of removing heat from the lung and dissipating phlegm antitussive relievings asthma and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Ermuansou syrup function removing heat from the lung and dissipating phlegm, antitussive is relievingd asthma, function asthenia chronic cough, the cough phlegm dyspnea, osteopyrexia and fever, silent low voice speaking, dry mouth dry tongue, accumulation and obstruction of sputum.The clinical treatment that is used for genus lung-heat yin-deficiency persons such as pulmonary tuberculosis, chronic bronchitis.
Upper respiratory tract infection, acute/chronic bronchitis, pulmonary infection take place in winter-spring season easily.These sick most meetings are with symptoms such as cough, abundant expectoration or asthma.But Ermuansou ball clearing away lung-heat, reduce phlegm, antitussive, relieving asthma.Thick, the osteopyrexia and fever of cough expectorant that be used for pulmonary tuberculosis, chronic bronchitis, causes, silent low voice speaking, dry mouth dry tongue, accumulation and obstruction of sputum person.The clear purte the white of the Rhizoma Anemarrhenae in the side, nourishing YIN and moistening the lung; The Bulbus Fritillariae Thunbergii preventing phlegm from forming and stopping coughing is monarch drug altogether.Flos Farfarae, Radix Asteris relieving cough and resolving phlegm, the respectful lung of Semen Armeniacae Amarum is relievingd asthma, and auxilliary altogether monarch drug preventing phlegm from forming and stopping coughing is ministerial drug.Radix Scrophulariae heat clearing away eliminating stagnation, Radix Ophiopogonis nourishing YIN and moistening the lung, the Bulbus Lilii nourishing the lung to arrest cough, the Pericarpium Papaveris astringing lung-QI and relieving cough is adjuvant drug altogether.All medicines share, and play removing heat from the lung and dissipating phlegm altogether, the merit of relieving cough and asthma.
Bring up phlegm when one coughs, the traditional Chinese medical science thinks that lung-heat is one of main pathogenesis.Lung-heat divides the heresy of diseases caused by exogenous pathogenic factor wind heat, or two kinds of the back heat-transformation of catching cold.Performance with cough, to cough up phlegm and pant be primary symptom, see again to tell yellow sputum and thickness is difficult for bringing up, has a fever, has a sore throat, thirsty, uncomfortable in chest dysphoria with smothery sensation, red tongue with yellow fur, full and large pulse or sliding number etc.Modern medical diagnosis is the pneumonia that causes of upper respiratory tract infection, acute bronchitis, acute episode of chronic bronchitis and bronchopneumonia, lobar pneumonia, viral pneumonia and other reason, pulmonary heart disease etc., all available Ermuansou pill for curing.To " lung-heat " coughing of causing, expectorant, disease such as breathe heavily,, auxiliary in the treatment with dispelling wind, cough-relieving, the medicine that reduces phlegm, relieving asthma generally removing exopathogen.
At present, this prescription type is a syrup, and preparation technology is: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris decoct with water secondary, and collecting decoction is concentrated into an amount of; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris make solvent with 60% ethanol, carry out percolation according to the percolation under fluid extract and the extractum item, and it is standby to collect percolate; Continue to collect percolate, reclaim ethanol and be concentrated in right amount; Semen Armeniacae Amarum extracts aqua armeniacae, and is standby; Above concentrated liquid, ethanol concentrated solution, aqua armeniacae and ethanol percolation liquid are merged, mixing, adjustment capacity and contain the alcohol amount left standstill three days, draw supernatant, surplus liquid filters removes precipitation and supernatant merging, adds simple syrup and stirs evenly, and leaves standstill seven days, mensuration contains the alcohol amount, adjusts total amount, fill, promptly.Present technology is comparatively complicated, and raw material time is extracted with three kinds of methods in three batches, mixes concentratedly, more consuming time again, and inconvenience is taken, carries, transported to syrup, sugar content height, also inconvenience preservation.
Summary of the invention
First technical problem that the present invention will solve provides the Chinese medicine composition that a kind of removing heat from the lung and dissipating phlegm antitussive evident in efficacy is relievingd asthma.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For achieving the above object, the present invention is by the following technical solutions: a kind of Chinese medicine composition of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma, its active component is made by the raw material of following parts by weight: 120 parts of the Rhizoma Anemarrhenaes, 120 parts of Radix Scrophulariaes, 240 parts of Pericarpium Papaveriss, 120 parts of Radix Ophiopogonis, 360 parts of Flos Farfaraees, 120 parts of Radix Asteriss, 120 parts of Semen Armeniacae Amarums, 120 parts of the Radixs Stemonae, 60 parts of Bulbus Fritillariae Thunbergiis.
Described active component adopts following method to prepare: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 6-14 times of water gaging and decoct 2-3 time, and each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; It is the ethanol of 90-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 12-36 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; The concentration of volume percent that Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured with 10-20 is the 60%-80% ethanol percolation, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
Described active component adopts following method to prepare: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 8-10 times of water gaging and decoct 2-3 time, and each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is the ethanol of 95-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 20-30 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured the ethanol percolation that concentration of volume percent is 60%-80% with 10-20, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
Described active component adopts following method to prepare: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 10 times of water gagings and decoct 2 times, and each 2 hours, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Concentrated solution adding concentration of volume percent is 95% ethanol, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are the ethanol percolation of 60%-80% with 15 times of amount concentration of volume percent, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
Described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
A kind of preparation method of Chinese medicine composition of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma is characterized in that: take by weighing 120 parts of the Rhizoma Anemarrhenaes, 120 parts of Radix Scrophulariaes, 240 parts of Pericarpium Papaveriss, 120 parts of Radix Ophiopogonis, 360 parts of Flos Farfaraees, 120 parts of Radix Asteriss, 120 parts of Semen Armeniacae Amarums, 120 parts of the Radixs Stemonae, 60 parts of Bulbus Fritillariae Thunbergiis; Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 6-14 times of water gaging and decoct 2-3 time, and each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; It is the ethanol of 90-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 12-36 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; The concentration of volume percent that Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured with 10-20 is the 60%-80% ethanol percolation, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.This preparation technology's paste-forming rate is 8-15%.
Described Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 8-10 times of water gaging and decoct 2-3 time, and each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is the ethanol of 95-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 20-30 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; But Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, hardship core are doubly measured the ethanol percolation that concentration of volume percent is 60%-80% with 10-20, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
Described Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 10 times of water gagings and decoct 2 times, and each 2 hours, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Concentrated solution adding concentration of volume percent is 95% ethanol, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are the ethanol percolation of 60%-80% with 15 times of amount concentration of volume percent, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
Chinese medicine composition that technical solution of the present invention is protected and preparation thereof all have good removing heat from the lung and dissipating phlegm antitussive antiasthmatic effect; by zoopery; we unexpectedly find, the active constituents of medicine that adopts technical solution of the present invention to obtain possesses and eliminates the phlegm significantly and antiasthmatic effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, has simplified the preparation method that process research has obtained reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, have remarkable economical and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1.2kg, Radix Scrophulariae 1.2kg, Pericarpium Papaveris 2.4kg, Radix Ophiopogonis 1.2kg, Flos Farfarae 3.6kg, Radix Asteris 1.2kg, Semen Armeniacae Amarum 1.2kg, Radix Stemonae 1.2kg, Bulbus Fritillariae Thunbergii 0.6kg.
Two. method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 2 times, and each 2 hours, 10 times of water gagings, collecting decoction, being evaporated to density is 1.06 (50-60 ℃); Concentrated solution adds 95% ethanol, and making the supernatant concentration of alcohol is 60%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to density is 1.06 (50-60 ℃); Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are 80% ethanol percolation with 15 times of amount concentration, receive percolate, and being evaporated to density is 1.06 (50-60 ℃), merges above concentrated solution, and drying under reduced pressure or spray drying get the about 1.2kg of extract powder.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 12kg, Radix Scrophulariae 12kg, Pericarpium Papaveris 24kg, Radix Ophiopogonis 12kg, Flos Farfarae 36kg, Radix Asteris 12kg, Semen Armeniacae Amarum 12kg, Radix Stemonae 12kg, Bulbus Fritillariae Thunbergii 6kg.
Two, method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 2 times, and 3 hours 10 times of water gagings added 8 times of water gagings in 2 hours for the second time for the first time, collecting decoction, and being evaporated to density is 1.05 (50-60 ℃).Concentrated solution adds 95% ethanol, and making the supernatant concentration of alcohol is 70%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to density is 1.05 (50-60 ℃).Bulbus Fritillariae Thunbergii, Flos Farfarae, Bulbus Lilii, Radix Asteris, Semen Armeniacae Amarum are 60% ethanol percolation with 15 times of amount concentration, receive percolate, and being evaporated to density is that 1.05 (50-60 ℃) merge above concentrated solution, and drying under reduced pressure or spray drying get the about 11.6kg of extract powder.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1200g, Radix Scrophulariae 1200g, Pericarpium Papaveris 2400g, Radix Ophiopogonis 1200g, Flos Farfarae 3600g, Radix Asteris 1200g, Semen Armeniacae Amarum 1200g, Radix Stemonae 1200g, Bulbus Fritillariae Thunbergii 600g.
Two, method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 2 times, and 1 hour 6 times of water gaging added 14 times of water gagings in 3 hours for the second time for the first time, collecting decoction, and being evaporated to density is 1.03 (50-60 ℃).Concentrated solution adds 90% ethanol, and making the supernatant concentration of alcohol is 60%, leaves standstill 12 hours, filters, and gets supernatant, and being evaporated to density is 1.03 (50-60 ℃).Bulbus Fritillariae Thunbergii, Flos Farfarae, Bulbus Lilii, Radix Asteris, Semen Armeniacae Amarum are 70% ethanol percolation with 10 times of amount concentration, receive percolate, and being evaporated to density is that 1.03 (50-60 ℃) merge above concentrated solution, and drying under reduced pressure or spray drying get extract powder 1110g.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1200g, Radix Scrophulariae 1200g, Pericarpium Papaveris 2400g, Radix Ophiopogonis 1200g, Flos Farfarae 3600g, Radix Asteris 1200g, Semen Armeniacae Amarum 1200g, Radix Stemonae 1200g, Bulbus Fritillariae Thunbergii 600g.
Two, method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 2 times, and 1.5 hours 8 times of water gagings added 12 times of water gagings in 2.5 hours for the second time for the first time, collecting decoction, and being evaporated to density is 1.10 (50-60 ℃).Concentrated solution adds 98% ethanol, and making the supernatant concentration of alcohol is 80%, leaves standstill 36 hours, filters, and gets supernatant, and being evaporated to density is 1.10 (50-60 ℃).Bulbus Fritillariae Thunbergii, Flos Farfarae, Bulbus Lilii, Radix Asteris, Semen Armeniacae Amarum are 80% ethanol percolation with 20 times of amount concentration, receive percolate, and being evaporated to density is that 1.10 (50-60 ℃) merge above concentrated solution, and drying under reduced pressure or spray drying get extract powder 1998g.
Embodiment 5: the preparation Chinese medicine extract
. prescription: Rhizoma Anemarrhenae 1200g, Radix Scrophulariae 1200g, Pericarpium Papaveris 2400g, Radix Ophiopogonis 1200g, Flos Farfarae 3600g, Radix Asteris 1200g, Semen Armeniacae Amarum 1200g, Radix Stemonae 1200g, Bulbus Fritillariae Thunbergii 600g.
Two, method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 3 times, and 2 hours 8 times of water gagings added 12 times of water gagings in 2.5 hours for the second time for the first time, 1.5 hours for the third time 10 times of water gagings, and collecting decoction, being evaporated to density is 1.08 (50-60 ℃).Concentrated solution adds 95% ethanol, and making the supernatant concentration of alcohol is 70%, leaves standstill 20 hours, filters, and gets supernatant, and being evaporated to density is 1.08 (50-60 ℃).Bulbus Fritillariae Thunbergii, Flos Farfarae, Bulbus Lilii, Radix Asteris, Semen Armeniacae Amarum are 75% ethanol percolation with 18 times of amount concentration, receive percolate, and being evaporated to density is that 1.08 (50-60 ℃) merge above concentrated solution, and drying under reduced pressure or spray drying get extract powder 1540g.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1200g, Radix Scrophulariae 1200g, Pericarpium Papaveris 2400g, Radix Ophiopogonis 1200g, Flos Farfarae 3600g, Radix Asteris 1200g, Semen Armeniacae Amarum 1200g, Radix Stemonae 1200g, Bulbus Fritillariae Thunbergii 600g.
Two, method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 3 times, and each 2 hours, 8 times of water gagings for the first time, 10 times of water gagings for the second time, 14 times of water gagings for the third time, collecting decoction, being evaporated to density is 1.05 (50-60 ℃).Concentrated solution adds 95% ethanol, and making the supernatant concentration of alcohol is 75%, leaves standstill 30 hours, filters, and gets supernatant, and being evaporated to density is 1.05 (50-60 ℃).Bulbus Fritillariae Thunbergii, Flos Farfarae, Bulbus Lilii, Radix Asteris, Semen Armeniacae Amarum are 65% ethanol percolation with 15 times of amount concentration, receive percolate, and being evaporated to density is that 1.08 (50-60 ℃) merge above concentrated solution, and drying under reduced pressure or spray drying get extract powder 1638g.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Rhizoma Anemarrhenae 1200g, Radix Scrophulariae 1200g, Pericarpium Papaveris 2400g, Radix Ophiopogonis 1200g, Flos Farfarae 3600g, Radix Asteris 1200g, Semen Armeniacae Amarum 1200g, Radix Stemonae 1200g, Bulbus Fritillariae Thunbergii 600g.
Two, method for making: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae decoct with water 3 times, and each 2 hours, 8 times of water gagings were all used 10 times of water gagings for the second time, for the third time for the first time, collecting decoction, and being evaporated to density is 1.07 (50-60 ℃).Concentrated solution adds 95% ethanol, and making the supernatant concentration of alcohol is 70%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to density is 1.06 (50-60 ℃).Bulbus Fritillariae Thunbergii, Flos Farfarae, Bulbus Lilii, Radix Asteris, Semen Armeniacae Amarum are 60% ethanol percolation with 15 times of amount concentration, receive percolate, and being evaporated to density is that 1.08 (50-60 ℃) merge above concentrated solution, and drying under reduced pressure or spray drying get extract powder 1897g.
Embodiment 8: the preparation capsule
Get drug extract (active component) 100g that embodiment 1 prepares, add starch 15g, Pulvis Talci 1g uses 80% alcohol granulation, the fill capsule.Every is 0.18g.
Embodiment 9: the preparation tablet
Get drug extract (active component) 100g that embodiment 3 prepares, add starch 10g, cross-linked pvp 5g, tabletting gets tablet, and every is 0.45g.
Embodiment 10: zoopery one
One. material and method:
Ermuansou ball (lot number 090201), reaching core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin provides.
Ermuansou sheet (lot number: 081025), provide along banyan pharmaceutical factory by new Pharmaceutical limited company is grand in the Tianjin.
Ermuansou syrup (lot number: 080301), provide along banyan development pharmaceutical Co. Ltd by Tianjin is grand.
Animal: the ICR mice, 18-22g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
Ammonium chloride (lot number: 080036): dragon Xinghua, Asia-Pacific, Tianjin worker's company limited
Urethane (lot number: 081215): chemical industry company limited far away in the permanent industry in Beijing
Get 84 of healthy ICR rats, divide 7 groups at random, labelling is got embodiment 1 gained active component, is made into the extract dosage respectively and is equivalent to 4.5g crude drug/kg and 9.0g crude drug/kg.Getting Ermuansou ball, Ermuansou sheet and Ermuansou syrup all is made into dosage and is equivalent to 4.5g crude drug/kg and irritates stomach, successive administration 5 days.Each organizes after the last administration 1 hour, urethane 1.0g/kg intraperitoneal injection of anesthesia, dorsal position is fixed, cut off skin of neck, separate trachea, insert one of 6cm long capillary between thyroid lower edge two cartilaginous rings, its smooth end in contact inner surface of trachea is drawn sputum, the back replacing is one in sputum is full of capillary tube.Per hour the sputum secretory volume is as the index of estimating the medicine phlegm-dispelling functions with sputum length computation that capillary tube is drawn, and experimental data is added up with variance analysis.
Two. result: see Table.
The influence to the rat phlegm-dispelling functions in five days of table 1 Ermuansou extract successive administration (x ± s)
Compare with model control group,
*P＜0.05,
*P＜0.01
The result shows: the Ermuansou extract compares P＜0.01 with the blank group under 4.5g/kg and 9.0g/kg dosage, utmost point significant difference is arranged, point out extract of the present invention can obviously increase the sputum secretory volume of rat trachea, and present certain dose-effect relationship, this extract and ball, sheet, each former dosage form Isodose of syrup are relatively, its phlegm-dispelling functions has the trend that is better than former dosage form, and the few advantage of dose is arranged.
Embodiment 11: zoopery two
One. material and method
Ermuansou ball (lot number 090201), reaching core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin provides.
Ermuansou sheet (lot number: 081002), provide along banyan pharmaceutical factory by new Pharmaceutical limited company is grand in the Tianjin.
Ermuansou syrup (lot number: 081205) provide along banyan development pharmaceutical Co. Ltd by Tianjin is grand.
Animal: Cavia porcellus, 180-200g, male and female half and half provide credit number by the flourish holy pool breed resultant field of practicing in Shanghai: SCXK (Shanghai) 2002-0012.
Aminophylline sheet (lot number: 090105): Tianjin Lisheng Pharmaceutical Co., Ltd.
Histamine phosphate standard substance (lot number: 081146): Nat'l Pharmaceutical ﹠ Biological Products Control Institute
Instrument: YLS-8A is multi-functional to be lured to breathe heavily to draw and breathes heavily instrument, and medical science equipment station, Shandong Province produces.
Selection is drawn and is breathed heavily 56 of the Cavia porcelluss that asthma attack in the test is no more than 120sec, divides 7 groups at random, and labelling is got embodiment 2 gained active component, is made into the extract dosage respectively and is equivalent to 4.5g crude drug/kg and 9.0g crude drug/kg.Get Ermuansou ball, Ermuansou sheet and Ermuansou syrup and all be made into dosage and be equivalent to 4.5g crude drug/kg and irritate stomach, successive administration 5 days, aminophylline is in experiment administration on the same day 1 time.Each organizes after the last administration 1 hour, put into respectively YLS-8A multi-functional lure to breathe heavily to draw breathe heavily instrument, the 0.4% histamine phosphate aerosol of spraying, record Cavia porcellus asthma incubation period (fall with tic and be as the criterion by asthma, the 5min person of keeping one's legs is designated as 360sec incubation period), experimental data is added up with variance analysis.
Two. result: see Table two.
Table two: the Ermuansou extract administration influence to the Cavia porcellus antiasthmatic effect in five days
With compare before the administration
*P＜0.01,
*P＜0.05; Compare ##P＜0.01 with model control group, #P＜0.05;
Compare Δ P＜0.05 with Ermuansou ball, sheet, the former dosage form group of syrup
The result shows: the Ermuansou extract is low, P＜0.01 relatively before high dose group and the administration, and utmost point significant difference is arranged, and points out this extract all to breathe heavily than drawing before the administration and obviously prolongs incubation period.Extract is low, high dose group and model control group P＜0.01 relatively, and utmost point significant difference is arranged; Under Isodose (4.5g/kg), extract and ball, sheet, each former dosage form of syrup be P＜0.05 relatively, and significant difference is arranged, and its antiasthmatic effect of extract that prompting is revised after the technology is better than each former dosage form.
Claims (10)
1. the Chinese medicine composition of a removing heat from the lung and dissipating phlegm relieving cough, relieving asthma, it is characterized in that: its active component is made by the raw material of following parts by weight: 120 parts of the Rhizoma Anemarrhenaes, 120 parts of Radix Scrophulariaes, 240 parts of Pericarpium Papaveriss, 120 parts of Radix Ophiopogonis, 360 parts of Flos Farfaraees, 120 parts of Radix Asteriss, 120 parts of Semen Armeniacae Amarums, 120 parts of the Radixs Stemonae, 60 parts of Bulbus Fritillariae Thunbergiis.
2. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 1, it is characterized in that: described active component adopts following method to prepare: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 6-14 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; It is the ethanol of 90-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 12-36 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; The concentration of volume percent that Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured with 10-20 is the 60%-80% ethanol percolation, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
3. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 2, it is characterized in that: described active component adopts following method to prepare: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 8-10 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is the ethanol of 95-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 20-30 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured the ethanol percolation that concentration of volume percent is 60%-80% with 10-20, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
4. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 3, it is characterized in that: described active component adopts following method to prepare: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Concentrated solution adding concentration of volume percent is 95% ethanol, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are the ethanol percolation of 60%-80% with 15 times of amount concentration of volume percent, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
5. according to the Chinese medicine composition of any one described a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma in the claim 1 to 4, it is characterized in that: described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 5 is characterized in that: described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, vitamin C, cysteine, citric acid and the sodium sulfite.
7. the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 5 is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of the described a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma of claim 1 is characterized in that: take by weighing 120 parts of the Rhizoma Anemarrhenaes, 120 parts of Radix Scrophulariaes, 240 parts of Pericarpium Papaveriss, 120 parts of Radix Ophiopogonis, 360 parts of Flos Farfaraees, 120 parts of Radix Asteriss, 120 parts of Semen Armeniacae Amarums, 120 parts of the Radixs Stemonae, 60 parts of Bulbus Fritillariae Thunbergiis; Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 6-14 times of water gaging and decoct 2-3 time, and each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; It is the ethanol of 90-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 12-36 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; The concentration of volume percent that Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured with 10-20 is the 60%-80% ethanol percolation, receives percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.03-1.10; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
9. the preparation method of the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 8, it is characterized in that: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 8-10 times of water gaging and decoct 2-3 time, each 1-3 hour, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; It is the ethanol of 95-98% that concentrated solution adds concentration of volume percent, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 20-30 hour, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are doubly measured the ethanol percolation that concentration of volume percent is 60%-80% with 10-20, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
10. the preparation method of the Chinese medicine composition of a kind of removing heat from the lung and dissipating phlegm relieving cough, relieving asthma according to claim 8, it is characterized in that: Radix Scrophulariae, Radix Ophiopogonis, Pericarpium Papaveris, the Rhizoma Anemarrhenae add 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction, being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Concentrated solution adding concentration of volume percent is 95% ethanol, and making supernatant ethanol concentration of volume percent is 60-80%, leaves standstill 24 hours, filters, and gets supernatant, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Bulbus Fritillariae Thunbergii, Flos Farfarae, the Radix Stemonae, Radix Asteris, Semen Armeniacae Amarum are the ethanol percolation of 60%-80% with 15 times of amount concentration of volume percent, receive percolate, and being evaporated to 50-60 ℃ of condition lower density is 1.05-1.08; Merge above concentrated solution, drying under reduced pressure or spray drying get extract powder.
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| CN107375801A (en) * | 2017-08-18 | 2017-11-24 | 何智 | Phthisical composition of clearing lung-heat heat cure and preparation method thereof |
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| CN107375801A (en) * | 2017-08-18 | 2017-11-24 | 何智 | Phthisical composition of clearing lung-heat heat cure and preparation method thereof |
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