CN102057942A - Emamectin benzoate and kadethrine compound insecticide - Google Patents
Emamectin benzoate and kadethrine compound insecticide Download PDFInfo
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- CN102057942A CN102057942A CN2011100063863A CN201110006386A CN102057942A CN 102057942 A CN102057942 A CN 102057942A CN 2011100063863 A CN2011100063863 A CN 2011100063863A CN 201110006386 A CN201110006386 A CN 201110006386A CN 102057942 A CN102057942 A CN 102057942A
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- emamectin
- benzoate
- kadethrin
- insecticide
- effective active
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- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 title claims abstract 12
- 239000002917 insecticide Substances 0.000 title abstract description 15
- -1 kadethrine compound Chemical class 0.000 title abstract 4
- UGWALRUNBSBTGI-ZKMZRDRYSA-N kadethrin Chemical compound C(/[C@@H]1C([C@@H]1C(=O)OCC=1C=C(CC=2C=CC=CC=2)OC=1)(C)C)=C1/CCSC1=O UGWALRUNBSBTGI-ZKMZRDRYSA-N 0.000 claims abstract description 51
- 239000003814 drug Substances 0.000 claims abstract description 45
- 239000002904 solvent Substances 0.000 claims abstract description 17
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 14
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Abstract
The invention relates to emamectin benzoate and kadethrine compound insecticide which comprises an effective active component, an auxiliary agent and a solvent. The emamectin benzoate kadethrine compound insecticide is characterized in that the effective active component accounts for 0.5-60 percent by weight of finished medicament; and the effective active component comprises emamectin benzoate and kadethrine, wherein the emamectin benzoate accounts for 0.1-90 percent by weight of the effective active component. The emamectin benzoate and kadethrine compound insecticide has the advantages of obviously improving effect compared with the traditional single insecticide after the kadethrine and the emamectin benzoate are compounded, greatly improving the activity of the insecticide, expanding the insecticidal spectrum, retarding the medicament resistance of pests and greatly reducing the medicament cost; and because two medicaments in the effective active component have the characteristic of easy degradation, the compounded insecticide is easier to degrade in environment, thereby reducing pollution and insecticide residual.
Description
Technical field
The invention belongs to the agricultural chemicals of control pest, the compounded pesticides that to relate to a kind of effective active composition be emamectin-benzoate and kadethrin.
Background technology
Agricultural production provides guarantee for the mankind's basic existence; plant protection is the most general in an agricultural production farming activities; spray chemical pesticide and then be in the plant protection means to the control of pests such as disease, worm, grass evil the most fast, the effective means of economy the most, irreplaceable in the foreseeable period of history.China dry crop mainly contains vegetables, tealeaves, fruit tree, cotton, corn, wheat class, herbage etc.These dry crops all can be subjected to pest invasion and attack in various degree such as disease Chinese caterpillar fungus in its process of growth, for output and the quality of crop all increases, will use agricultural chemicals inevitably.
Along with the progress of expanding economy and society, because the production of activity of human beings, especially industrial or agricultural, global environment pollutes more and more serious, has had a strong impact on people's healthy and normal life.Therefore, environmental pollution and environmental protection have been put on agenda; Along with a large amount of uses of agrochemicals such as chemical fertilizer, agricultural chemicals, harmful substance is assembled in soil and water body, and enters in crops and the livestock body.These all can influence human food's production, and the various harm that environmental resource, food and health are produced increasingly sharpen.Agricultural chemicals is to the pollution of agricultural product, and is main by due to the toxicity of residue of pesticide.General agricultural chemicals is more or less all toxic, behind a large amount of applying pesticides, has sub-fraction to be attached on the agricultural product surface, plays prevention and elimination of disease and pests; And major part is scattered in the soil, and wherein a part makes its conversion by a series of external environmental condition and action of microorganisms, decomposes and even disappearance; Remainder is water-soluble back by root absorption, but still has the small part residue of pesticide in soil, or remains in the agricultural product body, forms the harm of residue of pesticide toxicity, or in the water that permeates the ground.Therefore, the residual quantity of restriction agricultural chemicals, formulation residue of pesticide permission standard is that agricultural chemicals uses and the effective measures of managing with the agricultural chemicals that filters out low toxicity and low residue.
For a long time, people mainly rely on organic insecticide and prevent and treat the use of these crop pests, particularly single agricultural chemicals and cause it that various insecticides are produced in various degree resistance inevitably.The insecticide that pyrethroid pesticide is that a class has efficiently, be easy to decompose in the low toxicity, environment.To insect have repellent, knock down, effect such as poisoning.Because the breaking out of insect, repeatedly, during heavy dose of medication, insects such as diamond-back moth, cabbage caterpillar, cotton bollworm are speeded to above single agent resistance development speed.
(emamectin benzoate CAS:137512-74-4) contains two active principles of B1a and B1b to emamectin-benzoate, is that to be raw material by Avermectin modify a kind of macrolides compound that obtains through chemical constitution.Mechanism of action is by activating m receptor in the polypide muscle, makes polypide muscle that spastic contraction take place and causes the paralysis paralysis and excrete.Mainly be stomach poison function, have certain action of contace poison concurrently.Emamectin-benzoate is applicable to prevents and treats Lepidoptera, Homoptera, coleoptera and other insects on cotton, vegetables, the tobacco.As: cotton-plant pest-insects cotton bollworm, the double control of controlling cotten aphid, thrips; The control of vegetable-crop pest-insect cabbage caterpillar, black peach aphid, diamond-back moth; The control of peanut, soybean insect geometrid moth, beans first, ceiling light moth, leafhopper.And easily degraded noresidue is free from environmental pollution in soil and environment, in the routine dose scope to useful insect and natural enemy, people, animal safety, can with most of combined use of pesticides.
Kadethrin (kadethrine CAS:58769-20-3), is mainly used in the control sanitary insect pest, and higher knockdown effect is arranged, thus often kill active combined use of pesticides with having, but poor heat stability.
Agriculture chemical compounding is to improve preventive effect and expanding prevention object, slow down pest resistance to insecticide, reduce a kind of effective ways that pollute, reduce residue of pesticide, at present, yet there are no report at the compounded pesticides of emamectin-benzoate and kadethrin.
Summary of the invention
The objective of the invention is to: higher and make insect produce problems such as resistance easily at emamectin-benzoate and kadethrin list agent use cost, a kind of compounded pesticides by emamectin-benzoate and kadethrin is provided.
The object of the present invention is achieved like this: a kind of emamectin-benzoate kadethrin compounded pesticides, comprise effective active component, auxiliary agent and solvent, it is characterized in that: the percentage by weight that the effective active composition accounts for the finished product medicament is 0.5～60%, described effective active composition is made up of emamectin-benzoate and kadethrin, and the percentage by weight of emamectin-benzoate in the effective active composition is 0.1～90%.
In the compounded pesticides that the present invention relates to: the percentage by weight of auxiliary agent and solvent is respectively 5～40% and 5～93% in the finished product medicament.
In the compounded pesticides that the present invention relates to: described auxiliary agent is the conventional auxiliary agent of preparation missible oil or microemulsion or aqueous suspension agent agricultural chemicals; Described solvent is the conventional solvent of preparation missible oil or microemulsion or aqueous suspension agent agricultural chemicals.
In the compounded pesticides that the present invention relates to: the formulation of described finished product medicament is missible oil or microemulsion or aqueous suspension agent.
The invention has the advantages that: with pyrethroid insecticides kadethrin and big lopps ester insecticides emamectin-benzoate carry out composite after, compare with existing single agent use, notable synergistic, improved insecticidal activity greatly, enlarged insecticidal spectrum, slow down pest resistance to insecticide, reduced drug cost significantly; Owing to kadethrin, this two classes medicament of emamectin-benzoate all have the characteristic of easy degraded, emamectin-benzoate kadethrin compounded pesticides is more easily degraded in environment, has reduced pollution, has reduced residue of pesticide simultaneously.
Embodiment
Below the medicament that relates among each embodiment by the former medicine preparation of the former medicine and 90% kadethrin of 97% emamectin-benzoate.
Embodiment 1:
The preparation of 5% emamectin-benzoate kadethrin missible oil (the former medicine of emamectin-benzoate is 1: 4 with the ratio of the former medicine weight of kadethrin in the active drug composition):
Auxiliary agent is selected: DMF, farming breast 0206, farming breast 2201.
Solvent is selected: toluene.
Each component is got the raw materials ready according to percentage by weight by following:
Emamectin-benzoate: 1%; Kadethrin: 4%; DMF 5%; The newborn 1205:5% of farming; The newborn 0206:5% of farming; Solvent: toluene adds to 100g.
Preparation process: with the kadethrin acetone solution, add emamectin-benzoate, DMF more successively, farming breast 1205, farming breast 0206, be filled to 100% with toluene then, with said mixture volumetric flask mix 5% emamectin-benzoate kadethrin missible oil.
Embodiment 2:
The preparation of 10% emamectin-benzoate kadethrin aqueous suspension agent (the former medicine of emamectin-benzoate is 1: 9 with the ratio of the former medicine weight of kadethrin in the active drug composition):
Auxiliary agent is selected: sodium lignin sulfonate, OP-10; CMC; Organic silicone; Ethylene glycol.
Solvent is selected: water.
Each component is got the raw materials ready according to following percentage by weight:
Emamectin-benzoate: 1%; Kadethrin: 9%; Sodium lignin sulfonate: 10.0%; OP-10:5.0%; Thickener CMC:1.0%; Defoamer organic silicone: 0.01%; Antifreeze glycol: 8.0%; Water: add to 100g.
Preparation process: emamectin-benzoate, kadethrin, sodium lignin sulfonate, OP-10, thickener CMC, defoamer organic silicone, antifreeze glycol are placed reactor according to the above ratio, water adds to 100% and mixes, and mixture being introduced be milled to the material fineness in the sand mill again is 1～5 μ m; Mix after milling aqueous suspension agent.
Embodiment 3:
The preparation of 2% emamectin-benzoate kadethrin microemulsion (emamectin-benzoate is 1: 1 with the ratio of the former medicine weight of kadethrin in the active drug composition):
Emamectin-benzoate 1%, kadethrin 1%, solvent 5～20%, cosolvent 1～10%, emulsifier 5～30%, water supplies 100%.
Compound method: the former medicinal solvent of said components, cosolvent dissolving, the adding emulsifier is even, adds entry at last under stirring, obtains the product of homogeneous phase transparent.
Embodiment 4:
The test soup:
The former medicine of 97% emamectin-benzoate;
The former medicine of 90% kadethrin;
Emamectin-benzoate and kadethrin be mixed (ratio of weight is 1: 1).
For the examination insect: 2 age diamond-back moth and cabbage caterpillar larva (Jiangsu Province Agriculture Science Institute indoor feeding);
Assay method: dip method.
Test method:
1) former medicine of emamectin-benzoate and the former medicine of kadethrin are measured respectively the virulence of diamond-back moth: above-mentioned single agent and composite dose of test soup are diluted to 5 concentration gradients respectively, with 2 age diamondback moth larvae or 20 of cabbage caterpillar larvas immersed in the soup of each concentration gradient 15 seconds, take out and dry then, insert then and be placed with in the culture dish of fresh pollution-free dish leaf 3 repetitions of every processing.Handle in contrast with clear water simultaneously.Check the borer population of living after 24 hours, the calculation correction lethality is calculated the lethal concentration of 50 (LC with concentration logarithm value and dead probability value
50).LC by single agent and composite dose
50Calculate co-toxicity coefficient CTC, the result is referring to table 1.
Each single agent of table 1 and composite dose of toxicity test to diamond-back moth
2) former medicine of emamectin-benzoate and the former medicine of kadethrin are measured respectively the virulence of cabbage caterpillar: above-mentioned single agent and composite dose of test soup are diluted to 5 concentration gradients respectively, with 2 age diamondback moth larvae or 20 of cabbage caterpillar larvas immersed in the soup of each concentration gradient 15 seconds, take out and dry then, insert then and be placed with in the culture dish of fresh pollution-free dish leaf 3 repetitions of every processing.Handle in contrast with clear water simultaneously.Check the borer population of living after 24 hours, the calculation correction lethality is calculated the lethal concentration of 50 (LC with concentration logarithm value and dead probability value
50).LC by single agent and composite dose
50Calculate co-toxicity coefficient CTC, the result is referring to table table 2.
Each single agent of table 2 and composite dose of toxicity test to cabbage caterpillar
In the present embodiment, the calculating of co-toxicity coefficient is with reference to the abundant method of Sun Yun, that is:
The LC of toxicity index (TI)=standard medicament
50The LC of value/reagent agent
50Value * 100;
The LC of actual toxicity index (the ATI)=A medicament of mixture (M)
50The LC of value/M medicament
50Value * 100;
B%+...... in the TI * M medicament of A%+B medicament in the TI * M medicament of theoretical toxicity index (the TTI)=A medicament of mixture (M);
The co-toxicity coefficient of mixture (CTC)=ATI/TTI * 100;
CTC＞100 expressions have synergistic effect; CTC=100 is a summation action; CTC＜100 are antagonism.
By table 1 and table 2 as seen, after emamectin-benzoate and kadethrin are mixed, diamond-back moth and cabbage caterpillar all there is synergistic effect.
Embodiment 5:
The contrast agricultural chemicals
20% kadethrin missible oil (self-control according to a conventional method);
1% emamectin-benzoate water dispersant (self-control according to a conventional method).
1) 5% emamectin-benzoate kadethrin missible oil (embodiment 1 provides) is to the field efficiency test of diamond-back moth drug effect:
Field trial is carried out in the experimental field, Jiangsu Province Agriculture Science Institute.5 processing are established in test altogether, are provided with 1 simultaneously and are blank, and every processing repeats for 4 times, and every the repetition is a sub-district, every sub-district area 20m
2, amounting to 24 sub-districts, district's group is arranged at random.With the conventional dispenser of MATABA manual sprayer, use amount of liquid medicine 50Kg for every mu.5 samplings in every sub-district, every some fixed point is looked into 3 strains, totally 15 strains, investigation complete stool diamond-back moth radix.Investigation insect population radix before the medicine was investigated residual worm amount, calculation correction preventive effect in 2 days, 5 days behind the medicine.Adopt the new multipole difference of Deng Kenshi Duncan method that test data is analyzed (seeing Table 3).
Table 3 5% emamectin-benzoate kadethrin missible oil control diamond-back moth field test results
2) 2% emamectin-benzoate kadethrin microemulsion (embodiment 3 provides) is to the field efficiency test of cabbage caterpillar: field trial is carried out in the experimental field, Jiangsu Province Agriculture Science Institute.5 processing are established in test altogether, are provided with 1 simultaneously and are blank, and every processing repeats for 4 times, and every the repetition is a sub-district, every sub-district area 20m
2, amounting to 24 sub-districts, district's group is arranged at random.With the conventional dispenser of MATABA manual sprayer, use amount of liquid medicine 50Kg for every mu.5 samplings in every sub-district, every some fixed point is looked into 3 strains, totally 15 strains, investigation complete stool diamond-back moth radix.Investigation insect population radix before the medicine was investigated residual worm amount, calculation correction preventive effect in 2 days, 5 days behind the medicine.Adopt the new multipole difference of Deng Kenshi Duncan method that test data is analyzed (seeing Table 4).
The field test results of table 4 2% emamectin-benzoate kadethrin microemulsion control cabbage caterpillar
Embodiment 6:
The 10% residual test in emamectin-benzoate kadethrin aqueous suspension agent field:
Tested agricultural chemicals:
10% emamectin-benzoate kadethrin aqueous suspension agent (embodiment 2 provides);
The contrast agricultural chemicals:
10% kadethrin missible oil (self-control according to a conventional method);
1% emamectin-benzoate missible oil (self-control according to a conventional method).
Test method: field trial is carried out in the experimental field, Jiangsu Province Agriculture Science Institute.10% emamectin-benzoate kadethrin aqueous suspension agent, 10% kadethrin missible oil, 1% emamectin-benzoate missible oil are pressed 10ml/ mu, 5ml/ mu, the dispenser of 10ml/ mu respectively, and trial crops is green vegetables.The residual quantity of kadethrin and emamectin-benzoate is used gas chromatograph and the analysis of LC-MS instrument respectively.Utilize first _ order kinetics equation formula C
t=C
0e
-rtCalculate the half life period.Residual result of the test sees Table 5.As seen the present invention has reduced the residual of agricultural chemicals relatively.
The half life period of each medicament of table 5 on green vegetables
The various embodiments described above are not limitations of the present invention, during concrete enforcement, in the finished product medicament, the effective active composition is 0.5～60%, auxiliary agent is 5～40%, and solvent is 5～93%, wherein, the effective active composition is made up of emamectin-benzoate and kadethrin, and wherein the percentage by weight of emamectin-benzoate in the effective active composition is 0.1～90%.Described auxiliary agent and solvent can adopt traditional auxiliary agent and solvent to be mixed with missible oil, or microemulsion, or aqueous suspension agent.
Have for emamectin-benzoate and the agent of kadethrin list and to kill other active dry crop insects, the present invention has stronger insecticidal activity equally.
Claims (4)
1. emamectin-benzoate kadethrin compounded pesticides, comprise effective active component, auxiliary agent and solvent, it is characterized in that: the percentage by weight that the effective active composition accounts for the finished product medicament is 0.5～60%, described effective active composition is made up of emamectin-benzoate and kadethrin, and wherein the percentage by weight of emamectin-benzoate in the effective active composition is 0.1～90%.
2. emamectin-benzoate kadethrin compounded pesticides according to claim 1, it is characterized in that: the percentage by weight of auxiliary agent and solvent is respectively 5～40% and 5～93% in the finished product medicament.
3. emamectin-benzoate kadethrin compounded pesticides according to claim 1 and 2 is characterized in that: described auxiliary agent is the conventional auxiliary agent of preparation missible oil or microemulsion or aqueous suspension agent agricultural chemicals; Described solvent is the conventional solvent of preparation missible oil or microemulsion or aqueous suspension agent agricultural chemicals.
4. emamectin-benzoate kadethrin compounded pesticides according to claim 3 is characterized in that: the formulation of described finished product medicament is missible oil or microemulsion or aqueous suspension agent.
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| CN 201110006386 CN102057942B (en) | 2011-01-13 | 2011-01-13 | Emamectin benzoate and kadethrine compound insecticide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103109846A (en) * | 2013-03-13 | 2013-05-22 | 山东省农业科学院中心实验室 | Dichlorovos kadethrine compounded pesticide |
| CN106135276A (en) * | 2016-06-22 | 2016-11-23 | 赵思璐 | A kind of compositions preventing and treating Semen sojae atricolor red spider and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010025870A1 (en) * | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Synergistic combinations of thiadiazol carbonic acid derivatives |
| CN101796949A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Plant insecticidal protective agent and application thereof |
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010025870A1 (en) * | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Synergistic combinations of thiadiazol carbonic acid derivatives |
| CN101796949A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Plant insecticidal protective agent and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103109846A (en) * | 2013-03-13 | 2013-05-22 | 山东省农业科学院中心实验室 | Dichlorovos kadethrine compounded pesticide |
| CN103109846B (en) * | 2013-03-13 | 2014-08-27 | 山东省农业科学院农业质量标准与检测技术研究所 | Dichlorovos kadethrine compounded pesticide |
| CN106135276A (en) * | 2016-06-22 | 2016-11-23 | 赵思璐 | A kind of compositions preventing and treating Semen sojae atricolor red spider and preparation method thereof |
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| CN102057942B (en) | 2013-07-10 |
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