CN102057930B - Bactericidal composition containing fenbuconazole and thiocarbamate compound - Google Patents
Bactericidal composition containing fenbuconazole and thiocarbamate compound Download PDFInfo
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- CN102057930B CN102057930B CN201110025432.4A CN201110025432A CN102057930B CN 102057930 B CN102057930 B CN 102057930B CN 201110025432 A CN201110025432 A CN 201110025432A CN 102057930 B CN102057930 B CN 102057930B
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- mancozeb
- zineb
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- carbatene
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Abstract
The invention discloses a bactericidal composition containing fenbuconazole and a thiocarbamate compound. The bactericidal composition contains an active ingredient A and an active ingredient B, wherein the active ingredient A is fenbuconazole, the active ingredient B is selected from any one of the following bactericides: mancozeb, propineb, zineb and thioneb, and the weight percentage ratio of the active ingredient A to the active ingredient B is (1-40%): (1-80%). The composition can control various crop diseases, such as alternaria mali, cladosporium cucumerinum, leaf spot, powdery mildew, ring spot, rust disease, leaf blight, anthracnose, downy mildew, brown blotch and plague, has remarkable synergistic action, has high safety to crops and has the advantages of resistance to rain scouring, lasting drug effect, small dosage and the like.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of preparation and application of the bactericidal composition that contains two active components.
Background technology
RH-7592, English name: fenbuconazole, molecular formula: C
19h
17clN
4, chemical name: 4-(4-chlorphenyl)-2-phenyl-2 (1H-1,2,4-triazol-1-yl methyl) butyronitrile, structural formula:
RH-7592 belongs to sterol demethylation inhibitor, and inner sucting conduction type bactericide can suppress the elongation of pathogen mycelia, stops the germ spore having germinateed to be invaded and makes fabric texture.Germ, use latent period, can stop the growth of germ, after morbidity, use, can make spore distortion of future generation, lose continuation contagion probability, to disease, existing thick anti-effect has again therapeutic action.
Mancozeb (mancozeb), chemical name: the complex salt of the two two thiocarbamoyl manganese of ethylene and zinc, molecular formula: C
4h
6n
2s
4mnZn, mancozeb is the wider protective fungicide of a kind of fungicidal spectrum.It is mainly the oxidation that suppresses pyruvic acid in thalline.Effective to multiple diseases such as the anthracnose on fruit tree, vegetables, early blight, simultaneously its normal and systemic fungicide is mixed, for the generation of delaying drug resistance.
Propineb (propineb), chemical name: acrylic bisdithiocarbamic zinc, molecular formula: (C
5h
8n
2s
4zn)
x, Propineb acts on the synthetic of fungal cell wall and protein, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.And this medicine contains and is easy to zinc element absorbed by crops, the quality that is conducive to promote plant growth and improves fruit.
Zineb (zineb), chemical name: zinc ethylenebisdithiocarbamate, molecular formula: C
4h
6n
2s
4zn, zineb is the protectant that a kind of foliage spray is used, and many germs are had to stronger action of contace poison as Pseudoperonospora cubensis, late disease bacteria and anthrax bacteria etc.To plant safety, active ingredient chemical property is more active, in water, be easily oxidized to different thiocyanation compound, enzyme to contain-SH of cause of disease thalline base has strong inhibitory action, and the direct kill pathogens spore of energy, suppress the germination of spore, stop in germ invaded plants body, but very little to the mycelial lethal effect of cause of disease in invaded plants body.Therefore, use zineb to prevent and treat disease and should rest in the disease phase of beginning to see and carry out, just can obtain good effect.The drug effect phase of zineb is short, decomposes comparatively fast approximately 7 days its longevities of residure at solar radiation and after absorbing airborne moisture.
Carbatene (metriam), chemical name: two (the two thiocarbamate esters) zinc (2+) of three [ammonia] ethene)] [8-connects dithione for tetrahydrochysene-Isosorbide-5-Nitrae, 7-bis-thiophene diazocine-3], polymer.Carbatene is a kind of good protective fungicide, belongs to low-toxin farm chemicals.Because its bactericidal range is wide, be difficult for generation resistance, control efficiency is obviously better than other same series bactericidal agents, so consumption is large tonnage product in the world always.The substitute products of current other protective fungicides; domestic most composite bactericide is all formulated with mancozeb processing; but MnZn preparation can cause that crop trace element accumulation is poisoning; by field in recent years applying; remarkable to preventing and treating pear scab, alternaria leaf spot of apple, vegetable category epidemic disease, downy mildew, field crop rust texts; without other any bactericide, can effectively control disease completely and occur, steady quality, reliable.
Summary of the invention
The long-term use of RH-7592 single dose may bring degradation problem under resistance generation, drug effect.The present invention proposes a kind of bactericidal composition that contains RH-7592 and thiocarbamates compound, it is characterized in that: the percentage by weight of A, two kinds of active components of B is 1～40%: 1～80%, described A component is RH-7592, and B component is selected from a kind of in mancozeb, Propineb, zineb or Carbatene.
The described bactericidal composition that contains RH-7592, is characterized in that: the percentage by weight of A, two kinds of active components of B is 3～30%: 5～75%.
The described bactericidal composition that contains RH-7592, is characterized in that: the percentage by weight of RH-7592 and mancozeb is 5～20%: 10～60%.
The described bactericidal composition that contains RH-7592, is characterized in that: the percentage by weight of RH-7592 and Propineb is 5～20%: 10～60%.
The described bactericidal composition that contains RH-7592, is characterized in that: the percentage by weight of RH-7592 and zineb is 5～20%: 10～60%.
The described bactericidal composition that contains RH-7592, is characterized in that: the percentage by weight of RH-7592 and Carbatene is 5～20%: 10～60%.
The amount of application when content of active component depends on independent use in the present composition, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in composition, active weight percentage is gross weight 0.5～90%, is preferably 5%～85%.According to different preparation types, active component content scope is different.Conventionally, liquid preparation contains 1～70% active substance by weight, is preferably 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, is preferably 10～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, can also contain stabilizing agent known in those skilled in the art, antifreeze etc.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described disintegrant is selected from: one or more in sodium bicarbonate, sodium carbonate, bentonite, urea, ammonium sulfate, aluminium chloride.
Described wetting agent is selected from: lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, tea are withered, one or more in silkworm excrement, soapberry powder.
Described thickener is selected from: one or more in xanthans, gelatin, gum Arabic, melon glue, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, diethylene glycol (DEG), triethylene glycol, polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10aliphatic alcohols, C
10～20one or more in saturated fat acids (as capric acid) and acid amides, silicone oil, silicone compound.
Described emulsifier is selected from: agriculture breast 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 400# (benzyl dimethyl phenol polyoxy ethyl ether), agriculture breast 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), agriculture breast 36# (phenethyl fluosite polyoxy ethyl ether), agriculture breast 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), agriculture breast 33# (alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Described stabilizing agent is selected from: one or more in BHT, triphenyl phosphite, epoxychloropropane, tributyl phosphate, triethanolamine, diethanol amine, monoethanolamine.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by common processing method, after being about to active substance and mixing with liquid flux or solid carrier, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, adhesive, defoamer, stabilizing agent etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein comparatively preferably RH-7592 and mancozeb are processed into wetting powder, water dispersible granules, suspending agent or suspension emulsion; RH-7592 and Propineb are processed into wetting powder, water dispersible granules; RH-7592 and zineb are processed into wetting powder, water dispersible granules, suspending agent or suspension emulsion; RH-7592 and Carbatene are processed into wetting powder, water dispersible granules, suspending agent or suspension emulsion.
When making wetting powder, composition comprises following constituent content: RH-7592 1～40%, effective active composition B 1～80%, dispersant 5～10%, wetting agent 2～10%, filler 8～91%.
The former medicine of RH-7592, the former medicine of effective active composition B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: RH-7592 1～40%, effective active composition B 1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～92%.
The former medicine of RH-7592, the former medicine of effective active composition B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make the water dispersible granules product of the present composition.
When making suspending agent, composition comprises following constituent content: RH-7592 1～20%, effective active composition B 1～40%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, deionized water adds to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add the former medicine of RH-7592, the former medicine of effective active composition B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make the suspending agent product of the present composition.
When making suspension emulsion, composition comprises following constituent content: RH-7592 1～20%, effective active composition B 1～40%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formulation material are mixed through high speed shear, add the former medicine of effective active composition B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make effective active composition B suspending agent, then by the former medicine of RH-7592, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make the suspension emulsion product of the present composition.
The described bactericidal composition that contains RH-7592 and active component B is for preventing and treating sub-Gammaproteobacteria, disease due to the germ of Basidiomycetes and Fungi Imperfecti, can be used for for example being permitted various crop: fruit tree, wheat, cucumber, grape, vegetables and flowers and paddy rice, prevent and treat Basidiomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny are especially to basidiomycetes, the microbial disease of imperfect fungus and ascus is as spot defoliation, scab, leaf spot, powdery mildew, ring spot, rust, leaf blight, anthracnose, downy mildew, brown spot, the plant diseases such as epidemic disease have good preventive effect.
Beneficial effect of the present invention: (1) is because the mechanism of action of single dose in said composition is different, there is not the problem of cross resistance, so, the application of said composition can reach and delay the drug-fast generation of pathogen and development, contribute to extend the result of use of this medicament, reduce the object that pesticide resistance produces probability.(2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) with an organic solvent dosage is few in the present invention, is difficult for producing poisoning, is convenient to transportation and storage, has improved safety, and being mixed will be lower, safer on the impact of environment.(4) present composition has expanded fungicidal spectrum, and the plant diseases such as spot defoliation, scab, leaf spot, powdery mildew, ring spot, rust, leaf blight, anthracnose, downy mildew, brown spot, epidemic disease are had to special efficacy.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 55% RH-7592 mancozeb wettable powder
RH-7592 5%, mancozeb 50%, polyoxyethylene carboxylate 7%, wetting and penetrating agent F 6%, starch add to 100%, and mixture carries out air-flow crushing, make 55% RH-7592 mancozeb wettable powder.
Example 2 70% RH-7592 mancozeb wettable powders
RH-7592 10%, mancozeb 60%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, silkworm excrement 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 70% RH-7592 mancozeb wettable powder.
Example 3 63% RH-7592 mancozeb water dispersible granules
RH-7592 3%, mancozeb 60%, aliphatic amine polyoxyethylene are phonetic 7%, soapberry powder 5%, sodium carbonate 1.6%, kaolin add to 100%, mix and make 63% RH-7592 mancozeb water dispersible granule.
Example 4 80% RH-7592 mancozeb water dispersible granules
RH-7592 5%, mancozeb 75%, polycarboxylate 6%, Nekal BX 4%, aluminium chloride 2%, white carbon add to 100%, mix and make 80% RH-7592 mancozeb water dispersible granule.
Example 5 36% RH-7592 mancozeb suspending agents
RH-7592 6%, mancozeb 30%, alkyl benzene sulfonate calcium salt 7%, spaonin powder 6%, silicone oil 0.5%, xanthans 1.2%, triethylene glycol 1.3%, deionized water add to 100%, mix and make 36% RH-7592 mancozeb suspending agent.
Example 6 42% RH-7592 mancozeb suspending agents
RH-7592 8%, mancozeb 34%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 8%, silkworm excrement 6%, C
10～20saturated fat acids 0.3%, crospolyvinylpyrrolidone 0.8%, glycerine 1.5%, deionized water add to 100%, mix and make 42% RH-7592 mancozeb suspending agent.
Example 7 33% RH-7592 mancozeb suspension emulsions
RH-7592 3%, mancozeb 30%, lignosulfonates 7%, soapberry powder 5%, silicone compound 0.4%, methylcellulose 1.6%, tween series 7%, diethylene glycol (DEG) 1.2%, water add to 100%, aforementioned formula material is mixed, make 33% RH-7592 mancozeb suspension emulsion.
Example 8 45% RH-7592 mancozeb suspension emulsions
RH-7592 10%, mancozeb 35%, octylphenol polyethylene oxyethylene group ether sulfate 6%, wetting and penetrating agent F 5%, 600# phosphate 6%, gum Arabic 1.7%, propane diols 1.2%, C
8～10aliphatic alcohols 0.2%, water add to 100%, through mixing, make 45% RH-7592 mancozeb suspension emulsion.
Example 9 66% RH-7592 Wettable propineb powders
RH-7592 6%, Propineb 60%, the phonetic formaldehyde condensation products sulphate 8% of alkylphenol-polyethenoxy, silkworm excrement 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, makes 66% RH-7592 Wettable propineb powder.
Example 10 80% RH-7592 Wettable propineb powders
RH-7592 10%, Propineb 70%, lignosulfonates 7%, spaonin powder 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 80% RH-7592 Wettable propineb powder.
Example 11 42% RH-7592 Propineb water dispersible granules
RH-7592 2%, Propineb 40%, alkyl benzene sulfonate calcium salt 8%, Nekal BX 6%, sodium bicarbonate 1.8%, bentonite add to 100%, mix and make 42% RH-7592 Propineb water dispersible granules.
Example 12 80% RH-7592 Propineb water dispersible granules
RH-7592 20%, Propineb 60%, poly-hydroxy acid salt 7%, lauryl sodium sulfate 6%, sodium carbonate 2%, white carbon add to 100%, mix and make 80% RH-7592 Propineb water dispersible granules.
Example 13 62% RH-7592 Zineb wettable powders
RH-7592 7%, zineb 55%, polyoxyethylene carboxylate 8%, neopelex 6%, bentonite add to 100%, and mixture carries out air-flow crushing, make 62% RH-7592 Zineb wettable powder.
Example 14 75% RH-7592 Zineb wettable powders
RH-7592 15%, zineb 60%, lignosulfonates 7%, wetting and penetrating agent F 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 75% RH-7592 Zineb wettable powder.
Example 15 68% RH-7592 water dispersion granules agent of dithane
RH-7592 3%, zineb 65%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, spaonin powder 6%, urea 1.5%, bentonite add to 100%, mix and make 68% RH-7592 water dispersion granules agent of dithane.
Example 16 80% RH-7592 water dispersion granules agent of dithane
RH-7592 5%, zineb 75%, aryl phenol polyoxyethylene succinate sulfonate 6%, silkworm excrement 5%, bentonite add to 100%, mix and make 80% RH-7592 water dispersion granules agent of dithane.
Example 17 22% RH-7592 zineb suspending agents
RH-7592 2%, zineb 20%, alkyl benzene sulfonate calcium salt 7%, lauryl sodium sulfate 6%, C
8～10aliphatic alcohols 0.3%, gelatin 0.9%, glycerine 1.2%, deionized water add to 100%, mix and make 22% RH-7592 zineb suspending agent.
Example 18 42% RH-7592 zineb suspending agents
RH-7592 7%, zineb 35%, the phonetic formaldehyde condensation products sulphate 8% of alkylphenol-polyethenoxy, Nekal BX 6%, C
10～20saturated fat acids 0.4%, methylcellulose 1.2%, triethylene glycol 1.6%, deionized water add to 100%, mix and make 42% RH-7592 zineb suspending agent.
Example 19 12% RH-7592 zineb suspension emulsions
RH-7592 2%, zineb 10%, polyoxyethylene carboxylate 6%, wetting and penetrating agent F 5%, silicone oil 0.2%, gum Arabic 1.4%, diethylene glycol (DEG) 1.8%, agriculture breast 1600#6%, water add to 100%, aforementioned formula material is mixed, make 12% RH-7592 zineb suspension emulsion.
Example 20 40% RH-7592 zineb suspension emulsions
RH-7592 10%, zineb 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, lauryl sodium sulfate 4%, PAA 0.9%, propane diols 1%, silicone compound 0.3%, OP series phosphate 7%, water add to 100%, through mixing, make 40% RH-7592 zineb suspension emulsion.
Example 21 68% RH-7592 thioneb wettable powders
RH-7592 8%, Carbatene 60%, lignosulfonates 6%, spaonin powder 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 68% RH-7592 thioneb wettable powder.
Example 22 71% RH-7592 thioneb wettable powders
RH-7592 6%, Carbatene 65%, aryl phenol polyoxyethylene succinate sulfonate 7%, silkworm excrement 6%, diatomite add to 100%, and mixture carries out air-flow crushing, make 71% RH-7592 thioneb wettable powder.
Example 23 55% RH-7592 Carbatene water dispersible granules
RH-7592 5%, Carbatene 50%, naphthalene sulfonic acid-formaldehyde condensation product 8%, neopelex 6%, starch add to 100%, mix and make 55% RH-7592 Carbatene water dispersible granules.
Example 24 78% RH-7592 Carbatene water dispersible granules
RH-7592 3%, Carbatene 75%, polyoxyethylene carboxylate 6%, spaonin powder 4%, ammonium sulfate 1.7%, kaolin add to 100%, mix and make 78% RH-7592 Carbatene water dispersible granules.
Example 25 30% RH-7592 Carbatene suspending agents
RH-7592 5%, Carbatene 25%, polycarboxylate 8%, lauryl sodium sulfate 6%, C
8～10aliphatic alcohols 0.1%, methylcellulose 1.1%, polyethylene glycol 1.3%, deionized water adds to 100%, mixes and makes 30% RH-7592 Carbatene suspending agent.
Example 26 44% RH-7592 Carbatene suspending agents
RH-7592 4%, Carbatene 40%, alkyl benzene sulfonate calcium salt 5%, spaonin powder 4%, silicone compound 0.3%, xanthans 1%, diethylene glycol (DEG) 2%, deionized water adds to 100%, mixes and makes 44% RH-7592 Carbatene suspending agent.
Example 27 6% RH-7592 Carbatene suspension emulsions
RH-7592 3%, Carbatene 3%, lignosulfonates 6%, Nekal BX 6%, silicone oil 0.5%, propane diols 1.8%, PAA 2%, 600# phosphate 5%, water adds to 100%, mixes and makes 6% RH-7592 Carbatene suspension emulsion.
Example 28 35% RH-7592 Carbatene suspension emulsions
RH-7592 10%, Carbatene 25%, the phonetic formaldehyde condensation products sulphate 5% of alkylphenol-polyethenoxy, neopelex 4%, polyvinylpyrrolidone 2%, agriculture breast 1600#5%, C
10～20saturated fat acids 0.2%, glycerine 1.5%, water add to 100%, mix and make 35% RH-7592 Carbatene suspension emulsion.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
RH-7592 and active component B (active component B is selected from a kind of of mancozeb, Propineb, zineb, Carbatene) are composite to crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage by active constituent content and is processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component RH-7592 and active component B (mancozeb, Propineb, Carbatene, zineb) shared ratio in combination;
A is RH-7592;
B is a kind of in mancozeb, Propineb, zineb, Carbatene.
Implementation of an application example two:
RH-7592 and mancozeb are composite to alternaria leaf spot of apple Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining RH-7592, the former medicine of mancozeb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 RH-7592, mancozeb and the composite toxicity test analysis of results table to alternaria leaf spot of apple thereof
As shown in Table 1, RH-7592, the EC of mancozeb to alternaria leaf spot of apple
50be respectively 0.92mg/L and 21.54mg/L.The virulence of RH-7592 is higher than the virulence of mancozeb.RH-7592 and mancozeb proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that RH-7592 and mancozeb were mixed in scope and all show synergistic effect at 40: 1 to 1: 80, especially when the two proportioning is during at 1: 1 to 1: 20, synergistic effect is more obviously outstanding, wherein when RH-7592 and mancozeb weight ratio are 1: 10, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example three
RH-7592 and Propineb are composite to ring rot of apple Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining RH-7592, the former medicine of Propineb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 RH-7592, Propineb and the composite toxicity test analysis of results table to ring rot of apple thereof
As shown in Table 2, RH-7592, the EC of Propineb to ring rot of apple
50be respectively 0.97mg/L and 14.68mg/L.The virulence of RH-7592 is higher than the virulence of Propineb.RH-7592 and Propineb proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that RH-7592 and Propineb were mixed in scope and all show synergistic effect at 40: 1 to 1: 80, especially when the two proportioning is during at 1: 1 to 1: 20, synergistic effect is more obviously outstanding, wherein when RH-7592 and Propineb weight ratio are 1: 10, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example four
RH-7592 and zineb are composite to sigatoka Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining RH-7592, the former medicine of zineb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 RH-7592, zineb and the composite toxicity test analysis of results table to sigatoka thereof
As shown in Table 3, RH-7592, the EC of zineb to sigatoka
50be respectively 1.02mg/L and 12.17mg/L.The virulence of RH-7592 is higher than the virulence of zineb.RH-7592 and zineb proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that RH-7592 and zineb were mixed in scope and all show synergistic effect at 40: 1 to 1: 80, especially when the two proportioning is during at 1: 1 to 1: 20, synergistic effect is more obviously outstanding, wherein when RH-7592 and zineb weight ratio are 1: 10, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example five
RH-7592 and Carbatene are composite to pear scab Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining RH-7592, the former medicine of Carbatene and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 RH-7592, Carbatene and the composite toxicity test analysis of results table to pear scab thereof
As shown in Table 4, RH-7592, the EC of Carbatene to pear scab
50be respectively 0.98mg/L and 13.52mg/L.The virulence of RH-7592 is higher than the virulence of Carbatene.RH-7592 and Carbatene proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that RH-7592 and Carbatene were mixed in scope and all show synergistic effect at 40: 1 to 1: 80, especially when the two proportioning is during at 1: 1 to 1: 20, synergistic effect is more obviously outstanding, wherein when RH-7592 and Carbatene weight ratio are 1: 10, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Application Example six RH-7592 and mancozeb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This experimental establishment is at Shaanxi Province's Yan’an Luochuan County, and test medicine is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 24% RH-7592 missible oil (commercial), 80% mancozeb wettable powder (commercial).
The investigation alternaria leaf spot of apple state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 5 RH-7592, mancozeb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 5, after RH-7592 and mancozeb are composite, can effectively prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example seven RH-7592 and Propineb and the composite ring rot of apple test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Liquan County, Xianyang, Shanxi province city, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 24% RH-7592 missible oil (commercial), 70% Wettable propineb powder (commercial).
Investigation ring rot of apple disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, within after dispenser 7 days, 15 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 6 RH-7592, Propineb and the composite ring rot of apple test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 6, after RH-7592 and Propineb are composite, can effectively prevent and treat ring rot of apple, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example eight RH-7592 and zineb and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Nanning City, Guangxi province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 24% RH-7592 missible oil (commercial), 80% Zineb wettable powder (commercial).
The investigation sigatoka state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.For the second time after dispenser 7 days, 14 days, investigate disease index and calculate preventive effect respectively.Experimental result is as follows:
Table 7 RH-7592, zineb and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 7, after RH-7592 and zineb are composite, can effectively prevent and treat sigatoka, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example nine RH-7592 and Carbatene and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 24% RH-7592 missible oil (commercial), 70% Carbatene water dispersible granules (commercial).
Investigation pear scab disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, within after dispenser 7 days, 15 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 8 RH-7592, Carbatene and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, after RH-7592 and Carbatene are composite, can effectively prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Claims (5)
1. a bactericidal composition that contains RH-7592 and thiocarbamates compound, is characterized in that: the percentage by weight of A, two kinds of active components of B is 1 ~ 40% ︰ 1 ~ 80%, and described A component is RH-7592, and B component is mancozeb.
2. the bactericidal composition that contains RH-7592 and thiocarbamates compound according to claim 1, is characterized in that: the percentage by weight of A, two kinds of active components of B is 3 ~ 30% ︰ 5 ~ 75%.
3. the bactericidal composition that contains RH-7592 and thiocarbamates compound according to claim 2, is characterized in that: the percentage by weight of RH-7592 and mancozeb is 5 ~ 20% ︰ 10 ~ 60%.
4. the bactericidal composition that contains RH-7592 and thiocarbamates compound according to claim 1, is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent or suspension emulsion.
5. the bactericidal composition that contains RH-7592 and thiocarbamates compound according to claim 1 is for preventing and treating the purposes of the plant disease of basidiole Gammaproteobacteria, Ascomycetes and the microbial fruit tree of deuteromycetes cause of disease, wheat, vegetables and flowers and paddy rice.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0251775A2 (en) * | 1986-07-02 | 1988-01-07 | Rohm And Haas Company | Alpha-aryl-alpha-phenylethyl-1H-1,2,4-triazole-1-propanenitriles |
| CN101384173A (en) * | 2006-02-14 | 2009-03-11 | 巴斯夫欧洲公司 | A method of using a micronutrient as safener for a triazole for controlling harmful fungi |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0251775A2 (en) * | 1986-07-02 | 1988-01-07 | Rohm And Haas Company | Alpha-aryl-alpha-phenylethyl-1H-1,2,4-triazole-1-propanenitriles |
| CN101384173A (en) * | 2006-02-14 | 2009-03-11 | 巴斯夫欧洲公司 | A method of using a micronutrient as safener for a triazole for controlling harmful fungi |
Non-Patent Citations (1)
| Title |
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| 谢玲，等.杀菌剂对梨黑斑病菌的室内抑菌效果.《广西植保》.2007,第20卷(第3期),第16-17页. * |
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