CN102051313A - Honeysuckle-containing blood fat-reducing heath-care wine and preparation method thereof - Google Patents

Abstract

The invention relates to a honeysuckle-containing blood fat-reducing heath-care wine and a preparation method thereof. The honeysuckle-containing blood fat-reducing heath-care wine is prepared by using traditional Chinese medicines including 5 to 100 milligrams of lucid ganoderma, 20 to 100 milligrams of ginkgo leaves, 30 to 200 milligrams of selfheal and 1 to 200 milligrams of honeysuckle as raw materials and by soaking the traditional Chinese medicines in white spirit (over 12 DEG) by a normal method. The health-care wine does not contain any chemical additive and is an environmentally-friendly green food and health-care product.

Description

A kind of reducing blood-fat health wine that contains Japanese Honeysuckle and preparation method thereof

Technical field

The invention belongs to the technical field of protective foods, relate to a kind of health wine that contains the reducing blood-fat health factor and preparation method thereof.

Technical background

As everyone knows, drinking utensils has appetizing and orectic effect, but in fact wine also has many other effects.Current society, because the living environment complexity, rhythm is accelerated, people tend to feel uneasy, panic, anxiety, stress is very big.Having is " melancholy causing a disease ", and the visible mental status is very big to health affected.When spirit or health are felt fatigue, suitably to drink, alcoholic content can make personal gains in depth of comprehension to loosening to the effect of nervus centralis.According to theory of traditional Chinese medical science, the health of drinking is suitable for senior people, the slow person of QI-blood circulation, the depressed person of yang-energy, and cold air is arranged in the body, numbness resistance is arranged, the stasis of blood person that stagnates is arranged.This is with regard to simple wine, is not meant medicinal liquor.Medicinal liquor has different performances with the difference of used medicine, have with benefit person enrich blood, the difference of enriching yin, Wen Yang, beneficial gas, have with the person of attacking reduce phlegm, eliminating dampness, regulate the flow of vital energy, promoting circulation of blood, long-pending etc. the difference that disappears, thereby can not use it without exception.Body void person uses tonic wine, and the obstructed person of blood vessels then uses the medicinal liquor of promoting flow of QI and blood vein relaxing; There is cold person suitable warm, and has hot person suitable clear with wine with wine.Have a mind to row medicinal liquor and support the survivor and be preferably under doctor's the guidance and elect.Therefore, in wine, add reducing blood-fat Chinese medicines such as a certain amount of glossy ganoderma, Ginkgo Leaf, Spica Prunellae, Japanese Honeysuckle, make it organically to combine with liquor, the active ingredient of Chinese herbs that utilizes this carrier of wine will have reducing blood lipid is sent in the body of being accustomed to the crowd that drinks, reaches the health care purpose of reducing blood-fat.

Summary of the invention

The objective of the invention is to adopt advanced extracting technique of Chinese medicine to add Japanese Honeysuckle, produce pure taste, the health wine that can relieve the effect of alcohol, detoxify and have reducing blood lipid again.

Various active ingredient of Chinese herbs with health wine of reducing blood lipid of the present invention derive from be food be again glossy ganoderma, Ginkgo Leaf, the Spica Prunellae of the integration of drinking and medicinal herbs of medicine.Particularly add by the functional polymerization sugar Japanese Honeysuckle of 2-7 wood sugar molecule, strengthened the function of reducing blood-fat more with β (1-4) glycosidic link be combined into.Technical scheme of the present invention is as follows:

A kind of reducing blood-fat health wine that contains Japanese Honeysuckle, it is to be raw material with glossy ganoderma 5～100mg, Ginkgo Leaf 20～100mg, Spica Prunellae 30～200mg, Japanese Honeysuckle 1～200mg Chinese medicine, makes with the conventional immersion process of liquor (more than 12 °).

Reducing blood-fat health wine of the present invention is characterized in that the proportioning (w/v) of glossy ganoderma, Ginkgo Leaf, Spica Prunellae, Japanese Honeysuckle and liquor is 10mg～450mg/500ml.

Reducing blood-fat health wine of the present invention, preferred, contain glossy ganoderma 20～80mg, Ginkgo Leaf 25～75mg, Spica Prunellae 30～150mg, Japanese Honeysuckle 10～60mg in the 500ml liquor.

Reducing blood-fat health wine of the present invention more preferably, contains glossy ganoderma 25～75mg, Ginkgo Leaf 30～60mg, Spica Prunellae 30～120mg, Japanese Honeysuckle 15～60mg in the 500ml liquor.

Reducing blood-fat health wine of the present invention is characterized in that the liquor number of degrees are 12～65.The preparation method of its reducing blood-fat health wine comprises the steps:

(1) get the glossy ganoderma poach and carry 5 hours, cooling, centrifugal, supernatant concentration adds triplication ethanol alcohol precipitation, filters, the dry Crude polysaccharides that gets; The Crude polysaccharides water dissolution, centrifugal, get supernatant liquor, add chloroform and propyl carbinol, produce milky white precipitate, centrifugal, get supernatant liquor and add chloroform and propyl carbinol again, restir, centrifugal, so repeatedly till do not have a proteins react; Supernatant concentration to an amount of, with aquae destillata dialysis three days, placed and separated out the gray purple precipitation, and cryodrying promptly gets ganoderan;

(2) preparation of Spica Prunellae: use water extraction, extracting solution adds small diluted amount after being concentrated into and being equivalent to the medicinal material charging capacity, diluent is by macroporous resin column, and first water is eluted to colourless, uses 30%～60% ethanol elution again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains the crystallinity powder;

(3) above-mentioned crystalline powder and Ginkgo Leaf, Japanese Honeysuckle are dissolved in the 500ml liquor by prescription, make the reducing blood-fat health wine that contains Japanese Honeysuckle.What need be illustrated especially is that the extract of a lot of medicinal materials all has commercially available product, so active ingredient of Chinese herbs of the present invention also can be replaced with corresponding commercially available extract; The proportioning of extract is that the content according to index components is converted to the proportioning that is equivalent to described active ingredient of Chinese herbs, and these all belong to protection scope of the present invention.

The quality of medicinal material standard that the present invention uses all meets " the Chinese people are state's officinal relevant regulations altogether ", and the physico-chemical property and the pharmacological effect of used medicinal material are described below in the reducing blood-fat health wine:

The root of kudzu vine is the integration of drinking and medicinal herbs article, and Spica Prunellae is a main effective constituent in the root of kudzu vine, and its molecular formula is 4, and 7-dihydroxyl-8-8-D-glucose isoflavones is white needle, water-soluble and ethanol.The experiment report is arranged, Spica Prunellae can effectively reduce the value of high lipid diet rat blood serum TG, TC, LDL-C level and AI, Spica Prunellae intervention group rat blood serum HDL-C significantly raises, and normal feed group rat plasma HDL-C obviously reduces, and will play better action to the prevention hyperlipidemia.

But the Folium Ginkgo total flavones reducing cholesterol suppresses hyperlipemia animal TC, TG and improves the SOD vigor, reduces the generation of free radical, obviously reduces all lipid parameters, and hyperlipidaemia is had significant prevention and therapeutic action.The Ginkgo Leaf alcohol extract strengthens digestion, eliminates extravasated blood and can anti-arrhythmia and myocardial ischemia, but and step-down, reducing blood-fat; For hypertension, coronary heart disease, stenocardia, paroxysmal tachycardia certain curative effect is arranged all, obvious to the triglyceride reducing effect especially.

Glossy ganoderma and extract thereof have comprehensive provide protection to heart, and the supply of satisfying improvement cardiac muscle blood oxygen strengthens myocardial contraction, and clinical study proof Ganoderma extract has the effect of step-down reducing blood-fat.Glossy ganoderma energy anticoagulant and thrombin action, glossy ganoderma and extract thereof can strengthen the non-specific immune function of human body, and neural system is had the sedation and analgesia effect.There is antitussive and antiasthmatic effect glossy ganoderma also to have hypoglycemic, protecting liver and detoxication effect to respiratory system; Effects such as the anti-damage of anti-inflammatory, anti-ageing, antitumor, anti-mutation, antiviral, radioprotective.Ganoderma extract have strengthen the body resistance to consolidate the constitution, the function of enhancing body non-specific immunity etc.Glossy ganoderma, Ginkgo Leaf, Spica Prunellae, xylo-oligosaccharide etc. have cholesterol in the blood fat reducing, triglyceride level, improve the SOD vigor, reduce the generation of free radical, obviously reduce all lipid parameters, and hyperlipidaemia is had significant prevention and therapeutic action.

Drinking method: each cuvette, noon and evening respectively once also can increase the amount of drinking according to the capacity for liquor of oneself slightly, are as the criterion up to taking effect, and adhere to drinking resistibility and healthy being beneficial to health.

Actual effect of the present invention mainly is to taste experiment by people, and the real reaction effect of prolonged application, similar compare is verified.On probation through people more than 100, effect is obvious, and spirit is happy after drinking, and feels that generally health is comfortable.Contain cholesterol, triglyceride level health factor in the blood fat reducing of various compositions simultaneously, show through acute toxicity test and long term toxicity test: the glossy ganoderma among the present invention, Ginkgo Leaf, Spica Prunellae, Japanese Honeysuckle and liquor compatibility are without any side effects, safe and reliable.In different crowds, try out and obtained extraordinary result of treatment.

Drink its health wine according to required standard quantity of the present invention, different situations according to body constitution, emphasis has carried out the effect experiment to 40 hyperlipidemia examples of suffering from various degree: the male sex's 18 examples, women's 22 examples, age 45-65 year 3 examples, 50-78 year 12 examples, hypercholesterolemia 5 examples, hypertriglyceridemia 10 examples, combined hyperlipidemia familial 10 examples.Allow it drink the health wine that contains glossy ganoderma, Ginkgo Leaf, Spica Prunellae, Japanese Honeysuckle of the present invention; every day 2 times; each 30-50ml; after drinking half a year; by check (1) produce effects with index: for clinical symptom disappears substantially, CHO (hypercholesterolemia); TG (triglyceride) all reduces to normal or two declines surpass following standard: CHO＞0.25mmol/L, TG＞0.21mmol/L.(2) effectively symptom is clearly better, and CHO (hypercholesterolemia), TG (triglyceride) wherein a decline reach following standard: CHO＞0.25mmol/L, TG＞0.21mmol/L.(3) invalid: as not reach above standard person: its result: produce effects: 28 examples account for 70%, and effectively: 10 examples account for 25%, and invalid 2 examples account for 5%, and total effective rate reaches 95%.

Outstanding advantage of the present invention and beneficial effect are: the selected topic is novel, reasonable in design, the prescription unique solution is done things creatively, and technology is advanced simple, health-care and nutritious wine of the present invention, the chemistry sky that does not contain any composition adds agent, be a kind of green food and healthcare products of environment-friendly type, be not only in order to prevent or treat the health-care and nutritious wine of alcoholic liver injury, more for the health care as the application on human body, promote longevity, so higher using value and promotional value are arranged.

Embodiment

Following examples only are used to illustrate the present invention, but are not used for limiting protection scope of the present invention.Embodiment 1 has the preparation method of the health wine of reducing blood lipid:

(1) get glossy ganoderma 100g poach and carry 5 hours, cooling, centrifugal, supernatant concentration adds triplication ethanol alcohol precipitation, filters, the dry Crude polysaccharides that gets; The Crude polysaccharides water dissolution, centrifugal, get supernatant liquor, add chloroform and propyl carbinol, produce milky white precipitate, centrifugal, get supernatant liquor and add chloroform and propyl carbinol again, restir, centrifugal, so repeatedly till do not have a proteins react; Supernatant concentration to an amount of, with aquae destillata dialysis three days, placed and separated out the gray purple precipitation, and cryodrying promptly gets ganoderan;

(2) preparation of Spica Prunellae: root of kudzu vine 100g water extraction, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent passes through macroporous resin column, elder generation's water is eluted to colourless, use 30%～60% ethanol elution again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains the crystallinity powder; (3) above-mentioned crystalline powder and Ginkgo Leaf 100g, Japanese Honeysuckle 200mg are dissolved in the 500ml liquor by prescription, make the reducing blood-fat health wine that contains Japanese Honeysuckle.

Embodiment 2:

In 500ml (8%) wine, dissolve in glossy ganoderma 100mg, Ginkgo Leaf 100mg, root of kudzu vine 200mg, Japanese Honeysuckle 100mg that method for preparing obtains, placed 10-20 days, add a certain amount of carbonic acid gas, adjust the pH value to acid, add a certain amount of ammonium phosphate, add a certain amount of fruit wine yeast temperature controlled fermentation again, when the residual sugar amount is that a timing is removed slag, carry out secondary fermentation again, clarification, modulation are blent and are formed.

Embodiment 3:

In 500ml liquor (62%), dissolve in glossy ganoderma 80mg, Ginkgo Leaf 60mg, root of kudzu vine 75mg, Japanese Honeysuckle 50mg that method for preparing obtains, the Chinese medicine medicinal liquor that formed in 30 days with 62 ℃ of soaking in Chinese liquor.Measure content through the HPLC method, make sweet-smelling, reducing blood-fat health care wine stable and controllable for quality with wine.

Embodiment 4:

In 500ml liquor (38%), dissolve in glossy ganoderma 50mg, Ginkgo Leaf 70mg, root of kudzu vine 150mg, Japanese Honeysuckle 100mg that method for preparing obtains, the Chinese medicine medicinal liquor that formed in 15 days with 38 ℃ of soaking in Chinese liquor.Measure content through the HPLC method, make sweet-smelling, reducing blood-fat health wine stable and controllable for quality with wine.

Embodiment 5:

In 500ml liquor (50%), dissolve in glossy ganoderma 80mg, Ginkgo Leaf 60mg, root of kudzu vine 75mg, Japanese Honeysuckle 50mg that method for preparing obtains, the Chinese medicine medicinal liquor that formed in 30 days with 50 ℃ of soaking in Chinese liquor.Measure content through the HPLC method, make sweet-smelling, reducing blood-fat health wine stable and controllable for quality with wine.

Embodiment 6:

In 500ml liquor (52%), dissolve in glossy ganoderma 75mg, Ginkgo Leaf 30mg, root of kudzu vine 120mg, Japanese Honeysuckle 60mg, the Chinese medicine medicinal liquor that formed in 60 days with 52 ℃ of soaking in Chinese liquor.Measure content through the HPLC method, make sweet-smelling, reducing blood-fat health wine stable and controllable for quality with wine.

Embodiment 7

In 500ml liquor (15%), dissolve in glossy ganoderma 25mg, Ginkgo Leaf 60mg, root of kudzu vine 30mg, Japanese Honeysuckle 15mg.Add a certain amount of carbonic acid gas, adjust p H value to acid, add a certain amount of ammonium phosphate, add a certain amount of fruit wine yeast temperature controlled fermentation again, when the residual sugar amount is that a timing is removed slag, carry out secondary fermentation again, clarification, modulation are blent and are formed.

Embodiment 8

In 500ml liquor (18%), dissolve in glossy ganoderma 55mg, Ginkgo Leaf 50mg, root of kudzu vine 80mg, Japanese Honeysuckle 45mg.Measure content through the HPLC method, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine.

Claims (6)

1. reducing blood-fat health wine that contains Japanese Honeysuckle, it is to be raw material with glossy ganoderma 5～100mg, Ginkgo Leaf 20～100mg, Spica Prunellae 30～200mg, Japanese Honeysuckle 1～200mg Chinese medicine, makes with the conventional immersion process of liquor.

2. reducing blood-fat health wine as claimed in claim 1 is characterized in that the proportioning (w/v) of glossy ganoderma, Ginkgo Leaf, Spica Prunellae, Japanese Honeysuckle and liquor is 10mg～450mg/500ml.

3. reducing blood-fat health wine as claimed in claim 1 or 2 is characterized in that, contains glossy ganoderma 20～80mg, Ginkgo Leaf 25～75mg, Spica Prunellae 30～150mg, Japanese Honeysuckle 10～60mg in the 500ml liquor.

4. reducing blood-fat health wine as claimed in claim 1 or 2 is characterized in that, contains glossy ganoderma 25～75mg, Ginkgo Leaf 30～60mg, Spica Prunellae 30～120mg, Japanese Honeysuckle 15～60mg in the 500ml liquor.

5. as the described reducing blood-fat health of claim 1-4 wine, it is characterized in that the liquor number of degrees are 12～65.

6. a method for preparing the described reducing blood-fat health of claim 1 wine comprises the steps:

(1) get the glossy ganoderma poach and carry 5 hours, cooling, centrifugal, supernatant concentration adds triplication ethanol alcohol precipitation, filters, the dry Crude polysaccharides that gets; The Crude polysaccharides water dissolution, centrifugal, get supernatant liquor, add chloroform and propyl carbinol, produce milky white precipitate, centrifugal, get supernatant liquor and add chloroform and propyl carbinol again, restir, centrifugal, so repeatedly till do not have a proteins react; Supernatant concentration to an amount of, with aquae destillata dialysis three days, placed and separated out the gray purple precipitation, and cryodrying promptly gets ganoderan;

(2) preparation of Spica Prunellae: use water extraction, extracting solution adds small diluted amount after being concentrated into and being equivalent to the medicinal material charging capacity, diluent is by macroporous resin column, and first water is eluted to colourless, uses 30%～60% ethanol elution again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains the crystallinity powder;

(3) above-mentioned crystalline powder and Ginkgo Leaf, Japanese Honeysuckle are dissolved in the 500ml liquor by prescription, make the reducing blood-fat health wine that contains Japanese Honeysuckle.