CN102048977B - Chinese medicinal composition for treating chronic myeloid leukemia - Google Patents
Chinese medicinal composition for treating chronic myeloid leukemia Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating chronic myeloid leukemia, which consists of the following components: 15 to 25 grams of rehmanniae praeparatum, 8 to 16 grams of tree peony bark, 18 to 28 grams of honey-fried extract glycyrrhiza, 18 to 32 grams of spreading hedyotis herb, 14 to 20 grams of lalang grass rhizome, 18 to 28 grams of glossy privet fruit, 14 to 28 grams of desertliving cistanche, 4 to 8 grams of cordyceps sinensis, 12 to 20 grams of Indian iphigenia bulb, 8 to 16 grams of stiff silkworm and 8 to 16 grams of eupolyphaga. The Chinese medicinal composition can carry out pertinence treatment on chronic myeloid leukemia, selectively inhibits and kills immature cells, induces apoptosis of leukemia cells, has strong pertinence and better treatment effect, promotes differentiation and maturation of leukemia cells, regulates qi and blood, strengthens the immunity, promotes recovery of the normal hematopoietic function of bone marrow, reduces reversion, prevents tolerance from being generated, reduces the toxic or side effects of chemotherapy and strengthens physical fitness.
Description
Technical field
The present invention relates to the leukemic medicine of a kind of treatment, be specifically related to a kind of Chinese medicine composition of treating chronic myelocytic leukemia.
Background technology
Leukemia (leukemia) is
plants hematopoietic stem cell malignant clone property disease; It is characterized by leukocyte unusual in the bone marrow (leukaemia) diffusivity hypertrophy and replace the normal marrow tissue; And the intrusion peripheral blood, make the change of interior leukocyte appearance amount of peripheral blood and matter.The normal showed increased of quantity of leucocyte in the blood, but also can normally even reduce sometimes.The leukaemia can extensively be soaked into whole bodies such as liver, spleen, lymph node each tissue and organ, and often causes anemia and hemorrhage.
According to the Ministry of Public Health statistics, 2009, the leukemic annual morbidity of China was 3.99/10 ten thousand, and wherein, the city is 4.17/10 ten thousand, and the rural area is 3.84/10 ten thousand, and mortality rate is 4.12/10 ten thousand, in various tumors, occupied the 7th, and in rising trend.According to another China " red base meeting " investigation, China has 4,000,000 leukaemics at present, and with the speed increase in every year 30000 to 40,000, wherein 50% is the child.Malignancies in children and adolescents in the
Leukemia is ranked
bit.The children acute leukemia is prevalence and the highest disease of mortality rate in the Childhood malignancy disease; Account for 30%～40% of whole tumors in children; In child patient; Have only the child of twenty percent can be treated timely and effectively and smooth recovery, most of infants are lost chance for survival because of can not get treatment in time.
Leukemia generally is divided into acute and chronic by natural history and the inmature degree of cell, be divided into types such as granulocyte, lymphocyte, mononuclear cell by cell type, and clinical manifestation is had nothing in common with each other.According to the cell series of mainly getting involved, leukemia can be divided into following type again: one, acute leukemia comprises acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML) etc.; Two, chronic leukemia, common have a chronic myelocytic leukemia (CML) etc.China's acute leukemia is seen (about 5.5:1) than chronic leukemia more, and wherein anxious granulocyte leukemia is (1.62/10 ten thousand, slow grain leukemia 0.36/10 ten thousand) at most, sees at most with acute myeloblastic leukemia in adult's acute leukemia.China's leukemia sickness rate is close with Asian countries, is lower than American-European countries.
In recent years, along with the development of medical skill, leukemia can be checked the leukocyte of pathological changes with the chemotherapy and radiation method, through killing and wounding leukocyte, alleviates leukemic load, prolongs patient's life.But the side effect of this method is big, as kills and wounds, suppresses the normal hematopoiesis stem cell, causes anemia, hemorrhage; Suppress normal immunologic function, immunity of organisms descends, and merges various infection easily; Damage gastrointestinal tract mucously, cause that anorexia is felt sick, vomiting, influence darling renal function; Even dosage is big again, also can not kill intravital leukocyte fully, and residual leukaemia is the root of palindromia.This brings great misery not only for the patient, and causes heavy mental burden and loss economically for its family and society.Therefore, a lot of people stopped treatment of having to is arranged, painful and helpless in wait for and dislike the arrival of interrogating.
Summary of the invention
The objective of the invention is to solve the above-mentioned technical problem that existing western medicine leukemia exists, a kind of Chinese medicine composition of treating chronic myelocytic leukemia is provided.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is following:
The Chinese medicine composition of treatment chronic myelocytic leukemia of the present invention is made up of following component:
The Radix Rehmanniae 15～25 grams
Cortex Moutan 8～16 grams
Processed with honey Radix Glycyrrhizae 18～28 grams
Hedyotidis Diffusae 18～32 grams
Rhizoma Imperatae 14～20 grams
Fructus Ligustri Lucidi 18～28 grams
Herba Cistanches 14～28 grams
Cordyceps 4～8 grams
Pseudobulbus Cremastrae Seu Pleiones 12～20 grams
Bombyx Batryticatus 8～16 grams
Eupolyphaga 8～16 grams.
The Chinese medicine composition of treatment chronic myelocytic leukemia of the present invention preferably is made up of following component:
The Radix Rehmanniae 18～23 grams
Cortex Moutan 10～15 grams
Processed with honey Radix Glycyrrhizae 20～258 grams
Hedyotidis Diffusae 20～28 grams
Rhizoma Imperatae 15～18 grams
Fructus Ligustri Lucidi 20～25 grams
Herba Cistanches 20～25 grams
Cordyceps 5～8 grams
Pseudobulbus Cremastrae Seu Pleiones 15～18 grams
Bombyx Batryticatus 10～15 grams
Eupolyphaga 10～15 grams.
Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Hedyotidis Diffusae is picked up only, and the per kilogram SHECAO is dried after 30 minutes with the stewing profit of 50 grammeter vinegar.
The decocting method of Chinese medicine composition of the present invention is following:
(1) water of boiling medicine: adopt phreatic water or mineral water, the city is drunk (from the beginning) water and should be inserted earlier in the porcelain basin and placed 2 hours.
(2) immersion process: before boiling medicine, should earlier medicine be put into marmite, add cold water 700ml～900ml, soak 30 minutes.
(3) decocting method: every dose of medicine boils twice.With big fire soaked medicine is boiled earlier for the first time, use middle or small fire again instead, fry in shallow oil truce in 25 minutes, the leaching medicinal liquid; Add for the second time water 500ml～600ml, with big fire medicine is boiled earlier, use middle or small fire again instead, fry in shallow oil truce in 20 minutes, the leaching medicinal liquid; With the first time institute's taking liquid mix.
The instructions of taking of medicine of the present invention:
Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 250ml～350ml that is grown up, the each 120ml～180ml of child.Decoction being taken warmly.
Theory of Chinese medical science is thought, causes the i.e. generation of " mass formed by blood stasis " of leukemia a little less than the liver of suffering from a deficiency of the kidney.Kidney is claimed water, kidney intrinsic energy water, and liver is claimed wood, wood can be lit a fire.Liver does not have then hyperactivity of fire of kidney water, and kidney does not have liver-fire, and then water is cold.Suffer from a deficiency of the kidney a little less than the liver then that blood does not have life, liver-kidney diseases is disorders of blood then.According to this principle, warp studies repeatedly and test obtains following proved recipe.
In the prescription of the present invention, Radix Rehmanniae sweet in the mouth is gone into the heart, liver, kidney channel, can removing heat from blood, again can YIN nourishing, and the effect of tool heat clearing away YIN nourishing, cooling blood for hemostasis, promoting the production of body fluid to quench thirst.Modern pharmacological research shows, Radix Rehmanniae has radioprotective, protects the liver, blood sugar lowering, heart tonifying, hemostasis, diuresis, antifungal effect.It is cool in nature for Cortex Moutan, bitter in the mouth, suffering, and the function heat clearing away, removing heat from blood and blood, the clear stasis of blood are applicable to thermal man's blood system, send out speckle, frightened pain, haematemesis, carbuncle and ulcer, diseases such as traumatic injury.Radix Glycyrrhizae is sweet, and is flat, and GUIXIN, lung, spleen, stomach warp have the function of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Herba Hedyotidis Diffusae is sweet, salty, temperature; Return Liver Channel, heat-clearing and toxic substances removing, diuresis of blood circulation promoting are used for tonsillitis, tumor.Especially the tumor cell to acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type has strong inhibitory action (methylene blue test tube method).Rhizoma Imperatae is sweet, and is cold, returns lung, stomach, urinary bladder channel.Has cooling blood for hemostasis, the effect of clearing away heat and promoting diuresis.Be used for heat in blood and spit blood epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria.Fructus Ligustri Lucidi is sweet, bitter, cold.Return liver, kidney channel, have raise immunity, the platelet of ging up fast and anti-gene mutation and antineoplastic action can reduce and remove the damage of chemotherapeutics to internal organs.Herba Cistanches sweet in the mouth, salty, warm in nature.Ability kidney-replenishing, benefiting essence-blood enhancing immunity are adjusted microcirculatory effect.Cordyceps sweet in the mouth, warm in nature.Return kidney, lung meridian.Be China's tradition rare Chinese medicine, include compositions such as Cordyceps element, cordycepic acid, adenosine and polysaccharide.The Cordyceps element can suppress pathogen growth such as streptococcus, Actinobacillus mallei anthrax bacillus, is again anticancer active substance, and the hormonal system and the nervous system of human body had reasonable regulating action; Use cordycepin to be mostly adjuvant therapy of malignant tumor clinically, symptom is improved more than 91.7%; Be mainly used in rhinocarcinoma, pharyngeal cancer, pulmonary carcinoma, leukemia, the patient of the brain cancer and other malignant tumor.The Pseudobulbus Cremastrae Seu Pleiones sweet in the mouth; Little suffering; Cold in nature; Mild toxicity is returned liver, stomach, lung meridian.Repellent; The eliminating stagnation medicine; Antidote.Bombyx Batryticatus salty in the mouth, suffering, property is flat.Effect: endogenous wind stopping spasmolytic, dispelling wind and heat pathogens, dissipating phlegm and resolving masses.Mainly contain compositions such as enzyme, plant steroid, beauvericin.Tumor there is inhibitory action.The eupolyphaga salty in the mouth, cold in nature, little poison is arranged, the effect of have blood-activating analgetic, subsiding a swelling and stopping blooding, connect the muscle symplectic bone also has certain curative effect to cancer.More than all medicines according to the Therapeutic Principle of monarch, minister, the combination principle of helping, making and vital base and primordial QI consolidating, kill pathogenic cell fast, system regulates the function and the body immunity of each internal organs.Patient's long-term surviving is got well.
Medicine of the present invention has following effect aspect the treatment chronic myelocytic leukemia: the specific aim treatment is carried out to the treatment chronic myelocytic leukemia in (1); Selectively suppress and kill juvenile cell; Induced apoptosis in leukemia cell lines, specific aim is stronger, and therapeutic effect is higher.(2) promotion leukaemia's differentiation, maturation.(3) regulate QI and blood, raise immunity.(4) recovery of promotion bone marrow normal hematopoiesis function.(5) reduce reverse, prevent drug-fast generation.(6) toxic and side effects of minimizing chemotherapy, health invigorating.
Compare with prior art, the beneficial effect that the present invention has is following: (1) curative effect is higher than chemicotherapy and bone marrow transplantation therapy far away.(2) cheap expense.(3) efficacy consolidation, less recurrence.No pain, seldom toxic and side effects is easy to accept.(4) seldom produce the drug resistance phenomenon, chemotherapy is produced the drug-fast curative effect preferably that also has.Especially those cases of not alleviating of chemotherapy repeatedly more show the curative effect of its uniqueness, reopen new life's road for the patient.(5) strengthening vital QI to eliminate pathogenic factors protection internal organs, the toxic and side effects of minimizing chemotherapy is taken patient's overwhelming majority organ functions of Chinese medicine and is well protected, and simultaneously the chemotherapy left drug is had detoxifcation, scavenging action.
For showing the therapeutic effect of Chinese medicine composition of the present invention to chronic myelocytic leukemia, adopt medicine of the present invention, 15 routine patients are carried out the overall process treatment observe.The patient takes medicine of the present invention by above-mentioned decocting method and the method for taking, and wherein clinical cure 12 examples are alleviated 1 example fully, and part is alleviated 1 example, does not alleviate 1 example.
The chronic myelocytic leukemia criterion of therapeutical effect is following:
1. alleviate fully:
1. clinical: no anemia, hemorrhage, infection and leukemiacell infiltration performance;
2. hemogram: hemoglobin>100g/L, total white blood cells < 10 X 109/L, the no juvenile cell of classifying, platelet 100-400 x 109/L; 3. bone marrow smear: normal basically.
2. part is alleviated: have in three of the clinical manifestations, hemogram, bone marrow smear one or binomial do not reach and alleviate standard fully.
3. alleviate: all do not reach in three of the clinical manifestations, hemogram, bone marrow smear and alleviate standard and nonresponder fully.
4. clinical cure: after taking medicine CR of the present invention, anosis (leukemia) survives more than 5 years.
The specific embodiment
Embodiment 1
The Chinese medicine composition of treatment chronic myelocytic leukemia is made up of following component:
The Radix Rehmanniae 18 grams
Cortex Moutan 8 grams
Processed with honey Radix Glycyrrhizae 18 grams
Hedyotidis Diffusae 20 grams
Rhizoma Imperatae 15 grams
Fructus Ligustri Lucidi 25 grams
Herba Cistanches 14 grams
Cordyceps 4 grams
Pseudobulbus Cremastrae Seu Pleiones 12 grams
Bombyx Batryticatus 10 grams
Eupolyphaga 8 grams.
Embodiment 2
The Chinese medicine composition of treatment chronic myelocytic leukemia is made up of following component:
The Radix Rehmanniae 15 grams
Cortex Moutan 10 grams
Processed with honey Radix Glycyrrhizae 25 grams
Hedyotidis Diffusae 18 grams
Rhizoma Imperatae 17 grams
Fructus Ligustri Lucidi 23 grams
Herba Cistanches 20 grams
Cordyceps 8 grams
Pseudobulbus Cremastrae Seu Pleiones 15 grams
Bombyx Batryticatus 16 grams
Eupolyphaga 14 grams.
Embodiment 3
The Chinese medicine composition of treatment chronic myelocytic leukemia is made up of following component:
The Radix Rehmanniae 20 grams
Cortex Moutan 12 grams
Processed with honey Radix Glycyrrhizae 20 grams
Hedyotidis Diffusae 25 grams
Rhizoma Imperatae 18 grams
Fructus Ligustri Lucidi 20 grams
Herba Cistanches 28 grams
Cordyceps 5 grams
Pseudobulbus Cremastrae Seu Pleiones 17 grams
Bombyx Batryticatus 13 grams
Eupolyphaga 16 grams.
Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Hedyotidis Diffusae is picked up only, and the per kilogram SHECAO is dried after 30 minutes with the stewing profit of 50 grammeter vinegar.
Embodiment 4
The Chinese medicine composition of treatment chronic myelocytic leukemia is made up of following component:
The Radix Rehmanniae 23 grams
Cortex Moutan 16 grams
Processed with honey Radix Glycyrrhizae 23 grams
Hedyotidis Diffusae 32 grams
Rhizoma Imperatae 14 grams
Fructus Ligustri Lucidi 18 grams
Herba Cistanches 23 grams
Cordyceps 6 grams
Pseudobulbus Cremastrae Seu Pleiones 20 grams
Bombyx Batryticatus 16 grams
Eupolyphaga 15 grams.
Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Hedyotidis Diffusae is picked up only, and the per kilogram SHECAO is dried after 30 minutes with the stewing profit of 50 grammeter vinegar.
Embodiment 5
The Chinese medicine composition of treatment chronic myelocytic leukemia is made up of following component:
The Radix Rehmanniae 25 grams
Cortex Moutan 15 grams
Processed with honey Radix Glycyrrhizae 28 grams
Hedyotidis Diffusae 28 grams
Rhizoma Imperatae 20 grams
Fructus Ligustri Lucidi 28 grams
Herba Cistanches 25 grams
Cordyceps 8 grams
Pseudobulbus Cremastrae Seu Pleiones 18 grams
Bombyx Batryticatus 8 grams
Eupolyphaga 10 grams.
Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Hedyotidis Diffusae is picked up only, and the per kilogram SHECAO is dried after 30 minutes with the stewing profit of 50 grammeter vinegar.
Model case
Case one: Zhang Guicheng, man, 35 years old, Sichuan sun at tenth of the twelve Earthly Branches people.Be diagnosed as chronic myelocytic leukemia on July 18th, 2004 in 173 hospitals of PLA, the bone marrow examination result shows former myelocyte 8.8%, neutrophilic myelocyte 2.9%, normoblast 2%, all blood laboratory leukocytes 66 * 10
9/ L.Began to take the Chinese medicine of our inventive embodiments 1 prescription on the 5th in December in 2004.Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 250ml～350ml, decoction being taken warmly.Check neutrophilic myelocyte 5%, normoblast 6.2%, leukocyte 8.9 * 10 on April 8th, 2005 in southwest hospital of Third Military Medical University
9/ L belongs to normal value.Pay a return visit once every half a year now, the patient feels good.
Case two: Yao Wanyu, the woman, 19 years old, Fujian people from Nanan was diagnosed as chronic myelocytic leukemia on August 21st, 2009 in First People's Hospital, Xiamen City, and the bone marrow examination result shows promyelocyte 28%, former myelocyte 32%, leukocyte 284 * 10
9/ L begins to take the Chinese medicine that begins to take our inventive embodiments 2 prescriptions on November 2nd, 2009.Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 250ml～350ml, decoction being taken warmly.In on May 11st, 2010 review result show that former myelocyte and promyelocyte all find all blood leukocytes 9.1 * 10
9/ L belongs to normal value.Jede Woche is paid a return visit once now, and the patient feels good.
Case three: Chen Wei, the woman, 23 years old, people from Yingshan County, Sichuan was diagnosed as chronic myelocytic leukemia on June 20th, 2005 at Huaxi Hospital Attached to Sichuan Univ, and the bone marrow examination result shows promyelocyte 5%, former myelocyte 15%, leukocyte 3.88 * 10
9/ L began to take the Chinese medicine that begins to take our inventive embodiments 3 prescriptions on the 10th in December in 2005.Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 250ml～350ml, decoction being taken warmly.Show all discoveries of former myelocyte and promyelocyte on April 30th, 2006 in Concord Hospital of Medical University Of Fujian review result, chromosome is normal, all blood leukocytes 6.8 * 10
9/ L belongs to normal value.Paid a return visit once in present every month, the patient feels good.
Case four: Lu Zongwang, the man, 11 years old, people from Xingtai was diagnosed as chronic myelocytic leukemia on March 22nd, 2010 in the 3rd Affiliated Hospital of Hebei Medical University, and the bone marrow examination result shows neutrophilic myelocyte 15%, metamyelocyte 28%, leukocyte 92 * 10
9/ L begins to take the Chinese medicine that begins to take our inventive embodiments 4 prescriptions on May 3rd, 2010.Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 120ml～180ml, decoction being taken warmly.In on October 13rd, 2010 review result show that former myelocyte and promyelocyte all find all blood leukocytes 8.2 * 10
9/ L belongs to normal value.Jede Woche is paid a return visit once now, and the patient feels good.
Case five: Bi Lifeng, the man, 14 years old, people from Kunming, Yunnan was diagnosed as chronic myelocytic leukemia on April 2nd, 2008 in No. 1 People's Hospital of Kunming, and the bone marrow examination result shows promyelocyte 25%, former myelocyte 41%, leukocyte 267 * 10
9/ L begins to take the Chinese medicine that begins to take our inventive embodiments 5 prescriptions on May 2nd, 2008.Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 120ml～180ml, decoction being taken warmly.In on JIUYUE 11st, 2008 review result show that former myelocyte and promyelocyte all find all blood leukocytes 8.8 * 10
9/ L belongs to normal value.Jede Woche is paid a return visit once now, and the patient feels good.
Claims (2)
1. Chinese medicine composition of treating chronic myelocytic leukemia is characterized in that it is made up of following component:
The Radix Rehmanniae 15～25 grams
Cortex Moutan 8～16 grams
Processed with honey Radix Glycyrrhizae 18～28 grams
Hedyotidis Diffusae 18～32 grams
Rhizoma Imperatae 14～20 grams
Fructus Ligustri Lucidi 18～28 grams
Herba Cistanches 14～28 grams
Cordyceps 4～8 grams
Pseudobulbus Cremastrae Seu Pleiones 12～20 grams
Bombyx Batryticatus 8～16 grams
Eupolyphaga 8～16 grams.
2. the Chinese medicine composition of treatment chronic myelocytic leukemia according to claim 1 is characterized in that it is made up of following component:
The Radix Rehmanniae 18～23 grams
Cortex Moutan 10～15 grams
Processed with honey Radix Glycyrrhizae 20～25 grams
Hedyotidis Diffusae 20～28 grams
Rhizoma Imperatae 15～18 grams
Fructus Ligustri Lucidi 20～25 grams
Herba Cistanches 20～25 grams
Cordyceps 5～8 grams
Pseudobulbus Cremastrae Seu Pleiones 15～18 grams
Bombyx Batryticatus 10～15 grams
Eupolyphaga 10～15 grams.
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| CN105287903A (en) * | 2015-11-27 | 2016-02-03 | 黄德禄 | Treating medicine for subacute myelogenous leukemia |
| CN106038923A (en) * | 2016-07-31 | 2016-10-26 | 孙书芳 | Traditional Chinese medicine for treating chronic myeloid leukemia and hepatosplenomegaly complication |
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