CN102048976B - Traditional Chinese medicine composition for treating acute myeloblastic leukemia (AML) M1 - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating acute myeloblastic leukemia (AML) M1. The composition is prepared from the following components: 15-25g of radix rehmanniae, 8-16g of cortex moutan, 4-8g of honey-fried liquorice, 18-32g of oldenlandia diffusa, 14-20g of lalang grass rhizome, 18-28g of glossy privet fruit, 14-28g of herba cistanche, 4-8g of cordyceps sinensis, 15-25g of folium isatidis, 8-16g of wild radix ophiopogonis and 8-16g of honeysuckle. The medicine provided by the invention has the following functions: pertinently treating specific AML-M1, selectively inhibiting and killing immature cells, inducing leukemia cell apoptosis and having stronger pertinence and higher treatment effect; promoting differentiation and maturity of leukemia cells; regulating qi and blood and enhancing immunity; promoting recovery of normal hematopoietic function of marrows; and reducing reversion and preventing medicine resistance.

Description

The acute granulocyte AML of a kind of treatment-leukemic Chinese medicine composition of M1 type

The present invention relates to the leukemic medicine of a kind of treatment, be specifically related to the acute granulocyte AML of a kind of treatment-leukemic Chinese medicine composition of M1 type.

Background technology

Leukemia (leukemia) is

plants hematopoietic stem cell malignant clone property disease; It is characterized by leukocyte unusual in the bone marrow (leukaemia) diffusivity hypertrophy and replace the normal marrow tissue; And the intrusion peripheral blood, make the change of interior leukocyte appearance amount of peripheral blood and matter.The normal showed increased of quantity of leucocyte in the blood, but also can normally even reduce sometimes.The leukaemia can extensively be soaked into whole bodies such as liver, spleen, lymph node each tissue and organ, and often causes anemia and hemorrhage.

According to the Ministry of Public Health statistics, 2009, the leukemic annual morbidity of China was 3.99/10 ten thousand, and wherein, the city is 4.17/10 ten thousand, and the rural area is 3.84/10 ten thousand, and mortality rate is 4.12/10 ten thousand, in various tumors, occupied the 7th, and in rising trend.According to another China " red base meeting " investigation, China has 4,000,000 leukaemics at present, and with the speed increase in every year 30000 to 40,000, wherein 50% is the child.In child and teen-age malignant tumor, leukemia then occupy

position.The children acute leukemia is prevalence and the highest disease of mortality rate in the Childhood malignancy disease; Account for 30%～40% of whole tumors in children; In child patient; Have only the child of twenty percent to be treated timely and effectively and smooth recovery, most of infants are lost chance for survival because of can not get treatment in time.

Leukemia generally is divided into acute and chronic by natural history and the inmature degree of cell, be divided into types such as granulocyte, lymphocyte, mononuclear cell by cell type, and clinical manifestation is had nothing in common with each other.According to the cell series of mainly getting involved, leukemia can be divided into following type again: one, acute leukemia comprises acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML) etc.; Two, chronic leukemia, common have a chronic myelocytic leukemia (CML) etc.China's acute leukemia is seen (about 5.5:1) than chronic leukemia more, and wherein anxious granulocyte leukemia is (1.62/10 ten thousand, slow grain leukemia 0.36/10 ten thousand) at most, sees at most with acute myeloblastic leukemia in adult's acute leukemia.China's leukemia sickness rate is close with Asian countries, is lower than American-European countries.The AML-M1 leukemia is the acute myeloblastic leukemia undifferentiated type, is a kind of in the acute myeloblastic leukemia.

In recent years, along with the development of medical skill, leukemia can be checked the leukocyte of pathological changes with the chemotherapy and radiation method, through killing and wounding leukocyte, alleviates leukemic load, prolongs patient's life.But the side effect of this method is big, as kills and wounds, suppresses the normal hematopoiesis stem cell, causes anemia, hemorrhage; Suppress normal immunologic function, immunity of organisms descends, and merges various infection easily; Damage gastrointestinal tract mucously, cause that anorexia is felt sick, vomiting, influence darling renal function; Even dosage is big again, also can not kill intravital leukaemia fully, and residual leukaemia is the root of palindromia.This brings great misery not only for the patient, and causes heavy mental burden and loss economically for its family and society.Therefore, a lot of people stopped treatment of having to is arranged, painful and helpless in wait for and dislike the arrival of interrogating.

Summary of the invention

The objective of the invention is to solve the above-mentioned technical problem that existing western medicine leukemia exists, the acute granulocyte AML of a kind of treatment-leukemic Chinese medicine composition of M1 type is provided.

For solving the problems of the technologies described above, the technical scheme that the present invention adopts is following:

The acute granulocyte AML of treatment of the present invention-leukemic Chinese medicine composition of M1 type is made up of following component:

The Radix Rehmanniae 15～25 grams

Cortex Moutan 8～16 grams

Radix Glycyrrhizae (processed with honey) 4～8 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 18～32 grams

Rhizoma Imperatae 14～20 grams

Fructus Ligustri Lucidi 18～28 grams

Herba Cistanches 14～28 grams

Cordyceps 4～8 grams

Folium Isatidis 15～25 grams

Wild Radix Ophiopogonis 8～16 grams

Flos Lonicerae 8～16 grams.

The acute granulocyte AML of treatment of the present invention-leukemic Chinese medicine composition of M1 type preferably is made up of following component:

The Radix Rehmanniae 18～23 grams

Cortex Moutan 10～12 grams

Radix Glycyrrhizae 5～7 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 1 15～25 grams

Rhizoma Imperatae 15～18 grams

Fructus Ligustri Lucidi 20～25 grams

Herba Cistanches 20～25 grams

Cordyceps 5～8 grams

Folium Isatidis 18～20 grams

Wild Radix Ophiopogonis 10～15 grams

Flos Lonicerae 10～15 grams.

Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Herba Hedyotidis Diffusae (Hedyotidis Diffusae) is picked up only, and per kilogram Herba Hedyotidis Diffusae (SHECAO) is dried after 30 minutes with the stewing profit of 50 grammeter vinegar; The leaf of Folium Isatidis before with the florescence, promptly six, the July plucks.

The decocting method of Chinese medicine composition of the present invention is following:

(1) water of boiling medicine: adopt phreatic water or mineral water, the city is drunk (from the beginning) water and should be inserted earlier in the porcelain basin and placed 2 hours.

(2) immersion process: before boiling medicine, should earlier medicine be put into marmite, add cold water 700ml～900ml, soak 30 minutes.

(3) decocting method: every dose of medicine decocts twice.With big fire soaked medicine is boiled earlier for the first time, use middle or small fire again instead, fry in shallow oil truce in 25 minutes, the leaching medicinal liquid; Add for the second time water 500ml～600ml, with big fire medicine is boiled earlier, use middle or small fire again instead, fry in shallow oil truce in 20 minutes, the leaching medicinal liquid; With the first time institute's taking liquid mix.

The instructions of taking of medicine of the present invention:

Every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 250ml～350ml that is grown up, the each 120ml～180ml of child.Decoction being taken warmly.

Theory of Chinese medical science is thought, causes the i.e. generation of " mass formed by blood stasis " of leukemia a little less than the liver of suffering from a deficiency of the kidney.Kidney is claimed water, kidney intrinsic energy water, and liver is claimed wood, wood can be lit a fire.Liver does not have then hyperactivity of fire of kidney water, and kidney does not have liver-fire, and then water is cold.Suffer from a deficiency of the kidney a little less than the liver then that blood does not have life, liver-kidney diseases is disorders of blood then.According to this principle, warp studies repeatedly and test obtains following proved recipe.

In the prescription of the present invention, Radix Rehmanniae sweet in the mouth is gone into the heart, liver, kidney channel, can removing heat from blood, again can YIN nourishing, and the effect of tool heat clearing away YIN nourishing, cooling blood for hemostasis, promoting the production of body fluid to quench thirst.Modern pharmacological research shows, the Radix Rehmanniae has radioprotective, protects the liver, blood sugar lowering, heart tonifying, hemostasis, diuresis, antifungal effect.It is cool in nature for Cortex Moutan, bitter in the mouth, suffering, and the function heat clearing away, removing heat from blood and blood, the clear stasis of blood are applicable to thermal man's blood system, send out speckle, frightened pain, haematemesis, carbuncle and ulcer, diseases such as traumatic injury.Radix Glycyrrhizae is sweet, and is flat; GUIXIN, lung, spleen, stomach warp have the function of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Herba Hedyotidis Diffusae (Herba Hedyotidis Diffusae) is sweet, salty, temperature; Return Liver Channel, heat-clearing and toxic substances removing, diuresis of blood circulation promoting are used for tonsillitis, tumor, and especially the tumor cell to acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type has strong inhibitory action (methylene blue test tube method).Rhizoma Imperatae is sweet, and is cold, returns lung, stomach, urinary bladder channel, has cooling blood for hemostasis, the effect of clearing away heat and promoting diuresis; Be used for heat in blood and spit blood epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria.Fructus Ligustri Lucidi is sweet, bitter, and liver, kidney channel are returned in cold, have raise immunity, and the platelet of ging up fast and anti-gene mutation and antineoplastic action can reduce and remove the damage of chemotherapeutics to internal organs.Herba Cistanches sweet in the mouth, salty, warm in nature, ability kidney-replenishing, benefiting essence-blood enhancing immunity are adjusted microcirculatory effect.Cordyceps sweet in the mouth, warm in nature is returned kidney, lung meridian, is China's tradition rare Chinese medicine, includes compositions such as Cordyceps element, cordycepic acid, adenosine and polysaccharide; The Cordyceps element can suppress pathogen growth such as streptococcus, Actinobacillus mallei anthrax bacillus, is again anticancer active substance, and the hormonal system of human body and nervous system are had good regulating action; Use cordycepin to be mostly adjuvant therapy of malignant tumor clinically, symptom is improved more than 91.7%; Be mainly used in rhinocarcinoma, pharyngeal cancer, pulmonary carcinoma, leukemia, the patient of the brain cancer and other malignant tumor.The Folium Isatidis bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing is arranged, the function of the clear speckle of removing heat from blood.Be used for pathogenic warmth and join the army, unconsciousness due to high fever is sent out the speckle dermexanthesis, jaundice, and hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle has stronger antibacterial action.Sweet, the little hardship of wild Radix Ophiopogonis is slightly cold.Return stomach, lung, heart channel YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Flos Lonicerae is sweet, and is cold, returns lung, the heart, stomach warp.Be usually used in heat-clearing and toxic substances removing, the heating of treatment epidemic febrile disease, toxic-heat and blood stasis, diseases such as carbuncle and ulcer, Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ".Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate effect such as immunity.More than all medicines according to the Therapeutic Principle of monarch, minister, the combination principle of helping, making and vital base and primordial QI consolidating, kill pathogenic cell fast, system regulates the function and the body immunity of each internal organs.Patient's long-term surviving is got well.

Medicine of the present invention has following effect aspect treatment acute granulocyte AML-M1 type leukemia: the specific aim treatment is carried out to the concrete typing AML-M1 type of acute myeloblastic leukemia in (1); Selectively suppress and kill juvenile cell; Induced apoptosis in leukemia cell lines; Specific aim is stronger, and therapeutic effect is higher.(2) promotion leukaemia's differentiation, maturation.(3) regulate QI and blood, raise immunity.(4) recovery of promotion bone marrow normal hematopoiesis function.(5) reduce reverse, prevent drug-fast generation.

Compare with prior art, the beneficial effect that the present invention has is following:

(1) evident in efficacy, cure rate is higher than chemicotherapy and bone marrow transplantation therapy far away.(2) efficacy consolidation, less recurrence.Seldom toxic and side effects is easy to accept.(3) cheap expense is the selection that common people can think highly of disease.(4) seldom produce the drug resistance phenomenon, chemotherapy is produced the drug-fast curative effect preferably that also has.Especially those cases of not alleviating of chemotherapy repeatedly more show the curative effect of its uniqueness, reopen new life's road for the patient.(5) strengthening vital QI to eliminate pathogenic factors protection internal organs, the toxic and side effects of minimizing chemotherapy is taken patient's overwhelming majority organ functions of Chinese medicine and is well protected, and simultaneously the chemotherapy left drug is had detoxifcation, scavenging action.

For showing that Chinese medicine composition of the present invention to acute granulocyte AML-leukemic therapeutic effect of M1 type, adopts medicine of the present invention, 16 routine patients are carried out the overall process treatment observe.The patient takes medicine of the present invention by above-mentioned decocting method and the method for taking, clinical cure 12 examples wherein, and long-term surviving 1 example is alleviated 1 example fully, and part is alleviated 1 example, alleviates (invalid) 1 example.

Acute myeloblastic leukemia treatment criterion of therapeutical effect is following:

One, alleviate (CR) fully: bone marrow: leukaemia≤5%, hyperplasia degree is normal, respectively is that ratio is normal basically.Hemogram Hb >=100g/L, neutrophilic granulocyte number >=1.5 * 109/L, platelet >=100 * 109/L divides apoplexy due to endogenous wind not have the leukaemia.Sings and symptoms due to clinical no leukemia is soaked into, life is normal or basic near normal.

Two, part is alleviated (PR): leukaemia in the bone marrow>5%, but 20%, or have 1 not reach the CR standard in the hemogram, clinical 2.

Three, do not alleviate (NR): do not reach (PR) standard person.

Four, recurrence: have following thrin person to be recurrence:

(1) bone marrow leukemia cells>5%, but < 20%, the effective leukemia of warp is treated and is not reached CR person a course of treatment yet.

(2) bone marrow leukemia cells>20%.

(3) the clinical outer leukemia of marrow that occurs is soaked into (bone marrow and hemogram are still normal).

Five, continued complete remission (CCR): from reaching CR, no leukemia relapse>3～5 years.

Six, long-term surviving: make a definite diagnosis leukemia and rise, anosis or existence in spite of illness>5 years.

Seven, clinical cure: after taking medicine CR of the present invention, anosis (leukemia) survives more than 5 years.

The specific embodiment

Embodiment 1

Treating acute granulocyte AML-leukemic Chinese medicine composition of M1 type is made up of following component:

The Radix Rehmanniae 15 grams

Cortex Moutan 10 grams

Radix Glycyrrhizae (processed with honey) 8 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 25 grams

Rhizoma Imperatae 14 grams

Fructus Ligustri Lucidi 28 grams

Herba Cistanches 14 grams

Cordyceps 8 grams

Folium Isatidis 20 grams

Wild Radix Ophiopogonis 10 grams

Flos Lonicerae 12 grams.

Embodiment 2

Treating acute granulocyte AML-leukemic Chinese medicine composition of M1 type is made up of following component:

The Radix Rehmanniae 18 grams

Cortex Moutan 12 grams

Radix Glycyrrhizae (processed with honey) 7 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 32 grams

Rhizoma Imperatae 20 grams

Fructus Ligustri Lucidi 18 grams

Herba Cistanches 20 grams

Cordyceps 7 grams

Folium Isatidis 18 grams

Wild Radix Ophiopogonis 15 grams

Flos Lonicerae 8 grams.

Embodiment 3

Treating acute granulocyte AML-leukemic Chinese medicine composition of M1 type is made up of following component:

The Radix Rehmanniae 20 grams

Cortex Moutan 8 grams

Radix Glycyrrhizae (processed with honey) 6 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 15 grams

Rhizoma Imperatae 15 grams

Fructus Ligustri Lucidi 25 grams

Herba Cistanches 25 grams

Cordyceps 6 grams

Folium Isatidis 25 grams

Wild Radix Ophiopogonis 16 grams

Flos Lonicerae 16 grams.

Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Herba Hedyotidis Diffusae (Hedyotidis Diffusae) is picked up only, and per kilogram Herba Hedyotidis Diffusae (SHECAO) is dried after 30 minutes with the stewing profit of 50 grammeter vinegar; The leaf of Folium Isatidis before with the florescence, promptly six, the July plucks.

Embodiment 4

Treating acute granulocyte AML-leukemic Chinese medicine composition of M1 type is made up of following component:

The Radix Rehmanniae 23 grams

Cortex Moutan 14 grams

Radix Glycyrrhizae (processed with honey) 5 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 18 grams

Rhizoma Imperatae 18 grams

Fructus Ligustri Lucidi 20 grams

Herba Cistanches 28 grams

Cordyceps 5 grams

Folium Isatidis 15 grams

Wild Radix Ophiopogonis 8 grams

Flos Lonicerae 10 grams.

Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Herba Hedyotidis Diffusae (Hedyotidis Diffusae) is picked up only, and per kilogram Herba Hedyotidis Diffusae (SHECAO) is dried after 30 minutes with the stewing profit of 50 grammeter vinegar; The leaf of Folium Isatidis before with the florescence, promptly six, the July plucks.

Embodiment 5

Treating acute granulocyte AML-leukemic Chinese medicine composition of M1 type is made up of following component:

The Radix Rehmanniae 25 grams

Cortex Moutan 16 grams

Radix Glycyrrhizae (processed with honey) 4 grams

Herba Hedyotidis Diffusae (Hedyotidis Diffusae) 28 grams

Rhizoma Imperatae 19 grams

Fructus Ligustri Lucidi 26 grams

Herba Cistanches 18 grams

Cordyceps 4 grams

Folium Isatidis 23 grams

Wild Radix Ophiopogonis 12 grams

Flos Lonicerae 15 grams.

Said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Herba Hedyotidis Diffusae (Hedyotidis Diffusae) is picked up only, and per kilogram Herba Hedyotidis Diffusae (SHECAO) is dried after 30 minutes with the stewing profit of 50 grammeter vinegar; The leaf of Folium Isatidis before with the florescence, promptly six, the July plucks.

Model case

Case one: the summer so-and-so; The woman; 12 years old; On JIUYUE 30th, 2004 was diagnosed as M1 type leukemia at attached first examination in hospital of Zhengzhou University's medical college, and the bone marrow examination result shows that myeloblast is 94.40%, all blood blood test platelet 30 * 109/L, neutrophilic granulocyte 0.1 * 109/L, HB81g/L, WBC90.6 * 109/L.The patient begins to take the Chinese medicine of the embodiment of the invention 5 prescriptions on October 6th, 2004, and every day, potion was taken at twice, and each clothes is half the sooner or later, is separated by 12 hours for twice.Each 120ml～180ml, decoction being taken warmly.And in December in 2004 check chemical examination on the 11st; Bone marrow blast is 0.9% (normal fully), all blood blood test platelet 117 * 109/L (normal fully), neutrophilic granulocyte 2.5 * 109/L (normal fully), HB115g/L (normal fully), WBC5 * 109/L (normal fully).Its resume speed is fast, and is effective.Following the tracks of so far, its each item index all keeps normal.

Case two: thank certain, the woman, 30 years old, people from Fengtai, Beijing was diagnosed as M1 type leukemia on JIUYUE 3rd, 2006 at PLA General Hospital.The bone marrow aspiration inspection shows that myeloblast is 95.60%, all blood blood test platelet 65 * 109/L, neutrophilic granulocyte 9.0 * 109/L, HB66g/L, WBC92.2 * 109/L.Begin to take the Chinese medicine of the embodiment of the invention 4 prescriptions on October 2nd, 2006, every day, potion was taken at twice, and each clothes is half the sooner or later, was separated by 12 hours for twice.Each 250ml～350ml, decoction being taken warmly.Check on November 1st, 2006, all blood chemical examinations show platelet 121 * 109/L (normal fully), neutrophilic granulocyte 3.5 * 109/L (normal fully), HB125g/L (normal fully), WBC6.7 * 109/L (normal fully).Following the tracks of so far, its each item index all keeps normal.

Case three: Zhao; The woman; 29 years old, people from Xuzhou was diagnosed as acute granulocyte M1 type leukemia on January 4th, 2005 in the People's Hospital, Xuzhou; The bone marrow examination result shows that myeloblast is 97%, all blood blood test platelet 46 * 109/L, neutrophilic granulocyte 0.3 * 109/L, HB86g/L, WBC91.9 * 109/L.Begin to take the Chinese medicine that the present invention implements 3 prescriptions on January 7th, 2005, every day, potion was taken at twice, and sooner or later each clothes is half the, was separated by 12 hours for twice.Each 250ml～350ml, decoction being taken warmly.Chemical examination on March 10th, 2005 is the result show; Myeloblast is 0.7% (normal fully), and all blood chemical examinations show platelet 221 * 109/L (normal fully), neutrophilic granulocyte 6.5 * 109/L (normal fully), HB110g/L (normal fully), WBC8.7 * 109/L (normal fully).Pay a return visit once every month now, Zhao's condition is good.

Case four: Song; The man; 16 years old, people from Zhengzhou City was diagnosed as granulocyte leukemia M1 type on March 24th, 2009 in the People's Hospital, Zhengzhou City; The bone marrow examination result shows myeloblast 93.60%, all blood blood test platelet 77 * 109/L, neutrophilic granulocyte 0.2 * 109/L, HB85.4g/L, WBC91 * 109/L.Begin to take the Chinese medicine of the embodiment of the invention 2 prescriptions on March 28th, 2009; Chemical examination on May 30th, 2009; Bone marrow myeloblast 0.8% (normal fully), all blood chemical examinations show platelet 221 * 109/L (normal fully), neutrophilic granulocyte 6.5 * 109/L (normal fully), HB110g/L (normal fully), WBC8.7 * 109/L (normal fully).Paid a return visit once in per two months now, Song's condition is good.Life happiness.

Case five: Wei so-and-so, woman, 47 years old; People from Xinyang; On April 25th, 1998 is uncomfortable, and the large tracts of land purple dot appears in whole body, is diagnosed as acute myeloblastic leukemia M1 type through Hospital No.1 Attached to Henan Medical Univ.; The bone marrow testing result shows myeloblast 92. 70%, all blood blood test platelet 79 * 109/L, neutrophilic granulocyte 0.25 * 109/L, HB81.4g/L, WBC92.1 * 109/L.Chemotherapy is not alleviated two courses of treatment.Begin to take the Chinese medicine of the embodiment of the invention 1 prescription on October one, 1998; Chemical examination on January 20th, 1999; Bone marrow myeloblast 0.96%, all blood chemical examinations show that platelet 132 * 109/L, neutrophilic granulocyte 4.5 * 109/L, HB151g/L, WBC8.8 * 109/L are all in normal range.13 years now.Follow the trail of and pay a return visit annually, Wei is healthy, life happiness.Wei, so-and-so told us, and her health is seldom caught a cold than also good before not falling ill.

Claims (3)

1. treatment acute granulocyte AML-leukemic Chinese medicine composition of M1 type is characterized in that it is made up of following component:

The Radix Rehmanniae 15～25 grams

Cortex Moutan 8～16 grams

Radix Glycyrrhizae (processed with honey) 4～8 grams

Herba Hedyotidis Diffusae 18～32 grams

Rhizoma Imperatae 14～20 grams

Fructus Ligustri Lucidi 18～28 grams

Herba Cistanches 14～28 grams

Cordyceps 4～8 grams

Folium Isatidis 15～25 grams

Wild Radix Ophiopogonis 8～16 grams

Flos Lonicerae 8～16 grams.

2. the acute granulocyte AML of the treatment according to claim 1-leukemic Chinese medicine composition of M1 type is characterized in that it is made up of following component:

The Radix Rehmanniae 18～23 grams

Cortex Moutan 10～12 grams

Radix Glycyrrhizae (processed with honey) 5～7 grams

Herba Hedyotidis Diffusae 15～25 grams

Rhizoma Imperatae 15～18 grams

Fructus Ligustri Lucidi 20～25 grams

Herba Cistanches 20～25 grams

Cordyceps 5～8 grams

Folium Isatidis 18～20 grams

Wild Radix Ophiopogonis 10～15 grams

Flos Lonicerae 10～15 grams.

3. the acute granulocyte AML of the treatment according to claim 1 and 2-leukemic Chinese medicine composition of M1 type is characterized in that: said Fructus Ligustri Lucidi steamed 30 minutes with the big fire of copper pot bamboo cage, and taking-up is dried, and steamed again, and nine steam nine shines; Herba Hedyotidis Diffusae is picked up only, and the per kilogram SHECAO is dried after 30 minutes with the stewing profit of 50 grammeter vinegar; The leaf of Folium Isatidis before with the florescence.