CN102048806A - Composition for protection and treatment of gastroenteropathy and digestive system cancer and preparation method thereof - Google Patents
Composition for protection and treatment of gastroenteropathy and digestive system cancer and preparation method thereof Download PDFInfo
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Abstract
A composition for protection and treatment of gastroenteropathy and digestive system cancer and the preparation method of the composition belong to the technical field of food and medicine and solve the problem of protection and treatment of gastroenteropathy and digestive system cancer. Through large-prescription dosage form reform, the composition is composed of three groups of prescriptions, wherein the group A is a medicine and food preparation used for treating gastrointestinal diseases and supplementing human nutrition, the group B is a pharmaceutical preparation containing antibacterial traditional Chinese medicine and used for treating gastrointestinal diseases, and the group C is a pharmaceutical preparation used for treating digestive system cancer. Each of the three groups of prescriptions has own functions and characteristics, and the prescriptions supplement one another in regulating medicinal effectiveness, so that symptomatic treatment is facilitated, and the purposes of being homologous in treatment and nourishing and treating both principal and secondary aspect of disease are achieved. Clinical trials prove that 100% of user aiming at health care and beauty take on completely new looks after taking the nutrient for 7 to 15 days, more than 95% of patients suffering from gastroenteropathy are cured after taking medicine for 3 to 7 days, and symptoms of more than 85% of patients suffers from digestive system cancer disappear after the patients taking the medicine for 10 to 30 days, so that preeminent curative effect of the composition is demonstrated fully; and the invention is one of the up-to-date invention technologies.
Description
Technical field
The present invention relates to a kind of composition and method of making the same of protecting treatment gastrointestinal disease and cancers in digestive system disease, belong to food medicine technical field.Specifically being divided into three prescription agent by its pharmacological action, using according to the feelings plus-minus, is the novel invention technology of a class.
Background technology
Because people's rhythm of life is accelerated, contain reasons such as chemical analysis height in the food in recent years, the number of suffering from gastrointestinal disease and cancer is ascendant trend year by year, has a strong impact on the healthy of people.Add up according to World Health Organization (WHO): nearly 400,000,000 people of China's patients with gastric disease, sickness rate is up to 90%, and with annual 20% speed increment; Annual last more than 100 ten thousand people lose one's life because of cancer.Therefore, the research and development of medical technology successfully are significant.
At present, though it is various to treat the medicament categories of various gastrointestinal disease and cancer, great majority can only play temporary transient control and mitigation in treatment, cure also recurrence easily of back, and there is toxic and side effects in some.For treatment for cancer, can only adopt the way of excision, cancer patient for middle and advanced stage, postoperative relapse rate is high, and put, chemotherapy also can cause multiple toxic and side effects, treatment has not only increased patient's misery and economic loss repeatedly, and more serious is to make disease form Drug resistance, increases the treatment difficulty.
The invention provides a kind of compositions; in the process of research protection treatment gastrointestinal disease and cancers in digestive system disease pathological changes; according to " distinguish the disease of curing the disease support internal organs dissolving blood stasis and detoxication QI and blood logical " this principle, hide difficulty in early days at disease and discover, mid-term indefinite changeableization; worsen the refractory reason late period; its old complaint can cause the characteristics of whole body concurrency disease in vivo, takes the method for the body resistance strengthening and constitution consolidating, sets about from changing the interior environment that produces the source of disease cell; by improving the immunity of human body self, reach and cure purpose in a short time.
The invention provides a kind of compositions, be that secret prescription handed down in the family from generation to generation is gone through succession in thousand, the principles of science research and development in conjunction with the present age form, be primarily characterized in that the form improvement of prescription, established superior on drug effect, concentrate the main component in crude drug and the compound recipe, bring into play pharmacological action from multi-level aspect, avoid the multi-flavor medicament mixed and make the loss of effective element, under the prerequisite that does not change therapeutic effect, reduce the consumption of Chinese herbal medicine, more helped symptomatic treatment, realized controlling the target of supporting the homology treating both the principal and secondary aspects of a disease.
The present composition by its pharmacological action configuration fully uses flexibly, and therapeutic domain is wide, and curative effect is short, non-relapse after healing, the characteristics that have no side effect.Gastrointestinal disease cure rate 93.2%, cancers in digestive system disease cure rate 71.4%, the fact shows that said composition is the greatness innovation of more preceding technology.
Summary of the invention
The compositions of protection treatment gastrointestinal disease and cancers in digestive system disease is made up of A, B, C three prescription agent, the A group: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition; B group: a kind of pharmaceutical preparation that contains antibiotic treatment by Chinese herbs gastrointestinal disease; C group: a kind of pharmaceutical preparation for the treatment of cancers in digestive system disease.
Said composition has the cellular immune function of significantly improving, and promotes lymphocyte transformation, strengthens the effect of humoral immunization.Form improvement by big prescription; help protecting human body health; efficient in a short time multiple gastrointestinal disease of healing and cancers in digestive system disease; mainly show urgency; chronic gastroenteritis; gastric injury; pyloric obstruction; helicobacter pylori; bleeding of gastro-duodenal ulcer; gastrointestinal tract companion carcinoma syndrome; the proteins lose gastrointestinal syndrome; bile reflux gastritis; gastroparesis syndrome; chronic atrophic gastritis; benign tumor of stomach; leiomyosarcoma of stomach; chronic erosive gastritis; gastric cancer; intestinal cancer; hepatocarcinoma; esophageal carcinoma; pulmonary carcinoma; leukemia and small cell carcinoma etc. have significant curative effect; it is short to have curative effect simultaneously; the cure rate height; more do not recur the characteristics that have no side effect after.
The implementation of the technology of the present invention:
One, the preparation of A group medicine food preparation
1, basic prescription parts by weight of raw materials
Os Canitis 1-40 weight portion Radix Ginseng 1-30 weight portion Radix Notoginseng 1-30 weight portion Semen Canavaliae 1-25 weight portion
Radix Angelicae Dahuricae 1-35 weight portion Radix Glycyrrhizae 1-15 weight portion
2, add the flavor parts by weight of raw materials
Semen Armeniacae Amarum 1-20 weight portion Flos Lonicerae 1-50 weight portion Pseudobulbus Bletillae (Rhizoma Bletillae) 1-50 weight portion Agkistrodon halys 1-30 weight portion
Radix Glehniae 1-25 weight portion Radix Angelicae Sinensis 1-25 weight portion Rhizoma Chuanxiong 1-25 weight portion Fructus Lycii 1-25 weight portion
Rhizoma Atractylodis Macrocephalae 1-25 weight portion is seen Stigma Maydis 1-60 weight portion
3, preferred prescription parts by weight of raw materials
Os Canitis 25 weight portion Radix Ginsengs 25 weight portion Radix Angelicae Sinensis 25 weight portion Radix Notoginseng 15 weight portions
The Rhizoma Chuanxiong 15 weight portion Fructus Lyciis 20 weight portion Radixs Angelicae Dahuricae 15 weight portion Radix Glycyrrhizaes 10 weight portions
Radix Glehniae 20 weight portion Semen Canavaliaes 15 weight portion Stigma Maydis 30 weight portions
4, preparation method
(1) with fresh Os Canitis warm water cleaning, be hung on the ventilation and dry, the calcining sustainability is ground 80 order fine powders into powder.
(2) fresh and alive Agkistrodon halys is taken out internal organs, clean vexed with quantitative yellow wine, take out, place 60 ℃ of drying baker dry, grind 80 order fine powders into powder.
(3) will remain 14 flavors and grind 10-20 order coarse powder respectively into powder, and place Decocting pot, and soak 30～60min for 40 ℃ with warm water, and add 5 times in water and repeat to decoct 2 times, each 60min merges extract, filters, and concentrates; Concentrated solution is added 75% ethanol 3-5 doubly, stirs 10-20min, extract supernatant after leaving standstill 36h, merge supernatant, reclaim ethanol, concentrated extract, spray-dried mixture dry powder.
(4) by weight (1), (2), (3) and Mel are mixed, place vacuum drying oven,, promptly get mixture, prepare the preparation of needs through sterilization, adding adjuvant according to a conventional method with 60 ℃ of temperature dryings.
Two, the preparation of B group pharmaceutical preparation
1, basic prescription parts by weight of raw materials:
Radix Ginseng 1-30 weight portion Radix Notoginseng 1-25 weight portion Os Sepiae 1-25 weight portion Radix Angelicae Dahuricae 1-35 weight portion
Rhizoma Corydalis 1-25 weight portion Mel 1-100 weight portion
2, add the flavor parts by weight of raw materials:
Furazolidone 0.1-1 weight portion Cortex Phellodendri 1-25 weight portion Radix Scutellariae 1-30 weight portion Radix Linderae 1-20 weight portion
Alumen 1-10 weight portion Semen Canavaliae 1-20 weight portion Rhizoma Atractylodis Macrocephalae 1-25 weight portion Radix Aucklandiae 1-25 weight portion
Sanguis Draxonis 1-20 weight portion Herba Cassiopes selaginoidis 1-60 weight portion
3, preferred prescription parts by weight of raw materials
The Radix Angelicae Dahuricae 15 weight portion Radixs Linderae 10 weight portion Radix Ginsengs 20 weight portion Radix Notoginseng 15 weight portions
The Os Sepiae 20 weight portion Radix Aucklandiae 9 weight portion Rhizoma Atractylodis Macrocephalaes 15 weight portion Alumens 6 weight portions
Rhizoma Corydalis 20 weight portion Mel 20 weight portions
4, preparation method:
(1), with fresh Os Canitis warm water cleaning, be hung on the ventilation and dry, the calcining sustainability, grind 80 order fine powders into powder.
(2), Alumen, Sanguis Draxonis are ground into powder 80 order fine powders.
(3) furazolidone and Mel are taken with the agent proportioning.
(4), will remain 11 flavors and grind 10-20 order coarse powder respectively into powder, place Decocting pot, soak 30～60min with 40 ℃ in warm water, add 5 times in water and repeat to decoct 2 times, each 60min merges extract, filters, and concentrates; Concentrated solution is added 75% ethanol 3-5 doubly, stirs 10-20min, extract supernatant after leaving standstill 36h, merge supernatant, reclaim ethanol, concentrated extract, spray-dried mixture dry powder.
(5), by weight (1), (2), (4) are mixed, through sterilizing, add the preparation that adjuvant prepares needs according to a conventional method.
Three, the preparation of C group pharmaceutical preparation
1, basic prescription parts by weight of raw materials:
Octacosanol 0.1-3 weight portion Radix Notoginseng 1-25 weight portion Rhizoma Arisaematis 1-25 weight portion Hirudo 1-15 weight portion
Bufo siccus 1-35 weight portion Rhizoma Pinelliae 1-25 weight portion
2, add the flavor parts by weight of raw materials:
Rhizoma Dioscoreae Bulbiferae 1-35 weight portion Agkistrodon 1-20 weight portion Radix Et Rhizoma Rhei 1-35 weight portion Radix Ampelopsis 1-25 weight portion
Rhizoma Atractylodis Macrocephalae 1-30 weight portion Galla Chinensis 1-20 weight portion Radix Sophorae Tonkinensis 1-20 weight portion Semen Canavaliae 1-25 weight portion
Give birth to EYI 1-30 weight portion Radix Tripterygii Wilfordii 1-50 weight portion Cinnabaris 0.1-2 weight portion Rhizoma Chuanxiong 1-20 weight portion
Radix Scrophulariae 1-35 weight portion Rhizoma Paridis 1-25 weight portion arsenicum 0.01-0.15 weight portion
3, preferred prescription parts by weight of raw materials
Give birth to EYI 20 weight portion Radix Tripterygii Wilfordiis 25 weight portion Rhizoma Dioscoreae Bulbiferaes 20 weight portion Radix Et Rhizoma Rhei 25 weight portions
Cinnabaris 0.6 weight portion Rhizoma Chuanxiong 20 weight portion Bufo siccuss 25 weight portion Rhizoma Pinelliae 15 weight portions
Radix Notoginseng 20 weight portion Rhizoma Arisaematiss 20 weight portion Hirudos 10 weight portion octacosanol 1 weight portion
4, preparation method:
(1), octacosanol white powder and Cinnabaris, arsenicum three flavors are mixed, grind 200 order fine powders into powder.
(2), will remain 18 flavors and grind 10-20 order coarse powder respectively into powder, place Decocting pot, soak 30～60min with 40 ℃ in warm water, add 5 times in water and repeat to decoct 2 times, each 60min merges extract, filters, and concentrates; Concentrated solution is added 75% ethanol 3-5 doubly, stirs 10-20min, extract supernatant after leaving standstill 36h, merge supernatant, reclaim ethanol, concentrated extract, spray-dried mixture dry powder.
(3), by weight (1), (2) are mixed, through sterilizing, add the preparation that adjuvant prepares needs according to a conventional method.
The present invention has improved characteristics:
1, compositions is by the form improvement of big prescription, established superior on drug effect, avoids multiple medicine to mix and makes the loss of effective element, reduced drug cost and to the toxic and side effects of human body.
2, big prescription under the prerequisite that does not change therapeutic effect, helps nursing one's health medication mechanism symptomatic treatment by its pharmacological action segmentation, realizes controlling the target of supporting the homology treating both the principal and secondary aspects of a disease.
3, advocate to adopt powder, capsule be main to the present composition, keeping the highest effective ingredient that biology contains, clinical trial certificate, the dosage of decoct be powder 3-5 doubly, significantly reduce the cost of medicine food product.
4, a kind of medicine of additional human nutrition food preparation can promote patient's antibody, blood yiqi, invigorating the spleen and regulating the stomach, enhancing immunity, epidemic prevention influenza, bird flu and the effect that possesses looks improving and the skin nourishing;
5, the application of octacosanol in treatment cancers in digestive system disease prescription has the fast Absorption that promotes medicine, plays active osmosis in vivo, simultaneously Primary hyperlipemia and Secondary cases hyperlipemia all had effect for reducing fat.
6, present composition short treating period instant effect, the gastrointestinal disease patient more than 90% takes medicine and can fully recover in 3-7 days, and the cancers in digestive system disease patient more than 60% takes medicine and can reach the optimum efficiency of treatment in 15-30 days.
Specific embodiments:
The Therapeutic Principle of the traditional Chinese medical science is the cause of disease from the organic conception analysis of disease, and sick position, pathogenesis and patient's body constitution and onset condition thereof and lapse to are distinguished the principal contradiction and the contingent evolution of pathological changes, seek the way and the universal rule of resolving contradiction.
The present composition is determined prescription according to mentioned above principle at different syndromes, further specify the present invention in conjunction with the embodiments below by the compositions that proposes.
Embodiment 1
The Qin, man, 42 years old.Mainly show as shortness of breath and palpitation, malaise, inappetence, eat do not change, cough dyspnea due to deficiency, soreness of the waist and knees etc.To these deficiency syndrome continue 1 year surplus, once bought according to purport capsule/strong word G20041160 of state's food, American Ginseng Tea/strong word G20040588 of state's food and took several months commentariess on classics of not getting better, the traditional Chinese medical science calls " deficiency syndrome " to the disease that each pathological state causes, the health food of application benefiting vital QI and blood.
Use prescription: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition
Os Canitis 90g Radix Ginseng 75g Radix Notoginseng 60g Semen Canavaliae 50g Radix Angelicae Dahuricae 75g Radix Glycyrrhizae 35g Stigma Maydis 90g
Above-mentioned prescription is prepared into powder or capsule by pharmaceutically acceptable method, every day 3 times, each 6 grams, warm water delivery service takes that complexion, spirit are clearly better after 8 days.
Embodiment 2
Huang, woman, 26 years old.Epigastric fullness, inappetence 6 months is treated the commentaries on classics of not getting better through the number treatment.Existing disease: epigastric distension and distress, the singultus vomiting, anorexia, the thin yellowish complexion of shape, red tongue tongue root is yellow greasy, wiry and frequent pulse.Gastroscope shows: chronic superficial moderate gastritis.
Dialectical: resistance, stomach-QI being unable to descend normally in damp and hot
Use prescription: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition
Os Canitis 75g Radix Ginseng 60g Radix Notoginseng 45g Semen Canavaliae 50g Semen Armeniacae Amarum 35g Radix Glehniae 55g
Radix Angelicae Dahuricae 60g Radix Glycyrrhizae 30g Stigma Maydis 100g
Above-mentioned prescription is prepared into powder or capsule by pharmaceutically acceptable method, every day 3 times, each 6 grams, warm water delivery service is taken transference cure after 7 days.
Embodiment 3:
The Wang, man, 41 years old.Gastralgia was shown effect 5 years repeatedly, did not whenever freely bring out or increased the weight of because of injury due to diet or feelings will, with the scorching hot feeling of distension and oppression of gastral cavilty, belch, nausea, poor appetite.Informal dress is with medicines such as Western medicine motilium, ranitidines, but heavy when light during the state of an illness, not thoroughly healing, subjective symptoms increases the weight of closely over the past half year.Gastroscope and histopathologic examination are diagnosed as: chronic atrophic gastritis, gastric antrum mucosa wall severe piebald shape changes, and is red and white.Examine and see: the scorching hot distension pain of gastral cavilty, it is easypro slightly to get belch, xerostomia desire drink,
Eating little and nausea is hard and dry, and it is weak to become thin, shallow complexion, and dry tongue is red, and tongue is few, thready and rapid pulse.
Dialectical: deficiency of stomach-Yin
Use prescription: a kind of pharmaceutical preparation that contains antibiotic treatment by Chinese herbs gastrointestinal disease
Os Sepiae 50g Radix Angelicae Dahuricae 70g Radix Ginseng 70g Alumen 35g Rhizoma Corydalis 60g Radix Notoginseng 80g
Rhizoma Atractylodis Macrocephalae 60g Mel 160g furazolidone 2.5g
Above-mentioned prescription is prepared into powder or capsule by pharmaceutically acceptable method, every day 3 times, each 6 grams, warm boiled water, take gastroscope check after 8 days: gastric antrum portion is red and white, and the piebaldism district disappears, and gastric mucosa is normal.
Embodiment 4:
Lee, man, 51 years old.Vague epigastralgia, outbreak when hungry, melena is surplus May, accompany noisy, acid regurgitation, borborygmus, shortness of breath and fatigue, red tongue, thready and weak pulse.Gastroscope shows: the pyloric cap antetheca has a roun ulcer, and the about 2cm of diameter, rear wall have a gingival pocket to form.Dialectical: deficiency of both the heart and spleen, deficient QI failing to control.
Use prescription one: a kind of pharmaceutical preparation that contains antibiotic treatment by Chinese herbs gastrointestinal disease
Os Sepiae 45g Radix Aucklandiae 25g Radix Ginseng 45g Alumen 25g Rhizoma Corydalis 50g Radix Notoginseng 70g
Radix Angelicae Dahuricae 60g Mel 130g furazolidone 3g Sanguis Draxonis 50 weight portions
Use prescription two: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition
Os Canitis 75g Radix Ginseng 60g Radix Angelicae Sinensis 45g Radix Notoginseng 60g Semen Canavaliae 50g Fructus Lycii 50g
Radix Angelicae Dahuricae 60g Radix Glycyrrhizae 30g Stigma Maydis 120g
Above-mentioned prescription is prepared into powder or capsule by pharmaceutically acceptable method, use prescription early in the morning, take every day 2 times, each 6 grams, warm boiled water evening.Use and take before prescription two is slept, every day 1 time, each 6 grams, warm water delivery service.After two prescriptions are taken 8 days simultaneously, the ulcer healing transference cure.
Embodiment 5:
Wei, woman, 27 years old.The intermittent pain of right flank 1 year is surplus, and heavy when light during local pain, mistaken diagnosis originally is an omarthritis, and through the hospitalize commentaries on classics of not getting better, subjective symptoms increases the weight of closely over the past half year.Existing disease: go up abdominal lump, right shoulder pain, spiritlessness and weakness, lack of appetite is indigestion and loss of appetite, distension and fullness in the abdomen, susceptible to lose temper due to restlessness, bitter taste in the mouth and dry throat etc.Image radiography and histopathologic examination are diagnosed as: primary hepatocarcinoma.Dialectical: liver stasis of blood spleen deficiency
Use prescription one: a kind of pharmaceutical preparation for the treatment of cancers in digestive system disease
Octacosanol 15g Radix Notoginseng 75g Rhizoma Arisaematis 60g Hirudo 30g Rhizoma Dioscoreae Bulbiferae 75g Agkistrodon 60g
Radix Et Rhizoma Rhei 80g Bufo siccus 90g Rhizoma Pinelliae 60g gives birth to EYI 75g Radix Tripterygii Wilfordii 120g Rhizoma Atractylodis Macrocephalae 80g
Use prescription two: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition
Os Canitis 75g Radix Ginseng 50g Radix Angelicae Sinensis 45g Radix Notoginseng 50g Semen Canavaliae 50g Fructus Lycii 50g
Radix Angelicae Dahuricae 55g Radix Glycyrrhizae 30g Stigma Maydis 110g
Above-mentioned prescription is prepared into powder or capsule by pharmaceutically acceptable method, use prescription early in the morning, take every day 2 times, each 6 grams, warm boiled water evening.Use and take before prescription two is slept, every day 1 time, each 6 grams, warm water delivery service.Two prescriptions are taken transference cure after 15 days simultaneously.The clothes that continue replenish the medicine food preparation of human nutrition and were consolidated curative effect in 15 days.
Embodiment 6:
Permitted certain, woman, 37 years old.The indistinct pain of abdominal part 3 years increases the weight of recently, and process is failed to respond to any medical treatment before March.Symptom: constipation, the time vomiting is arranged, dry mouth with bitter taste is liked cool aversion to heat, red tongue, thready pulse.Lab testing and image radiography are represented: the moderate colon cancer.Dialectical: the liver stomach yin deficiency type.
Use prescription one: a kind of pharmaceutical preparation that contains antibiotic treatment by Chinese herbs gastrointestinal disease
Os Sepiae 25g Radix Angelicae Dahuricae 25g Radix Ginseng 35g Alumen 15g Rhizoma Corydalis 20g Mel 50g
Radix Et Rhizoma Rhei 30g Radix Notoginseng 25g Radix Aucklandiae 20g
Use prescription two: a kind of pharmaceutical preparation for the treatment of cancers in digestive system disease
Octacosanol 12g Radix Notoginseng 65g Rhizoma Arisaematis 60g Hirudo 35g Bufo siccus 65g Rhizoma Pinelliae 50g
Give birth to EYI 60g Radix Tripterygii Wilfordii 100g Cinnabaris 8g Rhizoma Chuanxiong 50g Radix Scrophulariae 60g
Use prescription three: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition
Os Canitis 65g Radix Ginseng 50g Radix Angelicae Sinensis 45g Radix Notoginseng 50g Semen Canavaliae 50g Agkistrodon halys 60g
Radix Angelicae Dahuricae 55g Radix Glycyrrhizae 30g Stigma Maydis 120g
Above-mentioned prescription is prepared into powder or capsule by pharmaceutically acceptable method, begins to take 3 days morning, evenings and use prescription one, every day 2 times, each 6 grams, warm boiled water.Take used prescription one in 3 days after, early, take and used prescription two in 12 days, every day 2 times, each 6 grams, warm water delivery service evening.Take before the course of treatment, slept (15 days) entirely and use prescription three, every day 1 time, each 6 grams, warm water delivery service.Three prescriptions are taken transference cure after 15 days, can continue according to the state of an illness and obey the medicine food preparation that replenishes human nutrition, and every day 1 time, each 6 grams are consolidated curative effect.
Experimental example 1: at the efficacy analysis of gastric ulcer, duodenal bulbar ulcer, gastric cancer, rectal cancer
1, clinical data
Mainly, choose case as the object of observation according to patient's medical history and the bonded mode of symptom.Select case 327 people, wherein: male's 193 examples, women 134 people; 30 years old with 36 people, 79 people more than 50 years old, 31-49 year 212 people.
2, diagnosis basis
Mainly diagnose according to medical history, symptom and Signs, part patient is through digestive canel barium meal contrast examination, fibergastroscope and check pathological section.
3, criterion of therapeutical effect
Produce effects: clinical symptom disappearance, sign remain to be recovered normal;
Effectively: disease takes a turn for the better to some extent, and diseased region reduces;
Invalid: the state of an illness does not have improvement or enlarges;
3, Therapeutic Method
Disposable prescription on individual diagnosis 251 examples of 327 routine patients are followed the tracks of treatment 76 examples, and diagnostic period is taken the present composition, wherein, gastric ulcer, duodenal bulbar ulcer case, early, take the B group pharmaceutical preparation that embodiment 4 makes evening, takes the A group medicine food preparation that embodiment 1 makes before sleeping; Gastric cancer, rectal cancer case, early, take embodiment 6 and use the C group pharmaceutical preparation that prescriptions two make evening, takes the A group medicine food preparation that embodiment 1 makes before sleeping.
Usage and dosage: use warm water delivery service, every day 3 times, each 1 bag, every bag 6g.
Period in a medicine is withdrawn the medicine outside the present invention, the shortest person 3 days of taking medicine, and elder 15 days on average takes medicine 7 days courses of treatment.
Table 1: the present composition is to the therapeutic effect of gastric ulcer, duodenal bulbar ulcer, gastric cancer, rectal cancer
| Name of disease | The example number | Produce effects | Effectively | Invalid | Inefficiency % | Total effective rate % |
| Gastric ulcer | 103 | 91 | 12 | 0 | 0 | 100 |
| Duodenal bulbar ulcer | 56 | 45 | 10 | 1 | 1.8 | 98.2 |
| Gastric cancer | 97 | 79 | 16 | 2 | 2.1 | 97.9 |
| Rectal cancer | 71 | 56 | 12 | 3 | 4.2 | 95.8 |
| Add up to | 327 | 271 | 50 | 6 | 1.8 | 98.2 |
4, efficacy analysis
Among the 327 routine patients, gastric ulcer 103 examples, duodenal bulbar ulcer 56 examples, gastric cancer 97 examples, rectal cancer 71 examples.The situation of change of therapeutic outcome and treatment back symptom, as above-mentioned table 1:
5, conclusion
The clinical observation in 1 year proves that compositions of the present invention is evident in efficacy to gastrointestinal disease and cancers in digestive system disease, and comprehensive effective percentage 98.2% is excellent good to the digestive tract disease curative effect.This compositions has the effect of tangible invigorating the spleen and regulating the stomach, relieving gastric hyperacidity to alleviate stomachache, elimination distension, anticancer removing food stagnancy, eliminating fire and detoxication, blood yiqi, stimulating appetite.A group medicine food preparation is to enhancing immunity, and epidemic prevention influenza, bird flu and looks improving and the skin nourishing have certain effect.
Experimental example 2: the present invention protects the compositions clinical control viewing test of treatment gastrointestinal disease and cancers in digestive system disease
1, case data
According to case sex, age, the cardinal symptom grade before the treatment, tcm syndrome differentiation and typing and experimental apparatus diagnosis are divided into groups, and difference does not have significance meaning (P＞0.05) between the conditioning grouping by statistics, has neat same comparability.
Case is selected 726 examples, according to related standards, makes a definite diagnosis gastrointestinal disease patient 618 examples, cancers in digestive system disease patient 108 examples.Tcm syndrome differentiation and typing: asthenic cold type 379 examples, excess-heat type 347 examples.Clinical manifestation has the epigastrium distension, causalgia, belch pantothenic acid, diarrhoea, singultus, constipation, nausea and vomiting, inappetence, wiry and frequent pulse.
2, criterion
Cure: clinical symptom disappearance, sign recover normal;
Produce effects: transference cure, sign remain to be recovered normal;
Effectively: disease takes a turn for the better to some extent, and diseased region reduces; Invalid: the state of an illness does not have improvement or enlarges;
Recurrence: disease is still as seen after 1 year to follow the tracks of treatment.
3, observational technique
At first according to the sick kind of patient, syndrome-classification, the design of randomized double-blind observation again.
Treatment A group: gastrointestinal disease 512 examples, early, take the B group pharmaceutical preparation that embodiment 4 makes evening, takes the A group medicine food preparation that embodiment 1 makes before sleeping.
Treatment B group: cancers in digestive system disease 63 examples, early, take embodiment 6 and use the C group pharmaceutical preparation that prescriptions two make evening, takes the A group medicine food preparation that embodiment 1 makes before sleeping.
Usage and dosage: treatment A group, B group, equal every day 3 times, each 1 bag, every bag 6g uses warm water delivery service.
Contrast A group: gastrointestinal disease 106 examples, 106 routine patients all take the Chinese medicinal composition capsules that patent CN100362585C makes, and every day 3 times, each 6, every 0.35g uses warm water delivery service.
Contrast B group: cancers in digestive system disease patient 45 examples, take the Chinese medicine composition decoct that patent CN100172692C makes, every dose with 23 flavors totally 250 gram Chinese herbal medicine decoct 2 times, make medicinal liquid 500ml, 1 dose of every day, take for twice.
Treatment A group was a course of treatment with contrast A group with continuous 6 days, and treatment B group was a course of treatment with contrast B group with continuous 9 days,
After finishing the course of treatment, drug withdrawal was followed the tracks of 6 months, all kept equal conditions in the observation process.
4, therapeutic outcome
See Table 2: treatment A, B group, contrast A, B group, in the curative effect of protecting treatment gastrointestinal disease, cancers in digestive system disease relatively
5, conclusion
Clinical observation studies show that, the total obvious effective rate 93.2% of present composition treatment gastrointestinal disease, total effective rate 99.8%, the total obvious effective rate 71.4% of treatment cancers in digestive system disease, total effective rate 88.9%, same A, B two matched groups compare, and curative effect difference has statistical significance (P＜0.005) between group.Do not have obvious adverse reaction in the observation process, recheck not invention abnormal change of blood, urine, stool routine examination and hepatic and renal function, more than studies show that,
The curative effect of Chinese medicine and flavour of a drug how much not to be into positivity relevant, only suit the remedy to the case to show its effect fully and be only best Therapeutic Method.
We's compositions is by the form improvement of big prescription, not only reduced the consumption of Chinese herbal medicine in a large number, reduced cost, guaranteed effective ingredient in the compositions simultaneously, the prescription classification reaches the medication mechanism based on powder, capsule, and the realization giving consideration to both the exterior and interior is controlled the target of supporting homology, 90% above gastrointestinal disease patient takes medicine and can fully recover in 3-7 days, the cancers in digestive system disease patient 15-30 days transference cures of taking medicine fully show the good result of clinical treatment, are present good effect, short best group compound of cycle.
The foregoing description and experimental example mode only are used to illustrate the present invention, and are not limitation of the present invention, and scope of patent protection of the present invention is defined by the claims.
Claims (9)
1. the compositions of protection treatment gastrointestinal disease and cancers in digestive system disease is characterized in that, is made of the A group A, B, C three prescription agent: a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition; B group: a kind of pharmaceutical preparation that contains antibiotic treatment by Chinese herbs gastrointestinal disease; C group: a kind of pharmaceutical preparation for the treatment of cancers in digestive system disease.
2. according to claim 1, the medicine food preparation of A group is characterized in that, comprises following 6 kinds of basic prescription raw materials and 10 kinds of weight portion and preparation methoies that add the raw material of distinguishing the flavor of.
(1) basic prescription parts by weight of raw materials:
Os Canitis 1-40 weight portion Radix Ginseng 1-30 weight portion Semen Canavaliae 1-25 weight portion Radix Notoginseng 1-30 weight portion
Radix Angelicae Dahuricae 1-35 weight portion Radix Glycyrrhizae 1-15 weight portion
(2) add the flavor parts by weight of raw materials:
Semen Armeniacae Amarum 1-20 weight portion Flos Lonicerae 1-50 weight portion Radix Angelicae Sinensis 1-25 weight portion Agkistrodon halys 1-30 weight portion
Radix Glehniae 1-25 weight portion Pseudobulbus Bletillae (Rhizoma Bletillae) 1-50 weight portion Rhizoma Chuanxiong 1-25 weight portion Fructus Lycii 1-25 weight portion
Rhizoma Atractylodis Macrocephalae 1-25 weight portion Stigma Maydis 1-60 weight portion
(3) preparation method:
A, with fresh Os Canitis warm water cleaning, be hung on the ventilation and dry, the calcining sustainability, grind 80 order fine powders into powder.
B, fresh and alive Agkistrodon halys is taken out internal organs, clean vexedly with quantitative yellow wine, taking-up places 60 ℃ of drying baker dryings, grinds 80 order fine powders into powder.
C, will remain 14 flavors and grind 10-20 order coarse powder respectively into powder, and place Decocting pot, and soak 30～60min with 40 ℃ in warm water, and add 5 times in water and repeat to decoct 2 times, each 60min merges extract, filters, and concentrates; Concentrated solution is added 75% ethanol 3-5 doubly, stirs 10-20min, extract supernatant after leaving standstill 36h, merge supernatant, reclaim ethanol, concentrated extract, spray-dried mixture dry powder.
D, by weight a, b, c and Mel are mixed, place vacuum drying oven,, promptly get mixture, prepare the preparation of needs through sterilization, adding adjuvant according to a conventional method with 60 ℃ of temperature dryings.
3. according to claim 1, the pharmaceutical preparation of B group is characterized in that, comprises following 6 kinds of basic prescription raw materials and 10 kinds of weight portion and preparation methoies that add the raw material of distinguishing the flavor of.
(1) basic prescription parts by weight of raw materials:
Radix Ginseng 1-30 weight portion Radix Notoginseng 1-25 weight portion Os Sepiae 1-25 weight portion Radix Angelicae Dahuricae 1-35 weight portion
Rhizoma Corydalis 1-25 weight portion Mel 1-100 weight portion
(2) add the flavor parts by weight of raw materials:
Furazolidone 0.1-1 weight portion Cortex Phellodendri 1-25 weight portion Radix Scutellariae 1-30 weight portion Radix Linderae 1-20 weight portion
Alumen 1-10 weight portion Semen Canavaliae 1-20 weight portion Rhizoma Atractylodis Macrocephalae 1-25 weight portion Radix Aucklandiae 1-15 weight portion
Sanguis Draxonis 1-20 weight portion Herba Cassiopes selaginoidis 1-60 weight portion
(3) preparation method:
A, with fresh Os Canitis warm water cleaning, be hung on the ventilation and dry, the calcining sustainability, grind 80 order fine powders into powder.
B, grind Alumen, Sanguis Draxonis into powder 80 order fine powders.
C, furazolidone and Mel are taken with the agent proportioning.
D, will remain 11 flavors and grind 10-20 order coarse powder respectively into powder, and place Decocting pot, and soak 30～60min with 40 ℃ in warm water, and add 5 times in water and repeat to decoct 2 times, each 60min merges extract, filters, and concentrates; Concentrated solution is added 75% ethanol 3-5 doubly, stirs 10-20min, extract supernatant after leaving standstill 36h, merge supernatant, reclaim ethanol, concentrated extract, spray-dried mixture dry powder.
E, by weight a, b, d are mixed, through sterilization, add the preparation that adjuvant prepares needs according to a conventional method.
4. according to claim 1, the pharmaceutical preparation of C group is characterized in that, comprises following 6 kinds of basic prescription raw materials and 15 kinds of weight portion and preparation methoies that add the raw material of distinguishing the flavor of.
(1) basic prescription parts by weight of raw materials:
Rhizoma Pinelliae 1-25 weight portion Radix Notoginseng 1-25 weight portion Rhizoma Arisaematis 1-25 weight portion Hirudo 1-15 weight portion
Bufo siccus 1-35 weight portion octacosanol 0.1-3 weight portion
(2) add the flavor parts by weight of raw materials:
Rhizoma Dioscoreae Bulbiferae 1-35 weight portion Agkistrodon 1-20 weight portion Radix Et Rhizoma Rhei 1-35 weight portion Radix Ampelopsis 1-25 weight portion
Rhizoma Atractylodis Macrocephalae 1-30 weight portion Galla Chinensis 1-20 weight portion Radix Sophorae Tonkinensis 1-20 weight portion Semen Canavaliae 1-25 weight portion
Give birth to EYI 1-30 weight portion Radix Tripterygii Wilfordii 1-50 weight portion Cinnabaris 0.1-2 weight portion Rhizoma Chuanxiong 1-20 weight portion
Radix Scrophulariae 1-35 weight portion Rhizoma Paridis 1-25 weight portion arsenicum 0.01-0.15 weight portion
(3) preparation method:
A, octacosanol white powder and Cinnabaris, arsenicum three flavors are mixed, grind 200 order fine powders into powder.
B, will remain 18 flavors and grind 10-20 order coarse powder respectively into powder, and place Decocting pot, and soak 30～60min with 40 ℃ in warm water, and add 5 times in water and repeat to decoct 2 times, each 60min merges extract, filters, and concentrates; Concentrated solution is added 75% ethanol 3-5 doubly, stirs 10-20min, extract supernatant after leaving standstill 36h, merge supernatant, reclaim ethanol, concentrated extract, spray-dried mixture dry powder.
C, by weight a, b are mixed, through sterilization, add the preparation that adjuvant prepares needs according to a conventional method.
5. according to claim 2, a kind of medicine food preparation for the treatment of gastrointestinal disease and additional human nutrition is characterized in that, when medicine food preparation is medicated wine, and Os Canitis 1-500 weight portion, Agkistrodon halys 1-300 weight portion.
6. according to claim 2,3,4 described, A, B, C three prescription agent is characterized in that, the basic prescription raw material that comprises can with add the flavor raw material any simply, multi-flavor or all combinations, add the flavor raw material and belong to the scope of the invention.
7. according to claim 1, the compositions of protection treatment gastrointestinal disease and cancers in digestive system disease is characterized in that, A, B, C three prescription agent can be that the folk prescription agent is used, and two prescriptions or three prescriptions are used in combination.
8. according to claim 1, the compositions of protection treatment gastrointestinal disease and cancers in digestive system disease is characterized in that A, B, the pharmaceutically acceptable any dosage form of C three prescription agent food prepared therefroms; The extraction of material processing and effective ingredient comprises the pharmaceutically acceptable any method of food.
9. according to claim 1, the compositions of protection treatment gastrointestinal disease and cancers in digestive system disease is characterized in that, comprises respectively the distinguish the flavor of Chinese herbal medicine and the food of all prescriptions, is not limited to " Chinese Pharmacopoeia " or the another name of being put down in writing that is commonly called as among the people.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638318A (en) * | 2013-12-19 | 2014-03-19 | 王文兮 | Traditional Chinese medicine formula for radically treating helicobacter pylori infection and preparation method thereof |
| CN105998800A (en) * | 2016-06-24 | 2016-10-12 | 佛山煜新科技有限公司 | Traditional Chinese medicine composition |
| CN106236929A (en) * | 2016-08-25 | 2016-12-21 | 陕西必康制药集团控股有限公司 | A kind of medicine treating gastropathy and preparation method thereof |
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|---|---|---|---|---|
| CN1748726A (en) * | 2004-09-14 | 2006-03-22 | 张建浩 | Chinese medicine capsule for treating gastropathy and its preparing method |
| CN1857708A (en) * | 2006-03-21 | 2006-11-08 | 王文台 | Chinese medicine preparation for treating cavitative gastric ulcer |
| CN101569717A (en) * | 2009-06-12 | 2009-11-04 | 邓柏福 | Pharmaceutical composition for treating gastrointestinal diseases and cancer and preparation method thereof |
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2010
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1748726A (en) * | 2004-09-14 | 2006-03-22 | 张建浩 | Chinese medicine capsule for treating gastropathy and its preparing method |
| CN1857708A (en) * | 2006-03-21 | 2006-11-08 | 王文台 | Chinese medicine preparation for treating cavitative gastric ulcer |
| CN101569717A (en) * | 2009-06-12 | 2009-11-04 | 邓柏福 | Pharmaceutical composition for treating gastrointestinal diseases and cancer and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638318A (en) * | 2013-12-19 | 2014-03-19 | 王文兮 | Traditional Chinese medicine formula for radically treating helicobacter pylori infection and preparation method thereof |
| CN103638318B (en) * | 2013-12-19 | 2016-07-06 | 王文兮 | A kind of Chinese drugs agentia effecting a radical cure Helicobacter pylori infection and preparation method thereof |
| CN105998800A (en) * | 2016-06-24 | 2016-10-12 | 佛山煜新科技有限公司 | Traditional Chinese medicine composition |
| CN106236929A (en) * | 2016-08-25 | 2016-12-21 | 陕西必康制药集团控股有限公司 | A kind of medicine treating gastropathy and preparation method thereof |
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