CN102028920A - Application of Tibetan medicine composition to preparation of medicine for treating bronchial asthma - Google Patents
Application of Tibetan medicine composition to preparation of medicine for treating bronchial asthma Download PDFInfo
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Abstract
The invention discloses application of a Tibetan medicine composition to the preparation of a medicine for treating bronchial asthma. The Tibetan medicine composition consists of the following raw materials in part by weight: 5 to 15 parts of lamiophlomis, 2 to 10 parts of whin, 15 to 60 parts of turmeric, 7 to 20 parts of pricklyash peel, 5 to 15 parts of buffalo horn, 15 to 40 parts of myricaria, 0.1 to 2.5 parts of safflower, 0.1 to 5 parts of borneol and 0.1 to 5 parts of camphor. Further researches on the pharmacology of the conventional Tibetan medicine composition prove that the Tibetan medicine composition has good curative effect of treating the bronchial asthma; in addition, the Tibetan medicine composition is prepared from purely natural wild medicinal materials produced in Tibet plateau, is not added with any chemically synthesized stabilizer, does not have any toxic or side effect on human bodies, and is safe and effective and suitable for various people.
Description
Technical field
The present invention relates to field of medicaments, the application of specifically a kind of Tibetan medicine compositions in preparation treatment bronchial asthma medicine.
Background technology
Bronchial asthma is called for short asthma, is by the various kinds of cell chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte particularly; This inflammation makes the susceptible person have airway hyperreactivity to various motivating factors, and can cause repeatedly symptoms such as the panting of outbreak, tachypnea, uncomfortable in chest and/or cough, how to take place at night or morning; This type of symptom is often limited with extensive and changeable exhalation flow rate, but natural remission or alleviate through treatment partly; In addition, also multiple stimulating factor reactivity is increased with air flue.
Asthma is one of modal chronic disease in the world today, and bronchial asthma prevalence, mortality rate are held ascendant trend both at home and abroad, and over particularly past 20 years, because the abuse 17-hydroxy-11-dehydrocorticosterone, asthma prevalence and mortality rate continue to increase.According to the data show of World Health Organization (WHO) issue, present global number of patients is nearly 300,000,000, and just increases with the ratio of per ten years 20%-50%.Therefore asthma has become the second-biggest-in-the-world deadly and disabling disease that is only second to cancer, causes the death of annual 180000 examples or per 10 years 1000000 examples.Human beings'health in serious threat, also brings huge stress and financial burden to the patient.Though the asthma prevalence more developed country of China is low, the asthma mortality rate is in first of the world, up to 36.7/100000ths.
The clinical symptoms of bronchial asthma has cough, pants, dyspnea, uncomfortable in chest, expectoration etc.Typical performance is ictal expiratory dyspnea with wheezing sound.Early stage or patient with slight symptoms most with ictal cough and uncomfortable in chest serve as mainly to show.Severe patient can be forced to take seat or be orthopnea, and dry cough or cough up a large amount of white foam expectorant, even symptoms such as cyanosis occur.Symptoms of asthma can be shown effect in several minutes, through a few hours to a couple of days, with bronchodilator or spontaneous remission.Pathogenesis of asthma has following feature: 1. ictal: be ictal increasing the weight of when running into risk factor.2. temporal rhythm: night and the morning outbreak or increase the weight of of being everlasting.3. seasonal: the autumn and winter season of being everlasting shows effect or increases the weight of.4. reversibility: anti-asthmatic usually can relief of symptoms, and the tangible catabasis can be arranged.
At present, medical circle also imperfectly understands for the pathogenesis of bronchial asthma.Majority think, allergy, air flue chronic inflammatory disease, airway reactivity increases and factor interaction such as vegetative nerve functional disturbance, fellowship pathogenesis of asthma process.I.e. (one) allergy: after anaphylactogen enters body,, can induce the bone-marrow-derived lymphocyte of body to generate IgE (IgE) antibody, and firmly be adsorbed on mastocyte and basophil cellular surface by macrophage and the lymphocytic transmission of T.In identical antigen enters the body with allergic constitution once more, with the IgE antibodies, thereby inspire the series reaction of cell membrane, make this cell synthetic and discharge that the various active medium causes smooth muscle contraction, mucous secretion to increase, vascular permeability increases with inflammatory cell infiltration etc.Inflammatory cell can be secreted multiple medium again under the effect of medium, the air flue pathological changes is increased the weight of, and inflammatory infiltration increases, thereby produces the clinical symptoms of asthma.(2) airway inflammation: the main pathophysiological mechanism that the air flue chronic inflammatory disease is considered to the basic pathological change of asthma and shows effect repeatedly.No matter the asthma of any type, the asthma of which phase all shows as based on infiltration and the gathering at air flue of the multiple inflammatory cell of mastocyte, eosinophilic granulocyte and T lymphocyte.These cell interactions can secrete tens of kinds of inflammatory mediators and cytokine.These media, cytokine and inflammatory cell interact and constitute complicated network, interact and influence, make airway inflammation continue to exist.When body ran into risk factor, these inflammatory cells can discharge multiple inflammatory mediator and cytokine, caused that airway smooth muscle shrinks, and mucous secretion increases, and blood plasma oozes out and myxedema, thereby produces the clinical symptoms of asthma.(3) airway hyperreactivity (AHR): showing as air flue strong or too early contractile response was appearred in various stimulating factors, is another key factor that development takes place asthmatic patient.From clinical angle, extremely slight AHR needs to diagnose in conjunction with clinical manifestation, but the above AHR of moderate can be an asthma certainly almost.(4) neuromechanism: neural factor also is considered to the important step of asthma morbidity.Bronchus is arranged by complicated vegetative nerve, except that cholinergic nerve, adrenergic nerve, also has non-adrenergic non-cholinergic (NANC) nervous system.Bronchial asthma is hyperfunction relevant with B-adrenergic receptor hypofunction and vagal tone.In addition, NANC can discharge the neurotransmitter of diastole bronchial smooth muscle, as blood vessel enterokinin (VIP), nitric oxide (NO), and the medium that shrinks bronchial smooth muscle, as P material, neurokinin etc.Both dysequilibriums can cause that then bronchial smooth muscle shrinks, thereby produce the clinical symptoms of asthma.
At present, as long as bronchial asthma is through standard ground long-term treatment, and most patients can make symptoms of asthma can obtain ideal control, and minimizing is recurred and even do not shown effect.If to this sick untimely treatment, dead serious consequence then may appear.
At present, for THE TREATMENT OF BRONCHIAL ASTHMA, mainly adopt the western medical treatment method, medicine all has antiasthmatic effect because of it, often is called anti-asthmatic, again it is divided into according to their the main aspect of effect clinically:
(1) bronchodilatation medicine, this type of medicine remove and mainly act as the diastole bronchus, the acute symptom of control asthma.This type of drug main will comprise 1. β2Ji Dongji, it mainly passes through the beta 2-receptor of exciting airway smooth muscle, the activation adenyl cyclase, thereby lax bronchial smooth muscle, the beta 2-receptor on also can exciting mast cell membrane suppresses the release of medium, can cause that downward modulation of beta 2-receptor function and airway reactivity increase but take for a long time, therefore, the person that often needs use the β2Ji Dongji should cooperate long-term rule to use the suction hormone; 2. theophylline class, the decapacitation of theophylline class medicine suppresses PDE, promotes adrenergic secretion in the body; Strengthen the air flue cilium and remove function and antiinflammatory action; Slow release type serum theophylline concentration is steady, help improving curative effect and reduce untoward reaction, but onset time is longer; 3. anticholinergic agent sucks anticholinergic agent, can block joint back vagus nerve path, reduces vagal excitation and a bronchorelaxing activity, and can block the reflexive bronchoconstriction; But must strictly control its taking dose for taking of this kind medicine, in case dosage is excessive, then central nervous excitation symptom such as dysphoria, delirium can occur, so that faint from fear, superexcitation can change inhibition over to, and dyspnea can cause death and die.
(2) anti-inflammatory agent is because the pathologic basis of asthma is a chronic nonspecific inflammation, so the control chronic airway inflammation is the base therapy of asthma.This type of medicine comprises 1. glucocorticoid, and this medicine is the current the most effective medicine of asthma of preventing and treating, and main mechanism is the migration and the activation of inflammation-inhibiting cell; Suppress the generation of cytokine; The release of inflammation-inhibiting medium; Strengthen the reactivity of smooth muscle cell beta 2 receptor; But the 17-hydroxy-11-dehydrocorticosterone side effect is bigger, can cause symptoms such as hormone dependence, obesity, endocrine regulation, having brought greatly to extensive patients, misery, the state of an illness increase the weight of, produce drug dependence, the asthma great majority are that virus causes, with the breeding that 17-hydroxy-11-dehydrocorticosterone is concentrated virus, increased the difficulty of clinical treatment; 2. color thuja acid disodium, this medicine is a kind of non-17-hydroxy-11-dehydrocorticosterone anti-inflammatory drug, can stablize mast cell membrane, suppressing medium discharges, other inflammatory cell release medium also there is certain inhibitory action, administration before antigen is attacked can suppress anaphylactic type and delayed-type hypersensitivity asthma, the asthma that also can prevent to move and bring out with other stimulations; But this medicine need be taken for a long time, and drug withdrawal midway, otherwise can increase the weight of the state of an illness.
As seen, the medicine of existing treatment bronchial asthma is just at sensitinogen, anaphylaxis metamorphosis and clinical symptoms, and the method that adopts antiinflammatory, antiallergic and spasmolytic to relieving asthma can not fundamentally solve asthma, and needs to take in a large number for a long time the specific aim medicine.In addition, a lot of medicines particularly side effect of 17-hydroxy-11-dehydrocorticosterone are bigger, and are very big to the patient body injury.
In the Tibetanmedicine, bronchial asthma belongs to the category of " asthma card ", " difficult to understand rice imbrication ", mainly contains in the pathogen because of factors such as diseases caused by exogenous pathogenic factor, improper diet, overstrain cause, thereby blocks the collateral dredging of carrying elite, or accumulation and obstruction of sputum, and the cough due to deficiency of the lung is due to the obstructing airway.Conditioning digestive system, adjusting immunologic function when the principle of Tibetan medicine and pharmacology treatment bronchial asthma is heat clearing and lung benefiting, relieving cough and asthma, thus reach the purpose of fundamentally treating asthma.
So when bronchial asthma was treated, if can adopt raw material of Chinese medicine as the treatment bronchial asthma medicine, the injury to human body will reduce much relatively so.
Radix Lamiophlomidis Rotatae is the dry herb of dicotyledon Labiatae Radix Lamiophlomidis Rotatae Lamiophlomis rotata (Benth.) Kudo., and excavate latter stage in autumn, cleans, and dries.Its property is sweet, bitter, flat.Often be born in high mountain rubble beach, flood land or the stone matter grassy marshland of height above sea level 3900-5100m, be distributed in highlandss such as Tibet, Qinghai, Sichuan, Gansu.Have promoting blood circulation and hemostasis, wind-expelling pain-stopping effect, cure mainly diseases such as traumatic injury, traumatic hemorrhage, rheumatic arthralgia, grasserie, fracture, lumbar strain.
Herba Oxytropis Kansuensis is the dry herb of leguminous plant Herba Oxytropis falcatae Oxytropis falcata Bunge and Herba Oxytropis chiliophyllae Oxytropis falcataBunge.Excavate herb at the beginning of autumn late summer, clean earth, Ex-all is assorted takes out, and dries.Herba Oxytropis Kansuensis is the common plant in HOh Xil.Gas is different, mildly bitter flavor.Have the heal effect of skin ulcer, hesitant pulse hemostasis, relieving constipation of heat-clearing and toxic substances removing, granulation promoting, cure mainly epidemic disease, toxonosis, grasserie, constipation, diseases such as anthrax.
Rhizoma Curcumae Longae is a zingiberaceous plant Rhizoma Curcumae Longae Curcuma Longa L. rhizome.Excavate when stem and leaf is withered winter, cleans, and boils or steam to the saturating heart, dries, and removes fibrous root.Main product Sichuan, Fujian, Guangdong, Jiangxi, its property suffering, hardship, temperature are returned spleen, Liver Channel.Has the removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia.Cure mainly diseases such as the breast side of body twinges, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.
Pericarpium Zanthoxyli is the dry mature skin of rutaceae green pepper Zanthoxylum schinifolium Sieb.etZucc. or Pericarpium Zanthoxyli Zanthoxylumbungeanum Maxim..The mature fruit of gathering autumn is dried, and removes seed and impurity, its property suffering, temperature.Return spleen, stomach, kidney channel.Be born in the bushes of hillside or on the sunny side, the roadside.Main product Sichuan, Shaanxi, Hebei.Have warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching cures mainly that coldness and pain in the epigastrium, vomiting are had loose bowels, diseases such as abdominal pain due to worm stagnation, ascariasis, eczema pruritus.
Cornu Bubali is the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.After getting the angle, decocting in water is except that chamfering plug, drying.Its hardship is salty, cold, goes into the heart, liver, spleen, stomach four warps.Have heat clearing away, removing heat from blood, Detoxication.Cure mainly calentura headache, high fever coma, macule, tell diseases such as nosebleed, infantile convulsion, sore throat pharyngeal swelling.
Cacumen Myricariae Germanicae is plant Cacumen Myricariae Germanicae Myricaria germanica (L.) Desv. of Cacumen Tamaricis section and the dry twig that belongs to several plants together, is used as medicine with sprout.Gather spring and summer, and the clip twig dries.Its property is puckery, sweet, cold.Be distributed in Hubei the east of Sichuan, Zigui and Wushan, Sichuan, be born in low bank, the mountains and rivers and roadside.Have heat-clearing and toxic substances removing, disperse the effect of rash, cure mainly diseases such as measles without adequate eruption, laryngopharynx swelling and pain, nosotoxicosis, grasserie, heat in blood disease, pestilence epidemic disease, internal organs be scorchingly hot.
Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Summer flower is plucked when red by xanthochromia, dries in the shade or dries.Its property suffering, temperature, GUIXIN, Liver Channel.Have promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing cures mainly diseases such as amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.
Borneolum Syntheticum is that the resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum extracts the crystallization that obtains, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.Its property is arduous, cool, GUIXIN, lung meridian.It can be used for being used for the excess syndrome of stroke coma, is used for conjunctival congestion and swelling pain, the sore throat aphtha, is used for skin infection and swells and ache, and does not hold back after bursting etc.
Camphora is a kind of cyclohexane extraction monoterpene derivative, from the ketone that bark and the wooden distillation of Lignum cinnamomi camphorae makes, and also can be synthetic from Oleum Terebinthinae.Its property suffering, heat, poisonous.GUIXIN, spleen channel.Effect dehumidifying parasite killing, warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Cure mainly scabies pruritus, traumatic pain, toothache.
In the prior art, Chinese patent literature CN1709445 discloses Tibetan medicine of a kind for the treatment of acute and chronic bruise, rheumatism, rheumatoid disease and preparation method thereof, and its crude drug is made up of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, Cacumen Myricariae Germanicae.Another Chinese patent literature CN101574505A discloses a kind of Tibetan medicine aerosol for the treatment of acute and chronic bruise, rheumatism, rheumatoid disease, its crude drug is to add Flos Carthami, Borneolum Syntheticum and Camphora on the basis of the crude drug of above-mentioned patent documentation CN1709445, promptly is made up of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, Cacumen Myricariae Germanicae, Flos Carthami, Borneolum Syntheticum, Camphora.Above-mentioned two kinds of Tibetan medicine compositionss have the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Above-mentioned two kinds of Tibetan medicine compositionss only are used for the treatment of acute and chronic bruise, rheumatism, rheumatoid disease at present, do not find the purposes of this Tibetan medicine compositions in preparation treatment bronchial asthma medicine, and treatment acute and chronic bruise, rheumatism, rheumatoid disease are different fully with the pharmacological action of treatment bronchial asthma.
Summary of the invention
The object of the present invention is to provide a kind of application of Tibetan medicine compositions known in the state of the art.
For achieving the above object, the present invention is by the following technical solutions:
The application of a kind of Tibetan medicine compositions in preparation treatment bronchial asthma medicine, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part.
Described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part.
Described Tibetan medicine compositions is made up of following bulk drugs: 10 parts of Radix Lamiophlomidis Rotataes, 5 parts of Herba Oxytropis Kansuensiss, 30 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 10 parts of Cornu Bubalis, 30 parts of Cacumen Myricariae Germanicaes.
Described Tibetan medicine compositions is made up of following bulk drugs: 12 parts of Radix Lamiophlomidis Rotataes, 4 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 10 parts in Pericarpium Zanthoxyli, 11 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes.
Described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
The application of a kind of Tibetan medicine compositions in preparation treatment bronchial asthma medicine, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part.
Described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part, Flos Carthami 0.5-2 part, Borneolum Syntheticum 0.2-4 part, Camphora 0.2-4 part.
Described Tibetan medicine compositions is made up of following bulk drugs: 9.1 parts of Radix Lamiophlomidis Rotataes, 4.5 parts of Herba Oxytropis Kansuensiss, 40.9 parts in Rhizoma Curcumae Longae, 13.6 parts in Pericarpium Zanthoxyli, 9.1 parts of Cornu Bubalis, 22.7 parts of Cacumen Myricariae Germanicaes, 1.8 parts on Flos Carthami, 2 parts of Borneolum Syntheticums, 2 parts of Camphoras.
Described Tibetan medicine compositions is made up of following bulk drugs: 7 parts of Radix Lamiophlomidis Rotataes, 6 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 8 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes, 1 part on Flos Carthami, 0.5 part of Borneolum Syntheticum, 0.5 part of Camphora.
Described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
Tibetan medicine compositions described in the present invention has the effect of blood circulation promoting and blood stasis dispelling.This Tibetan medicine prescription is that the doctor among the people of Tibetan is carried, and formed in conjunction with the practical experience prescription according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " two secretaries.The natural quality authentic medicinal herbs is produced in raw materials used medicine polyphyly Qinghai-Tibet Platean, concocts according to the Tibetan medicine theory provision.Radix Lamiophlomidis Rotatae sweet-bitter flavor in the side; The digestion back is cool; Usefulness: sterilization, yellow fluid is drawn in bone and muscle strengthening, synthetism.The Cacumen Myricariae Germanicae heat-clearing and toxic substances removing, disperse rash.Be applicable to measles without adequate eruption, laryngopharynx swelling and pain, nosotoxicosis, grasserie, heat in blood disease, pestilence epidemic disease, internal organs are scorchingly hot, meat is malicious and close poison etc.Rhizoma Curcumae Longae detoxifcation, antiinflammatory.The Herba Oxytropis Kansuensis bitter in the mouth; The digestion back is cool; Usefulness: healing of wound, hemostasis, detumescence, antiinflammatory, yellow fluid reducing, detoxifcation, ventilation effect.Pericarpium Zanthoxyli meridians dredging, parasite killing, antipruritic, go halitosis.Assistant is with Cornu Bubali, Flos Carthami, Borneolum Syntheticum, Camphora yellow fluid reducing, and heat-clearing and toxic substances removing is treated diseases such as lung-heat, influenza, pestilence, the effect of playing heat-clearing and toxic substances removing, clearing lung, relieving asthma altogether.All medicine compatibilities more can strengthen its curative effect to bronchial asthma.
Technique scheme of the present invention has the following advantages compared to existing technology:
The present invention is by to further having discovered this Tibetan medicine compositions heat clearing and lung benefiting, relieving cough and asthma effectively to the pharmacology of the disclosed Tibetan medicine compositions of patent documentation CN1709445 in the prior art, and can nurse one's health digestive system, adjusting immunologic function, realized radical cure effectively to bronchial asthma.Simultaneously, further finding after further adding Flos Carthami, Borneolum Syntheticum and Camphora on the basis of above-mentioned Tibetan medicine composition component, equally bronchial asthma to be had fine therapeutical effect in the research.In addition, adopt the Qinghai-Tibet Platean to produce the natural crude drugs of pure natural in these two kinds of Tibetan medicine compositionss, do not add the stabilizing agent of any chemosynthesis, human body is not had toxic and side effects, safety, effective is applicable to all kinds of crowds, is suitable for treating various bronchial asthmas.
The specific embodiment
Embodiment 1
The preparation of powder
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 5 weight portions, Herba Oxytropis Kansuensis 2 weight portions, Rhizoma Curcumae Longae 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Cornu Bubali 5 weight portions, Cacumen Myricariae Germanicae 15 weight portions;
Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, the selection of Cacumen Myricariae Germanicae medical material of above-mentioned specified weight part is standby, the above-mentioned raw materials medicine is made the superfine powder of 1-10 μ m through superfine communication technique, make powder.
Embodiment 2
The preparation of capsule
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 8 weight portions, Herba Oxytropis Kansuensis 3 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 20 weight portions, Flos Carthami 0.5 weight portion, Borneolum Syntheticum 0.2 weight portion, Camphora 0.2 weight portion;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami of all the other specified weight parts are mixed, after it is pulverized, water with 10 times of medical material weight decocts it, decoct and extract 3 times, each 1 hour, collect afterwards and merge above-mentioned three extracting solution, it is that 1.25 extractum is standby that extracting solution is condensed into relative density; In the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-25 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 16 hours, mixture after freezing is pulverized, and the Camphora, Borneolum Syntheticum and an amount of starch, sodium carboxymethyl cellulose, the carboxymethyl starch sodium granulation that add above-mentioned specified weight part, filling, packing promptly get capsule.
Embodiment 3
The preparation of granule
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is:
Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions, Flos Carthami 1.8 weight portions, Borneolum Syntheticum 2.0 weight portions, Camphora 2.0 weight portions;
Pericarpium Zanthoxyli with above-mentioned specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-200 μ m, to all the other specified weight parts through remove impurity, clean, dried Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami mixing also is ground into coarse powder, 75% ethanol with 8 times of above-mentioned mixing medical material weight extracts 3 times above-mentioned mixing medical material, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.20 extractum that extracting solution is condensed into relative density, in the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali fine powder, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-40 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 12 hours, mixture after freezing is pulverized, the Borneolum Syntheticum and the Camphora that add above-mentioned specified weight part mix and add an amount of starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium is granulated, and makes granule.
Embodiment 4
The preparation of tablet
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 15 weight portions, Herba Oxytropis Kansuensis 10 weight portions, Rhizoma Curcumae Longae 60 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 15 weight portions, Cacumen Myricariae Germanicae 40 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material of all the other specified weight parts are mixed, after it is pulverized, water with 20 times of medical material weight decocts it, decoct and extract 2 times, the each extraction 2 hours collected and merge extractive liquid, afterwards, and it is 1.15 extractum that extracting solution is condensed into relative density, the water that reuse extractum volume is 7 times dilutes it, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 10 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol to there not being the alcohol flavor, concentrate, spray drying, obtain extract dry powder, and this extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder mix homogeneously again, make the superfine powder of 0.1-1 μ m through superfine communication technique, add starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium granulation in above-mentioned superfine powder, add the Pulvis Talci mix homogeneously again, tabletting, packing promptly get tablet.
Embodiment 5
The preparation of pill
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 15 weight portions, Herba Oxytropis Kansuensis 10 weight portions, Rhizoma Curcumae Longae 60 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 15 weight portions, Cacumen Myricariae Germanicae 40 weight portions, Flos Carthami 2.5 weight portions, Borneolum Syntheticum 5 weight portions, Camphora 5 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by, Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami to all the other specified weight parts mix and pulverizing, 50% ethanol with 15 times of above-mentioned mixing medical material weight extracts 2 times above-mentioned mixing medical material, each 2h that extracts, collect afterwards and merge above-mentioned extracted twice liquid, it is 1.25 extractum that extracting solution is condensed into relative density, the water that reuse extractum volume is 5 times dilutes it, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 60% ethanol at last; Desorbed solution is reclaimed ethanol to there not being the alcohol flavor, concentrate, lyophilization, obtain extract dry powder, and this extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, mix homogeneously, make the superfine powder of 1-10 μ m through superfine communication technique, the Borneolum Syntheticum, the Camphora that add above-mentioned specified weight part in above-mentioned superfine powder mix, and add the debita spissitudo hydromel and make pill.
Embodiment 6
The preparation of soft capsule
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 10 weight portions, Herba Oxytropis Kansuensis 5 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 15 weight portions, Cornu Bubali 10 weight portions, Cacumen Myricariae Germanicae 30 weight portions;
Pericarpium Zanthoxyli with above-mentioned specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-200 μ m, the Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and pulverizes, vinegar (total acid 〉=3.5g/100ml acetic acid) with 6 times of medical material weight soaked 7 days, after medical material is fully expanded, place percolator, percolate is slowly flowed out, collect percolate, reclaiming solvent, to get relative density be 1.15 extractum, the Pericarpium Zanthoxyli that in above-mentioned extractum, adds above-mentioned specified weight part again, the Cornu Bubali fine powder stirs evenly the back to wherein adding the certain proportion gelatin, glycerol, water etc. are made soft capsule.
Embodiment 7
The preparation of spray
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 13 weight portions, Herba Oxytropis Kansuensis 8 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 13 weight portions, Cacumen Myricariae Germanicae 35 weight portions, Flos Carthami 2.0 weight portions, Borneolum Syntheticum 4.0 weight portions, Camphora 4.0 weight portions;
Adjuvant is: polyvidone 6 weight portions, glycerol 2 weight portions, tween 80 9 weight portions, tetrafluoroethane 30 weight portions;
It is stand-by that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m superfine powder; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and it are pulverized, with 70% ethanol of 10 times of above-mentioned mixing medical material weight to mixing medicinal material extract 3 times, the each extraction 0.5 hour, collect afterwards and merge above-mentioned three extracting solution, it is that 1.15 extractum is standby that extracting solution is condensed into relative density; Again that Borneolum Syntheticum, Camphora, glycerol, Tween 80, the polyvidone of above-mentioned specified weight part is standby with 60% dissolve with ethanol.Above-mentioned solution and extractum and the Pericarpium Zanthoxyli after micronizing, Cornu Bubali are merged, add ethanol and make and contain the alcohol amount in the mixed liquor and be 40%-50%, make 1000ml altogether, mixing, static, filter the back filling and sealing and get final product.
Embodiment 8
The preparation of ointment
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 12 weight portions, Herba Oxytropis Kansuensis 4 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 11 weight portions, Cacumen Myricariae Germanicae 25 weight portions;
It is stand-by that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m superfine powder; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and it is pulverized, with 75% ethanol of 8 times of above-mentioned mixing medical material weight to mixing medicinal material extract 3 times, each 1h, collect afterwards and merge above-mentioned three extracting solution, it is 1.15 extractum that extracting solution is condensed into relative density, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali superfine powder, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-40 ℃, be provided with its internal vacuum for (＜10Pa), the taking-up that opens a position after 24 hours is pulverized the mixture after freezing, and to wherein adding an amount of glycerol, polyoxyethylene sorbitan monoleate mixes, and is heated to 80 degrees centigrade as water; With liquid paraffin, span mix homogeneously, be heated to 80 degrees centigrade as oil phase; Then that oil phase is mixed with water, below the restir to 37 degree centigrade, go out cream, fill, packing is promptly.
Embodiment 9
The preparation of gel
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 7 weight portions, Herba Oxytropis Kansuensis 6 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 15 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 25 weight portions, Flos Carthami 1 weight portion, Borneolum Syntheticum 0.5 weight portion, Camphora 0.5 weight portion;
Pericarpium Zanthoxyli with specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-200 μ m, the Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mixes and pulverizes, vinegar (total acid 〉=3.5g/100ml acetic acid) with 10 times of above-mentioned mixing medical material weight soaked 2 days, after medical material is fully expanded, place percolator, percolate is slowly flowed out, collect percolate, reclaiming solvent, to get relative density be 1.30 extractum, the Pericarpium Zanthoxyli that in above-mentioned extractum, adds above-mentioned specified weight part again, Cornu Bubali fine powder and Camphora, Borneolum Syntheticum mixes, add an amount of carbomer again, glycerol, propylene glycol, triethanolamine and suitable quantity of water, mixing and stirring, filling and package are promptly.
Embodiment 10
The preparation of rubber-emplastrum
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 8 weight portions, Herba Oxytropis Kansuensis 3 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 20 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of specified weight part is broken into 0.01-50 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and pulverizes, water with 10 times of above-mentioned mixing medical material weight decocts and extracts it 3 time, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.25 extractum that extracting solution is condensed into relative concentration, add above-mentioned Pericarpium Zanthoxyli, the Cornu Bubali fine powder is reduced to room temperature and this mixture is put into the aluminum dish, and described aluminum dish is put into the vacuum freezing storehouse after stirring evenly, the temperature in described vacuum freezing storehouse is reduced temperature to-30 ℃, be provided with its internal vacuum for (＜10Pa), the taking-up that opens a position after 24 hours is pulverized the mixture after freezing, and to wherein adding natural rubber, zinc oxide, lanoline, liquid paraffin is made rubber-emplastrum, coating, cut, packing, packing is promptly.
Embodiment 11
The preparation of cataplasma
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 5 weight portions, Herba Oxytropis Kansuensis 2 weight portions, Rhizoma Curcumae Longae 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Cornu Bubali 5 weight portions, Cacumen Myricariae Germanicae 15 weight portions, Flos Carthami 0.1 weight portion, Borneolum Syntheticum 0.1 weight portion, Camphora 0.1 weight portion;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and pulverize, water with 8 times of above-mentioned mixing medical material weight decocts and extracts it 2 time, each 1h that extracts, reclaiming solvent, to get relative density be 1.20 extractum, the water that reuse extractum volume is 8 times dilutes it, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate, vacuum drying (0.08MPa), after the gained extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali fine powder, mix homogeneously, make the superfine powder of 0.01-50 μ m through superfine communication technique, the Borneolum Syntheticum that in above-mentioned superfine powder, adds above-mentioned specified weight part, Camphora and sodium polyacrylate 3 weight portions, gelatin 1 weight portion, glycerol 14 weight portions, propylene glycol 7 weight portions, dihydroxyaluminum aminoacetate 0.2 weight portion, methyl hydroxybenzoate 0.2 weight portion, butoben 0.2 weight portion and 50 weight parts waters mix, stir coating, lid lining, cut, packing promptly gets cataplasma.
Embodiment 12
The preparation of slow releasing preparation
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 13 weight portions, Herba Oxytropis Kansuensis 8 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 13 weight portions, Cacumen Myricariae Germanicae 35 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix and pulverize, with 75% ethanol of 8 times of amounts of medical material weight to above-mentioned mixing medicinal material extract 2 times, each 1h that extracts, reclaiming solvent, to get relative density be 1.20 extractum, the dilution of the water of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate vacuum drying, after the gained extract dry powder is ground into fine powder, add stand-by Pericarpium Zanthoxyli, Cornu Bubali fine powder again, mix homogeneously, make the superfine powder of 0.01-0.1 μ m through superfine communication technique, add hydroxypropyl emthylcellulose and lactose in mortar, its mixing, add 80% alcoholic solution system soft material, cross 18 mesh sieves and granulate, wet granular is 50-60 ℃ of drying, dried granule is through 16 mesh sieve granulate, and weighing adds magnesium stearate, mixing, tabletting, encapsulation promptly.
Embodiment 13
The preparation of powder nose inhalant
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 12 weight portions, Herba Oxytropis Kansuensis 4 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 11 weight portions, Cacumen Myricariae Germanicae 25 weight portions, Flos Carthami 2.5 weight portions, Borneolum Syntheticum 1.0 weight portions, Camphora 1.0 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami of all the other specified weight parts are mixed, pulverize, with 75% ethanol extraction of 8 times of above-mentioned mixing medical material weight 2 times, each 1h that extracts, collect afterwards and merge above-mentioned extracted twice liquid, it is 1.20 extractum that extracting solution is condensed into relative density, the water dilution of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate, vacuum drying, obtain extract dry powder, and this extract dry powder is ground into fine powder, add Borneolum Syntheticum, the Camphora of above-mentioned specified weight part, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder mix homogeneously again, add an amount of insoluble support MCC and bioadhesive polymers H-HPC, adopt grinding and freeze drying process to prepare powder spray, encapsulation promptly.
Embodiment 14
The preparation of slow-release paster
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is:
Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions;
Pericarpium Zanthoxyli with above-mentioned specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-50 μ m, to all the other specified weight parts through remove impurity, clean, dried Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the mixing of Cacumen Myricariae Germanicae medical material also is ground into coarse powder, 70% ethanol with 10 times of above-mentioned mixing medical material weight extracts 3 times above-mentioned mixing medical material, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.15 extractum that extracting solution is condensed into relative density, in the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali fine powder, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-30 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 16 hours, mixture after freezing is pulverized, add the dense thick liquid of gelatin (get gelatin and add an amount of distilled water heated and stirred) to even dense thick liquid, polyvinylpyrrolidone, Mentholum stirs, and makes slow-release paster.
Embodiment 15
The preparation of tincture
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix and pulverize, with 75% ethanol of 8 times of amounts of medical material weight to above-mentioned mixing medicinal material extract 2 times, each 1h that extracts, reclaiming solvent, to get relative density be 1.20 extractum, the dilution of the water of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, vacuum drying, the gained extract dry powder is ground into fine powder after, add stand-by Pericarpium Zanthoxyli, Cornu Bubali fine powder again, mix homogeneously is made the superfine powder of 0.01-0.1 μ m through superfine communication technique, encapsulation gets final product.
Embodiment 16
The preparation of emplastrum
The crude drug that can be used for treating the Tibetan medicine compositions of bronchial asthma of the present invention is: Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions, Flos Carthami 1.5 weight portions, Borneolum Syntheticum 2.5 weight portions, Camphora 2.5 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 50 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and pulverize, water with 10 times of above-mentioned mixing medical material weight decocts and extracts it 3 time, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.20 extractum that extracting solution is condensed into relative concentration; The dilution of the water of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 5 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate vacuum drying, after the gained extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, stir, the condition vacuum drying of 70 ℃ of temperature, vacuum 0.075MPa 24 hours, be ground into 120 purpose fine powders after taking out then.Pack into behind the Borneolum Syntheticum of the above-mentioned specified weight part of adding, the Camphora mix homogeneously in above-mentioned fine powder in the non-woven bag, seal, stick at and make emplastrum on the adhesive plaster, packing promptly.
As the distortion of the foregoing description, described Tibetan medicine compositions can be the arbitrary dosage form in pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, sublimed preparation, injection, cream, spray, drop pill, unguentum, ointment, cataplasma, gel, liniment, resin subsides, patch, slow releasing preparation, controlled release preparation or the freeze-dried powder preparation.
Experimental example
In order to show that above-mentioned two kinds of Tibetan medicine compositionss have the obvious treatment effect when being used for preparation treatment bronchial asthma medicine, the present invention has carried out record to the clinical use of said medicine:
1 case is selected
1.1 diagnostic criteria
Chinese Medical Association's respiratory disease credit meeting asthma group, prevention and control of bronchial asthma guide (definition of bronchial asthma, diagnosis curative effect, evaluation judgment criteria and education scheme)
1.1.1 repeated relapsing is panted, dyspnea, uncomfortable in chest or cough, and is many with to contact allergen, cold air, physics, chemical irritation, viral upper respiratory tract infection, motion relevant;
1.1.2 when outbreak two lung audibles and be dispersed in or diffusivity based on the wheezing sound of expiratory phase, expiratory phase prolongation;
1.1.3 above-mentioned symptom can be alleviated or spontaneous remission through treatment;
1.1.4 atypical symptom person (obviously not panting or Signs as having) is positive with the next item down test at least: the Bronchodilation Test positive (FEV1 increases more than 15%), the brinchial provocation test or the exercise test positive, aberration rate or day and night fluctuation rate 〉=20% (5) in PEF day. except panting of causing of other diseases, uncomfortable in chest, cough, as chronic bronchitis, obstructive emphysema, bronchiectasis, interstitial pulmonary fibrosis, acute left heart failure etc.
1.2 meet the bronchial asthma diagnostic criteria
The symptom relevant with asthma has cough, pants, dyspnea, uncomfortable in chest, expectoration etc.Typical performance is ictal expiratory dyspnea with wheezing sound.Severe patient can be forced to take seat or be orthopnea, dry cough or cough up a large amount of white foam expectorant, even cyanosis etc. appears.Symptoms of asthma can be shown effect in several minutes, through a few hours to a couple of days, with bronchodilator or spontaneous remission.Patient's majority of early stage or light disease with ictal cough and uncomfortable in chest serve as main performance.These performances lack characteristic.The pathogenesis of asthma feature is 1. ictal: be ictal increasing the weight of when running into risk factor.2. temporal rhythm: night and the morning outbreak or increase the weight of of being everlasting.3. seasonal: the autumn and winter season of being everlasting shows effect or increases the weight of.4. reversibility: anti-asthmatic usually can relief of symptoms, and the tangible catabasis can be arranged.Be familiar with these features, help the diagnosis and the discriminating of asthma.
1.3 the standard of including in
1.3.1 meet the bronchial asthma diagnostic criteria of GINA (being called for short GINA) in 2004 recommendation;
1.3.2TCD diagnosis: cerebral artery blood flow velocity is lower than lower limits of normal, blackout or adverse current;
1.3.3 the age is in 18-65 year;
1.3.4 voluntary accepting treatment, observation and inspection and signature informed consent person.
1.4 exclusion standard
1.4.1 to the Chinese medicine ingredients allergy sufferers;
1.4.2 the age is less than 18 years old or greater than 65 years old;
1.4.3 serious body complication is arranged, the heart, liver, kidney, pulmonary dysfunction person;
1.4.4 accept other clinical trial persons all around;
1.4.5 method is not used medicine, the shadow therapeutic evaluation in accordance with regulations.
1.5 therapeutic evaluation:
Recovery from illness: the symptom of panting and lung wheezing sound disappear, and the FEV1 value added is greater than more than 30%;
Produce effects: symptom and lung wheezing sound take a turn for the better, and the FEV1 value added is greater than more than 30%;
Do not meet above standard person be considered as invalid.
1.6 reaching, patient's grouping respectively organizes medication
1.6.1 grouping:, be divided into the 1-14 group at random, 45～75 years old age, the course of disease 2～JIUYUE with the patient of in January, the 2006～2,010 260 routine bronchial asthmas that I institute accept for medical treatment, make a definite diagnosis in year June.The above-mentioned 1-14 group age and the preceding course of disease of going to a doctor are checked P＜0.01 through t.
1.6.2 it is as follows respectively to organize Therapeutic Method
In above-mentioned 14 groups, the 1-13 group is the treatment group of the Tibetan medicine compositions among the present invention, and the 14th group is matched group.
The 1st group: with the granule (every bag 6 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 3 methods, each oral 1 bag, every day 1-2 time.
The 2nd group: with the soft capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 6 methods, each oral 4, every day 1-2 time.
The 3rd group: with the pill (every ball 0.2 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 5 methods, each oral 8 balls, every day 1-2 time.
The 4th group: with the powder (every bag 5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 1 method, each oral 2.5g, every day 1-2 time.
The 5th group: with the cataplasma (every subsides 10 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 11 methods, spread on painful area, paste every day 1.
The 6th group: with the rubber-emplastrum (every subsides 5 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 10 methods, spread on painful area, paste every day 1.
The 7th group: with the slow releasing preparation (every slice 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 12 methods, each oral 3, every day 1 time.
The 8th group: with the tablet (every slice 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 4 methods, each oral 3, every day 1-2 time.
The 9th group:, be applied in painful area, every day 1-2 time with the ointment (every 20 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 8 methods.
The 10th group:, be sprayed on painful area, every day 3-5 time with the spray (every bottle 50 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 7 methods.
The 11st group:, be applied in painful area, every day 1-2 time with the gel (every bottle 5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 9 methods.
The 12nd group: with the slow-release paster (every subsides 5mg gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 14 methods, spread on painful area, 1-2 pastes weekly.
The 13rd group: with the capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 2 methods, each oral 4, every day 1-2 time.
The 14th group (matched group), the oral azithromycin of by specification (Xi'an Lijun pharmaceutical Co., Ltd's production).
2, statistical method:
EPIdata software is adopted in data management; Statistical analysis adopts the SPASS12.0 statistical package to carry out analyzing and processing.Constituent ratio is with the t check between two groups, two groups of means relatively with the t check, curative effect is relatively used Ridit between two groups.The P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.
3, therapeutic outcome
1-13 group (treatment group) is all carried out Drug therapy with the 14th group (matched group), through t check, P＜0.01.Tibetan medicine compositions 1-13 group total effective rate of the present invention is respectively 80.00%, 73.68%, 77.78%, 77.27%, 82.61%, 80.00%, 76.19%, 75.00%, 80.00%, 82.35%, 76.19%, 78.95%, 75.00%, the azithromycin effective percentage is 55.00%, P＜0.01 is analysed in credit by statistics statistical significance, the treatment group all is better than matched group, t checks P＜0.01, influences such as no liver, renal function.The results are shown in Table 1:
Table 1 treatment bronchial asthma result
Tibetan medicine compositions 1-13 group curative effect of the present invention obviously is better than matched group (P＜0.01).
4, untoward reaction
The treatment group is during treating, and obvious adverse reaction does not all take place all experimenters.
By above the clinical research result of Tibetan medicine compositions among the present invention to the bronchial asthma treatment shown, described Tibetan medicine compositions effective percentage is respectively 80.00%, 73.68%, 77.78%, 77.27%, 82.61%, 80.00%, 76.19%, 75.00%, 80.00%, 82.35%, 76.19%, 78.95%, 75.00%, curative effect is better than azithromycin matched group 55.00%, P＜0.01 is analysed in credit by statistics statistical significance, and the treatment group all is better than matched group.Therefore, the Tibetan medicine compositions among the present invention has excellent curative to bronchial asthma.
Obviously, the foregoing description only is for example clearly is described, and is not the qualification to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here need not also can't give exhaustive to all embodiments.And conspicuous variation of being extended out thus or change still are among the protection domain of the invention.
Claims (10)
1. the application of Tibetan medicine compositions in preparation treatment bronchial asthma medicine, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part.
2. application according to claim 1 is characterized in that, described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part.
3. application according to claim 1 is characterized in that, described Tibetan medicine compositions is made up of following bulk drugs: 10 parts of Radix Lamiophlomidis Rotataes, 5 parts of Herba Oxytropis Kansuensiss, 30 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 10 parts of Cornu Bubalis, 30 parts of Cacumen Myricariae Germanicaes.
4. application according to claim 1 is characterized in that, described Tibetan medicine compositions is made up of following bulk drugs: 12 parts of Radix Lamiophlomidis Rotataes, 4 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 10 parts in Pericarpium Zanthoxyli, 11 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes.
5. according to the arbitrary described application of claim 1-4, it is characterized in that described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
6. the application of Tibetan medicine compositions in preparation treatment bronchial asthma medicine, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part.
7. application according to claim 6, it is characterized in that described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part, Flos Carthami 0.5-2 part, Borneolum Syntheticum 0.2-4 part, Camphora 0.2-4 part.
8. application according to claim 6, it is characterized in that described Tibetan medicine compositions is made up of following bulk drugs: 9.1 parts of Radix Lamiophlomidis Rotataes, 4.5 parts of Herba Oxytropis Kansuensiss, 40.9 parts in Rhizoma Curcumae Longae, 13.6 parts in Pericarpium Zanthoxyli, 9.1 parts of Cornu Bubalis, 22.7 parts of Cacumen Myricariae Germanicaes, 1.8 parts on Flos Carthami, 2 parts of Borneolum Syntheticums, 2 parts of Camphoras.
9. application according to claim 6, it is characterized in that described Tibetan medicine compositions is made up of following bulk drugs: 7 parts of Radix Lamiophlomidis Rotataes, 6 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 8 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes, 1 part on Flos Carthami, 0.5 part of Borneolum Syntheticum, 0.5 part of Camphora.
10. according to the arbitrary described application of claim 6-9, it is characterized in that described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
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| CN103638444A (en) * | 2012-12-20 | 2014-03-19 | 浙江农林大学 | Effective part of cheezheng pain relieving plaster and preparation method therefor |
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| CN1709445A (en) * | 2005-07-06 | 2005-12-21 | 甘肃奇正藏药有限公司 | Tibetan medicine for major functions of acute-chronic sprain-contusion, rheumatism, rheumatoid diseases, and its preparing method |
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| CN1709445A (en) * | 2005-07-06 | 2005-12-21 | 甘肃奇正藏药有限公司 | Tibetan medicine for major functions of acute-chronic sprain-contusion, rheumatism, rheumatoid diseases, and its preparing method |
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| Title |
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| 《中华人民共和国卫生部药品标准 中药成方制剂 第十二册》 19971231 中华人民共和国卫生部药典委员会 消痛贴膏 164 1-5 , 1 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103638444A (en) * | 2012-12-20 | 2014-03-19 | 浙江农林大学 | Effective part of cheezheng pain relieving plaster and preparation method therefor |
| CN103638444B (en) * | 2012-12-20 | 2020-07-14 | 浙江农林大学 | Effective part of Qizheng pain-relieving plaster and its preparation method |
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