CN102028910B - Chinese medicinal preparation for treating Alzheimer's disease and preparation method thereof - Google Patents
Chinese medicinal preparation for treating Alzheimer's disease and preparation method thereof Download PDFInfo
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- CN102028910B CN102028910B CN2009100184697A CN200910018469A CN102028910B CN 102028910 B CN102028910 B CN 102028910B CN 2009100184697 A CN2009100184697 A CN 2009100184697A CN 200910018469 A CN200910018469 A CN 200910018469A CN 102028910 B CN102028910 B CN 102028910B
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Abstract
The invention discloses a Chinese medicinal preparation for treating Alzheimer's disease, which is prepared from the following raw materials in part by weight: 90 to 110 parts of liquoric root, 80 to 100 parts of stiff silkworm, 80 to 100 parts of rhubarb, 90 to 100 parts of safflower, 50 to 80 parts of mint, 100 to 120 parts of cicada slough, 70 to 90 parts of turmeric, 80 to 90 parts of golden thread, 80 to 100 parts of gardenia, 100 to 140 parts of tall gastrodia tuber and 20 to 50 parts of borneol. A preparation method comprises the following steps of: mixing the raw materials, soaking in water for 20 minutes, putting into a casserole, decocting over slow fire for 30 minutes, pouring decoction out, adding water, decocting over the slow fire again, mixing two-time decoction, filtering by using gauze, and concentrating to obtain the Chinese medicinal preparation. The Chinese medicinal preparation can improve the activity of superoxide dismutase (SOD), has an obvious anti-oxidation effect, can prevent brain tissues from being damaged in various ways of resisting oxygen free radical, resisting lipid peroxidation and the like, and can be used for treating the Alzheimer's disease.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of treating senile dementia and preparation method thereof, belong to tcm field.
Background technology
Senile dementia; Be one of four big common neurodegenerative diseases (other three kinds are Huntington's disease, Lu Jialeishi disease, parkinson), claim again Alzheimer (Alzheimer ' s disease, AD); It is a kind of PDCD that occurs in geratic period and presenium; Refer to a kind of persistence higher nerve functional activity obstacle, promptly do not having under the state of disturbance of consciousness, the obstacle of aspects such as memory, thinking, analytical judgment, visual space identification, emotion.Its characteristic pathological change is the cerebral cortex atrophy, and with amyloid-beta (β-amyloid, β-AP) deposit; Neurofibrillary tangles (neurofibrillarytangles, NFT), mass memory property neuron number reduces; And senile plaque (senileplaque, formation SP).
Senile dementia patient's activity of daily living descends, and they are not familiar with spouse, children, wears the clothes, has a meal, defecation all can not take care of oneself; The auditory hallucination hallucination in addition that has brings endless misery and worried for people own and on every side.Senile dementia patient's mean survival time (MST) is 5.5 years, and senile dementia has become " the fourth-largest killer " of aged health after cardiovascular diseases, cerebrovascular and cancer.
The reason that senile dementia takes place mainly comprises the following aspects: one, the age.The probability of big more generation senile dementia of age is high more.Two, heredity.There is the ill probability of people of family history high.Three, life style.Like smoking excessive drinking, unreasonable diet, do not get enough athletic exercise, with social interactions few.Four, educational level.Schooling is low more, and prevalence is high more.Five, various diseases.Like arteriosclerosis, hypertension, diabetes, coronary heart disease, apoplexy, encephalitis, gassing etc., can bring out dementia.
Investigation is found: the mean age that northern China is suffered from senile dementia is 75,76 years old, and the age of suffering from vascular dementia is many about 68 years old.The ratio of suffering from the severe senile dementia among the over-65s crowd reaches more than 5%, and by 80 years old, this ratio just rose to 15-20%.This shows that senile dementia has become one of killer who threatens the senior health and fitness, be badly in need of a kind ofly can treating this sick medicine.But the medicine that does not still have at present, specific treatment or reverse PD in the prior art.
Summary of the invention
To above-mentioned prior art, the invention provides a kind of Chinese medicine preparation of treating senile dementia, the present invention also provides its preparation method.
The present invention realizes through following technical scheme:
A kind of Chinese medicine preparation of treating senile dementia is to be processed by the raw material of following weight portion: 90～110 parts in Radix Glycyrrhizae, 80～100 parts of Bombyx Batryticatus; 80～100 parts of Radix Et Rhizoma Rhei, 90～100 parts on Flos Carthami, 50～80 parts of Herba Menthaes; 100～120 parts of Periostracum Cicadaes, 70～90 parts in Rhizoma Curcumae Longae, 80～90 parts of Rhizoma Coptidis; 80～100 parts of Fructus Gardeniaes, 100～140 parts in Rhizoma Gastrodiae, 20～50 parts of Borneolum Syntheticums.
Optimization formula is: 100 parts in Radix Glycyrrhizae, 90 parts of Bombyx Batryticatus, 90 parts of Radix Et Rhizoma Rhei, 950 parts on Flos Carthami, 60 parts of Herba Menthaes, 110 parts of Periostracum Cicadaes, 80 parts in Rhizoma Curcumae Longae, 85 parts of Rhizoma Coptidis, 90 parts of Fructus Gardeniaes, 120 parts in Rhizoma Gastrodiae, 40 parts of Borneolum Syntheticums.
A kind of method for preparing of treating the Chinese medicine preparation of senile dementia: get each raw material, mix, 20～40min is soaked in water; Go into marmite slow fire boiling 30～50min, pour out medicine juice, in medicinal residues, add water slow fire boiling 20～30min once more; Pour out medicine juice, merge medicine juice twice, filtered through gauze; The simmer down to thick liquid is the Chinese medicine preparation of treating senile dementia.
During treatment, oral, every day twice, each potion, three months one courses of treatment.Take effect a general course of treatment, continues to take two and can obviously take effect to a plurality of courses of treatment, though can not fully recover, action, distinguishes that the people knows thing etc. and has not big harm.Wherein, the implication of potion is meant: composition of raw materials is: Radix Glycyrrhizae 9～11 grams, Bombyx Batryticatus 8～10 grams, Radix Et Rhizoma Rhei 8～10 grams; Flos Carthami 9～10 grams, Herba Menthae 5～8 grams, Periostracum Cicadae 10～12 grams, Rhizoma Curcumae Longae 7～9 grams; Rhizoma Coptidis 8～9 grams, Fructus Gardeniae 8～10 grams, Rhizoma Gastrodiae 10～14 grams; Borneolum Syntheticum 2～5 grams after the decoction, are concentrated into 100ml with decocting liquid.
Research now thinks that oxygen-derived free radicals causes lipid peroxidation, and the cytotoxic effect of MDA is dead at neuronal degeneration, causes occupying critical role in the incidence and development of alzheimer disease.The anti-peroxidation medicine is removed free radical through different approaches, can prevent to organize peroxide injury, delays the deterioration of the dull-witted state of an illness, and the medicine antioxidation is to the effect of alzheimer disease, depend primarily on arrive cerebral tissue effective ingredient what.Some antioxidant (vitamin E, deprenyl etc.) is owing to being difficult to through blood brain barrier, so its effectiveness to dementia is restricted.Chinese medicine preparation of the present invention is through experimental verification; Can obviously improve Model of Dementia Mus serum activity of SOD; Explain that Chinese medicine preparation of the present invention has tangible antioxidation to the Model of Dementia Mus, thereby show that Chinese medicine preparation of the present invention can be used to treat senile dementia.
Discover the activity of senile dementia disease human peripheral and erythrocyte (RBC) and levels of serum cu-Zn SOD, all significantly reduce.After taking Chinese medicine preparation of the present invention, old experimenter SOD, CAT, Ceruloplasmin raise, and old and feeble disease is with regard to corresponding improvement.Animal experiment proves that also heat-clearing and toxic substances removing can make senile rat liver tissue homogenate, intracellular plastochondria, and microsome and soluble fraction lipid peroxide have reduction in various degree, and SOD content increases in the cardiac muscle, conforms to clinical efficacy.Most scholars thinks that the active mechanism of action that Chinese medicine can obviously improve the SOD enzyme mainly contains: (1) promotes the biosynthesis of protein and nucleic acid; (2) generation and the secretion of raising or quickening pheron; (3) functional metabolism of protection and each internal organs of coordination body; (4) regulate intravital physiological equilibrium; (5) purification of antioxidation and removing free radical; (6) compensatory and activation; (7) additional and stimulation.
Contain Radix Et Rhizoma Rhei, Flos Carthami, Rhizoma Coptidis etc. in the Chinese medicine preparation of the present invention and can make all that RNA shifts in cytoplasm in the liver cell nuclear, make again that poly nucleoglucoprotein body increases in the cytoplasm, accelerated the generation and the secretion of pheron.SOD is the antioxidizing enzyme, and chemical nature still belongs to protein.The synthetic of the interior SOD of cell accelerated in synthetic increase of pheron and secretion, and its content is improved with active, and then can protect cerebral tissue to avoid damaging through number of ways such as antioxidant radical, anti peroxidation of lipid.
In sum; Chinese medicine preparation of the present invention can improve the activity of SOD enzyme; Accelerate the synthetic of the interior SOD of cell, its content is improved with active, had tangible antioxidation; Can protect cerebral tissue to avoid damage through number of ways such as antioxidant radical, anti peroxidation of lipid, can be used for treating senile dementia.
The specific embodiment
Below in conjunction with embodiment the present invention is further described:
Embodiment 1: the Chinese medicine preparation of preparation treatment senile dementia
Prescription is: Radix Glycyrrhizae 9 grams, Bombyx Batryticatus 10 grams, Radix Et Rhizoma Rhei 8 grams, Flos Carthami 10 grams, Herba Menthae 5 grams, Periostracum Cicadae 12 grams, Rhizoma Curcumae Longae 7 grams, Rhizoma Coptidis 9 grams, Fructus Gardeniae 8 grams, Rhizoma Gastrodiae 14 grams, Borneolum Syntheticum 2 grams.
Method for preparing is: get each raw material, mix, the 20min that is soaked in water goes into marmite slow fire boiling 50min; Pour out medicine juice, in medicinal residues, add water slow fire boiling 20min once more, pour out medicine juice, merge medicine juice twice; Filtered through gauze is concentrated into 100ml, is the Chinese medicine preparation of treatment senile dementia.
During treatment, oral, every day twice, each potion, three months one courses of treatment.
Embodiment 2: the Chinese medicine preparation of preparation treatment senile dementia
Prescription is: Radix Glycyrrhizae 11 grams, Bombyx Batryticatus 8 grams, Radix Et Rhizoma Rhei 10 grams, Flos Carthami 9 grams, Herba Menthae 8 grams, Periostracum Cicadae 10 grams, Rhizoma Curcumae Longae 9 grams, Rhizoma Coptidis 8 grams, Fructus Gardeniae 10 grams, Rhizoma Gastrodiae 10 grams, Borneolum Syntheticum 5 grams.
Method for preparing is: get each raw material, mix, the 40min that is soaked in water goes into marmite slow fire boiling 30min; Pour out medicine juice, in medicinal residues, add water slow fire boiling 30min once more, pour out medicine juice, merge medicine juice twice; Filtered through gauze is concentrated into 100ml, is the Chinese medicine preparation of treatment senile dementia.
Embodiment 3: the Chinese medicine preparation of preparation treatment senile dementia
Prescription is: Radix Glycyrrhizae 10 grams, Bombyx Batryticatus 9 grams, Radix Et Rhizoma Rhei 9 grams, Flos Carthami 9.5 grams, Herba Menthae 6 grams, Periostracum Cicadae 11 grams, Rhizoma Curcumae Longae 8 grams, Rhizoma Coptidis 8.5 grams, Fructus Gardeniae 9 grams, Rhizoma Gastrodiae 12 grams, Borneolum Syntheticum 4 grams.
Method for preparing is: get each raw material, mix, the 30min that is soaked in water goes into marmite slow fire boiling 40min; Pour out medicine juice, in medicinal residues, add water slow fire boiling 25min once more, pour out medicine juice, merge medicine juice twice; Filtered through gauze is concentrated into 100ml, is the Chinese medicine preparation of treatment senile dementia.
Embodiment 4: the Chinese medicine preparation of preparation treatment senile dementia
Prescription is: Radix Glycyrrhizae 9 grams, Bombyx Batryticatus 9 grams, Radix Et Rhizoma Rhei 9 grams, Flos Carthami 10 grams, Herba Menthae 7 grams, Periostracum Cicadae 10 grams, Rhizoma Curcumae Longae 8 grams, Rhizoma Coptidis 9 grams, Fructus Gardeniae 9 grams, Rhizoma Gastrodiae 11 grams, Borneolum Syntheticum 3 grams.
Method for preparing is: get each raw material, mix, the 30min that is soaked in water goes into marmite slow fire boiling 40min; Pour out medicine juice, in medicinal residues, add water slow fire boiling 20min once more, pour out medicine juice, merge medicine juice twice; Filtered through gauze is concentrated into 100ml, is the Chinese medicine preparation of treatment senile dementia.
Claims (2)
1. a Chinese medicine preparation of treating senile dementia is characterized in that, is to be processed by the raw material of following weight portion: 90～110 parts in Radix Glycyrrhizae, 80～100 parts of Bombyx Batryticatus; 80～100 parts of Radix Et Rhizoma Rhei, 90～100 parts on Flos Carthami, 50～80 parts of Herba Menthaes; 100～120 parts of Periostracum Cicadaes, 70～90 parts in Rhizoma Curcumae Longae, 80～90 parts of Rhizoma Coptidis; 80～100 parts of Fructus Gardeniaes, 100～140 parts in Rhizoma Gastrodiae, 20～50 parts of Borneolum Syntheticums.
2. a kind of method for preparing of treating the Chinese medicine preparation of senile dementia according to claim 1 is characterized in that: get each raw material, mix; 20～the 40min that is soaked in water goes into marmite slow fire boiling 30～50min, pours out medicine juice; In medicinal residues, add water slow fire boiling 20～30min once more, pour out medicine juice, merge medicine juice twice; Filtered through gauze, the simmer down to thick liquid is the Chinese medicine preparation of treating senile dementia.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100184697A CN102028910B (en) | 2009-09-29 | 2009-09-29 | Chinese medicinal preparation for treating Alzheimer's disease and preparation method thereof |
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| CN2009100184697A CN102028910B (en) | 2009-09-29 | 2009-09-29 | Chinese medicinal preparation for treating Alzheimer's disease and preparation method thereof |
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| CN102028910A CN102028910A (en) | 2011-04-27 |
| CN102028910B true CN102028910B (en) | 2012-05-02 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327568A (en) * | 2011-09-30 | 2012-01-25 | 许士杰 | Medicine for treating senile dementia |
| CN105943674B (en) * | 2016-06-22 | 2019-09-20 | 深圳市老年医学研究所 | A kind of Chinese materia medica preparation and preparation method thereof for preventing and treating Alzheimer disease |
| CN109620942B (en) * | 2019-01-17 | 2021-05-18 | 上海中华药业有限公司 | Application of Rendan in preparing medicine for preventing or treating Huntington chorea |
| CN113528551B (en) * | 2021-08-03 | 2023-03-24 | 昆明理工大学 | Gastrodia elata superoxide dismutase gene and application thereof |
| CN116270943B (en) * | 2023-03-21 | 2024-01-26 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Chinese herbal compound preparation for treating ischemic cerebral apoplexy and preparation method thereof |
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2009
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Non-Patent Citations (3)
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| 丁向东等.升黄益智颗粒治疗阿尔茨海默病的临床研究.《中国老年学杂志》.2009,第29卷(第16期),2023-2024. * |
| 徐青等.升黄益智方对痴呆模型小鼠脑组织SOD活性的影响.《中国老年学杂志》.2007,第27卷(第8期),734-735. * |
| 钟华等.中医药抗氧化损伤防治阿尔茨海默病.《长春中医药大学学报》.2007,第23卷(第5期),99-100. * |
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