CN102028822B - Mulberry and tuber fleeceflower root hair growing medicinal tea for treating alopecia and poliosis, and preparation method and application thereof - Google Patents
Mulberry and tuber fleeceflower root hair growing medicinal tea for treating alopecia and poliosis, and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides mulberry and tuber fleeceflower root hair growing medicinal linimentum for treating alopecia and poliosis, and a preparation method and application thereof. The mulberry and tuber fleeceflower root hair growing medicinal tea is prepared from winter mulberry, tuber fleeceflower root, simpleleaf shrub chastetree fruit, skunk bugbane, yerbadetajo herba ecliptae and glossy privet fruit according to a certain weight part. The preparation method comprises the following steps of: packaging the simpleleaf shrub chastetree fruit and the glossy privet fruit with cloth, placing into a container, decocting by adding water, removing dregs and retaining the medicinal liquid; placing the winter mulberry, the tuber fleeceflower root, the skunk bugbane and theyerbadetajo herba ecliptae into the container, decocting by adding water, removing dregs and retaining the medicinal liquid; and finally, combining the medicinal liquid, filtering, adding crystal sugar and boiling to obtain brown medicinal liquid with a slightly sweet and slightly bitter taste, and bottling the brown medicinal liquid to obtain the mulberry and tuber fleeceflower root hair growing medicinal tea. The mulberry and tuber fleeceflower root hair growing medicinal tea has the advantages of scientific formula, obvious curative effect, convenience of use, low price, no toxic or side effect and the like; when using the product, a user drinks 100 milliliters of the tepid medicinal tea in the morning and at night each day; generally, after two weeks, pores are protruded and new hairs grow; furthermore, the mulberry and tuber fleeceflower root hair growing medicinal tea can blacken the hairs and relieve itching as well as control reappearance of alopecia and poliosis.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically relate to a kind of Sang He that treats alopecia and poliosis and educate and send out medicinal tea and preparation method thereof, particularly a kind of medicated diet medicinal tea that forms with decocting is used to treat alopecia, poliosis and helps educating the medicated tea of sending out.
Background technology
Alopecia, poliosis are commonly encountered diseases, the frequently-occurring diseases in the department of dermatologry; The two clinical normal phase is also seen; Though direct life threatening not; But the lighter often is the important behaviour of sub-health state, and weight person is senilism or the unusual external reflection of body physiological index generation often, has seriously influenced the external attractive in appearance of people.Pursue today of quality of life day by day people, alopecia and poliosis have brought great psychic pain and mental maladjustment to extensive patients.
Modern medicine treatment alopecia method commonly used has hormone, contact sensitizing agent, photochemotherapy etc., though these have certain curative effect, side effect is in various degree arranged, and the figure for taking stopgap measures.Modern medicine does not have specific short basically to the treatment of poliosis.The difficult point of Chinese traditional treatment alopecia is that present treatment to alopecia does not have specific drug; And the present situation and the clinical data that shows of treating alopecia, poliosis are from ancient times to the present seen; There is tangible limitation; Treat many check weighings and nourish in sweet temperature, this to heat stagnation, the deficiency of YIN, worm-eaten, stagnation of phlegm etc. cause alopecia, the poliosis person then has the heresy of staying to help the anxiety of heat, has tangible limitation.
Through the clinical research prompting, alopecia at present, poliosis patient outstanding behaviours are the pathological factor of " deficiency of YIN is hot and suffocating ".The secular operating pressure of its reason, study are nervous, and feelings will is not smooth, are prone to cause that the stagnated QI transforming into fire consumption is cloudy gives birth to heat, or ponder over the transition consumption liquid of overtaxing one's nerves, and interior-heat is spontaneous; Growth in the living standard, the delicious food savoury, pungent drinks is too much, and is nondigestible, strongly fragrant and living hot; Occupy warming by air conditioner for a long time, too much liquid heat dissipation such as have a bath is given birth to; Chamber is excessive, damage of essence liquid consumption, and interior-heat is spontaneous, so clinical no matter be that void is that alopecia, poliosis due to the reality is often with this common pathological factor " deficiency of YIN is hot and suffocating ".
Promoting moist regeneration of hair and control to dry up and come off, is the final goal of treatment poliosis, alopecia.Thereby the relation of correct handling whole body and local disease damage is the basic demand that improves curative effect.See its therapeutic effect from the characteristics of incidence of clinical alopecia, poliosis, all need the process characteristics that a treatment transforms, so it is stable how to seek dosage form; Take for a long time and have no side effect; Existing therapeutical effect has the square medicine of health-care effect again, is the development trend of alopecia, poliosis clinical research; Also be the effective way of performance Chinese medicine advantage, traditional Chinese medical science medicated diet has such characteristic and advantage just.
Summary of the invention
The objective of the invention is to overcome the weak point of said medicine, provide a kind of Sang He to educate and send out medicinal tea.This is educated and sends out that a medicinal tea causes alopecia to " deficiency of YIN is hot and suffocating ", the poliosis patient has obvious therapeutic effect and health-care effect, and has easy to usely, and growing and blacking hair, the antipruritic power of heat radiation are strong, and advantage has no side effect again.
Another object of the present invention provides the method for preparing of this medicinal tea.
The objective of the invention is to realize through following technical scheme:
A kind of Sang He educates and sends out medicinal tea, and this medicinal tea has following bulk drugs made: 10～30 parts of winter folium moris, 10～50 parts of Radix Polygoni Multiflori, 15～40 parts of Fructus Viticises, 5～15 parts of Rhizoma Cimicifugaes, 15～40 parts of Herba Ecliptaes, 10～50 parts of Fructus Ligustri Lucidi.
It is made by following bulk drugs that this Sang He educates a medicinal tea: 20～25 parts of winter folium moris, 30～35 parts of Radix Polygoni Multiflori, 25～30 parts of Fructus Viticises, 10～15 parts of Rhizoma Cimicifugaes, 30～35 parts of Herba Ecliptaes, 30～40 parts of Fructus Ligustri Lucidi.
Said Sang He educates the method for preparing of sending out medicinal tea, and its preparation process is following:
A) take by weighing each crude drug: winter folium mori, Radix Polygoni Multiflori, Fructus Viticis, Rhizoma Cimicifugae, Herba Ecliptae, Fructus Ligustri Lucidi, subsequent use;
B) Fructus Viticis, the Fructus Ligustri Lucidi of alleged weight proportion are wrapped with cloth respectively and be placed in the first marmite container, add water and decoct in right amount, go dregs to filter, medicinal liquid is continued to employ;
C) with the winter folium mori of said weight proportion, Radix Polygoni Multiflori, Rhizoma Cimicifugae, Herba Ecliptae, clean and be placed in the second container marmite respectively, add water and decoct in right amount, go dregs to filter, medicinal liquid is continued to employ;
D) combining medicine in above-mentioned two containers is boiled dregs with crystal sugar in the container more in right amount and filter, the little sweet poor coffee-like medicinal liquid that obtains is Sang He and educates and send out a medicinal tea.
The addition of said crystal sugar is in the 500ml medicinal liquid, to add 30 grams.
Said Sang He educates and sends out the application of medicinal tea in preparation treatment alopecia medicine.
Said Sang He educates and sends out the application of medicinal tea in preparation treatment poliosis medicine.
Medicinal tea of the present invention is mainly selected dispelling wind and heat pathogens for use, the winter folium mori of removing heat from blood long hair.Compendium of Material Medica is called it: " making eye bright long hair "; Bitter sweet puckery tepor is returned the Radix Polygoni Multiflori of liver, kidney channel, and " Radix Polygoni Multiflori biographys " called it: " long biceps, beneficial marrow is strengthened gas, preserves youthful looks, hair color is prolonged life ".Compendium of Material Medica meaning its " muscle reinforcing and bone strengthening, black moustache is sent out for the liver benefiting that nourishes blood, controlling nocturnal emission with astringent drugs kidney tonifying "; Frivolous liter looses, the light hot and suffocating Rhizoma Cimicifugae that passes through the whole body; Dispelling wind and heat pathogens, the Fructus Viticis of clear sharp head's ability long hair; Go into the kidney nourishing YIN and the hair of growing can be gone into blood again, be the Herba Ecliptae of the article of cooling blood for hemostasis; Sweetness and bitterness is cool in nature, the Fructus Ligustri Lucidi of tonifying liver kidney yin, and " book on Chinese herbal medicine covers bamboo fish trap " called it: " the black palpus of hair color, strong rigidity of soft tissues power ".Take its effective ingredient, make each efficacy of drugs produce synergism, thereby notable therapeutic effect can be arranged alopecia, the poliosis patient of deficiency of YIN stagnated heat type and educate the hair-care and health effect.
Of the present invention educating sent out medicated tea; Mainly be to have miscellaneous pathological factor to present clinical alopecia, poliosis patient majority---" deficiency of YIN is hot and suffocating " and draft; Effects such as this side of clinical effectiveness reaction has the YIN nourishing removing heat from blood, it is antipruritic to dispel the heat, growing and blacking hair, through laboratory observation, this medicinal tea can promote local blood circulation; Activate hair follicle cell, promote hair regeneration; Simultaneously tryrosinase there is activation.Can be used for treating alopecia areata, alopecia totalis, alopecia universalis and withered, poliosis, more can prevent alopecia, early white.Have scientific formulation, evident in efficacy, easy to use, low price, advantage such as have no side effect.
Sang Heyu sends out the pharmacological testing of medicinal tea:
(1) Sang He educates and sends out the influence of tea to the rat hair growth
1 test objective
Observe Sang He and educate the influence of a tea the rat hair growth.
2 test materials
2.1 receive the reagent thing
ZHANGGUANG 101 are provided by BeiJing ZhangGuang's 101 development in science and technology company limiteies, defend and make up special word (2005) No. 0568
Normal saline is provided by Nanjing Xiaoying Medicine Group Co.,Ltd, lot number: 2008031708
Sang Heyu sends out tea, by Nanjing University of Traditional Chinese Medicine's pharmacological evaluation chamber preparation.
2.2 experimental apparatus
Slide gauge Harbin measurer stage property factory model (96) amount system surplus MC01000167
The model FAH04N of electronic balance Shanghai Precision Scientific Apparatus Co., Ltd
Laser doppler microcirculation appearance Biopac systems model LDF100C.
2.3 laboratory animal
The SD rat, the cleaning level, body weight 150-200g, totally 72, male and female half and half are supplied with by Zhejiang Province's Experimental Animal Center.Laboratory animal credit number: SCXK (Zhejiang) 2003-0001.
2.4 experimental condition
Experiment Nanjing University of Traditional Chinese Medicine's Experimental Animal Center (laboratory animal occupancy permit number: accomplish room temperature SCXK (Soviet Union) 2002-0027): 18～24 ℃, humidity: 40～70%.
2.5 statistical method: variance analysis
3 test methods
3.1 the laboratory observation of rat hair self-sow under the normal condition
Get 24 rats, male and female half and half.Preserved skin is used 10%Na
2The cotton balls applying light rat back hair of S solution impregnation makes Na
2S infiltrates Rhizoma Imperatae, and is with dried cotton swab wiping that hair removing is clean when light yellow gel appears in the back, and with clear water with the Na of QUMAO place
2It serves as clean that S cleans to remove Rhizoma Imperatae
[1], [1] Ma Pingbo. and hair tonic is joined invigorating blood circulation addiction and short hair growth experimental study of effect. No.1 Military Medical Univ.'s journal, 2002:22 (5): 421, observe its self-sow situation.Respectively at 2 weeks of depilation back, 3 weeks, respectively get 8 execution (male and female half and half) 4 weeks, at the administered area 10 Mus hairs of choosing, magnifier writes down meansigma methods with vernier caliper measurement Mus staple length down at random.Take off the skin of medicine-feeding part.Use diameter to lay three skin grafts that area is identical successively as the card punch of 1cm in same position, get hair and weigh, trying to achieve meansigma methods is hair weight.Calculate the speed of hair growth under the normal condition.The result sees table 1.
Hair growth rate under the table 1 rat normal condition
Compare *＜0.05**P＜0.01 with sex mouse data with two weeks
The result shows, under the normal condition, the 3rd week of rat depilation back is compared with second week with all around the hair length, and significant difference (P＜0.01, P＜0.05) is all arranged.Can know by experimental data; Under the situation that does not add the medicine intervention, the depilation of second week is distinguished hair length and is equivalent to about 35% of the district's hair length that do not lose hair or feathers, and hair length is shorter with respect to the zone of not losing hair or feathers before this; Weighing is inaccurate when drawing materials, and the suggestion depilation was drawn materials after two weeks.What the 3rd week depilation district's hair length was equivalent to not lose hair or feathers district's hair length is about 60%; Female Mus depilation district hair length is equivalent to 100% of the district's hair length that do not lose hair or feathers around the; The hero Mus then reaches 95.5%, shows that experimental mouse depilation back hair self-sow is approaching basically or reach normal all around.Therefore giving under the situation of pharmaceutical intervention, no matter medicine has inefficacy, respectively organizes rat hair self-sow in the time of around the and has not had the visible difference of naked eyes, and the prompting administration time should be controlled in three weeks.Therefore can know that administration time is that 2-3 week is more suitable.In the experimentation between female Mus and the male Mus each stage hair growth ratio more all do not see significant difference (P＞0.05); Do not see the asynchronous of female Mus and male Mus hair self-sow; But do not get rid of the diversity of medicine to female Mus and male Mus hair growth facilitation; Therefore, the concrete administration time of female Mus and male Mus is looked in the administration process administration group rat hair growth degree and blank control group rat and the time of the visible difference of naked eyes occurred and decide.
3.2 educating, Sang He sends out the influence of tea to the rat hair growth
3.2.1 experimental procedure
Get 48 rats, male and female half and half.Na
2The S depilation, concrete grammar is with reference to the laboratory observation of rat hair self-sow under the normal condition.By body weight and the equilibrium of depilation clean level female Mus and male Mus are divided into three groups respectively, that is: the blank group gives distilled water; Positive controls gives ZHANGGUANG 101; Sang Heyu sends out the tea group, gives Sang He and educates a tea.Every group of 8 rats.Same area is chosen the area of 3 * 3cm in the depilation district, and labelling is as administered area.Draw the 0.25ml relative medicine with the 1ml syringe, evenly coat administered area.Every day twice, twice dosing interval 8h.Male Mus successive administration 14 days, female Mus successive administration 19 days.Behind last administration 1h, measure administration local skin microcirculation, put to death, measure hair length, weight, the administration local skin is done the pathology histological examination.
3.2.2 detection index
3.2.2.1 rat depilation district chaeta was grown and scoring after medication was respectively organized in observation
Per 2 days to the virgin wool upgrowth situation scoring of rat depilation district once, and standards of grading are not grown to 0 fen by there being hair; The shallow staple length district of completely losing hair or feathers is 1 minute, newborn staple length and density be about not the depilation district half be 2 minutes, the virgin wool growth is 3 minutes with end depilation district indifference.(calculate every group of mean scores, carry out the t check)
3.2.2.2 microcirculation detects Wang Yanrong. the experimentation of the short hair growth of Chinese medicine " " zaishengling " for curing alopecia ". the anti-system of medical faunae, 2003; 19 (9): 539
1h surveys administration local skin microcirculation with laser doppler microcirculation appearance after the last administration.Draw the about 0.5 * 0.5cm of medicine zone lower left corner area, preserved skin after stablizing, writes down rat administered area microcirculation in 20 seconds with laser doppler microcirculation appearance.
3.2.2.3 depilation district's new formation staple length and weight
Put to death rat, at the administered area 10 Mus hairs of choosing, magnifier writes down meansigma methods with vernier caliper measurement Mus staple length down at random.Take off the skin of medicine-feeding part, use diameter to lay three skin grafts that area is identical successively, get hair and weigh, average and count hair weight as the card punch of 1cm in same position.
3.2.2.4 pathological observation
With the medicine-feeding part diameter is that the skin histology of 1cm is used 10% formalin fixed, carries out conventional organization dehydration, FFPE, HE dyeing, light microscopic microscopy, observes the skin histology index relevant with hair growth.
A, high dermis blood vessels caliber (mm): measure 5 crosscut blood capillary calibers at random, the calculating horizontal mean;
B, high dermis blood vessel number (individual): with 200 times of big subtotal figures in the visual field, several 5 visuals field, calculating horizontal mean;
C, the new saccus setigerus number of high dermis (individual): with 100 times of big subtotal figures in the visual field, several 5 visuals field, calculating horizontal mean.
4. experimental result
4.1 Sang He educates and sends out tea the result that influences of rat medicine-feeding part hair growth scoring is shown; Female Mus Sang He educates and sends out tea group and positive controls in administration after 19 days; Length to hair growth is compared with the blank group with density scores, and significant difference (P＜0.05) is arranged; Male Mus Sang He educates and sends out the tea group at administration 4d, 6d, and the appraisal result of 12d is compared with the blank group, and significant difference (P＜0.05) is all arranged, and concrete outcome is seen table 2, table 3.
Hair growth scoring after the female Mus administration of table 2 (X ± SD, n=8)
Compare * P＜0.05 with the blank group
Hair growth scoring after the male Mus administration of table 3 depilation (X ± SD, n=8)
Compare * P＜0.05 with the blank group
The microcirculatory result of influence of rat medicine-feeding part is shown that Sang He educates a tea female Mus and the microcirculatory effect of male Mus medicine-feeding part are superior to the blank group, and significant difference (P＜0.01) is arranged 4.2 Sang He educates a tea; Do not see significant difference with positive controls.Prompting Sang He educates a tea all can increase local amount of blood supply to female, male rat, improves local microcirculation.The result sees table 4, table 5
Table 4 Sang He educate send out tea to the microcirculatory influence of female Mus medicine-feeding part (X ± SD, n=8)
Compare * * P＜0.01 with the blank group
Table 5 Sang He educate send out tea to the microcirculatory influence of male Mus medicine-feeding part (X ± SD, n=8)
Compare * * P＜0.01 with the blank group
4.3 Sang He educates and sends out tea the result that influences of rat medicine-feeding part hair length is shown; Female Mus administration group and blank group, positive controls are not more all seen significant difference (P＞0.05); Positive controls medicine-feeding part hair length is longer than blank group and administration group, and with the blank group significant difference (P＜0.01) is arranged relatively; Male Mus administration group hair length compares with blank group, positive controls that all there were significant differences (P＜0.01), and hair length is longer than blank group and positive controls.
The result sees table 6, table 7.
Table 6 Sang He educate send out tea to the influence of female Mus medicine-feeding part hair length (X ± SD, n=8)
Compare * * P＜0.01 with the blank group
Table 7 Sang He educate send out tea to the influence of male Mus medicine-feeding part hair length (X ± SD, n=8)
Compare * * P＜0.01 with the blank group; Compare ##P＜0.01 with positive controls
4.4 educating to send out between tea each group of the female Mus of influence to rat medicine-feeding part hair weight, compares Sang He; All do not see significant difference (P＞0.05); More also do not see significant difference (P＞0.05) between each group of male Mus; But the hair weight of male Mus administration group and positive controls has significant difference (P＜0.05) greater than the blank group.The result sees table 8, table 9.
Table 8 Sang He educate send out tea to the influence of female Mus medicine-feeding part hair weight (X ± SD, n=8)
Table 9 Sang He educate send out tea to the influence of male Mus medicine-feeding part hair weight (X ± SD, n=8)
4.5 Sang He educates and sends out tea the result that influences of rat medicine-feeding part skin histology is shown; The blood capillary caliber of female Mus administration group, positive controls and hair follicle number and blank group more all have significant difference (P＜0.01), and significant difference (P＜0.05) is relatively arranged for blood vessel number and blank group but administration group and positive controls are not more all seen significant difference (P＞0.05) at blood capillary caliber, hair follicle number and blood vessel number.The blood capillary caliber of male Mus administration group, positive controls; Hair follicle number and blood vessel number and blank control group are relatively; Significant difference (P＜0.01) is all arranged; But the blood capillary caliber of administration group and blood vessel number and positive controls are not more all seen significant difference (P＞0.05), the visible significant difference (P＜0.05) of the two hair follicle number.Sang Heyu sends out tea can expand rat back high dermis blood capillary, increases local amount of blood supply, strengthens hair follicle nutrition, promotes the growth and the regeneration of hair.The result sees table 10, table 11.
Table 10 Sang He educate send out tea to the histological influence of female Mus skin of back (X ± SD, n=8)
Compare * P＜0.05, * * P＜0.01 with blank control group
Table 11 Sang He educate send out tea to the histological influence of male Mus skin of back (X ± SD, n=8)
Compare * * P＜0.01 with blank control group; Compare #P＜0.05 with positive controls
5 discuss
In order to confirm the time of experiment administration and index observing, rat hair self-sow under the normal condition has at first been observed in this experiment, and the result is visible, and rat is through 10%Na
2After the local depilation of S solution; Under routine raising condition; Hair length and weight are compared with second week and significant difference are all arranged (P＜0.01) around the 3rd week, the; The rat regional hair growth that loses hair or feathers is identical with the regional hair length of non-depilation in the time of around the, and the prompting administration time is easy to control at 2-3 within week, does not see hair growth speed asynchronous of female Mus and male Mus in the experiment.
Send out in the experiment of tea to the influence of rat hair growth at Sang Heyu,, regularly depilation district hair growth situation is marked behind the self administration of medication for confirming concrete administration time.Stop administration during the obvious difference of between each group, marking.Can be known that by experimental result female Mus administration is after 19 days, Sang He educates a tea group and positive controls is marked apparently higher than the blank group, with the blank group significant difference (P＜0.05) is arranged more all; And male Mus Sang He educates a tea group at administration 4d, 6d, and 12d, scoring is compared with blank control group behind the 14d, significant difference (P＜0.05) is all arranged, but when 4d and 6d, hair length is too short, the inaccuracy of drawing materials.So final definite female Mus administration time is 19 days, male Mus is 14 days.Under administration time and the normal condition in the experiment of rat hair self-sow the conclusion of gained administration time consistent; The female Mus and the male Mus speed of growth occur asynchronously in this experiment, and inconsistent with rat hair self-sow experimental result under the normal condition, reason remains further experiment research.
Experimental result shows; Female Mus administration group and blank group are relatively; On several three indexs of microcirculation, blood capillary caliber and hair follicle; Significant difference (P＜0.01) is arranged, and counting at blood vessel has significant difference (P＜0.05) on the index, but on staple length and gross weight index, does not see significant difference (P＞0.05); Relatively microcirculation is higher for administration group and positive controls, significant difference (P＜0.01) is arranged, but on several five indexs of hair length, weight, hair follicle number, caliber and blood vessel, the positive control class value is higher than the administration group, but does not all see significant difference (P＞0.05).
Male Mus administration group and blank group relatively all have significant difference (P＜0.01) on several five indexs of microcirculation, hair length, blood capillary caliber, hair follicle number and blood vessel; Administration group and positive controls are relatively; The microcirculation value is higher than positive controls and significant difference (P＜0.01) is arranged, and the hair length value is higher than positive controls, and significant difference (P＜0.05) is arranged; The hair follicle number is lower than positive controls, and significant difference (P＜0.05) is arranged.
Can know that in conjunction with female Mus and male Mus experimental result it is apparent in view to the facilitation of rat hair growth that Sang He educates a tea, but compare with ZHANGGUANG 101, do not demonstrate the difference on the curative effect, the numerical value of some index is lower than positive drug simultaneously.Possibly educate that to send out tea different relevant with ZHANGGUANG 101 composition and mechanism of action with Sang He.
Sang Heyu sends out tea and is made up of Radix Polygoni Multiflori, winter folium mori, Fructus Viticis, Fructus Ligustri Lucidi etc., has growing and blacking hair, YIN nourishing removing heat from blood, the effect of heat radiation itching relieving.Alopecia, poliosis due to the treatment deficiency of YIN is hot and suffocating.The integral result analysis can know, Sang He educates and sends out tea the growth of rat hair is had facilitation, the hair growth speed of the rat that can significantly promote to lose hair or feathers; Expansion rat back high dermis blood capillary increases local amount of blood supply, microcirculation improvement; Strengthen hair follicle nutrition, promote the growth and the regeneration of hair.ZHANGGUANG 101 have the stimulation contrafluxion, improve local microcirculation, promote the hair growth effect.
(2) Sang He educates and sends out the clinical observation of tea to alopecia, poliosis
Sang Heyu sends out the effect side that tea is my clinical treatment alopecia and poliosis; Be to have " deficiency of YIN is hot and suffocating " this pathological factor and draft to present clinical alopecia, poliosis patient majority; Be made up of Radix Polygoni Multiflori, winter folium mori, Fructus Viticis, Fructus Ligustri Lucidi etc., this side of clinical effectiveness reaction has growing and blacking hair, YIN nourishing removing heat from blood, the effect such as antipruritic of dispelling the heat.This paper is contrast with ZHANGGUANG 101 liquid, observes the clinical effectiveness of this side to alopecia and poliosis.
1 case selection
The diagnostic criteria of (1) diagnostic criteria alopecia, alopecia areata, poliosis is with reference to (current clinical medicine diagnostic criteria book series " oral cavity cutaneous diseases diagnostic criteria ") (calendar year 2001 Science Press).
(2) include standard in 1. for meeting alopecia, all genus of poliosis " deficiency of YIN " " hot and suffocating " type.2. the symptom performance that has the alopecia of " deficiency of YIN " " hot and suffocating " type, poliosis.3. part or system do not use the growing and blacking hair medicine, and not taking hormone, contraceptive and other anti-androgens medicines in nearly 3 months.4. patient that can tracing study includes clinical observation in.
(3) exclusion standard is with reference to " new Chinese medicine clinical research guideline " 1. cicatrix property alopecia.2. uncooperative, not by the regulation medication or data is not congruent affects the treatment or safety judgement person.
(4) criterion of therapeutical effect is with reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " (State Administration of Traditional Chinese Medicine's promulgation 1994).
2 object of study and Therapeutic Method
(1) object of study: case is collected in Nanjing University of Traditional Chinese Medicine's traditional Chinese medical science hall alopecia, poliosis medical expert's consultation, observes eligible and sets up treatment group, each 30 example of matched group respectively.
(2) Therapeutic Method
1. treatment group: observe 30 examples, educate with Sang He and send out tea, local outer putting on the skin, an amount of, 2 times on the 1st.
2. matched group: observe 30 examples, use ZHANGGUANG 101, local outer putting on the skin, an amount of, 2 times on the 1st.
3. observing time: 6 months.Wherein every treatment 3 months was 1 course of treatment, judged clinical efficacy after treating 2 courses of treatment continuously.
3 observational techniques and index
(1) observational technique: formulate " deficiency of YIN " " hot and suffocating " and cause the clinical observation table of alopecia, poliosis.Let patient's further consultation 1 time weekly, continuous use 6 months.During the treatment,, fill in clinical observation registration analytical table at quarterly intervals by the evaluation that patient and observation doctor accomplish each symptom jointly.
(2) observation index: 1. observation of symptoms: local hair changes; The clinical symptoms of whole body " deficiency of YIN " " hot and suffocating "; Picture of the tongue, pulse condition.
4 curative effect determinate standards
Clinical cure: alopecia all grows, blackening hair, and symptom all disappears, and symptom is evaluated more than 85%;
Produce effects: alopecia all grows, and hair is moist, and 50% changes black, and main clinic symptoms disappears, and symptom is evaluated more than 50%;
Take a turn for the better: alopecia partly grows, and hair portion is moist changes black, and cardinal symptom takes a turn for the better, and symptom is evaluated more than 20%;
Invalid: local and clinical symptoms does not have the improver.
5 observed results
Educate a tea, ZHANGGUANG 101 treatment alopecia, each 30 example of poliosis, result: treatment group: cure 11 examples, produce effects 8 examples, 7 examples that take a turn for the better, invalid 4 examples with Sang He.Total effective rate is 86.6%; Matched group: cure 9 examples, produce effects 8 examples, 8 examples that take a turn for the better, invalid 5 examples.Total effective rate is 83%
6 discuss
Alopecia, poliosis pathogeny are intricate, do not draw consistent conclusion at present as yet.The tradition traditional Chinese medical science is thought " hair is the sign of blood condition ", the abundance of liver blood and kidney essense, its Hua Zaifa; Deficiency of the liver and kindey, essence and blood lose void and then are prone to cause alopecia, poliosis, so the many check weighings of treatment from ancient times to the present nourish in sweet temperature.But observe from a large amount of clinical datas, alopecia at present, poliosis patient outstanding behaviours are the pathological factor of " deficiency of YIN is hot and suffocating ".The secular operating pressure of its reason, study are nervous, and feelings will is not smooth, are prone to cause that the stagnated QI transforming into fire consumption is cloudy gives birth to heat, or ponder over the transition consumption liquid of overtaxing one's nerves, and interior-heat is spontaneous; Growth in the living standard, the delicious food savoury, pungent drinks is too much, and is nondigestible, strongly fragrant and living hot; Occupy warming by air conditioner for a long time, too much liquid heat dissipation such as have a bath is given birth to; Chamber is excessive, damage of essence liquid consumption, and interior-heat is spontaneous, so clinical no matter be that void is that alopecia, poliosis due to the reality is often with this common pathological factor " deficiency of YIN is hot and suffocating ".See, control, the growing and blacking hair of alopecia, poliosis to be had significant effect through growing and blacking hair, YIN nourishing removing heat from blood, the treatment of heat radiation itching relieving method from the effect of clinical treatment.Sang Heyu sends out tea to there was " deficiency of YIN is hot and suffocating " this pathological factor in patient's majority and drafted in vain present clinical alopecia, morning.The bitter sweet puckery tepor of Radix Polygoni Multiflori is returned liver, kidney channel in the side." Radix Polygoni Multiflori biography ": " strong gas is preserved youthful looks for long biceps, beneficial marrow, and hair color is prolonged life ".Compendium of Material Medica meaning its " muscle reinforcing and bone strengthening, black moustache is sent out for the liver benefiting that nourishes blood, controlling nocturnal emission with astringent drugs kidney tonifying ".Winter folium mori is bitter sweet cold, dispelling wind and heat pathogens, removing heat from blood long hair.Compendium of Material Medica meaning its: " making eye bright long hair ", " Bencao Congxin " meaning: " grows dry, removing heat from blood stops blooding ".Fructus Viticis is arduous cold, dispelling wind and heat pathogens, and the clear sharp head can long hair." medicineization justice " called it: " all the excessive institute of heat in blood wind extremely, with this cold." Fructus Ligustri Lucidi, sweetness and bitterness is cool in nature, the tonifying liver kidney yin." book on Chinese herbal medicine covers bamboo fish trap " called it: " the black palpus of hair color, strong rigidity of soft tissues power ".All medicines share, and have effects such as growing and blacking hair, YIN nourishing removing heat from blood, heat radiation be antipruritic.We not only have better curative effect to the hot and suffocating alopecia of the deficiency of YIN, poliosis, and building body, improving sight and hearing are also had certain effect, and use has no side effect, and is worthy to be popularized.
Sang He of the present invention educates and sends out tea, has carried out trial test and mechanism research, animal rat has been made the pharmacodynamic observation of hair growth; This can make the chaeta speed of growth accelerate, and gross weight increases, and dermis thickness is increased; The hair follicle number increases; Can promote local blood circulation, activate hair follicle cell, the obvious trichogenous effect of tool.In addition this side has been carried out the laboratory observation that tyrosinase activity is measured, the result shows that this side has activation to tryrosinase, and the prompting we have certain black hair effect.
Clinical effectiveness and pharmacological action: through to 300 routine alopecias, 200 routine poliosis patients, especially 30 routine alopecias, poliosis patient have been made detailed curative effect tracing observation, total effective rate is divided into 86.6%, shows that clinical effectiveness is remarkable.The alopecia of clinical user obviously reduces, and it is moist that hair changes, and during use, every day is the warm 100ml that drinks sooner or later.Can see that pore is protruding general two weeks, later New Development grows, and ability black hair, antipruritic, more can control recurrence.
The specific embodiment
Sang He of the present invention educates a medicinal tea and can process with following bulk drugs:
1,10 parts of winter folium moris, 10 parts of Radix Polygoni Multiflori, 15 parts of Fructus Viticises, 5 parts of Rhizoma Cimicifugaes, 15 parts of Herba Ecliptaes, 10 parts of Fructus Ligustri Lucidi.
Prepare Sang He and educate the method for sending out medicinal tea, preparation process is following:
A) Fructus Viticis, the Fructus Ligustri Lucidi of alleged weight proportion are wrapped with cloth respectively and be placed in the first marmite container, add water and decoct in right amount, boiled the back 50 minutes at a simmer, go dregs to filter, medicinal liquid is continued to employ;
B) with the winter folium mori of said weight proportion, Radix Polygoni Multiflori, Rhizoma Cimicifugae, Herba Ecliptae, clean and be placed in the second container marmite respectively, add water and decoct in right amount, boiled the back 50 minutes at a simmer, go dregs to filter, medicinal liquid is continued to employ;
C) combining medicine in above-mentioned two containers is boiled dregs with crystal sugar in the container more in right amount and filter, the little sweet poor coffee-like medicinal liquid that obtains is packed in the bottle, is Sang He and educates and send out a medicinal tea.
2,30 parts of winter folium moris, 50 parts of Radix Polygoni Multiflori, 40 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 40 parts of Herba Ecliptaes, 50 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
3,20 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 25 parts of Fructus Viticises, 10 parts of Rhizoma Cimicifugaes, 30 parts of Herba Ecliptaes, 30 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
4,25 parts of winter folium moris, 35 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
5,20 parts of winter folium moris, 35 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
6,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
7,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
8,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 25 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
9,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 10 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
10,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 30 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
11,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 30 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
12,25 parts of winter folium moris, 30 parts of Radix Polygoni Multiflori, 30 parts of Fructus Viticises, 15 parts of Rhizoma Cimicifugaes, 35 parts of Herba Ecliptaes, 40 parts of Fructus Ligustri Lucidi.
Its preparation methods steps is with 1.
Be preferably: 20～25 parts of winter folium moris, 30～35 parts of Radix Polygoni Multiflori, 25～30 parts of Fructus Viticises, 10～15 parts of Rhizoma Cimicifugaes, 30～35 parts of Herba Ecliptaes, 30～40 parts of Fructus Ligustri Lucidi.
Claims (5)
1. a Sang He who treats alopecia and poliosis educates a liniment, it is characterized in that this liniment is made by following bulk drugs:
10～30 parts of winter folium moris, 10～50 parts of Radix Polygoni Multiflori, 15～40 parts of Fructus Viticises, 5～15 parts of Rhizoma Cimicifugaes, 15～40 parts of Herba Ecliptaes, 10～50 parts of Fructus Ligustri Lucidi;
Its preparation method is following:
A) take by weighing each crude drug: winter folium mori, Radix Polygoni Multiflori, Fructus Viticis, Rhizoma Cimicifugae, Herba Ecliptae, Fructus Ligustri Lucidi, subsequent use;
B) Fructus Viticis, the Fructus Ligustri Lucidi of alleged weight proportion are wrapped with cloth respectively and be placed in the first marmite container, add water and decoct in right amount, go dregs to filter, medicinal liquid is continued to employ;
C) with the winter folium mori of said weight proportion, Radix Polygoni Multiflori, Rhizoma Cimicifugae, Herba Ecliptae, clean and be placed in the second container marmite respectively, add water and decoct in right amount, go dregs to filter, medicinal liquid is continued to employ;
D) combining medicine in above-mentioned two containers is boiled dregs with crystal sugar in the container more in right amount and filter, the little sweet poor coffee-like medicinal liquid that obtains is Sang He and educates and send out a liniment.
2. Sang He as claimed in claim 1 educates and sends out liniment, it is characterized in that this liniment is made by following bulk drugs:
20～25 parts of winter folium moris, 30～35 parts of Radix Polygoni Multiflori, 25～30 parts of Fructus Viticises, 10～15 parts of Rhizoma Cimicifugaes, 30～35 parts of Herba Ecliptaes, 30～40 parts of Fructus Ligustri Lucidi.
3. Sang He educates and sends out a liniment according to claim 1, it is characterized in that method for preparing step D) described in the addition of crystal sugar be to add 30 grams in every 500ml medicinal liquid.
4. Sang He educates the application of a liniment in preparation treatment alopecia medicine according to claim 1 or claim 2.
5. Sang He educates the application of a liniment in preparation treatment poliosis medicine according to claim 1 or claim 2.
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