CN102018995A - 生物降解型泪道栓子及其制备方法 - Google Patents
生物降解型泪道栓子及其制备方法 Download PDFInfo
- Publication number
- CN102018995A CN102018995A CN2010105806105A CN201010580610A CN102018995A CN 102018995 A CN102018995 A CN 102018995A CN 2010105806105 A CN2010105806105 A CN 2010105806105A CN 201010580610 A CN201010580610 A CN 201010580610A CN 102018995 A CN102018995 A CN 102018995A
- Authority
- CN
- China
- Prior art keywords
- lactide
- lacrimal duct
- copolymer
- embolus
- biodegradable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000005189 Embolism Diseases 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 229920001577 copolymer Polymers 0.000 claims abstract description 113
- 239000003814 drug Substances 0.000 claims abstract description 37
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 238000001125 extrusion Methods 0.000 claims abstract description 13
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims abstract description 11
- 230000001028 anti-proliverative effect Effects 0.000 claims abstract description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 72
- 125000004122 cyclic group Chemical group 0.000 claims description 24
- -1 hydroxy- Chemical class 0.000 claims description 24
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 12
- 230000003115 biocidal effect Effects 0.000 claims description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 208000005494 xerophthalmia Diseases 0.000 claims description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 239000012046 mixed solvent Substances 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 21
- 239000002260 anti-inflammatory agent Substances 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 7
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 4
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 239000001569 carbon dioxide Substances 0.000 abstract description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 238000001356 surgical procedure Methods 0.000 abstract description 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 8
- 238000007710 freezing Methods 0.000 description 8
- 230000008014 freezing Effects 0.000 description 8
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 6
- 229960003957 dexamethasone Drugs 0.000 description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
- 229960000707 tobramycin Drugs 0.000 description 6
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 6
- 238000002513 implantation Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 238000013019 agitation Methods 0.000 description 4
- 229940124599 anti-inflammatory drug Drugs 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 description 3
- 239000004099 Chlortetracycline Substances 0.000 description 3
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
- 229930182566 Gentamicin Natural products 0.000 description 3
- GZENKSODFLBBHQ-ILSZZQPISA-N Medrysone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@H](C(C)=O)CC[C@H]21 GZENKSODFLBBHQ-ILSZZQPISA-N 0.000 description 3
- 239000004100 Oxytetracycline Substances 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 3
- 229960002537 betamethasone Drugs 0.000 description 3
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 229940106164 cephalexin Drugs 0.000 description 3
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 3
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 3
- 229940097572 chloromycetin Drugs 0.000 description 3
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 3
- 229960004475 chlortetracycline Drugs 0.000 description 3
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 3
- 235000019365 chlortetracycline Nutrition 0.000 description 3
- 229960003405 ciprofloxacin Drugs 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229960001347 fluocinolone acetonide Drugs 0.000 description 3
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 3
- 229960001048 fluorometholone Drugs 0.000 description 3
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 229960001067 hydrocortisone acetate Drugs 0.000 description 3
- 229960001011 medrysone Drugs 0.000 description 3
- 229960004584 methylprednisolone Drugs 0.000 description 3
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 3
- 229960000349 nitrofural Drugs 0.000 description 3
- 229960000625 oxytetracycline Drugs 0.000 description 3
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 3
- 235000019366 oxytetracycline Nutrition 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 3
- 229960002180 tetracycline Drugs 0.000 description 3
- 229930101283 tetracycline Natural products 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- 229960005294 triamcinolone Drugs 0.000 description 3
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 3
- 229960002117 triamcinolone acetonide Drugs 0.000 description 3
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 3
- 206010013774 Dry eye Diseases 0.000 description 2
- 208000001435 Thromboembolism Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000002430 laser surgery Methods 0.000 description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
- 229960002930 sirolimus Drugs 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000003500 flue dust Substances 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010580610 CN102018995B (zh) | 2010-12-09 | 2010-12-09 | 生物降解型泪道栓子及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010580610 CN102018995B (zh) | 2010-12-09 | 2010-12-09 | 生物降解型泪道栓子及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102018995A true CN102018995A (zh) | 2011-04-20 |
CN102018995B CN102018995B (zh) | 2013-08-21 |
Family
ID=43861044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201010580610 Active CN102018995B (zh) | 2010-12-09 | 2010-12-09 | 生物降解型泪道栓子及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102018995B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104984411A (zh) * | 2015-07-17 | 2015-10-21 | 厦门浩益视生物科技有限公司 | 一种泪小管栓子及其制备方法 |
CN106237396A (zh) * | 2016-07-27 | 2016-12-21 | 何伟 | 一种基于原位成纤技术的可降解高分子共混材料及其制备方法和应用 |
CN106667656A (zh) * | 2016-06-30 | 2017-05-17 | 广州聚明生物科技有限公司 | 生物可降解泪道栓及其制备方法和应用 |
CN111558093A (zh) * | 2020-05-19 | 2020-08-21 | 温州医科大学附属眼视光医院 | 一种中长期可降解的泪道栓及其制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3949750A (en) * | 1974-10-07 | 1976-04-13 | Freeman Jerre M | Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same |
WO2002011783A1 (en) * | 2000-08-04 | 2002-02-14 | Medennium, Inc. | Ocular plug for punctal and intracanalicular implants |
US20050197614A1 (en) * | 2004-03-04 | 2005-09-08 | Wilson Pritchard | Occlusive biomedical devices, punctum plugs, and methods of use thereof |
CN1724072A (zh) * | 2005-07-12 | 2006-01-25 | 何伟 | 可载药的降解型泪道栓子及其制备方法 |
WO2006031658A2 (en) * | 2004-09-10 | 2006-03-23 | Allergan, Inc. | Therapeutic lacrimal canalicular inserts and related methods |
US20060074370A1 (en) * | 2004-09-24 | 2006-04-06 | Medennium, Inc. | Ocular occluder and method of insertion |
CN1760231A (zh) * | 2005-10-13 | 2006-04-19 | 同济大学 | 用于泪点栓的可降解高分子材料的制备方法 |
US20070299516A1 (en) * | 2006-06-21 | 2007-12-27 | Han Cui | Punctal plugs for the delivery of active agents |
-
2010
- 2010-12-09 CN CN 201010580610 patent/CN102018995B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3949750A (en) * | 1974-10-07 | 1976-04-13 | Freeman Jerre M | Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same |
WO2002011783A1 (en) * | 2000-08-04 | 2002-02-14 | Medennium, Inc. | Ocular plug for punctal and intracanalicular implants |
US20050197614A1 (en) * | 2004-03-04 | 2005-09-08 | Wilson Pritchard | Occlusive biomedical devices, punctum plugs, and methods of use thereof |
WO2006031658A2 (en) * | 2004-09-10 | 2006-03-23 | Allergan, Inc. | Therapeutic lacrimal canalicular inserts and related methods |
US20060074370A1 (en) * | 2004-09-24 | 2006-04-06 | Medennium, Inc. | Ocular occluder and method of insertion |
CN1724072A (zh) * | 2005-07-12 | 2006-01-25 | 何伟 | 可载药的降解型泪道栓子及其制备方法 |
CN1760231A (zh) * | 2005-10-13 | 2006-04-19 | 同济大学 | 用于泪点栓的可降解高分子材料的制备方法 |
US20070299516A1 (en) * | 2006-06-21 | 2007-12-27 | Han Cui | Punctal plugs for the delivery of active agents |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104984411A (zh) * | 2015-07-17 | 2015-10-21 | 厦门浩益视生物科技有限公司 | 一种泪小管栓子及其制备方法 |
CN106667656A (zh) * | 2016-06-30 | 2017-05-17 | 广州聚明生物科技有限公司 | 生物可降解泪道栓及其制备方法和应用 |
CN106237396A (zh) * | 2016-07-27 | 2016-12-21 | 何伟 | 一种基于原位成纤技术的可降解高分子共混材料及其制备方法和应用 |
CN111558093A (zh) * | 2020-05-19 | 2020-08-21 | 温州医科大学附属眼视光医院 | 一种中长期可降解的泪道栓及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102018995B (zh) | 2013-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2020257142B2 (en) | Biodegradable, active ingredient-eluting structural support | |
DE69628783T2 (de) | Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung | |
CN102018995B (zh) | 生物降解型泪道栓子及其制备方法 | |
EP0537559B1 (en) | Polymeric compositions useful as controlled release implants | |
US20150073476A1 (en) | Shape memory polymer compositions | |
AU2019240562B2 (en) | Intravitreal drug delivery systems for the treatment of ocular conditions | |
CN106580868B (zh) | 一种植入剂及其制备方法 | |
US9089412B2 (en) | Multilayer bioabsorbable scaffolds and methods of fabricating | |
JP2007535566A5 (zh) | ||
CN101083976A (zh) | 由双挤压法制备的眼植入物 | |
US20120215184A1 (en) | Cylindrical ocular inserts | |
EP3494959A2 (en) | Sustained release latanoprost implant | |
US20120213840A1 (en) | Ocular strips | |
WO2009073658A1 (en) | Self solidifying bioerodible barrier implant | |
KR20210116521A (ko) | 약물 전달을 위한 확장성 부재 시스템 및 방법 | |
Saher et al. | Levofloxacin hemihydrate ocular semi-sponges for topical treatment of bacterial conjunctivitis: Formulation and in-vitro/in-vivo characterization | |
WO2021017461A1 (zh) | 一种植入件及其制备方法和应用 | |
TW201505629A (zh) | 一種酮咯酸植入劑及其製備方法 | |
AU2020260132A1 (en) | Biodegradable nasal splint | |
TW202216159A (zh) | 具高負載前列腺素醯胺之眼內植入物 | |
WO2016196365A1 (en) | Implant for treatment of an ocular condition | |
CN212140660U (zh) | 可降解泪道管 | |
CA2993340C (en) | Intravitreal drug delivery systems for the treatment of ocular conditions | |
CN115607746A (zh) | 一种自膨式宫腔防粘连修复器及其用途 | |
US20160022669A1 (en) | Self-solidifying barrier implant and method of making the implant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200219 Address after: 110163 No. 66, Surabaya street, Dongling District, Liaoning, Shenyang Patentee after: SHENYANG BAIAO MEDICAL DEVICES CO.,LTD. Address before: Gaokan town Qipanshan scenic tourism development zone in Shenyang City, Liaoning province 110163 Patentee before: He Wei |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210705 Address after: 110000 No.66 Sishui street, Dongling District, Shenyang City, Liaoning Province Patentee after: SHENYANG HESHI EYE INDUSTRY GROUP Co.,Ltd. Address before: No. 66, Sishui street, Dongling District, Shenyang City, Liaoning Province Patentee before: SHENYANG BAIAO MEDICAL DEVICES Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20231009 Address after: 110163 Surabaya street, Hunnan District, Shenyang, Liaoning 66 Patentee after: SHENYANG BAIAO MEDICAL DEVICES CO.,LTD. Address before: 110000 No.66 Sishui street, Dongling District, Shenyang City, Liaoning Province Patentee before: SHENYANG HESHI EYE INDUSTRY GROUP CO.,LTD. |
|
TR01 | Transfer of patent right |