CN102018715A - 免疫调节及对涉及血清素家族受体及血脑屏障的细胞过程的作用 - Google Patents

免疫调节及对涉及血清素家族受体及血脑屏障的细胞过程的作用 Download PDF

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CN102018715A
CN102018715A CN2010101667387A CN201010166738A CN102018715A CN 102018715 A CN102018715 A CN 102018715A CN 2010101667387 A CN2010101667387 A CN 2010101667387A CN 201010166738 A CN201010166738 A CN 201010166738A CN 102018715 A CN102018715 A CN 102018715A
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serotonin
cells
receptor
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B·A·詹姆森
A·A·特雷蒂亚科瓦
H·C·戴维森
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Philadelphia Health and Education Corp
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CN2010101667387A 2002-06-17 2003-06-17 免疫调节及对涉及血清素家族受体及血脑屏障的细胞过程的作用 Pending CN102018715A (zh)

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Application Number Priority Date Filing Date Title
US38957702P 2002-06-17 2002-06-17
US60/389,577 2002-06-17
US41483102P 2002-09-27 2002-09-27
US60/414,831 2002-09-27

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CN102018715A true CN102018715A (zh) 2011-04-20

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CNA038195291A Pending CN1674879A (zh) 2002-06-17 2003-06-17 免疫调节及对涉及血清素家族受体及血脑屏障的细胞过程的作用

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US (2) US20060183757A1 (https=)
EP (1) EP1534256A4 (https=)
JP (1) JP2005538065A (https=)
CN (2) CN102018715A (https=)
AU (1) AU2003276445A1 (https=)
CA (1) CA2488708A1 (https=)
WO (1) WO2003106660A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116731165A (zh) * 2023-03-23 2023-09-12 北京巴瑞医疗器械有限公司 一种抗血清素抗体及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060003996A1 (en) * 2002-06-17 2006-01-05 Stephen Roth Intralesional treatment of psoriasis
KR100675432B1 (ko) * 2004-10-04 2007-01-29 캄텍주식회사 차량 배기 가스 재순환 밸브의 개폐 구조
US20060287301A1 (en) * 2005-06-17 2006-12-21 Mcnair Douglas Novel formulations for phenothiazines, including fluphenazine and its derivatives
CA2662215A1 (en) 2006-09-01 2008-03-06 Immune Control, Inc. Novel compositions and methods for treatment of diseases related to activated lymphocytes
JP2008156297A (ja) * 2006-12-25 2008-07-10 Hokkaido Univ セロトニン２ｂおよび／または２ｃ受容体拮抗剤
GB0701170D0 (en) * 2007-01-22 2007-02-28 Imp Innovations Ltd Compositions and uses thereof
CA2683316A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
WO2009108635A2 (en) * 2008-02-29 2009-09-03 Immune Control, Inc. Novel compositions and methods for treatment of diseases related to activated lymphocytes
DK3106166T3 (da) 2008-02-29 2021-01-11 Vm Therapeutics Llc Forbindelser til behandling af smertesyndrom og andre lidelser
AU2009231892A1 (en) * 2008-03-31 2009-10-08 The Trustees Of Columbia University In The City Of New York Methods of diagnosing, preventing and treating bone mass diseases
WO2010124100A1 (en) * 2009-04-22 2010-10-28 Immune Control, Inc. Novel selective 5-ht4 receptor antagonists
WO2011053977A1 (en) 2009-11-02 2011-05-05 The Trustees Of Columbia University In The City Of New York Compounds and methods for inhibiting serotonin synthesis
CA2816551A1 (en) * 2010-11-03 2012-05-10 Mcmaster University Method of treating mucosal inflammation
TR201903280T4 (tr) * 2011-08-02 2019-04-22 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh Malt1 proteazının fenotiazin türevleri ile selektif inhibisyonu.
WO2019175332A1 (en) * 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN119789869A (zh) * 2022-06-30 2025-04-08 嘉惟思远制药有限公司 医药组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058979A (en) * 1957-05-13 1962-10-16 Smith Kline French Lab New perfluoroalkylphenothiazine derivatives
US5104858A (en) * 1988-09-29 1992-04-14 Yale University Sensitizing multidrug resistant cells to antitumor agents
EP0489108B1 (en) * 1989-08-21 1996-03-13 Beth Israel Hospital Association Use of spiperone derivatives for immunosuppression
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
WO1992016226A1 (en) * 1991-03-19 1992-10-01 Smithkline Beecham Corporation Il-1 inhibitors
US5658955A (en) * 1994-11-01 1997-08-19 Hitzig; Pietr Combined use of dopamine and serotonin agonists in the treatment of immune disorders
WO1999062537A1 (en) * 1998-06-04 1999-12-09 The Rockefeller University Methods and agents for modulating the immune response and inflammation involving monocyte and dendritic cell membrane proteins
IL139975A0 (en) * 2000-11-29 2002-02-10 Univ Ramot Anti proliferative drugs
US20050013853A1 (en) * 2000-11-29 2005-01-20 Irit Gil-Ad Anti-proliferative drugs
WO2002057244A1 (en) * 2001-01-19 2002-07-25 Cytokinetics, Inc. Phenothiazine kinesin inhibitors
AU2002305123B2 (en) * 2001-03-30 2006-10-05 Philadelphia Health And Education Corporation Immunomodulation and effect on cell processes relating to serotonin family receptors
US20040072824A1 (en) * 2001-06-01 2004-04-15 Adam Telerman Methods and compositions for the treatment of cancer
DE10129320A1 (de) * 2001-06-19 2003-04-10 Norbert Mueller Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116731165A (zh) * 2023-03-23 2023-09-12 北京巴瑞医疗器械有限公司 一种抗血清素抗体及其应用
CN116731165B (zh) * 2023-03-23 2024-08-13 北京巴瑞医疗器械有限公司 一种抗血清素抗体及其应用

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