CN102015701B - Pim激酶抑制剂及其应用方法 - Google Patents

Pim激酶抑制剂及其应用方法 Download PDF

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Publication number
CN102015701B
CN102015701B CN200980115821.7A CN200980115821A CN102015701B CN 102015701 B CN102015701 B CN 102015701B CN 200980115821 A CN200980115821 A CN 200980115821A CN 102015701 B CN102015701 B CN 102015701B
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tert
solution
pyridin
methyl
synthesis
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Chinese (zh)
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CN102015701A (zh
Inventor
M·伯格
兰炯
M·林德瓦尔
G·尼希古奇
M·泰特尔曼
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200980115821.7A 2008-03-03 2009-03-03 Pim激酶抑制剂及其应用方法 Active CN102015701B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3335908P 2008-03-03 2008-03-03
US61/033,359 2008-03-03
PCT/EP2009/052506 WO2009109576A1 (en) 2008-03-03 2009-03-03 Pim kinase inhibitors and methods of their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410286911.5A Division CN104098559A (zh) 2008-03-03 2009-03-03 Pim激酶抑制剂及其应用方法

Publications (2)

Publication Number Publication Date
CN102015701A CN102015701A (zh) 2011-04-13
CN102015701B true CN102015701B (zh) 2014-07-23

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ID=41055566

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CN200980115821.7A Active CN102015701B (zh) 2008-03-03 2009-03-03 Pim激酶抑制剂及其应用方法
CN201410286911.5A Pending CN104098559A (zh) 2008-03-03 2009-03-03 Pim激酶抑制剂及其应用方法

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CN201410286911.5A Pending CN104098559A (zh) 2008-03-03 2009-03-03 Pim激酶抑制剂及其应用方法

Country Status (21)

Country Link
EP (2) EP2596790B1 (enExample)
JP (1) JP5412448B2 (enExample)
KR (1) KR20100120709A (enExample)
CN (2) CN102015701B (enExample)
AR (1) AR070531A1 (enExample)
AU (1) AU2009221134B2 (enExample)
BR (1) BRPI0909102A2 (enExample)
CA (1) CA2717388A1 (enExample)
CL (1) CL2009000483A1 (enExample)
CO (1) CO6290687A2 (enExample)
EA (1) EA201001412A1 (enExample)
EC (1) ECSP10010447A (enExample)
ES (2) ES2443496T3 (enExample)
IL (1) IL207865A0 (enExample)
MA (1) MA32135B1 (enExample)
MX (1) MX2010009739A (enExample)
PE (1) PE20091577A1 (enExample)
TW (1) TW200942536A (enExample)
UY (1) UY31679A1 (enExample)
WO (1) WO2009109576A1 (enExample)
ZA (1) ZA201006128B (enExample)

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PT2344474E (pt) * 2008-09-02 2015-12-28 Novartis Ag Derivados de picolinamida como inibidores de cinase
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TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
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JP2014516941A (ja) 2011-04-29 2014-07-17 アムジェン インコーポレイテッド Ｐｉｍ阻害剤としての二環式ピリダジン化合物
US8691807B2 (en) 2011-06-20 2014-04-08 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
DK2734205T3 (en) 2011-07-21 2018-06-14 Tolero Pharmaceuticals Inc Heterocyclic Protein Kinase Inhibitors
CN102924445B (zh) * 2011-08-11 2015-07-08 上海吉铠医药科技有限公司 Pim激酶抑制剂及其制备方法与在制药中的应用
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
EP2760857A1 (en) 2011-09-27 2014-08-06 F.Hoffmann-La Roche Ag Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CN104334546B (zh) * 2012-05-21 2017-05-03 诺华股份有限公司 作为激酶抑制剂的新的环‑取代的n‑吡啶基酰胺
WO2014033631A1 (en) * 2012-08-31 2014-03-06 Novartis Ag N-(3-pyridyl) biarylamides as kinase inhibitors
WO2014033630A1 (en) * 2012-08-31 2014-03-06 Novartis Ag Novel aminothiazole carboxamides as kinase inhibitors
WO2014048939A1 (en) 2012-09-26 2014-04-03 F. Hoffmann-La Roche Ag Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
KR102242077B1 (ko) 2012-11-15 2021-04-20 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
EP2943485B1 (en) 2013-01-14 2017-09-20 Incyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
TWI662030B (zh) * 2013-01-15 2019-06-11 英塞特控股公司 適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物
EP3489239B1 (en) 2013-03-06 2021-09-15 Incyte Holdings Corporation Processes and intermediates for making a jak inhibitor
MX376856B (es) 2013-08-07 2025-03-07 Incyte Holdings Corp Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
US9556197B2 (en) * 2013-08-23 2017-01-31 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
JP7233433B2 (ja) * 2017-09-20 2023-03-06 リード ディスカバリー センター ゲーエムベーハー クマリン誘導体、それらの調製方法及びそれらのがん処置のための使用
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
MD3746429T2 (ro) 2018-01-30 2022-08-31 Incyte Corp Procedee pentru prepararea de (1-(3-fluoro-2-(trifluorometil)izonicotinil)piperidin-4-onă)
KR20260080448A (ko) 2018-03-30 2026-06-02 인사이트 코포레이션 Jak 억제제를 사용하는 화농성 한선염의 치료
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HUE072069T2 (hu) 2019-02-12 2025-10-28 Sumitomo Pharma America Inc 2-((1R,4R)-4-((3-(3-(trifluormetil)fenil)imidazo[1,2- b]piridazin-6-il)amino)ciklohexil)propán-2-ol sósavas sójának kristályos formája
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WO2008054702A1 (en) * 2006-10-31 2008-05-08 Schering Corporation Anilinopiperazine derivatives and methods of use thereof

Also Published As

Publication number Publication date
MA32135B1 (fr) 2011-03-01
TW200942536A (en) 2009-10-16
AR070531A1 (es) 2010-04-14
EP2596790B1 (en) 2015-12-09
EP2262802B1 (en) 2013-10-23
PE20091577A1 (es) 2009-11-05
MX2010009739A (es) 2010-09-28
EP2262802A1 (en) 2010-12-22
JP5412448B2 (ja) 2014-02-12
ECSP10010447A (es) 2010-10-30
CN102015701A (zh) 2011-04-13
AU2009221134B2 (en) 2012-02-23
CN104098559A (zh) 2014-10-15
ES2443496T3 (es) 2014-02-19
CL2009000483A1 (es) 2010-02-19
CO6290687A2 (es) 2011-06-20
AU2009221134A1 (en) 2009-09-11
WO2009109576A1 (en) 2009-09-11
ES2562306T3 (es) 2016-03-03
IL207865A0 (en) 2010-12-30
BRPI0909102A2 (pt) 2019-01-15
KR20100120709A (ko) 2010-11-16
CA2717388A1 (en) 2009-09-11
EA201001412A1 (ru) 2011-06-30
ZA201006128B (en) 2011-10-26
EP2596790A1 (en) 2013-05-29
JP2011513363A (ja) 2011-04-28
UY31679A1 (es) 2009-09-30

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