CN102008653A - Saliva increasing mixture - Google Patents
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- CN102008653A CN102008653A CN 201010580408 CN201010580408A CN102008653A CN 102008653 A CN102008653 A CN 102008653A CN 201010580408 CN201010580408 CN 201010580408 CN 201010580408 A CN201010580408 A CN 201010580408A CN 102008653 A CN102008653 A CN 102008653A
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Abstract
The invention relates to a saliva increasing mixture which is used for treating dry mouth caused by taking psychotropic medicaments. The active ingredients of the saliva increasing mixture are mainly prepared from the following raw material medicaments in part by weight: 1,500 to 2,000 parts of figwort, 1,500 to 2,000 parts of rehmannia root, 1,800 to 2,200 parts of dendrobium, 1,500 to 2,000 parts of dwarf lilyturf root, 180 to 220 parts of trichosanthes root and 180 to 220 parts of rhubarb; and the raw material medicaments of the saliva increasing mixture also comprise 3 to 7 parts of benzoic acid. The invention also provides the application of saliva increasing mixture used for treating the dry mouth caused by taking the psychotropic medicaments. The saliva increasing mixture has the advantages that: the medicament needs less raw material medicaments; the raw material medicaments are easy to obtain; the medicament is convenient to prepare and is simple in operation; and the saliva increasing mixture has a quick and remarkable curative effect and less side effects, and is suitable for clinical application.
Description
Technical field
The present invention relates to a kind of being used for the treatment of because of taking the medicine of the xerostomia that psychotropic drugs causes, specifically a kind of with the Chinese herbal medicine be feedstock production increase the liquid mixture.
Background technology
Psychotropic drugs has experienced by the application of classics to the atypia psychotropic drugs, the alleviating by certainly and generally acknowledge of its curative effect and drug side effect, but still enough attention should be arranged to its side effect.
In the treatment clinical course of psychiatric department disease, psychotropic drugs causes xerostomia because of the effect of its blocking-up M cholinoceptor, this is modal adverse effect, and lack effective treatment means, though the symptom weight differs, but caused very big influence for patient's quality of life, and influence the compliance that patient takes medicine, be unfavorable for the rehabilitation of disease.
At present, though some treatments are also arranged because of taking the medicine of the xerostomia that psychotropic drugs causes, effect is not fairly obvious, and the flavour of a drug in the Chinese patent medicine are more, is not easy to the preparation use, and some medicine also can cause other side effect.Yet there are no report about treatment because of the medicine of taking the xerostomia that psychotropic drugs causes.
Summary of the invention
The objective of the invention is at deficiency of the prior art, provide a kind of the treatment to increase the liquid mixture because of what take xerostomia that psychotropic drugs causes.
One purpose more of the present invention is that a kind of purposes that increases the liquid mixture is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of liquid mixture that increases, the described liquid mixture that increases mainly is to be made by following bulk drugs: Radix Scrophulariae 1500-2000 part, Radix Rehmanniae 1500-2000 part, Herba Dendrobii 1800-2200 part, Radix Ophiopogonis 1500-2000 part, Radix Trichosanthis 180-220 part, Radix Et Rhizoma Rhei 180-220 part.
The described liquid mixture that increases mainly is to be made by following bulk drugs: Radix Scrophulariae 1600-1900 part, Radix Rehmanniae 1600-1900 part, Herba Dendrobii 1900-2100 part, Radix Ophiopogonis 1600-1900 part, Radix Trichosanthis 190-210 part, Radix Et Rhizoma Rhei 190-210 part.
The described liquid mixture that increases mainly is to be made by following bulk drugs: 1800 parts of Radix Scrophulariaes, 1800 parts in the Radix Rehmanniae, 2000 parts of Herba Dendrobiis, 1800 parts of Radix Ophiopogonis, 200 parts of Radix Trichosanthis, 200 parts of Radix Et Rhizoma Rhei.
The described liquid mixture that increases also comprises benzoic acid 3-7 part.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: a kind of increase the liquid mixture in preparation treatment because of the application in the xerostomia disease medicament of taking psychotropic drugs and causing.
The invention has the advantages that:
1, the needed raw material medicine is less, is easy to obtain;
2, pharmacy is convenient, simple to operate;
3, curative effect is rapid, remarkable, and few side effects is fit to clinical practice.
The specific embodiment
Below in conjunction with form the specific embodiment provided by the invention is elaborated.
1 one kinds of preparations () that increase the liquid mixture of embodiment
Radix Scrophulariae 150 grams, the Radix Rehmanniae 150 grams, Herba Dendrobii 180 grams, restrain Radix Ophiopogonis 150, Radix Trichosanthis 18 grams, Radix Et Rhizoma Rhei 18 grams, decoct with water secondary, add 8 times of water gagings for the first time and boil, the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, adds 5 times of water gagings for the second time and boils, and the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, merges medicine juice twice, is concentrated into 2500ml, left standstill 16 hours, and got supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get benzoic acid 0.3 gram,, add in the medicinal liquid, stir, boil with an amount of 95% dissolve with ethanol, hot filling, sterilization, packing is standby.
2 one kinds of preparations (two) that increase the liquid mixture of embodiment
Radix Scrophulariae 200 grams, the Radix Rehmanniae 200 grams, Herba Dendrobii 220 grams, restrain Radix Ophiopogonis 200, Radix Trichosanthis 22 grams, Radix Et Rhizoma Rhei 22 grams, decoct with water secondary, add 8 times of water gagings for the first time and boil, the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, adds 5 times of water gagings for the second time and boils, and the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, merges medicine juice twice, is concentrated into 2500ml, left standstill 16 hours, and got supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get benzoic acid 0.7 gram,, add in the medicinal liquid, stir, boil with an amount of 95% dissolve with ethanol, hot filling, sterilization, packing is standby.
3 one kinds of preparations (three) that increase the liquid mixture of embodiment
Radix Scrophulariae 160 grams, the Radix Rehmanniae 190 grams, Herba Dendrobii 220 grams, restrain Radix Ophiopogonis 200, Radix Trichosanthis 22 grams, Radix Et Rhizoma Rhei 22 grams, decoct with water secondary, add 8 times of water gagings for the first time and boil, the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, adds 5 times of water gagings for the second time and boils, and the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, merges medicine juice twice, is concentrated into 2500ml, left standstill 16 hours, and got supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get benzoic acid 0.6 gram,, add in the medicinal liquid, stir, boil with an amount of 95% dissolve with ethanol, hot filling, sterilization, packing is standby.
4 one kinds of preparations (four) that increase the liquid mixture of embodiment
Radix Scrophulariae 200 grams, the Radix Rehmanniae 200 grams, Herba Dendrobii 190 grams, restrain Radix Ophiopogonis 180, Radix Trichosanthis 22 grams, Radix Et Rhizoma Rhei 22 grams, decoct with water secondary, add 8 times of water gagings for the first time and boil, the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, adds 5 times of water gagings for the second time and boils, and the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, merges medicine juice twice, is concentrated into 2500ml, left standstill 16 hours, and got supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get benzoic acid 0.4 gram,, add in the medicinal liquid, stir, boil with an amount of 95% dissolve with ethanol, hot filling, sterilization, packing is standby.
5 one kinds of preparations (five) that increase the liquid mixture of embodiment
Radix Scrophulariae 200 grams, the Radix Rehmanniae 200 grams, Herba Dendrobii 220 grams, restrain Radix Ophiopogonis 200, Radix Trichosanthis 20 grams, Radix Et Rhizoma Rhei 20 grams, decoct with water secondary, add 8 times of water gagings for the first time and boil, the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, adds 5 times of water gagings for the second time and boils, and the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, merges medicine juice twice, is concentrated into 2500ml, left standstill 16 hours, and got supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get benzoic acid 0.5 gram,, add in the medicinal liquid, stir, boil with an amount of 95% dissolve with ethanol, hot filling, sterilization, packing is standby.
6 one kinds of preparations (six) that increase the liquid mixture of embodiment
Radix Scrophulariae 180 grams, the Radix Rehmanniae 180 grams, Herba Dendrobii 200 grams, restrain Radix Ophiopogonis 180, Radix Trichosanthis 20 grams, Radix Et Rhizoma Rhei 20 grams, decoct with water secondary, add 8 times of water gagings for the first time and boil, the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, adds 5 times of water gagings for the second time and boils, and the back of boiling kept 45 minutes, medicine juice is crossed 120 mesh sieves, merges medicine juice twice, is concentrated into 2500ml, left standstill 16 hours, and got supernatant and cross 120 mesh sieves, be concentrated into 1000ml.Get benzoic acid 0.5 gram,, add in the medicinal liquid, stir, boil with an amount of 95% dissolve with ethanol, hot filling, sterilization, packing is standby.
Embodiment 7 adds the preparation of No. 1, Zengye Tang of flavor
Radix Rehmanniae 80g, Radix Scrophulariae 80g, Fructus Aurantii 40g, Semen Coicis 160g, Endothelium Corneum Gigeriae Galli 20g, Radix Glycyrrhizae 40g, Radix Ophiopogonis 50g, Fructus Cannabis 250g, Herba Cistanches 45g, Pericarpium Arecae 80g adds water boil, every dose of medicine decocts twice continuously, twice decocting liquid is merged be condensed into 1000ml, packing is standby.
Embodiment 8
Add the preparation of No. 2, Zengye Tang of flavor
Radix Scrophulariae 100g, Radix Ophiopogonis 70g, Radix Rehmanniae 50g, Fructus Schisandrae Chinensis 50g, Fructus Mume 35g, Radix Glycyrrhizae 35g adds water boil, every dose of medicine decocts twice continuously, twice decocting liquid is merged be condensed into 1000ml, packing is standby.
Embodiment 9
A kind of clinical experiment that increases the liquid mixture
1, experiment material
The experiment medicine: Chinese medicinal granule (Radix Scrophulariae, the Radix Rehmanniae, Herba Dendrobii, Radix Ophiopogonis, Radix Trichosanthis gram, Radix Et Rhizoma Rhei etc.) is available from common Chinese market.
Add No. 1, flavor Zengye Tang: the Radix Rehmanniae, Radix Scrophulariae, Fructus Aurantii, Semen Coicis, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Ophiopogonis, Fructus Cannabis, Herba Cistanches, Pericarpium Arecae (medicine that adopts embodiment 7 to prepare);
Add No. 2, flavor Zengye Tang: Radix Scrophulariae, Radix Ophiopogonis, the Radix Rehmanniae, Fructus Schisandrae Chinensis, Fructus Mume, Radix Glycyrrhizae (medicine that adopts embodiment 8 to prepare);
Increase the liquid mixture: Radix Scrophulariae, the Radix Rehmanniae, Herba Dendrobii, Radix Ophiopogonis, Radix Trichosanthis gram, Radix Et Rhizoma Rhei (medicine that adopts embodiment 6 to prepare).
Case is selected: selected case all is the cooperation patient who uses psychotropic drugs to cause xerostomia in Shanghai Mental Health Center's while in hospital, and male and female patient is totally 50 examples, 18 ~ 65 years old age.Exclusion standard: (1) uses medicine or treatment xerostomia medicine person between clozapine and other endorsement; (2) ordinary circumstance is too poor, and serious physical disease person is arranged; (3) hepatic and renal function grievous injury person is arranged; (4) severe cardiovascular disease person is arranged; (5) asthma and obstructive emphysema person are arranged; (6) glaucoma patient and detachment of retina history person is arranged; (7) gestation and women breast-feeding their children; (8) diabetics.
2, medication:
50 routine patient's random packet, double blind control.Per 10 artificial one group, be respectively A, B, C, D, E5 group, wherein the A group does not give Drug therapy for matched group; The B group is the placebo treatment group, doses a patient with and increase the liquid mixture and to add the similar placebo of Zengye Tang character of distinguishing the flavor of, and placebo does not play therapeutical effect; C group adds No. 1, the Zengye Tang of distinguishing the flavor of for adding No. 1 treatment group of flavor Zengye Tang, taking; D group adds No. 2, the Zengye Tang of distinguishing the flavor of for adding No. 2 treatment groups of flavor Zengye Tang, taking; The E group increases the liquid mixture for increasing liquid mixture treatment group, taking; Each treatment group medicine time every day, medicining times and drug dose unanimity were taken medicine for 1 week continuously, and period in a medicine psychotropic drugs, medicine and dosage thereof are constant.
3, observational technique:
Checked patient 3 times in first day, and checked patient 1 time later every day, inquiry clinical symptoms and uncomfortable reaction.That record is taken medicine is preceding, the back 45min that takes medicine for the first time, 90min and 180min and took medicine 7 days after salivation amount, xerostomia subjective symptoms.Write down untoward reaction simultaneously.The take medicine variation of each side such as routine blood test, routine urinalysis, hepatic and renal function, electrocardiogram, blood pressure and heart rate of preceding and take medicine back 4 days and 7 days of record.
The mensuration of salivation amount: the extracting degreasing cotton balls (0.50 ± 0.15g) weigh its weight in the balance after, place patient Sublingual 1min to take out, weigh its weight again in the balance, calculate the salivation amount.
4, efficacy assessment standard:
Invalid: with take medicine before compare, the back salivation amount value added of taking medicine is less than 20%; Effectively: with take medicine before compare, the back salivation amount value added of taking medicine is 20% ~ 40%; Produce effects: with take medicine before compare, the back salivation amount value added of taking medicine is greater than 40%.
5, statistical method:
The T check, variance analysis.
6, result:
Through 7 days observation treatment and record, as can be seen from Table 1:
The control group A group does not take the treatment measure that patient is taken medicine, so the salivation amount does not have significant change, difference with insignificance (p〉0.05);
Treatment group B group patient takes placebo, outpatients mental state has been produced the influence of certain enthusiasm, has increased so there is 1 people the salivation produce effects to occur, with take medicine before compare, curative effect has highly significant difference (p＜0.01), salivation appears in 1 people effectively to be increased, with take medicine before compare, there were significant differences for curative effect (p＜0.05), all the other patient's salivation liquid increase to some extent, but because secretory volume is less, still belong to futile treatment, difference with insignificance (p〉0.05);
Treatment group C group patient takes and adds No. 1, flavor Zengye Tang, 2 people salivation occurs after taking medicine 90 minutes effectively increase, with take medicine before compare, there were significant differences for curative effect (p＜0.05), 6 people salivation occurs after taking medicine 180 minutes effectively increase, with take medicine before compare, there were significant differences for curative effect (p＜0.05), and the salivation produce effects appears in 6 people after 7 days increases, with take medicine before compare, curative effect has highly significant difference (p＜0.01), effective increase appears in 2 people, with take medicine before compare, there were significant differences for curative effect (p＜0.05), other has 2 people to occur feeling sick, the diarrhoea phenomenon, untoward reaction disappears after the drug withdrawal;
Treatment group D group patient takes and adds No. 2, flavor Zengye Tang, having 8 patient's salivations to measure existing the effect after 3 days increases, with take medicine before compare, there were significant differences for curative effect (p＜0.05), the invalid increase of 2 people's salivation amounts, difference with insignificance (p〉0.05), there are 4 people's salivation amount produce effects to increase after 7 days, with take medicine before compare, curative effect has highly significant difference (p＜0.01), effective increase appears in 5 people, with take medicine before compare, there were significant differences for curative effect (p＜0.05), and giddy, watery nasal discharge symptom, transference cure after the drug withdrawal appear in 1 people;
Treatment group E group patient takes and increases the liquid mixture, salivation appears in 5 people after 45 minutes effectively increases, with take medicine before compare, there were significant differences for curative effect (p＜0.05), the salivation produce effects appears in 4 people after 90 minutes increases (p＜0.01), effective increase appears in 6 people, with take medicine before compare, there were significant differences for curative effect (p＜0.05), and 9 people's salivation produce effects increase after taking medicine 7 days, with take medicine before compare, curative effect has highly significant difference (p＜0.01), 1 people effectively increases, with take medicine before compare, there were significant differences for curative effect (p＜0.05).
The variation (mg/min) of salivation amount before and after table 1 is taken medicine
| Group | Before taking medicine | 45min takes medicine | 90min takes medicine | 180min takes medicine | 7d takes medicine |
| A | 0.025±0.023 | 0.024±0.020 | 0.025±0.022 | 0.028±0.025 | 0.026±0.018 |
| B | 0.028±0.022 | 0.029±0.018 | 0.030±0.024 | 0.029±0.020 | 0.032±0.021 |
| C | 0.030±0.024 | 0.035±0.024 | 0.039±0.021 | 0.051±0.019 | 0.162±0.043 |
| D | 0.029±0.021 | 0.033±0.023 | 0.035±0.022 | 0.040±0.021 | 0.145±0.033 |
| E | 0.028±0.025 | 0.038±0.021 | 0.052±0.026 | 0.068±0.033 | 0.226±0.052 |
7, conclusion:
By experimental result is analyzed, can reach a conclusion: taking the xerostomia that causes behind the psychotropic drugs needs Drug therapy, relies on psychological application can play certain effect, but DeGrain; When taking the xerostomia that psychotropic drugs causes, treatment have multiple medicine to select, add No. 1, flavor Zengye Tang and add flavor Zengye Tang and all can play curative effect preferably No. 2, but may cause some untoward reaction, and curative effect is slower, needs several days ability xerostomia to occur and alleviate; A kind of liquid mixture that increases of this experiment invention can be brought into play drug effect at short notice, and prescription is simple, and easy to prepare, side effect is little, and using clinically has better effect.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and replenish, these improvement and replenish and also should be considered as protection scope of the present invention.
Claims (5)
1. one kind increases the liquid mixture, and the described liquid mixture that increases mainly is to be made by following bulk drugs: Radix Scrophulariae 1500-2000 part, Radix Rehmanniae 1500-2000 part, Herba Dendrobii 1800-2200 part, Radix Ophiopogonis 1500-2000 part, Radix Trichosanthis 180-220 part, Radix Et Rhizoma Rhei 180-220 part.
2. the liquid mixture that increases according to claim 1, it is characterized in that, the described liquid mixture that increases mainly is to be made by following bulk drugs: Radix Scrophulariae 1600-1900 part, Radix Rehmanniae 1600-1900 part, Herba Dendrobii 1900-2100 part, Radix Ophiopogonis 1600-1900 part, Radix Trichosanthis 190-210 part, Radix Et Rhizoma Rhei 190-210 part.
3. the liquid mixture that increases according to claim 2 is characterized in that, the described liquid mixture that increases mainly is to be made by following bulk drugs: 1800 parts of Radix Scrophulariaes, 1800 parts in the Radix Rehmanniae, 2000 parts of Herba Dendrobiis, 1800 parts of Radix Ophiopogonis, 200 parts of Radix Trichosanthis, 200 parts of Radix Et Rhizoma Rhei.
4. according to the arbitrary described liquid mixture that increases of claim 1-3, it is characterized in that the described liquid mixture that increases also comprises benzoic acid 3-7 part.
5. according to the arbitrary described liquid mixture that increases of claim 1-4, it is characterized in that, described increase the liquid mixture in preparation treatment because of the application in the xerostomia disease medicament of taking anti-psychotropic drugs and causing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105804082A CN102008653B (en) | 2010-12-09 | 2010-12-09 | Saliva increasing mixture |
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| CN2010105804082A CN102008653B (en) | 2010-12-09 | 2010-12-09 | Saliva increasing mixture |
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| CN102008653A true CN102008653A (en) | 2011-04-13 |
| CN102008653B CN102008653B (en) | 2012-08-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138755A (en) * | 2016-08-17 | 2016-11-23 | 浙江中医药大学 | A kind of Herba Dendrobii mixture |
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|---|---|---|---|---|
| CN1583154A (en) * | 2004-06-06 | 2005-02-23 | 李永胜 | Oral liquid and capsules of Chinese medicine for diabete by supplementing Qi and nourishing Yin and promotnig production of body fluid and quenching thirst |
| CN101121001A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines dendrobium, ophiopogon Japonicus, and trichosanthin for heat-clearing fire-draining and treating diabetes |
| CN101642547A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for treating diabetes |
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2010
- 2010-12-09 CN CN2010105804082A patent/CN102008653B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583154A (en) * | 2004-06-06 | 2005-02-23 | 李永胜 | Oral liquid and capsules of Chinese medicine for diabete by supplementing Qi and nourishing Yin and promotnig production of body fluid and quenching thirst |
| CN101121001A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines dendrobium, ophiopogon Japonicus, and trichosanthin for heat-clearing fire-draining and treating diabetes |
| CN101642547A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for treating diabetes |
Non-Patent Citations (2)
| Title |
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| 《内蒙古中医药》 20071231 德学慧 《温病条辨》中增液汤的应用 34-35 1-5 , 第1期 2 * |
| 《贵阳中医学院学报》 20080331 寇文平 等 增液承气汤加减运用心得 44-45 1-5 第30卷, 第2期 2 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138755A (en) * | 2016-08-17 | 2016-11-23 | 浙江中医药大学 | A kind of Herba Dendrobii mixture |
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