CN102008542B - Compound neomycin sulfate soluble powder and production method thereof - Google Patents
Compound neomycin sulfate soluble powder and production method thereof Download PDFInfo
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- CN102008542B CN102008542B CN2010105813683A CN201010581368A CN102008542B CN 102008542 B CN102008542 B CN 102008542B CN 2010105813683 A CN2010105813683 A CN 2010105813683A CN 201010581368 A CN201010581368 A CN 201010581368A CN 102008542 B CN102008542 B CN 102008542B
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- soluble powder
- polygynax
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- anhydrous glucose
- doxycycline hydrochloride
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Abstract
The invention provides compound neomycin sulfate soluble powder and a production method thereof. The soluble powder is prepared by mixing neomycin sulfate, doxycycline hydrochloride, trimethoprim, atropine sulfate, astragalus root extract, silicon dioxide fine powder and anhydrous dextrose. The obtained neomycin sulfate soluble powder is compounded by using multiple components, and has the effects of greatly reducing diarrhea of livestock and poultry animals, quickly recovering health status and the like.
Description
Technical field
The present invention relates to the animal health field of pharmaceutical technology, be specifically related to a kind of compound neomycin sulphate soluble powder and production method thereof.
Background technology
The antimicrobial spectrum of polygynax is similar with kanamycin sulfate, mainly acts on most of gram negative bacilli, like escherichia coli, Bacillus proteus, Salmonella, pasteurella multocida etc.Enteritis curative effect to being caused by above-mentioned disease is particularly remarkable, takes orally to can be used for treating intestinal infection, like chicken colibacillosis, Pullorum Disease etc.But separately oral difficult absorption of polygynax, concentration is high in the intestinal, has only after for oral administration 3% of total amount to discharge from urine through absorbing the back, and all the other are directly discharge then, so controls enteritis and the diarrheal curative effect is general, and it is shorter to hold time.
Summary of the invention
The applicant is to the defective of above-mentioned existence; Carried out improving research; Propose a kind of compound neomycin sulphate soluble powder and production method thereof, the polygynax soluble powder that obtains forms by multiple composition is composite, has the effect that reduces livestock and poultry animal diarrhoea, speedy recovery to health situation significantly.
Technical scheme of the present invention is following:
A kind of compound neomycin sulphate soluble powder, the percentage by weight of contained component and each component is: (1) polygynax 5 ~ 10%; (2) doxycycline hydrochloride 1 ~ 10%; (3) the benzyl trimethyl ammonium pyrimidine 1 ~ 6%; (4) atropine sulfate 1 ~ 5%; (5) Radix Astragali extract 1 ~ 5%; (6) fine silica 1 ~ 5%; (7) anhydrous glucose 59 ~ 90%.
The present invention also provides a kind of production method of compound neomycin sulphate soluble powder, and step is following: with polygynax, doxycycline hydrochloride, benzyl trimethyl ammonium pyrimidine, atropine sulfate with etc. the anhydrous glucose of weight mix, the time is 5 minutes; Add Radix Astragali extract, fine silica and remaining anhydrous glucose again, mix, the time is 10 minutes, promptly gets final products; The composition of said each raw material is by weight percentage: (1) polygynax 5 ~ 10%; (2) doxycycline hydrochloride 1 ~ 10%; (3) the benzyl trimethyl ammonium pyrimidine 1 ~ 6%; (4) atropine sulfate 1 ~ 5%; (5) Radix Astragali extract 1 ~ 5%; (6) fine silica 1 ~ 5%; (7) anhydrous glucose 59 ~ 90%.
Its further technical scheme is: polygynax content>=5% in the said final products; Solution ph 4.5; Moisture≤10%.
Useful technique effect of the present invention is:
(1) compatibility of doxycycline hydrochloride and polygynax has significant synergism.The mechanism of action of polygynax and doxycycline hydrochloride is similar, all acts on the 70S ribosome of antibacterial, combines to stop aminoacyl-tRNA to connect with 30S subunit specificity, impede protein matter synthetic; The bacterial cell membrane permeability is increased, important substance outflow in the thalline.The two is just variant on effect stage, speed and characteristics: polygynax is the bacterial cell performance killing action to resting stage; And doxycycline hydrochloride is to imitate bacteriostatic soon; It is synthetic to block protein of bacteria rapidly; Antibacterial is remained static, help polygynax performance bactericidal action.
(2) doxycycline hydrochloride also has comparatively powerful inhibitory action to gram negative bacteria especially escherichia coli, and the doxycycline hydrochloride oral absorption is good, can reach 90 ~ 100%; The oral bioavailability rate is high; Significant enterohepatic circulation is arranged, can reach blood medicine peak in 2 ~ 3 hours, tissue penetration power is strong; It is wide to distribute, and is prone to diffuse in the bacterial cell.Drain also slowly, the effective blood drug concentration length of holding time can reach more than 8 hours, and toxicity is little, can not cause dysbacteriosis, can increase the absorption
of polygynax in intestinal.
(3) except curing mainly colibacillosis, the white scour of chicken, typhoid fever, fowl cholera, staphylococcus disease,, also can prevent and treat mycoplasma, chlamydial concurrent and secondary infection owing to added doxycycline hydrochloride.
(4) trimethoxy benzylamine pyrimidine has certain potentiation; A small amount of atropine sulfate plays certain stimulating central nervous system effect; An amount of Radix Astragali extract can effectively strengthen animal body immunity, promotes the cell antibody activation, the speedy recovery to health normality; Because Radix Astragali extract is very easy to the moisture absorption, adds fine silica and play the control Radix Astragali extract moisture absorption; Anhydrous glucose is as adjuvant (being carrier).
The specific embodiment
The present invention is further specified the present invention in order better to explain below in conjunction with the specific embodiment.
Embodiment 1
(1) polygynax 5kg, (2) doxycycline hydrochloride 2kg, (3) benzyl trimethyl ammonium pyrimidine 2kg, (4) atropine sulfate 1kg were mixed 5 minutes with 10kg (7) anhydrous glucose; Adding (5) Radix Astragali extract 2kg, (6) fine silica 1kg and remaining 77kg (7) anhydrous glucose again mixes; 10 minutes time, promptly get final products.Polygynax content is 5% in the final products; Solution ph 4.4; Moisture is 7.6%.
Embodiment 2
(1) polygynax 8kg, (2) doxycycline hydrochloride 5kg, (3) benzyl trimethyl ammonium pyrimidine 3kg, (4) atropine sulfate 3kg were mixed 5 minutes with 19kg (7) anhydrous glucose; Adding (5) Radix Astragali extract 2kg, (6) fine silica 2kg and remaining 58kg (7) anhydrous glucose again mixes; 10 minutes time, promptly get final products.Polygynax content is 8% in the final products; Solution ph 4.5; Moisture is 8.3%.
Embodiment 3
(1) polygynax 10kg, (2) doxycycline hydrochloride 8kg, (3) benzyl trimethyl ammonium pyrimidine 6kg, (4) atropine sulfate 4kg were mixed 5 minutes with 28kg (7) anhydrous glucose; Adding (5) Radix Astragali extract 4kg, (6) fine silica 4kg and remaining 36kg (7) anhydrous glucose again mixes; 10 minutes time, promptly get final products.Polygynax content is 10% in the final products; Solution ph 4.6; Moisture is 8.7%.
In the foregoing description 1 ~ 3, said polygynax, doxycycline hydrochloride, benzyl trimethyl ammonium pyrimidine, atropine sulfate, Radix Astragali extract, fine silica and anhydrous glucose are the commercially available universal product.
Through controlled trial effect of the present invention is described below:
Effective percentage to embodiment 1 ~ 3 product and common polygynax soluble powder treatment Pullorum Disease carries out controlled trial, and test grouping situation (comprising test method) is like following table:
Obtain the curative effect data after a period of time, like following table:
Above-mentioned test shows that product of the present invention has effectively improved the polygynax antibacterial effect owing to added composite composition, has the effect that reduces livestock and poultry animal diarrhoea, speedy recovery to health situation significantly.
Above-described only is preferred implementation of the present invention, the invention is not restricted to above embodiment.Be appreciated that other improvement and variation that those skilled in the art directly derive or associate under the prerequisite that does not break away from spirit of the present invention and design, all should think to be included within protection scope of the present invention.
Claims (3)
1. compound neomycin sulphate soluble powder is characterized in that being made up of and the percentage by weight of each component is: (1) polygynax 5 ~ 10% following component; (2) doxycycline hydrochloride 1 ~ 10%; (3) trimethyl benzylamine pyrimidine 1 ~ 6%; (4) atropine sulfate 1 ~ 5%; (5) Radix Astragali extract 1 ~ 5%; (6) fine silica 1 ~ 5%; (7) anhydrous glucose 59 ~ 90%.
2. the production method of a compound neomycin sulphate soluble powder is characterized in that step is following: with polygynax, doxycycline hydrochloride, trimethyl benzylamine pyrimidine, atropine sulfate with etc. the anhydrous glucose of weight mix, the time is 5 minutes; Add Radix Astragali extract, fine silica and remaining anhydrous glucose again, mix, the time is 10 minutes, promptly gets final products; The composition of said each raw material is by weight percentage: (1) polygynax 5 ~ 10%; (2) doxycycline hydrochloride 1 ~ 10%; (3) trimethyl benzylamine pyrimidine 1 ~ 6%; (4) atropine sulfate 1 ~ 5%; (5) Radix Astragali extract 1 ~ 5%; (6) fine silica 1 ~ 5%; (7) anhydrous glucose 59 ~ 90%.
3. according to the production method of the said compound neomycin sulphate soluble powder of claim 2, it is characterized in that polygynax content>=5% in the said final products; Solution ph 4.5; Moisture≤10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105813683A CN102008542B (en) | 2010-12-10 | 2010-12-10 | Compound neomycin sulfate soluble powder and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105813683A CN102008542B (en) | 2010-12-10 | 2010-12-10 | Compound neomycin sulfate soluble powder and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102008542A CN102008542A (en) | 2011-04-13 |
| CN102008542B true CN102008542B (en) | 2012-04-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105813683A Expired - Fee Related CN102008542B (en) | 2010-12-10 | 2010-12-10 | Compound neomycin sulfate soluble powder and production method thereof |
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Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101468030A (en) * | 2007-12-26 | 2009-07-01 | 天津瑞普生物技术集团有限公司 | Soluble powder for treating digestive system infection of livestock and poultry |
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- 2010-12-10 CN CN2010105813683A patent/CN102008542B/en not_active Expired - Fee Related
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Granted publication date: 20120404 Termination date: 20121210 |