CN102007917B - Composite bactericide and application thereof - Google Patents
Composite bactericide and application thereof Download PDFInfo
- Publication number
- CN102007917B CN102007917B CN 201010537038 CN201010537038A CN102007917B CN 102007917 B CN102007917 B CN 102007917B CN 201010537038 CN201010537038 CN 201010537038 CN 201010537038 A CN201010537038 A CN 201010537038A CN 102007917 B CN102007917 B CN 102007917B
- Authority
- CN
- China
- Prior art keywords
- procymidone
- bactericide
- composite bactericide
- composite
- rotten
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 74
- 239000003899 bactericide agent Substances 0.000 title claims abstract description 73
- 239000002131 composite material Substances 0.000 title claims abstract description 54
- QXJKBPAVAHBARF-BETUJISGSA-N procymidone Chemical compound O=C([C@]1(C)C[C@@]1(C1=O)C)N1C1=CC(Cl)=CC(Cl)=C1 QXJKBPAVAHBARF-BETUJISGSA-N 0.000 claims abstract description 46
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 16
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical group C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000005839 Tebuconazole Chemical group 0.000 claims abstract description 13
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical group O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000005760 Difenoconazole Substances 0.000 claims abstract description 12
- 241000894006 Bacteria Species 0.000 claims description 14
- 150000002825 nitriles Chemical class 0.000 claims description 12
- 150000003851 azoles Chemical class 0.000 claims description 11
- 240000008067 Cucumis sativus Species 0.000 claims description 7
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims description 7
- 210000005252 bulbus oculi Anatomy 0.000 claims description 4
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 3
- 241000222290 Cladosporium Species 0.000 claims description 2
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract description 17
- 235000013311 vegetables Nutrition 0.000 abstract description 14
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical group O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 abstract description 12
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical group O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 abstract description 12
- 208000031888 Mycoses Diseases 0.000 abstract description 4
- HZJKXKUJVSEEFU-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile Chemical group C=1C=C(Cl)C=CC=1C(CCCC)(C#N)CN1C=NC=N1 HZJKXKUJVSEEFU-UHFFFAOYSA-N 0.000 abstract description 2
- 239000005811 Myclobutanil Chemical group 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 42
- 238000012360 testing method Methods 0.000 description 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- 230000000694 effects Effects 0.000 description 15
- 239000012752 auxiliary agent Substances 0.000 description 14
- 239000007921 spray Substances 0.000 description 12
- 238000012216 screening Methods 0.000 description 11
- 239000000375 suspending agent Substances 0.000 description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- 241000220223 Fragaria Species 0.000 description 10
- 235000016623 Fragaria vesca Nutrition 0.000 description 10
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 10
- 239000005822 Propiconazole Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000009736 wetting Methods 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 241000221696 Sclerotinia sclerotiorum Species 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 239000000575 pesticide Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000945 filler Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 241000193738 Bacillus anthracis Species 0.000 description 5
- 244000061458 Solanum melongena Species 0.000 description 5
- 235000002597 Solanum melongena Nutrition 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000001018 virulence Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 241000221662 Sclerotinia Species 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000000417 fungicide Substances 0.000 description 4
- 239000004576 sand Substances 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 241001465180 Botrytis Species 0.000 description 3
- 241000123650 Botrytis cinerea Species 0.000 description 3
- 240000002791 Brassica napus Species 0.000 description 3
- 235000006008 Brassica napus var napus Nutrition 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 231100000053 low toxicity Toxicity 0.000 description 3
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 241000198596 Alternaria tomatophila Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000227653 Lycopersicon Species 0.000 description 2
- WLLGXSLBOPFWQV-UHFFFAOYSA-N MGK 264 Chemical compound C1=CC2CC1C1C2C(=O)N(CC(CC)CCCC)C1=O WLLGXSLBOPFWQV-UHFFFAOYSA-N 0.000 description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004562 water dispersible granule Substances 0.000 description 2
- WURBVZBTWMNKQT-UHFFFAOYSA-N 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one Chemical compound C1=NC=NN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 WURBVZBTWMNKQT-UHFFFAOYSA-N 0.000 description 1
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 241000223602 Alternaria alternata Species 0.000 description 1
- 241000222235 Colletotrichum orbiculare Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010072039 Histidine kinase Proteins 0.000 description 1
- 241000221775 Hypocreales Species 0.000 description 1
- 241001363490 Monilia Species 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 241000222291 Passalora fulva Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 241001518640 Sclerotinia homoeocarpa Species 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- 241001518615 Sclerotium cepivorum Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- -1 carbonyl imide Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- SHFGJEQAOUMGJM-UHFFFAOYSA-N dialuminum dipotassium disodium dioxosilane iron(3+) oxocalcium oxomagnesium oxygen(2-) Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Na+].[Na+].[Al+3].[Al+3].[K+].[K+].[Fe+3].[Fe+3].O=[Mg].O=[Ca].O=[Si]=O SHFGJEQAOUMGJM-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- XUZHLZDRCCUWEV-UHFFFAOYSA-N formaldehyde;methyl naphthalene-1-sulfonate Chemical compound O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 XUZHLZDRCCUWEV-UHFFFAOYSA-N 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 244000000004 fungal plant pathogen Species 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000010451 perlite Substances 0.000 description 1
- 235000019362 perlite Nutrition 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000004557 technical material Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a composite bactericide. The composite bactericide comprises the following components in percentage by weight: 5 to 90 percent of procymidone and 10 to 95 percent of component B, wherein the component B is difenoconazole, tebuconazole, triazolone, propiconazol or myclobutanil. The invention also discloses an emulsion-type bactericide which is prepared from the composite bactericide. Each L of the emulsion-type bactericide comprises 50 to 900 g of the composite bactericide. The invention also discloses a powder/grain-type bactericide which is prepared from the composite bactericide. The powder/grain-type bactericide comprises 10 to 90 weight percent of the composite bactericide. The composite bactericide can be used for preventing fungal diseases of vegetables, fruit trees or rape.
Description
Technical field
The present invention relates to a kind of bactericide, particularly a kind of composite bactericide for control vegetables, fruit tree and rape disease.
Background technology
The plant disease that procymidone [procymidone, N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-di carbonyl imide] causes Various Diseases fungal pathogenses such as Botrytis, Monilia, Sclerotinia and Alternarias has good control efficiency.There are some researches show that this medicament is the Antifungi growth by the bi-component histidine kinase signal pathway that activates fungi.Increase sharply through the germ of chemicals treatment such as the OS-2 phosphorylation level in the fungus bodies such as ash arrhizus bacteria (Botrytis cinerea) and cucumber anthrax (Colletotrichumlagenarium), the TCHK signal pathway of fungi is in the sustained activation state so that the glycerine in the fungus body accumulates in a large number, finally causes thalline dead.
Procymidone is the modern protective fungicide of broad spectrum activity contact killing type of releasing early 1970s, is the another class special efficacy bactericide of preventing and treating the diseases such as gray mold after benzimidazole germicide.The dicarboximide fungicides such as procymidone at present on producing Main Problems be drug-fast generation.Beever etc. just detect the existence of ash arrhizus bacteria field drug-fastness bacterial strain in nineteen eighty-three.Pomegranate spot alternaric bacteria (Alternaria alternate) namely develops immunity to drugs less than 5 years in the medication control.The important plant pathogenic fungi such as domestic vegetables, Botrytis cinerea germ, chain sclerotinia sclerotiorum (Moniliniaf ructicola), sclerotinite (Sclerotinia homoeocarpa) and white rot pyrenomycetes (Sclerotium cepivorum) all produces field resistance to dicarboximide fungicides such as procymidones.And the dual drug-fast strain of not only benzimidazoles-resisting bactericide but also anti-procymidone has appearred in field, is having a strong impact on effective use of procymidone.In addition, lack the application that enough therapeutic actions are also limiting procymidone.At present, delay with the main policies of administering the fungicide resistance development have the use that reduces medicament, with the composite reagent of different mechanism of action or by turns use.
Summary of the invention
The technical problem to be solved in the present invention provides the composite bactericide that a kind of energy is used for control vegetables, rape and fruit diseases, and this composite bactericide can be used for preventing and treating the pesticide resistance gray mold especially.
In order to solve the problems of the technologies described above, the invention provides a kind of composite bactericide, its component and weight content are: 5%～90% procymidone (component A) and 10%～95% (B component), B component is Difenoconazole or Tebuconazole (tebuconazole), triazolone (triadimefon), propiconazole (propiconazole) or nitrile bacterium azoles (Myclobutanil).
The present invention also provides the emulsion-type bactericide that utilizes above-mentioned composite bactericide to make simultaneously, contains the composite bactericide of 50～900g in the emulsion-type bactericide of every L.
The present invention also provides the powder that utilizes above-mentioned composite bactericide to make/grain type bactericide simultaneously, and the weight content of composite bactericide is 10%～90% in this powder/grain type bactericide.
The present invention also provides the purposes of above-mentioned composite bactericide simultaneously: be used for control vegetables, fruit tree and rape fungal disease.
Improvement as the purposes of composite bactericide of the present invention: fungal disease is eliminating vegetable botrytis, vegetable leaf mildew, vegetables stalk break, vegetables early blight, strawberry and grape grey mould, fruit tree dry rot or sclerotinia rot of colza.
Composite bactericide of the present invention according to the difference of controlling object, can be processed into the various pesticidal preparations of different content and formulation in actual use, for example emulsion-type bactericide and powder/grain type bactericide.The composite bactericide that contains 50～900g in every L emulsion-type bactericide, 1%～45% solvent (containing emulsifier), 1%～20% auxiliary agent, all the other are water; Above-mentioned percentage is the volume content of this composition in the emulsion-type bactericide.Component and the weight content of powder/grain type bactericide are: the auxiliary agent of 10%～90% composite bactericide, 9%～75% adsorbent or filler and 1%～20%.
Because the difference of constituent content, the emulsion-type bactericide can be divided into suspending agent (SC), aqueous emulsion (EW) and micro-emulsion type (ME), and powder/grain type bactericide can be divided into wetting powder (WP) and water dispersible granules (WG).The various formulations of above-mentioned composite bactericide all are to adopt conventional production process to be formed by the composite bactericide configuration, the conventional variety of the usefulness of producing when related emulsifier, solvent, auxiliary agent, adsorbent/filler is the configuration agricultural chemicals in the component.Such as: emulsifier can be selected agricultural newborn 33#, Nongru-700 # or agricultural newborn 602# etc., and solvent can be selected dimethylbenzene, DMF or ethanol etc., and adsorbent/filler can be selected diatomite, white carbon or perlite etc., and auxiliary agent can be selected organosilicon, polyethylene glycol etc.
The present invention is directed to use in existing the production the key medicament of preventing and treating gray mold, stalk break---procymidone has efficient, cheap but result for the treatment of is poor and drug-fast situation occurred; Utilize compatibility medicament such as Difenoconazole etc. to have with procymidone without mutual pesticide resistance, low toxicity, safety, Environmental compatibility is good, result for the treatment of is good characteristics, the composite bactericide of a group of control vegetables, fruit tree and rape disease (particularly pesticide resistance gray mold) is provided.By the bactericide with above-mentioned different mechanism of action---procymidone (component A) and B component (B component be in Difenoconazole, Tebuconazole, triazolone, propiconazole or the nitrile bacterium azoles a kind of) are carried out composite, bring out one's strengths to make up for one's weaknesses, reach and strengthen therapeutic action, raising effect, delay and administer drug-fast purpose.Composite bactericide of the present invention, can be used for control eliminating vegetable botrytis, vegetable leaf mildew, vegetables stalk break, vegetables early blight, strawberry and grape grey mould or the fungal diseases such as fruit tree mycotic ulcer disease, fruit tree dry rot and sclerotinia rot of colza, belong to novel, efficient, low toxicity bactericide.
The inventor by to the antibacterial mechanisms of the drug-fast generations such as gray mold, evolution and improvement technology, procymidone and drug-fast research for the invention provides technology and theoretical foundation.The present invention is by with a kind of compound screening that carries out in procymidone (component A) and the B component (B component is Difenoconazole or Tebuconazole or triazolone or propiconazole or nitrile bacterium azoles), its target is the improvement pesticide resistance, reduces production costs, and improves result for the treatment of.The present invention mainly prevents and treats gray mold, early blight and the stalk break of anti-procymidone.The present invention meets the needs that current green non-pollution agricultural product are produced.
Procymidone in the complex preparation has higher activity, cost very low but lack therapeutic action, develop immunity to drugs to gray mold etc.; Difenoconazole, Tebuconazole, triazolone, propiconazole and eyeball bacterium azoles all belong to efficient medicament (for gray mold, early blight and stalk break etc.), especially with procymidone without mutual pesticide resistance, have higher therapeutic action.After procymidone and Difenoconazole or Tebuconazole or triazolone or propiconazole or nitrile bacterium azoles two medicines are composite, drug effect significantly increases, production cost of the present invention is than using separately Difenoconazole, Tebuconazole, triazolone, propiconazole, eyeball bacterium azoles or procymidone will reduce by 15%～30%, can be stabilized in more than 70% the control efficiency of gray mold etc.
The present invention is through indoor bioassay and field control effectiveness test, and its result shows, 2 kinds of affine mutual appearances of composition, use safety, effect significantly, can effectively prevent and treat the disease such as gray mold.The present invention compares with other agricultural chemicals, has the following advantages:
1, formulation product of the present invention belongs to the agricultural chemicals of high-efficiency low-toxicity, low-residual, environmentally compatible, has protection and therapeutic action concurrently, meets the requirement of green agriculture production and environmental protection.
2, the present invention can also solve the undesirable problem of procymidone result for the treatment of effectively except solving the pesticide resistance problems to procymidone such as gray mold.
3, product using method of the present invention is simple, cost is low, and peasant household all can accept.
4, the present invention prevents and treats the effective of gray mold etc. to crop safety, and effect can be stabilized in more than 70%, is not easy to develop immunity to drugs.
When used in the actual field of composite bactericide of the present invention, every mu was used active ingredient 5～50 grams (these data are the amount of composite bactericide, i.e. the effective dose of emulsion-type bactericide or powder/grain type bactericide).During use the preparation of this composite bactericide being diluted with water to valid density is 0.01～5 gram/L, and using method is foliar spray.
In order to obtain composite bactericide of the present invention, the inventor had once carried out following experiment:
Experiment 1, formula indoor screening:
It is that procymidone is dissolved in respectively acetone with difenoconazole technical material by different part by weight that virulence is measured with coefficient of synergism, adopts mycelial growth method mensuration to the inhibitory action of Botrytis cinerea (table 1), then calculates EC
50Value and coefficient of synergism.According to main controlling object, can select the proportioning of coefficient of synergism (SR) 〉=1.5, and carry out appropriate dosage forms processing.
Table 1, prevent and treat the prescription screening of gray mold
Annotate: the weight ratio that refers to 2 kinds of components in the above bracket.
Experiment 2, formula indoor screening:
It is that procymidone is dissolved in respectively acetone with Original Tebuconazole by different part by weight that virulence is measured with coefficient of synergism, adopts mycelial growth method mensuration to the inhibitory action of Fulvia fulva (table 2), then calculates EC
50Value and coefficient of synergism.
Table 2, prevent and treat the prescription screening of cladosporium leaf and fruit mould of tomato
Annotate: the weight ratio that refers to 2 kinds of components in the above bracket.
Experiment 3, formula indoor screening:
It is that the former medicine of procymidone and triazolone is dissolved in respectively acetone by different part by weight that virulence is measured with coefficient of synergism, adopts mycelial growth method mensuration to the inhibitory action of eggplant sclerotium germ (table 3), then calculates EC
50Value and coefficient of synergism.
The prescription screening of table 3, control eggplant stalk break
Annotate: the weight ratio that refers to 2 kinds of components in the above bracket.
Experiment 4, formula indoor screening:
It is that procymidone is dissolved in respectively acetone with propiconazole by different part by weight that virulence is measured with coefficient of synergism, adopts mycelial growth method mensuration to the inhibitory action of Sclerotinia sclerotiorum (table 4), then calculates EC
50Value and coefficient of synergism.
The prescription screening of table 4, control sclerotinia rot of colza
Annotate: the weight ratio that refers to 2 kinds of components in the above bracket.
Experiment 5, formula indoor screening:
It is that procymidone is dissolved in respectively acetone with the former medicine of eyeball bacterium azoles by different part by weight that virulence is measured with coefficient of synergism, adopts mycelial growth method mensuration to the inhibitory action of cucumber anthracnose (table 5), then calculates EC
50Value and coefficient of synergism.
The prescription screening of table 5, control cucumber anthracnose
Annotate: the weight ratio that refers to 2 kinds of components in the above bracket.
Embodiment
Embodiment 1, a kind of composite bactericide, the procymidone by 75% and 25% Difenoconazole form; Above-mentioned % is % by weight.
It is 80% suspending agent (SC) that above-mentioned composite bactericide is made effective weight content, it is the composite bactericide that contains 800g in every L suspending agent, the auxiliary agent of the solvent of 45mL (glycerine), 70mL (alkylnaphthalene sulfonate, methyl naphthalene sulfonate formaldehyde condensate and silicone defoaming agent), all the other are deionized water.By the prescription requirement, will above-mentioned former medicine, auxiliary agent, solvent, deionized water etc. fully mix, put into the shearing of high shear emulsifying agent high speed, pump sand milling to the sand mill namely gets suspending agent after the filtration again.This suspending agent is hereinafter to be referred as 80% rotten benzene SC.
Field control effectiveness test:
Prevent and treat the test of grey mould fruit rot of strawberry with above-mentioned suspending agent (80% rotten benzene SC).This test is located at Suburban District of Hangzhou, every test area 0.50hm
2, subjects is the identical strawberry of upgrowth situation.Spray March 10 in 2008 is medicine for the first time, and spray in March 20 is medicine for the second time, sprays altogether 2 times.Formulation rate is respectively 80% rotten benzene SC per hectare 170 and 350mL.Contrast medicament I is 50% procymidone WP per hectare 600g; Contrast medicament II is 25% Difenoconazole EC per hectare 500mL.
Control efficiency sees Table 6.80% rotten benzene SC per hectare 170 and 350mL are respectively 72.95% and 82.37% to the control efficiency of gray mold.Therefore, under the prerequisite of identical effective dose, the present invention is better than contrasting medicament, significant difference.
Table 6,80% rotten benzene SC control grey mould fruit rot of strawberry effect
*: the different lowercase in same columns value back represents that the P=0.05 level difference is remarkable.
Embodiment 2, a kind of composite bactericide, the procymidone by 10% and 90% Tebuconazole form; Above-mentioned % is % by weight.It is 50% wetting powder (WP) that above-mentioned composite bactericide is made effective weight content, it is the composite bactericide that contains 500g in every kg pulvis, the auxiliary agent of 50g (lauryl sodium sulfate and sodium lignin sulfonate), the precipitated calcium carbonate of 35g, all the other are kaolin.Former medicine, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, can obtain.This wetting powder (WP) is hereinafter to be referred as 50% rotten penta WP.
Field control effectiveness test:
Prevent and treat the test of eggplant leaf mold with above-mentioned wetting powder (50% rotten penta WP).This test is located at the Zhuji City suburb, every test area 0.40hm
2, subjects is the identical eggplant of upgrowth situation.Spray Mays 15 in 2008 is medicine for the first time, and spray in Mays 22 is medicine for the second time, sprays altogether 2 times.Formulation rate is 50% rotten penta WP per hectare 350g and 500g.Contrast medicament I is 50% procymidone WP per hectare 500g.Contrast medicament II is 80% Tebuconazole WP per hectare 315g.
Control efficiency sees Table 7.50% rotten penta WP per hectare 350g and 500g are respectively 68.14% and 83.09% to the control efficiency of leaf mold.Under the prerequisite of identical effective dose, the present invention is better than contrasting medicament, significant difference.
The rotten penta WP control of table 750% eggplant leaf mold effect
| Medicament | Repeat 1 | Repeat 2 | Repeat 3 | Repeat 4 | On average | Average preventive effect (%) |
| 50% rotten penta WP 350g/hm 2 | 0.24 | 0.38 | 0.32 | 0.36 | 0.325 | 68.14b * |
| 50% rotten penta WP 500g/hm 2 | 0.21 | 0.15 | 0.19 | 0.14 | 0.1725 | 83.09a |
| 50% procymidone WP 500g/hm 2 | 0.48 | 0.42 | 0.46 | 0.47 | 0.4575 | 55.15c |
| 80% Tebuconazole WP 315g/hm 2 | 0.51 | 0.47 | 0.49 | 0.50 | 0.4925 | 51.7c |
| CK (clear water contrast) | 0.95 | 0.85 | 1.04 | 1.24 | 1.02 | / |
*: the different lowercase in same columns value back represents that the P=0.05 level difference is remarkable.
Embodiment 3, a kind of composite bactericide, the procymidone by 75% and 25% propiconazole form; Above-mentioned % is % by weight.
It is 40% suspending agent (SC) that above-mentioned composite bactericide is made effective weight content, it is the composite bactericide that contains 400g in every L suspending agent, the solvent of 50mL (ethylene glycol), the auxiliary agent of 65mL (fatty alcohol-polyoxyethylene ether, polyether antifoam agent and starch phosphate sodium), all the other are deionized water.By the prescription requirement, former medicine, auxiliary agent, solvent, deionized water etc. are fully mixed, put into high shear emulsifying agent high speed and shear, pump sand milling to the sand mill namely gets suspending agent after the filtration again.This suspending agent is hereinafter to be referred as 40% rotten the third SC.
Field control effectiveness test
(40% rotten the third SC) carries out the test of early blight of tomato with above-mentioned suspending agent.This test is located at Suburban District of Hangzhou, every test area 0.40hm
2, subjects is the identical tomato of upgrowth situation.Spray April 25 in 2009 is medicine for the first time, and spray in Mays 2 is medicine for the second time, sprays altogether 2 times.Formulation rate is 40% rotten the third SC per hectare 400 and 650mL.Contrast medicament I is 50% procymidone WP per hectare 650g.Contrast medicament II is 62% propiconazole EC per hectare 250mL.
Control efficiency sees Table 8.40% rotten the third SC per hectare 400 and 650mL are respectively 62.43b% and 74.60% to the control efficiency of early blight.Under the prerequisite of identical effective dose, the present invention is better than contrasting medicament, significant difference.
Table 8,40% rotten the third ME prevent and treat the early blight of tomato effect
| Medicament | Repeat 1 | Repeat 2 | Repeat 3 | Repeat 4 | On average | Average preventive effect (%) |
| 40% rotten the third SC 400mL/hm 2 | 0.35 | 0.38 | 0.42 | 0.47 | 0.355 | 62.43b * |
| 40% rotten the third SC 650mL/hm 2 | 0.32 | 0.25 | 0.27 | 0.34 | 0.24 | 74.60a |
| 50% procymidone WP 650g/hm 2 | 0.54 | 0.41 | 0.49 | 0.62 | 0.4525 | 52.12c |
| 62% propiconazole EC 250mL/hm 2 | 0.38 | 0.49 | 0.44 | 0.37 | 0.42 | 55.97c |
| CK (clear water contrast) | 0.86 | 0.95 | 0.81 | 0.94 | 0.954 | / |
*: the different lowercase in same columns value back represents that the P=0.05 level difference is remarkable.
Embodiment 4, a kind of composite bactericide, the procymidone by 75% and 25% triazolone form; Above-mentioned % is % by weight.
It is 50% wetting powder (WP) that above-mentioned composite bactericide is made effective weight content, namely contains the composite bactericide of 500g in every kg pulvis, the auxiliary agent of 50g (polyacrylamide and precipitated calcium carbonate), and the talcum powder of 12g, all the other are kaolin.Former medicine, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, can obtain.This wetting powder (WP) is hereinafter to be referred as 50% rotten three WP.
Protection and result for the treatment of are measured:
Cucumber is cultivated in the greenhouse, the artificial infection anthrax bacteria.Carrying out the medicament foliar spray respectively at 24 hours (therapeutic action) behind inoculation anthrax bacteria front 24 hours (protective effect) and the inoculation anthrax bacteria processes.Chemicals treatment is that 50% rotten three WP are diluted with water to 50mg/L (being the composite bactericide that contains 50mg among every L), be treated to CK (contrast) with clear water, contrast medicament I is 50% procymidone WP 50mg/L (being the procymidone that contains 50mg among every L), and contrast medicament II is 25% triazolone WP 50mg/L (being the triazolone that contains 50mg among every L).Effective dose is identical, in 7 days " Invest, Then Investigate " incidences of inoculation anthrax bacteria.Effect sees Table 9.50% rotten three WP 50mg/L are respectively 73.1% and 71.2% to protection and the result for the treatment of of cucumber anthracnose, are better than 2 kinds of contrast medicaments, significant difference.
Table 9,50% rotten three WP are to protection and the result for the treatment of of cucumber anthracnose
| Medicament | Protection effect (%) | Result for the treatment of (%) |
| 50% rotten three WP 50mg/L | 73.1 | 71.2 |
| 50% procymidone WP 50mg/L | 54.5 | 30.3 |
| 25% triazolone WP 50mg/L | 60.1 | 62.3 |
Embodiment 5, a kind of composite bactericide, the procymidone by 50% and 50% nitrile bacterium azoles form; Above-mentioned % is % by weight.
It is 50% wetting powder (WP) that above-mentioned composite bactericide is made effective weight content, namely contains the composite bactericide of 500g in every kg pulvis, the auxiliary agent of 75g (polyacrylamide and precipitated calcium carbonate), and the talcum powder of 50g, all the other are kaolin.Former medicine, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, can obtain.This wetting powder (WP) is hereinafter to be referred as 50% rotten nitrile WP.
The resistance management effect measuring:
(50% rotten nitrile WP) administers grey mould fruit rot of strawberry to the drug-fast test of procymidone with above-mentioned wetting powder.This test is carried out simultaneously at Zhuji City and Suburban District of Hangzhou, every test area 0.60hm
2, subjects is the identical strawberry of upgrowth situation.Examination spray on March 10th, 2008 is medicine for the first time, at the grey mould fruit rot of strawberry epidemic period every spray in 10 days once, continues on May 1st, 2010.Formulation rate is 50% rotten nitrile WP per hectare 500g.Contrast medicament I is 50% procymidone WP per hectare 500g, and contrast medicament II is 40% nitrile bacterium azoles WP per hectare 625g.
Respectively at the sampling of on March 10th, 2008 and on May 8th, 2010, analyze administer before and administer after experimental field gray mold to the development of drug resistance situation of procymidone.Regulation effect sees Table 10.50% rotten nitrile WP per hectare 500g is 48% to the resistance management effect of grey mould fruit rot of strawberry.And alone 50% procymidone WP per hectare 500g is-53.25% to the resistance management effect of grey mould fruit rot of strawberry.This proof the present invention better solved disease especially gray mold to the pesticide resistance problem of procymidone.
Table 10,50% rotten nitrile WP are to the drug-fast regulation effect of gray mold
At last, it is also to be noted that what more than enumerate only is several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (1)
1. composite bactericide, it is characterized in that this composite bactericide be following any one:
Formed procymidone by procymidone and Difenoconazole: the weight ratio of Difenoconazole=3: 1, described composite bactericide is used for preventing and treating gray mold;
Formed procymidone by procymidone and Tebuconazole: the weight ratio of Tebuconazole=1: 9, described composite bactericide is used for preventing and treating cladosporium leaf and fruit mould of tomato;
Form procymidone by procymidone and eyeball bacterium azoles: the weight ratio of nitrile bacterium azoles=1: 9, described composite bactericide are used for the control cucumber anthracnose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010537038 CN102007917B (en) | 2010-11-09 | 2010-11-09 | Composite bactericide and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010537038 CN102007917B (en) | 2010-11-09 | 2010-11-09 | Composite bactericide and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102007917A CN102007917A (en) | 2011-04-13 |
| CN102007917B true CN102007917B (en) | 2013-10-30 |
Family
ID=43838423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010537038 Expired - Fee Related CN102007917B (en) | 2010-11-09 | 2010-11-09 | Composite bactericide and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102007917B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103210926A (en) * | 2013-04-26 | 2013-07-24 | 华中农业大学 | Bactericide for preventing and treating sclerotinia rot of colza and preparation method thereof |
| CN103734195A (en) * | 2014-01-03 | 2014-04-23 | 灵川县金田农资经营部 | Biogas liquid compounded fungicide for preventing and treating anthrax |
| CN103739394A (en) * | 2014-01-03 | 2014-04-23 | 灵川县金田农资经营部 | Biogas liquid compounded fungicide for preventing and treating gray mold |
| CN103755471A (en) * | 2014-01-03 | 2014-04-30 | 灵川县金田农资经营部 | Biogas slurry compound bactericide for preventing and treating leaf mold |
| CN104621133A (en) * | 2015-01-19 | 2015-05-20 | 沈阳农业大学 | Sterilizing composition containing procymidone and difenoconazole and preparation method and application of sterilizing composition |
| CN108208005A (en) * | 2016-12-13 | 2018-06-29 | 丹阳市中药材科技发展协会 | One planting fruit-trees fungicide |
| CN110183453B (en) * | 2019-05-24 | 2021-08-24 | 浙江农林大学暨阳学院 | Method for preparing 3-phenyl- [1,2,4] triazolo [4,3-a ] pyridine compound under catalysis of no metal |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465245A (en) * | 2002-06-30 | 2004-01-07 | 周耀德 | Built disinfectant |
| CN1547911A (en) * | 1999-12-13 | 2004-11-24 | Fungicidal combinations of active substances |
-
2010
- 2010-11-09 CN CN 201010537038 patent/CN102007917B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547911A (en) * | 1999-12-13 | 2004-11-24 | Fungicidal combinations of active substances | |
| CN1465245A (en) * | 2002-06-30 | 2004-01-07 | 周耀德 | Built disinfectant |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102007917A (en) | 2011-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102007917B (en) | Composite bactericide and application thereof | |
| CN104137833B (en) | One is prevented and treated the biological composite bactericide of wheat scab and application thereof | |
| CN104839168B (en) | Bactericidal composition and its application | |
| CN105248424A (en) | Sterilization composition and application thereof | |
| CN101658171B (en) | Pesticide composition and application thereof | |
| CN107593717A (en) | Bactericidal composition | |
| CN101658175A (en) | Pesticide composition and application thereof | |
| CN103493828B (en) | Microbicide compositions containing chitosan oligomer | |
| CN107668039A (en) | Composition and application containing prothioconazoles and amino-oligosaccharide | |
| CN104823982B (en) | Bactericidal composition and application thereof | |
| CN103444721A (en) | Sterilization pesticide composition, pesticide preparation and application of pesticide preparation | |
| CN103503883A (en) | Sterilizing composition containing benzothiostrobin and triazole fungicide and application thereof | |
| CN105707106A (en) | Bactericidal composition | |
| CN101779636B (en) | Bactericidal composite containing tetraconazole | |
| CN103355303A (en) | Bactericidal composition containing picoxystrobin and amino-oligosaccharin, usage and application thereof | |
| CN103210936B (en) | Bactericide and purpose thereof | |
| CN104161041B (en) | Containing the bactericidal composition of amino-oligosaccharide and own azoles alcohol | |
| CN103168785A (en) | Ternary compound sterilizing composition containing trifloxystrobin and application of sterilizing composition | |
| CN103518743B (en) | Sterilizing composition containing boscalid and dimethomorph | |
| CN102550608B (en) | Composition containing epoxiconazole as fungicide and application of the composition | |
| CN101897336B (en) | Bactericidal composition containing imazalil and penconazole | |
| CN104757014A (en) | Pesticide composition containing iprodione and thiamethoxam | |
| CN104522037B (en) | A kind of Fungicidal insecticidal composition and its application | |
| CN101953343B (en) | Bactericidal composition containing imazalil and myclobutanil | |
| CN103798258B (en) | Bactericidal composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210826 Address after: Room 1011, 4 / F, building 5, No. 299, Hangfu Road, Chongfu Town, Tongxiang City, Jiaxing City, Zhejiang Province Patentee after: Tongxiang Beite Technology Co.,Ltd. Address before: 311300, No. 88, North Ring Road, Hangzhou, Zhejiang, Ling'an Patentee before: ZHEJIANG A & F University |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210907 Address after: 276000 south of Changshan Guanzhuang village, fine chemical park, Lushan project area, Yishui Economic Development Zone, Linyi City, Shandong Province Patentee after: LINYI GUOLI CHEMICAL Co.,Ltd. Address before: Room 1011, 4 / F, building 5, No. 299, Hangfu Road, Chongfu Town, Tongxiang City, Jiaxing City, Zhejiang Province Patentee before: Tongxiang Beite Technology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131030 Termination date: 20211109 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |