CN102000252B - 一种治疗血瘤的药及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗血瘤的药及其制备方法，轻粉8-10份，黄柏5-7份，镜锈2-4份，贝母2-4份，儿茶8-10份，水银2-4份，天然麝香3-4份，熊胆4-6份，天然牛黄3-4份，冰片0.5-1.5份，潮脑2-4份配制而成，所述份是指质量份。本发明纯属中草药配制而成，是一种外服中药，方中各有效成分相互起作用，杀菌消毒，收敛，祛湿寒，解热毒，化血瘀，对于血瘤有很好的治疗作用。
Description
技术领域 本发明涉及一种治疗血瘤的药，是纯中草药，实际是以清热解毒、化湿瘀为法治疗血瘤的药物制剂。本发明还涉及该药的制备方法。
背景技术 中医把表面肿瘤分为血瘤和粉瘤，现有治疗血瘤的药，特别是中成药甚少，且疗效不显著，毒性高，治愈率低。
发明内容 本发明旨在改进上述不足，提供一种通过治疗热毒内蕴、痰瘀互结、血行瘀阻，气血湿互结“积聚”发于外表而形成的肿瘤的药，以及其制备方法。本发明以清热解毒、化湿热寒法为主，生肌为辅，达到标本兼治的目的。
为了达到上述目的，本发明是这样实现的：
一种治疗血瘤的药，其特征是：轻粉8-10份，黄柏5-7份，镜锈2-4份，贝母2-4份，儿茶8-10份，水银2-4份，天然麝香3-4份，熊胆4-6份，天然牛黄3-4份，冰片0.5-1.5份，潮脑2-4份，配制而成。所述份是指质量份。
优选的组分含量是：轻粉9份，黄柏6份，镜锈3份，贝母3份，儿茶9份，水银3份，天然麝香3.5份，熊胆5份，天然牛黄3.5份，冰片1份，潮脑3份。
本发明的药的制备方法是：第一组药：取比例的轻粉，黄柏，镜绣，贝母，儿茶，熊胆研碎成100目细粉，备用；第二组药：取比例的其它药材用药杵捣3分钟，将两组药充分混合均匀，于46℃加热6分钟，冷却，制丸，分装即得。
本发明方剂主要的中草药根据传统医学及现代医学分析，药性及药理作用如下：
轻粉：性味归经：寒；辛；入肝、肾经；有毒。功能主治：杀虫，攻毒，利水，通便。治疥癣，瘰疬，梅毒，下疳，皮肤溃疡，水肿，膨胀，大小便闭。
黄柏：性味归经：寒；苦；归肾、膀胱经。功能主治：清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。
镜锈：青铜镜上绿锈。性寒，毒。功能主治：杀菌去死肌。
贝母：性味归经：微寒；苦、甘；归肺、心经。功能主治：清热润肺，化痰止咳。用于肺热燥咳，干咳少痰，阴虚劳嗽，咯痰带血。
儿茶：性味归经：凉；苦、涩；归肺经。功能主治：收湿生肌敛疮。用于溃疡不敛，湿疹，口疮，跌扑伤痛，外伤出血。
水银：味归经：寒；辛；入肝、肾经；有毒。功能主治：杀虫，攻毒，利水，通便。治疥癣，瘰疬，梅毒，下疳，皮肤溃疡，水肿，大小便闭。
天然麝香；性味归经：温；辛；归心、脾经.功能主治：开窍醒神，活血通经，消肿止痛。用于热病神昏，中风痰厥，气郁暴厥，中恶昏迷，经闭，瘕瘕，难产死胎，心腹暴痛，痈肿瘰疬，咽喉肿痛，跌扑伤痛，痹痛麻木。
熊胆：性味归经：寒；苦；归肝、胆、心经.功能主治：清热解毒，息风止痉，清肝明目。用于治热黄，暑泻；小儿惊？，疳疾，蛔虫痛；目翳，喉痹，鼻疮。
天然牛黄：性味归经：凉；甘；归肝、心经。功能主治：清心，豁痰，开窍，凉肝，息风，解毒。用于热病神昏，中风痰迷，惊痫抽搐，癫痫发狂，咽喉肿痛，口舌生疮，痈肿疔疮。
冰片：性味归经：微寒；辛、苦；归心、脾、肺经。功能主治：开窍醒神，清热止痛。用于热病神昏、痉厥，中风痰厥，气郁暴厥，中恶昏迷，目赤，口疮，咽喉肿痛，耳道流脓。
潮脑：性味归经：热；辛；归心、脾经；毒。功能主治：内服：开窍辟秽；外用：除湿杀虫，温散止痛。用于痧胀腹痛，吐泻，神昏；疥癣湿疮，瘙痒溃烂。
本发明纯属中草药配制而成，是一种外服中药，方中各有效成分相互起作用，杀菌消毒，收敛，祛湿寒，解热毒，化血瘀，对于血瘤有很好的治疗作用。
为了更好地理解和实施，下面结合实施例进一步说明本发明。
实施例一：
第一组药：取轻粉8份，黄柏5份，镜绣2份，贝母2份，儿茶8份，熊胆4份研碎成100目细粉，备用；第二组药：取水银2份，天然麝香3份，天然牛黄3份，冰片0.5份，潮脑2份混合用药杵捣3分钟。将两组药充分混合均匀，46℃加热6分钟，冷却，分装即得。
用量与用法：外服，每日2次，每次3克用75％酒精化开涂抹肿块表面。
实施例二：
第一组药：取轻粉9份，黄柏6份，镜锈3份，贝母3份，儿茶9份，熊5份研碎成100目细粉，备用；第二组药：取水银3份，天然麝香4份，天然牛黄4份，冰片1份，潮脑3份混合用药杵捣3分钟。将两组药充分混合均匀，46℃加热6分钟，冷却，分装即得。
用量用法同实施例一。
实施例三：
第一组药：取轻粉10份，黄柏7份，镜绣4份，贝母4份，儿茶10份，熊胆6份研碎成100目细粉，备用；第二组药：水银4份，天然麝香5份，天然牛黄5份，冰片1.5份，潮脑4份混合用药杵捣3分钟。将两组药充分混合均匀，于46℃加热6分钟，冷却，制丸，分装即得。
用量用法同实施例一。
【性状】本品为黄棕色至黑褐色的水丸；气微，味微苦。
【检查】应符合丸剂项下有关的各项规定(中华人民共和国药典2000年版一部附录IA)。
[水分]不得大于9％。检查结果为7.5％，符合规定。
[崩解时限]不得多于60分钟。实验结果为21分钟，符合规定。
[装量差异]取本品10丸为1份，称定重量，每粒与标示量相比较，应在±7％以内超出限度的不得多于2粒，并不得有1粒超出限度1倍，结果符合规定。
【功能与主治】杀菌消毒，收敛血瘀，化积聚，生肌。用于人体表面出现的血瘤，肿块。
【用量与用法】外服，每日2次，每次3克用75％酒精化开涂抹肿块表面。
【规格】3g/包。
药材来源由药材公司购买，药材标准符合《中华人民共和国药典》及《卫生部药品标准》等。
该发明制剂所采用药品，不违犯“十八反”、“十九畏”，相互配伍，无相恶相反情况。临床应用，未发现不良反应。
以下是临床使用疗效情。
以本发明的药治疗血瘤100例，并与非诺贝特治疗的30例做对照。结果表明本发明的药组显效率60％，总有效率92％；非诺贝特显效率33.33％，总有效率66.67％，两组间比较(P＜0.01)，有显著性差异。本发明的药在消除临床症状，恢复创面功能等方面均优于非诺贝特。
1、临床资料；全部病例均为1998年10月-1999年9月烟台大学医院门诊及病房患者，按完全随机原则分为用本发明的药口服治疗的试验组100例，用非诺贝特(广州威尔曼药业有限公司.9802112)口服治疗的对照组30例，具体资料见下表：
表一 病例来源
经统计学处理，P＞0.05，故认为两组病例来源无显著性差异。
表二 两组病人中医症状情况比较
经统计学处理，P＞0.05，两组病人主要中医症状比较，无显著差异。
表三 两组病人中医证型情况比较
经统计学处理，P＞0.05，两级病人证型分布无显著性差异。
2、治疗方法：试验组：外服本发明的药，每次3克，每天2次，连用10天为一疗程；对照组：用非诺贝特(广州威尔曼药业有限公司.9802112)，口服每次0.1g，日三次，45天为一疗程。
3、治疗结果，治疗组与对照组治疗后疗效比较，有显著性差异。
临床实验结果：本发明制成的药经临床病例观察，本药外服最佳时间是血瘤初起时，初见化脓或溃疡须破皮效果更好。
Claims (3)
1.一种治疗血瘤的药，其特征是：轻粉8-10份，黄柏5-7份，镜锈2-4份，贝母2-4份，儿茶8-10份，水银2-4份，天然麝香3-4份，熊胆4-6份，天然牛黄3-4份，冰片0.5-1.5份，潮脑2-4份配制而成；所述份是指质量份。
2.按照权利要求1所述的一种治疗血瘤的药，其特征是：轻粉9份，黄柏6份，镜锈3份，贝母3份，儿茶9份，水银3份，天然麝香3.5份，熊胆5份，天然牛黄3.5份，冰片1份，潮脑3份配制而成。
3.按照权利要求1或2所述的治疗血瘤的药的制备方法，其特征是：第一组药：取比例的轻粉，黄柏，镜绣，贝母，儿茶，熊胆研碎成100目细粉，备用；第二组药：取比例的其它药材用药杵捣3分钟，将两组药充分混合均匀，于46℃加热6分钟，冷却，制丸，分装即得。
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