CN101990639B - 自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法 - Google Patents

自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法 Download PDF

Info

Publication number
CN101990639B
CN101990639B CN200980112638.1A CN200980112638A CN101990639B CN 101990639 B CN101990639 B CN 101990639B CN 200980112638 A CN200980112638 A CN 200980112638A CN 101990639 B CN101990639 B CN 101990639B
Authority
CN
China
Prior art keywords
suction pipe
row
unit
magnetic particle
piston
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980112638.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN101990639A (zh
Inventor
金钟勋
金钟甲
李洋源
朴翰浯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioneer Corp
Original Assignee
Bioneer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of CN101990639A publication Critical patent/CN101990639A/zh
Application granted granted Critical
Publication of CN101990639B publication Critical patent/CN101990639B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • G01N35/1074Multiple transfer devices arranged in a two-dimensional array
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN200980112638.1A 2008-04-09 2009-04-08 自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法 Expired - Fee Related CN101990639B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2008-0032904 2008-04-09
KR20080032904 2008-04-09
PCT/KR2009/001804 WO2009125971A2 (ko) 2008-04-09 2009-04-08 자동정제장치, 멀티 웰 플레이트 키트 및 생물학적 시료로부터 핵산을 추출하는 방법

Publications (2)

Publication Number Publication Date
CN101990639A CN101990639A (zh) 2011-03-23
CN101990639B true CN101990639B (zh) 2014-08-13

Family

ID=41162385

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980112638.1A Expired - Fee Related CN101990639B (zh) 2008-04-09 2009-04-08 自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法

Country Status (4)

Country Link
US (1) US20110009608A1 (enExample)
JP (1) JP2011516075A (enExample)
CN (1) CN101990639B (enExample)
WO (1) WO2009125971A2 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5872765B2 (ja) * 2009-12-10 2016-03-01 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 空間的分離による増幅システム
KR101420094B1 (ko) * 2010-10-27 2014-07-17 (주)바이오니아 다양한 생체시료분석을 위한 전자동실시간정량증폭장비, 다양한 생체시료분석을 위한 자동정제 및 반응준비 장치, 전자동 핵산정제 및 실시간 정량 유전자증폭 방법, 전자동 핵산정제방법, 실시간정량pcr을 이용한 병원균의 전자동 생균수검사방법, 정량면역pcr을 이용한 전자동 항원농도획득방법 및 타겟항원에 라벨링된 부착용 타겟핵산의 정제방법
KR101400675B1 (ko) 2010-11-18 2014-05-29 (주)바이오니아 에어로졸방지를 위한 자동정제장비 및 자동정제방법
DE202011000837U1 (de) 2011-04-08 2011-06-09 CyBio AG, 07745 Pipetiervorrichtung
KR20130023091A (ko) * 2011-08-26 2013-03-07 (주)바이오니아 단백질 합성 키트, 자동추출장비를 이용한 단백질 발현 및 추출 방법
EP2618157A1 (en) * 2012-01-17 2013-07-24 Eppendorf Ag Laboratory apparatus for treating a sample reception section with a magnetic tool device, magnetic tool device, sample reception device for use with the magnetic tool device and method for performing a work step on at least one fluid sample using a magnetic field
KR101762295B1 (ko) * 2012-02-10 2017-08-04 (주)바이오니아 생체시료의 자동 분석 장치 및 방법
CN102580801A (zh) * 2012-03-13 2012-07-18 苏州捷美电子有限公司 一种多通道加样设备
EP2836835B1 (en) * 2012-04-12 2017-08-16 Becton Dickinson and Company Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples
CN102660458B (zh) * 2012-05-11 2013-11-06 苏州天隆生物科技有限公司 防止交叉污染的核酸提取装置
JP6159808B2 (ja) * 2012-11-30 2017-07-05 バイオニア コーポレーション 全自動無細胞タンパク質製造装備及びこれを利用したタンパク質の製造方法
TWI477755B (zh) * 2013-06-04 2015-03-21 Genereach Biotechnology Corp 核酸萃取設備
JPWO2015016315A1 (ja) * 2013-08-02 2017-03-02 株式会社ニコン プレート、プレートの製造方法、バイオチップの観察方法、及びスクリーニング方法
CN203866294U (zh) * 2013-11-01 2014-10-08 艾康生物技术(杭州)有限公司 核酸提取仪
EP3083059B1 (en) 2013-11-05 2025-06-25 Siemens Healthcare Diagnostics Inc. Multi-well wedge-shaped reagent container with auto-open capability
CN103897987B (zh) * 2014-02-18 2016-05-04 中国农业大学 基于纳米磁珠的核酸自动提取装置及其方法
GB2540307B (en) * 2014-03-31 2020-08-19 Agilent Technologies Inc Sealing moving with piston in a high-pressure pump
CN103949341A (zh) * 2014-04-29 2014-07-30 东南大学 一种全自动生物样本处理装置
WO2015192331A1 (zh) * 2014-06-17 2015-12-23 深圳迈瑞生物医疗电子股份有限公司 核酸提取装置及其工作方法
US9943092B1 (en) * 2014-12-22 2018-04-17 Roy Lee Garrison Liquid processing system and method
CN104531526B (zh) * 2015-01-14 2016-08-24 湖南圣维基因科技有限公司 一种磁珠法核酸提取装置
KR101810942B1 (ko) 2015-09-04 2018-01-25 (주)나노엔텍 샘플 전처리 시스템 및 그 제어방법
US10858643B2 (en) * 2015-10-30 2020-12-08 Sensor Electronic Technology, Inc. Vaccine preparation using ultraviolet radiation
JP6858008B2 (ja) * 2016-11-30 2021-04-14 シスメックス株式会社 粒子分散装置及び粒子分散方法
CN106918713B (zh) * 2017-03-14 2019-04-12 复旦大学附属中山医院 一种全自动生物样品组分分选装置
CN107058062B (zh) * 2017-06-09 2020-01-14 苏州天隆生物科技有限公司 一种旋转式核酸提取装置及其控制方法
CN109136061A (zh) * 2017-06-15 2019-01-04 山东见微生物科技有限公司 用于核酸提取设备的样本容器加热装置和核酸提取设备
KR20190001797A (ko) * 2017-06-28 2019-01-07 (주)오상헬스케어 자동화된 핵산 분리 장치
KR102378429B1 (ko) 2017-07-21 2022-03-25 주식회사 씨젠 자성 비드 이송 모듈, 상기 모듈을 포함하는 자동화 시스템 및 상기 모듈을 이용한 핵산 추출 방법
NL2020518B1 (en) * 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
CN108424838A (zh) * 2018-05-02 2018-08-21 烟台德迈生物科技有限公司 一种快速通过转移磁珠提取dna的装置
KR102256776B1 (ko) 2018-07-26 2021-05-27 (주)바이오니아 자석봉 블록의 교체가 가능한 표적물질 추출장치
KR102110197B1 (ko) * 2018-08-03 2020-05-14 바디텍메드(주) 자동화된 액상 면역반응 분석 장치 및 그 방법
US20220091147A1 (en) * 2019-01-28 2022-03-24 Formulatrix, Inc. Liquid handling instrument and pipetting head for and method of aspirating and/or dispensing liquids
KR102105639B1 (ko) * 2019-03-28 2020-04-28 주식회사 엘지화학 면역 검사 장치 및 면역 검사 방법
KR102102988B1 (ko) 2019-03-28 2020-04-22 주식회사 엘지화학 면역 검사 장치 및 면역 검사 방법
FI128808B (en) * 2019-12-03 2020-12-31 Thermo Fisher Scientific Oy Sample handling device and method of using the device
CN111826273B (zh) * 2020-07-22 2023-03-21 上海逢伙泰企业管理有限公司 一种用于核酸检测的自动化全封闭微流控芯片
CN111871598B (zh) * 2020-08-28 2022-06-21 南京汉尔斯生物科技有限公司 一种医疗垃圾分类用损伤性废物金属制品分离装置
CN111925935A (zh) * 2020-09-08 2020-11-13 广州市宝创生物技术有限公司 样本处理及检测多功能装置
CN112538414B (zh) * 2020-12-08 2025-08-15 杭州奥盛仪器有限公司 一种设有微流控结构的全密封式核酸智能化提取装置
CN113390702B (zh) * 2021-05-31 2022-08-16 烟台海关技术中心 放射性锶固相萃取、样品制备及活度测量集成装置
CN113621608B (zh) * 2021-08-10 2023-06-16 生工生物工程(上海)股份有限公司 一种提取细菌质粒dna的菌体裂解液、试剂盒及方法
CN114807117B (zh) * 2021-12-08 2024-09-24 深圳市爱康生物科技股份有限公司 一种核酸提取装置及方法
EP4475749A1 (en) * 2022-02-09 2024-12-18 Curi Bio, Inc. Devices and methods for magnetic detection of tissue motion

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555957A (en) * 1983-10-14 1985-12-03 Cetus Corporation Bi-directional liquid sample handling system
US6509193B1 (en) * 1996-05-20 2003-01-21 Precision System Science Co., Ltd. Method and apparatus for controlling magnetic particles by pipetting machine
US6908759B2 (en) * 2001-10-31 2005-06-21 Bionex, Inc. Method of manufacturing kit for isolation nucleic acids or biological materials

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985649A (en) * 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
FR2679660B1 (fr) * 1991-07-22 1993-11-12 Pasteur Diagnostics Procede et dispositif magnetique d'analyse immunologique sur phase solide.
US5897783A (en) * 1992-09-24 1999-04-27 Amersham International Plc Magnetic separation method
JP3142873B2 (ja) * 1993-02-01 2001-03-07 ラブシステムズ オユ 磁性粒子の特異的結合による検定の方法および装置
FI932866A0 (fi) * 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
JP3115501B2 (ja) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置
DE4423878A1 (de) * 1994-07-07 1996-01-11 Boehringer Mannheim Gmbh Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
JP3607320B2 (ja) * 1994-09-02 2005-01-05 株式会社日立製作所 微粒子を用いた分析における固相の回収方法及び装置
US5915284A (en) * 1996-07-22 1999-06-22 Cyberlab, Inc. Multiple channel pipetting device
DE69939622D1 (de) * 1998-03-19 2008-11-06 Prec System Science Co Ltd Apparat zur integration von magnetteilchen - verarbeitung und steuerungsverfahren
JPH11290059A (ja) * 1998-04-06 1999-10-26 Masashi Funayama 炭酸ガス培養器
EP2316571A3 (en) * 1998-05-01 2011-07-27 Gen-Probe Incorporated Automated diagnostic analyzer and method
CN1385518A (zh) * 2001-04-23 2002-12-18 株式会社百尼尔 生物学试料的微细排列用点样装置及该装置中使用的点样针
KR100483684B1 (ko) * 2003-01-29 2005-04-18 (주)바이오넥스 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템
JP4732683B2 (ja) * 2003-12-29 2011-07-27 ユニバーサル・バイオ・リサーチ株式会社 標的物質の検出方法
EP1621890A1 (en) * 2004-07-26 2006-02-01 bioMerieux B.V. Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods
US20070092403A1 (en) * 2005-10-21 2007-04-26 Alan Wirbisky Compact apparatus, compositions and methods for purifying nucleic acids
KR101194274B1 (ko) * 2005-12-30 2012-10-29 주식회사 효성 나일론 원착사의 제조방법
KR100720044B1 (ko) * 2006-04-27 2007-05-18 코아바이오시스템 주식회사 생물학적 물질 또는 핵산 추출 자동화 장치

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555957A (en) * 1983-10-14 1985-12-03 Cetus Corporation Bi-directional liquid sample handling system
US4555957B1 (enExample) * 1983-10-14 1987-12-22
US6509193B1 (en) * 1996-05-20 2003-01-21 Precision System Science Co., Ltd. Method and apparatus for controlling magnetic particles by pipetting machine
US6908759B2 (en) * 2001-10-31 2005-06-21 Bionex, Inc. Method of manufacturing kit for isolation nucleic acids or biological materials

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JP特开2004-229657A 2004.08.19

Also Published As

Publication number Publication date
WO2009125971A3 (ko) 2009-12-17
JP2011516075A (ja) 2011-05-26
WO2009125971A2 (ko) 2009-10-15
WO2009125971A9 (ko) 2010-03-04
CN101990639A (zh) 2011-03-23
US20110009608A1 (en) 2011-01-13

Similar Documents

Publication Publication Date Title
CN101990639B (zh) 自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法
US9187725B2 (en) Automatic biological sample purification apparatus equipped with magnetic filed applying part, method of extracting target substance from biological sample, and protein expression and purification method
KR101025135B1 (ko) 자동정제장치, 멀티 웰 플레이트 키트 및 생물학적 시료로부터 핵산을 추출하는 방법
US8753868B2 (en) Method and system for selective isolation of target biological molecules in a general purpose system
CN101010592B (zh) 将磁性粒子与流体分离、混合和浓缩的设备和方法及其在提纯方法中的用途
JP6040268B2 (ja) 試料破壊用ビーズを利用した生物検体の捕捉および溶出
US10081808B2 (en) Biomolecule isolation
RU2380418C1 (ru) Сменный микрофлюидный модуль для автоматизированного выделения и очистки нуклеиновых кислот из биологических образцов и способ выделения и очистки нуклеиновых кислот с его использованием
JP2011516075A5 (enExample)
JP6440699B2 (ja) 生体分子の単離および熱処理
CN101747397A (zh) 用于自动提取核酸的系统和方法
EP3816275B1 (en) Concentrated and enriched magnetic bead purification instrument
JP2017079766A (ja) 核酸抽出及び分画のためのマイクロ流体デバイス
AU2021420276B2 (en) Analyte inspection apparatus and analyte inspection method using same
CN205590667U (zh) 生物样品制备系统
CN104755169A (zh) 操纵固体载体的方法及操纵固体载体的设备
CN100415881C (zh) 用于预处理试样的装置
EP1437407B1 (en) Apparatus for collecting nucleic acid and method of collecting nucleic acid
JP2007068534A (ja) 核酸回収方法、微小流路、並びに核酸回収装置
HK1150166B (en) Apparatus, system, and method for purifying nucleic acids
HK1150166A1 (en) Apparatus, system, and method for purifying nucleic acids

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140813

CF01 Termination of patent right due to non-payment of annual fee