CN101987162B - Traditional Chinese medical preparation for treating anaphylatic purpura nephritis nephrotic syndrome - Google Patents
Traditional Chinese medical preparation for treating anaphylatic purpura nephritis nephrotic syndrome Download PDFInfo
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- CN101987162B CN101987162B CN2009100173762A CN200910017376A CN101987162B CN 101987162 B CN101987162 B CN 101987162B CN 2009100173762 A CN2009100173762 A CN 2009100173762A CN 200910017376 A CN200910017376 A CN 200910017376A CN 101987162 B CN101987162 B CN 101987162B
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Abstract
The invention belongs to the technical field of medicines, and discloses a traditional Chinese medical preparation for treating anaphylatic purpura nephritis nephrotic syndrome, which is prepared from the Chinese medical herbs in parts by weight: 30g of astragalus root, 15g of Tuckahoe, 15g of white atractylodes rhizome, 10g of glossy privet fruit, 10g of yerbadetajo herba ecliptae, 10g of cherokee rose fruit, 10g of fructus forsythia, 6g of bloodsucker, 10g of the rhizome of chuanxiong, 15g of the rhizome of oriental water plantain, 10g of rhizoma anemarrhenae and 6g of liquorice. One dose of the traditional Chinese medical preparation is taken per day. The traditional Chinese medical preparation has the effect of effectively treating the anaphylatic purpura nephritis nephrotic syndrome, can remarkably reduce 24h urine protein and cholesterol and increase plasma albumin, and has the advantages of no toxic and side effects because of a pure Chinese medical preparation, low side effect occurrence, and the like; and the total effective rate reaches 94.3 percent.
Description
The invention belongs to Chinese medicine preparation, the Chinese medicine preparation of the treatment henoch Schonlein purpura nephritis nephrotic syndrome type that particularly a kind of pure Chinese medicine is made.
Anaphylactoid purpura is to be the syndrome of characteristic with skin, gastroenteritis haemorrhagica, arthritis and kidney damage, is a kind of general polyangitis relevant with immunity.The renal damage that anaphylactoid purpura causes is called anaphy lactoid purpura nephritis, and its sickness rate is domestic to be reported as 30%～50%, is that diagnostic criteria statistics sickness rate is up to more than 90% with the kidney biopsy abroad.In henoch Schonlein purpura nephritis, nephrotic syndrome accounts for about 56%.Mostly occur before and after 4 weeks appearred in purpura, except that having " three-hypers one is low ", and with in various degree hematuria, often protracted course of disease.
The purpose of this invention is to provide a kind of Chinese medicine preparation of treating henoch Schonlein purpura nephritis nephrotic syndrome type.
The present invention is achieved in that
The Chinese medicine preparation of treatment henoch Schonlein purpura nephritis nephrotic syndrome type is characterized in that it being the decoction that the Chinese medicine by following weight parts is made: Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Fructus Rosae Laevigatae 10-g, Fructus Forsythiae 10g, Hirudo 6g, Rhizoma Chuanxiong 10g, Rhizoma Alismatis 15g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae 6g.Every day potion.
After the present invention adopts above-mentioned prescription, have following clinical effectiveness:
1. can effectively treat henoch Schonlein purpura nephritis nephrotic syndrome type, total effective rate reaches 94.3%.
2. can obviously reduce 24h urine protein, cholesterol reducing, rising plasma albumin.Pure Chinese medicinal preparation has no side effect.
3. pure Chinese medicinal preparation, taking convenience.
4. rate of side effects is low, and the central obesity incidence rate is 22.9%, and incidence rate 5.7% appears in purpura repeatedly, is starkly lower than matched group.
The present invention is made for pure Chinese medicine, and modern pharmacological research proves:
The Radix Astragali: benefiting QI for strengthening the superficies, inducing diuresis to remove edema.Can strengthen the phagocytic function of reticuloendothelial system, increase the ability of virus induction interferon, enhancing antibody is synthetic, and immune system is had dual regulation.Can improve blood plasma albumin level through regulating the renal glomerular disease protein metabolism disorder, reduce urine albumen amount, in renal glomerular disease, play a positive role, especially helpful to eliminating albuminuria.
Poria: promoting diuresis to eliminate damp pathogen.Diuretic and not feeling frustrated, the property of medicine is gentle.With the same usefulness of the Rhizoma Atractylodis Macrocephalae, the merit of its invigorating spleen to remove dampness benefit is clear.The cell immune response of suppressor T cell mediation optionally, but do not suppress the cell-mediated humoral immunization of B.Can avoid producing immunosuppressive action as side effect.
The Rhizoma Atractylodis Macrocephalae: air making-up and spleen enlivening has the effect of regulating immunologic function.
Fructus Ligustri Lucidi, Herba Ecliptae: the moon of nourishing the liver and kidney.Effect with antiinflammatory, immunostimulant.Fructus Ligustri Lucidi also has effect for reducing blood fat.
Fructus Rosae Laevigatae: the kidney invigorating, reinforce the kidney, the convergence arresting seminal emission is the principal agent of land and water Double Immortal Pill, is to treat albuminuretic basic medicine clinically.The Fructus Rosae Laevigatae ethanol extract has certain therapeutical effect to nephritis.
Fructus Forsythiae: hardship, be slightly cold, return lung, the heart, gallbladder meridian.Can the heat-clearing and toxic substances removing expelling pathogenic factors from the exterior.Antibacterial action is widely arranged, can also blood vessel dilating, microcirculation improvement, its contained rutin can strengthen the density of blood capillary.
Rhizoma Chuanxiong: blood-activating and qi-promoting is the gas medicine in the blood, the gas in the benefaction blood, current 12 warps.Can obviously reduce surface activity of blood platelet, anticoagulant, and can make the platelet of having condensed separate coalescence to remove erythrocyte aggregation, reduce blood viscosity, expansion small artery, microcirculation improvement.
Hirudo: removing blood stasis.Can expand blood capillary, the releasing arteriolospasm, the attenuating blood viscosity, microcirculation improvement has the effect of the Angiotensin II of inhibition conversion enzyme, main protein, hirudin, the antithrombotic element of containing, the ability Trombin inhibiting plays anticoagulation to fibrinogenic effect.
Rhizoma Alismatis: sweet in the mouth is cold, goes into kidney, urinary bladder channel, contains volatile oil, resin, choline, protein etc.Promoting diuresis to eliminate damp pathogen, the turbid descending expels the heat-evil.Can increase carbamide and muriatic drainage, bring high blood pressure down and blood glucose, and the hypercholesterolemia rabbit is had tangible cholesterol reducing effect and arteriosclerosis effect (relaxing the arteriosclerosis tendency).Also has blood coagulation resisting function simultaneously.
The Rhizoma Anemarrhenae: nourishing YIN to lower pathogenic fire.Not only have antiinflammatory action, platelet aggregation is also had very strong inhibitory action.Can alleviate glucocorticoid side effect, cholesterol reducing.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, it is treating stranguria to detoxify.Stronger Detoxication is arranged, the effect of corticoid appearance is arranged, can protect the patient adrenal gland who takes glucocorticoid for a long time in a large number to avoid atrophy, improve curative effect.Have blood fat reducing and study of anti-atherogenic effect, organize atherosclerotic formation.Rabbit or rat experiment property atherosclerosis are had the effect that reduces blood cholesterol, beta Lipoprotein and triglyceride extremely significantly, and its intensity surpasses the arteriosclerosis medicine.
Chinese medicine is thought the evil disturbance meridians that belong to six climate exopathogens at the beginning of the primary disease pathological changes, the blood system latent heat, and dominance of heat in the interior causes the resistance of the passages through which vital energy circulates stasis of blood, sickly just hindering for a long time, asthenia of both the spleen and kidney, blood is capable unable and cause blood-vessel obstructive, so blood-stasis internal-depression, being deposited on kidney is to run through primary disease pathological factor all the time.Therefore, primary disease is an excess caused by deficiency, and the card of simulataneous insufficiency and excessive answers the severe disease machine with the method treatment of living in the treatment, can not stick to established practice, promptly should execute benefit when mending, and should send an expedition against when cutting down promptly, is just containing heresy and is dispelling, sick just oriented hope of healing.Suitable treating both the principal and the secondary aspects of a disease at the same time eliminating evilly develops simultaneously with setting upright, and is main with benefiting QI and nourishing blood, strengthening spleen, tonifying kidney, in conjunction with clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, so just can suit pathogenesis, and As the medicine took effect, the symptoms lessened.Radix Astragali benefiting QI for strengthening the superficies in the present invention's prescription, inducing diuresis to remove edema, scalable renal glomerular disease protein metabolism disorder improves blood plasma albumin level, and level reduces urine albumen amount; Be equipped with the Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, the turbid descending is in the hope of reaching the purpose of blood fat reducing, blood pressure lowering, blood sugar lowering, correction lipodystrophy.Because the Rhizoma Alismatis sweet in the mouth is cold, go into kidney, urinary bladder channel, diuresis is arranged, can increase carbamide and muriatic drainage, bring high blood pressure down and blood glucose, and the hypercholesterolemia rabbit is had tangible cholesterol reducing effect and arteriosclerosis effect (relaxing the arteriosclerosis trend).Simultaneously, Hirudo, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, microcirculation improvement, the blood coagulation sexually transmitted disease (STD) that causes with activated by thrombin in the development of blocking-up nephropathy becomes the process that transfers inflammatory reaction to; Fructus Ligustri Lucidi, Herba Ecliptae invigorating the liver and kidney are to regulate immunologic function; Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire is in order to avoid the fiery high impairment of YIN due to the glucocorticoid; The Fructus Rosae Laevigatae the kidney invigorating, reinforce the kidney, spleen invigorating is astringent or styptic treatment for spontaneous sweating; Fructus Forsythiae has antibacterial action widely, and assistant is with the Radix Glycyrrhizae invigorating the spleen and replenishing QI, and it is treating stranguria to detoxify, the performance curative effect.
For verifying therapeutic effect of the present invention, the present invention is in January, 2006---and Liaocheng City second the People's Hospital has carried out following clinical trial in December, 2008 in the Shandong Province:
1 data and method
1.1 physical data 65 my gates of example are examined and inpatient, all meet standards: (1) has typical anaphylactoid purpura medical history; (2) in the course of disease or purpura naked eyes or microscopic hematuria and albuminuria appear after disappearing; (3) have the Clinical symptoms of nephrotic syndrome concurrently.Be a large amount of albuminuria, blood plasma total protein＜50gIL, or albumin＜30gIL T-CHOL＞5.2mmol/L, and the above edema of moderate is arranged.The conformance with standard patient is divided into matched group and observation group at random.Male 19 examples in observation group's 35 examples, women 16 examples, 12.87 ± 3.90 years old mean age.Male 14 examples in matched group 30 examples, women 16 examples, 13.03 ± 3.03 years old mean age.No difference of science of statistics between two groups.
1.2 Therapeutic Method
The oral prednisone 1mg/ of The control group (kgd).Oral persantin simultaneously, medicines such as quiet vitamin C and calcium gluconate advise patient to avoid eating suspicious irritated foods such as fish and shrimp, avoid suffering from cold.Observation group: on matched group medication basis, add and use medicine of the present invention: Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Fructus Rosae Laevigatae 10g, Fructus Forsythiae 10g, Hirudo 6g, Rhizoma Chuanxiong 10g, Rhizoma Alismatis 15g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae 6g..Every day potion.8 weeks of the course of treatment
1.3 observation index
Observe two groups of treatment front and back 24h urine protein quantitation, plasma albumin, cholesterolemia, adverse effect situation.
1.4 statistical method
All data are all handled with the SPSS software kit, and continuous data is represented with-x ± s, with the independent sample t check, relatively uses paired t-test between two groups before and after every group of treatment, the relatively employing x2 check of rate, inspection level α=0.05.
2 results
2.1 efficacy evaluation
1. curative effect determinate standard is alleviated fully: edema disappears fully, routine urinalysis urine protein (-), urine erythrocyte (-), 24hPro＜0.15/d, Alb＞35g/L.2. significantly alleviate: edema disappears basically, and urine erythrocyte obviously reduces to below 3～5/HP, and albuminuria reduces more than 50%, and Alb is near 30g/L.3. part is alleviated: edema, albuminuria reduce to below (+), and urine erythrocyte reduces to below (+)/HP, Alb takes a turn for the better before the treatment to some extent.4. invalid: These parameters does not have improvement, even renal function injury occurs.
Curative effect is relatively seen table 1.
Two groups of curative effects of table 1 are (%) relatively
Observation group's effective percentage obviously is superior to matched group (x2=5.448, P＜0.05).
2.2 table 2 is seen in two groups of test ratings variations before and after the treatment.24hPro, Alb, blood fat difference all have statistical significance (P＜0.01), and obviously are superior to matched group (P＜0.01) before and after observation group's treatment.
24h urine protein, plasma albumin and cholesterol change before and after two groups of treatments of table 2 (x ± s)
Annotate: relatively preceding with the treatment of this group
△P＜0.05
△ △Compare with matched group P＜0.01
*P＜0.01
2.3 untoward reaction and recurrence situation are relatively after two groups of treatments
Treatment back matched group generation central obesity 20 examples (66.7%), the person does not appear repeatedly in purpura has 8 examples, accounts for 26.7%.Fertile 8 examples (22.9%) of centration take place in observation group, and the person does not appear repeatedly in purpura has 2 examples, accounts for 5.7%.Observation group's central obesity incidence rate is starkly lower than matched group (x2=12.644, P＜0.01), and purpura occurs incidence rate repeatedly and is starkly lower than matched group (x2=5.45, P＜0.05).
Above-mentioned evidence: the present invention is used for henoch Schonlein purpura nephritis nephrotic syndrome type, and is respond well.Total effective rate obviously is superior to matched group, finds from the test rating inspection, and 24h urine protein, cholesterolemia obviously reduce, and with matched group significant difference arranged relatively before and after observation group's treatment; Plasma albumin treatment back obviously raises, and with matched group notable difference is more also arranged.Evidence simultaneously, the present invention can also alleviate the central obesity due to the hormone side effect, reduces purpura occurrence rate repeatedly, also has the adjusting immunologic function simultaneously, the effect of microcirculation improvement.
Below in conjunction with embodiment medicine of the present invention is elaborated.
Get Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Fructus Rosae Laevigatae 10g, Fructus Forsythiae 10g, Radix Angelicae Sinensis 15g, Hirudo 6g, Rhizoma Chuanxiong 10g, Rhizoma Alismatis 15g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae 6g..Fully mix, soaked 40 minutes, decoct twice then, each about 50 minutes, merge filtrating twice, precipitate 2 hours, get the supernatant decocting and concentrating again to 200ml, the patient is oral.Every day potion.
Below for utilizing the concrete case of Drug therapy of the present invention:
Example 1 Korea Spro * *, woman, 9 years old.On June 23rd, 2006, because of purpura appears in whole body behind the injection vaccine of epidemic menigitis, edema, hematuria take place then in certain County Hospital department of pediatrics prescription on individual diagnosis, be diagnosed as henoch Schonlein purpura nephritis; Adopt prednisone (45mg/ day), treated 40 days, moon facies occurs; Central obesity, stomachache, agitation etc. are satisfied and are come me institute to go to a doctor.The indagation routine urinalysis: urine protein (+++), RBC (++), WBC (+), epithelial cell is few.Twenty-four-hour urine protein quantification 4.82g, serum cholesterol 7.8mmol/L, total protein 50g/L, albumin 20.5g/L; Globulin 29.5g/L, blood pressure 16.8/10.7kPa, body weight 25kg; Abdominal circumference 60cm, pulse 104 times/minute, soft and rapid pulse; Red tongue, white and thin fur, red, the cardiopulmonary () of pharynx, abdominal distention, the extremity inboard is dispersed in purpura.Treatment gives prednisone 30mg/d, adds medicine potion every day of the present invention simultaneously.Treat after 15 days, body weight 23kg, abdominal circumference 57cm, urine protein is between (+) (++).Treated 28 days, body weight 20kg, edema disappears, abdominal circumference 56cm, urine protein is turned out cloudy, and check twenty-four-hour urine protein quantification is 0.12g, cholesterolemia 4.54mmol/L, total protein 62g/L, albumin 36g/L, globulin 27g/L.Hormone side effect disappears, and other side effect do not occur, and nephrotic syndrome is cured and left hospital.
Example 2 lists * *, the man, 16 years old, in August, 2007 went to a doctor in Liaocheng City second the People's Hospital in Shandong Province's.Show effect repeatedly two lower limb purpuras 4～5 months of patient are though the clothes prednisone can control easy the recurrence.The albumen 3+ that had urine examined before March, twenty-four-hour urine protein quantification 5.088g, plasma albumin 26.10g/L,, be diagnosed as henoch Schonlein purpura nephritis nephrotic syndrome type, to take prednisone treatment urine protein and disappear, edema is sent out in patient's drug withdrawal voluntarily again before January.Have a medical check-up: T36.9 ℃ of P80 time/minute BP125/75mmHg, refreshing clear, the puffiness of the eyes, two pulmonary respiration sounds are clear; Do not hear and rale, heart rate 81 times/minute, the neat no noise of rule, abdomen is soft; The liver spleen does not reach, and left kidney district kowtows pain, abdominal part shifting dullness (+), two lower limb moderate pitting edemas.Chemical examination and inspection: urine protein 3+, plasma albumin 15g/L, cholesterolemia 6.93mmol/L, diagnosis: henoch Schonlein purpura nephritis nephrotic syndrome type.Give infection after being admitted to hospital, generally protect kidney treatment, symptomatic treatment, mainly give heavy dose of glucocorticoid prednisone 60mg, once a day; Add 1 dose of Chinese medicine decoction of the present invention every day simultaneously; Treat after 10 days, urine protein is turned out cloudy, check 24h urine protein quantitation 0.69g; Cholesterolemia 5.14mmol/L, plasma albumin 32.2g/L.Be in hospital 30 days, edema disappears, and full moon face and central obesity do not occur, purpura not more not repeatedly, nephrotic syndrome is cured and is left hospital.
Claims (1)
1. the Chinese medicine preparation of treatment henoch Schonlein purpura nephritis nephrotic syndrome type is characterized in that: the decoction that is made by the Chinese medicine of following weight parts: Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Fructus Rosae Laevigatae 10g, Fructus Forsythiae 10g, Hirudo 6g, Rhizoma Chuanxiong 10g, Rhizoma Alismatis 15g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae 6g.
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Non-Patent Citations (2)
| Title |
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| 周云 等.紫癜性肾炎的中医治疗进展.《吉林中医药》.2008,第28卷(第2期), * |
| 韩翠翠 等.中医辨证论治小儿紫癜性肾炎的研究进展.《云南中医中药杂志》.2008,第29卷(第9期), * |
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