CN101693097B - Medicament for adjuvant therapy of tumors and preparation method thereof - Google Patents
Medicament for adjuvant therapy of tumors and preparation method thereof Download PDFInfo
- Publication number
- CN101693097B CN101693097B CN2009101144860A CN200910114486A CN101693097B CN 101693097 B CN101693097 B CN 101693097B CN 2009101144860 A CN2009101144860 A CN 2009101144860A CN 200910114486 A CN200910114486 A CN 200910114486A CN 101693097 B CN101693097 B CN 101693097B
- Authority
- CN
- China
- Prior art keywords
- grams
- herba
- radix
- medicament
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicament for adjuvant therapy of tumors and a preparation method thereof, wherein the medicament is prepared from twelve Chinese herbal medicines including long-nosed pit viper, convexutricle sedge herb, rhizoma zedoariae, saffron, ginseng, milk veteh, oldenlandia diffusa, herba scutellariae barbatae, purslane, radix isatidis, trichosanthes root and Chinese violet. The preparation method of the medicament comprises the working procedures of ethanol soaking, water cooking, concentration, settling and the like. The medicament has the efficacy of reinforcing insufficiency, removing toxin, cooling blood, removing blood stasis, eliminating stagnation and stopping pain, is used for the adjuvant therapy of various tumors and has good curative effect and no remarkable side effect.
Description
Technical field
The present invention relates to a kind of preparation method that is used for medicine and this medicine of adjuvant therapy of tumors.
Background technology
Traditional Chinese medical theory is thought: tumor is its basic feature with internal organs generation abnormal mass, the generation of lump many by the stagnation of QI, expectorant coagulate, humidity hysteresis, blood stasis, poison are poly-etc. is entangled with mutually, and be with the passing of time stagnant and become tangible lump.How empty the plain body of cancer patient is, and cancerous lesion consumes the qi-blood-body fluid of the body of hurting sb.'s feelings in addition, changes so the middle and advanced stage patient has more pathogenesis such as existing deficiency of qi and blood, deficiency of both YIN and YANG.
The modern Chinese medicine theory is mainly divided dialectical treatment and treatment according to differentiation of diseases to tumor treatment.Coryza Treated by Syndrome Differentiation is divided the body resistance strengthening and constitution consolidating (consolidating) and eliminating evil two Therapeutic Principle again.
1. the theoretical basis of the body resistance strengthening and constitution consolidating: theory of Chinese medical science thinks that deficiency syndrome are major reason and pathogenesis of tumor development, clinical practice fully proved the body resistance strengthening and constitution consolidating can relief of symptoms, improve life quality, prolong life cycle, reduce the toxic and side effects of chemicotherapy etc., the effect that may reduce relapse rate, improve cure rate for some tumor.Therefore the body resistance strengthening and constitution consolidating is the characteristic and the advantage of prevention with Chinese medicine, treatment tumor.Its indication mainly is a late tumor.Concrete measure: YIN nourishing, QI invigorating, YANG invigorating nourishes blood.
2. eliminating evil theoretical basis: theory of Chinese medical science thinks that exopathogen is a factor of tumor development.Because unclean, the disorder of emotion of chronic dietary, excessively impairment caused by overstrain etc. causes that body imbalance between YIN and YANG, visceral dysfunction, exopathogen take advantage of a weak point, cause a series of pathological changes such as qi depression to blood stasis, evil poison be coalescent, finally form tumor.Therefore, eliminating evil also is a big rule of treatment of Chinese traditional treatment tumor, has curative effect preferably.Its indication: infantile tumour and body constitution is patient preferably.Concrete measure: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, dispelling phlegm and eliminating dampness, treating the poisonous disease with poisonous drugs etc.
At present tumor treatment is mainly adopted following several method: (1) operative treatment, (2) chemotherapy, (3) radiotherapy, (4) Biotherapeutics, (5) Chinese medicine.Preceding four kinds of methods are big to the human body wound, and untoward reaction is many, expense height, but treatment cycle is shorter relatively, and treatment with strong points, therapeutic effect is estimated easily.Generally by whole conditioning, the course of treatment is long for Chinese medicine, few side effects, and expense is low, to the case that chronic disease and above-mentioned first three kind Therapeutic Method difficulty are proved effective, often receives curative effect preferably.But herbal species is few preferably for curative effect at present.
Summary of the invention
Technical problem to be solved by this invention provides the medicine of the various tumors of a kind of energy auxiliary treatment, and the preparation method of this medicine is provided.
The present invention solves the problems of the technologies described above with following technical scheme: medicine of the present invention is as follows by the required proportioning raw materials of the oral liquid formulations of every preparation 1000ml: Agkistrodon 50～100 grams, rhizoma sparganic 50～100 grams, Rhizoma Curcumae 50～100 grams, Stigma Croci 20 grams, Radix Ginseng 20～50 grams, the Radix Astragali 50～100 grams, Herba Hedyotidis Diffusae 80～100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 50～100 grams, Radix Trichosanthis 50～80 grams, Herba Violae 50～80 grams.
The preparation technology of medicine of the present invention is:
Above-mentioned raw materials is mixed the ethanol 4000ml that the back adds concentration 50%～95% by proportioning, flooded 24～48 hours, filter, standby behind the filtrate recycling ethanol; The decocting that adds 5 times of medicinal residues weight in the medicinal residues boils 3 times, and each 1 hour, collecting decoction, filter, filtrate and above-mentioned standby filtrate merging are concentrated into relative density and are 1.10～1.14 clear paste under 50～70 ℃, the water mixing that adds 3 times of clear paste weight again, left standstill 24～48 hours, and got supernatant and filter, filtrate adds water to 1000ml, stir evenly, fill, sterilization gets product.
But the Radix Ginseng strongly invigorating primordial QI in the present invention's prescription adds that Radix Astragali invigorating QI to consolidate the body surface resistance, benefiting QI for activating blood circulation can play the effect of tonify deficiency; But Stigma Croci blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, Herba Portulacae, Radix Isatidis, Herba Violae, Herba Hedyotidis Diffusae and Herba Scutellariae Barbatae have heat-clearing and toxic substances removing, removing heat from blood dampness removing, relieving sore throat and diminishing swelling; Agkistrodon is dispeled the wind, collateral dredging, relieving convulsion, rhizoma sparganic removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving, the circulation of qi promoting of Rhizoma Curcumae removing blood stasis, removing food stagnancy pain relieving, Radix Trichosanthis clearing away heat and promoting production of body fluid, detumescence and apocenosis.Therefore medicine of the present invention has tonify deficiency, detoxifcation, removing heat from blood, blood stasis dispelling, eliminating stagnation, analgesic effect.
The inventor of the application's case from 2002 so far, through the clinical practice in 6 years, by using Drug therapy 2000 many cases tumour patients of the present invention in Tumour Hospital, Guangxi Zhuang Nationality Autonomous District, effective percentage reached 73%, and does not have obvious toxic and side effects.
The specific embodiment
Used raw material in the present invention's prescription except that Stigma Croci, Radix Ginseng, all adopts common Chinese herbal medicine, and the medicine source is enriched, is easy to obtain.The attribute and the effect of herbal raw material of respectively distinguishing the flavor of in the prescription is as follows:
1. Agkistrodon: for Viperidae animal Agkistrodon or Elapidae animal Agkistrodon snakelet etc. is removed all of internal organs, latin name: 1. Agkistrodon Agkistrodon acutus (Gunther), 2. Agkistrodon Bungarus multicinctusBlyth.Meridian distribution of property and flavor: sweet, salty, temperature; Poisonous.Return Liver Channel.Function cures mainly: dispel the wind collateral dredging, relieving convulsion.Be used for rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
2. rhizoma sparganic: be the dry tuber of dicotyledon medicine Sparganiaceae plant rhizoma scirpi Common Burreed Rhizome, have the effect of removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving, cure mainly: it is swollen hard to control expand down painful, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer of lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body.
3, Rhizoma Curcumae: be Zingiberaceae (Zingiberaceae) plant Rhizoma Curcumae Curcuma aeruginosa Roxb. rhizome.Warm in nature, bitter in the mouth, suffering.But the removing blood stasis circulation of qi promoting, the removing food stagnancy pain relieving.Be used for abdominal pain due to blood stasis, hepatosplenomegaly, blood stasis amenorrhea, eating accumulation.
4, Stigma Croci: another name Stigma Croci, Stigma Croci are the chapiter of irides Stigma Croci Crocus sativus L..Nature and flavor are sweet, flat; GUIXIN, Liver Channel.But blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.Be used for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
5, Radix Ginseng: be the dry root and rhizome of araliad Panax ginseng C.A.Mey., stem, leaf and fruit also can be used as medicine.Sweet, the little hardship of nature and flavor, flat.Return spleen, lung, heart channel.But strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.
6, the Radix Astragali: the dry root that is leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge., it is a kind of traditional tonic medicine commonly used, beginning is stated from Shennong's Herbal, classify as top grade, " over sixty years of age, length also for the Li Mingzhen meaning.The Radix Astragali yellow skin is the length of tonic, so name ".The tool slightly warm in nature, sweet in the mouth has effects such as invigorating QI to consolidate the body surface resistance, benefiting QI for activating blood circulation, yang invigorating hidroschesis, inducing diuresis to remove edema, poison holding toxin expelling.
7, Herba Hedyotidis Diffusae: be the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae Hedyotis diffusa Willd..Bitter but sweet flavor, warm in nature, nontoxic.Go into the heart, liver, spleen three warps.Function with heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Cure mainly diseases such as malignant tumor, appendicitis, hepatitis, bronchitis, tonsillitis, laryngitis, urinary system infection, pelvic inflammatory disease, adnexitis; Furuncle carbuncle, venom are controlled in external.The clinical multiple cancers such as gastric cancer, the esophageal carcinoma, intestinal cancer, uterus carcinoma, nasopharyngeal carcinoma that are used for the treatment of of modern Chinese medicine.
8, Herba Scutellariae Barbatae: be the dry herb of labiate Herba Scutellariae Barbatae Scutellariae Barbata D.Don.Nature and flavor suffering, hardship, cold.Tight lung, liver, kidney channel.But heat-clearing and toxic substances removing, the blood stasis dispelling diuresis.Be used for furuncle swelling toxin, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, edema, jaundice.
9, Herba Portulacae: the dry aerial parts of portulacaceous plant Herba Portulacae Portulaca oleracea L..Have clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body is only quenched one's thirst, and controls the blindness nebula.Control the hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.
10, Radix Isatidis: be the dry root of cruciferae isatis Isatis indigotica Fort..Chemical constituent: contain sinigrin (sinigrin), indirubin, earthworm diindyl glycoside (indoxrylglucoside), BETA-sitosterol, adenosine (adenoside), Palmic acid and sucrose etc.Nature and flavor are cold in nature, bitter in the mouth.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.In epidemic febrile disease, a speckle, sore throat, erysipelas, carbuncle; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
11, Radix Trichosanthis: be the dry root of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms Trichosanthes rosthornii Harms.Sweet, the little hardship of nature and flavor is slightly cold.Attach to the lung and stomach meridians.Function: clearing away heat and promoting production of body fluid, detumescence and apocenosis.
12, Herba Violae: be the dry herb of dicotyledon medicine Violaceae Chinese violet Viola yedoensis Makino.Nature and flavor hardship, suffering, cold, GUIXIN, Liver Channel.Effect: heat-clearing and toxic substances removing, removing heat from blood detumescence.Be used to control the furuncle carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom etc.
The oral liquid formulations of medicine of the present invention is as follows by the required proportioning raw materials of every 1000ml:
Agkistrodon 50～100 grams, rhizoma sparganic 50～100 grams, Rhizoma Curcumae 50～100 grams, Stigma Croci 20 grams, Radix Ginseng 20～50 grams, the Radix Astragali 50～100 grams, Herba Hedyotidis Diffusae 80～100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 50～100 grams, Radix Trichosanthis 50～80 grams, Herba Violae 50～80 grams.
The preparation work step of medicine of the present invention is as follows:
Above-mentioned raw materials is mixed the ethanol 4000ml that the back adds concentration 50%～95% by proportioning, flooded 24～48 hours, filter, standby behind the filtrate recycling ethanol; The decocting that adds 5 times of medicinal residues weight in the medicinal residues boils 3 times, and each 1 hour, collecting decoction, filter, filtrate and above-mentioned standby filtrate merging are concentrated into relative density and are 1.10～1.14 clear paste under 50～70 ℃, the water mixing that adds 3 times of clear paste weight again, left standstill 24～48 hours, and got supernatant and filter, filtrate adds water to 1000ml, stir evenly, fill, sterilization promptly makes drug oral liquid formulation of the present invention.
The using method of medicine of the present invention: oral, a 20ml, three times on the one, the time spent shakes up, and 15 days is a course of treatment.No significant discomfort can continue second medication course of treatment.
Patient uses medicine of the present invention, can feel after the week that appetite increase, sleep improvement, pain relief, eliminating side effect of radiotherapy and chemotherapy to reduce.After medication course of treatment, 40% medication patient immune biochemical index is improved.
Embodiment 1:
Composition of raw materials: Agkistrodon 100 grams, rhizoma sparganic 50 grams, Rhizoma Curcumae 50 grams, Stigma Croci 20 grams, Radix Ginseng 20 grams, the Radix Astragali 50 grams, Herba Hedyotidis Diffusae 100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 50 grams, Radix Trichosanthis 50 grams, Herba Violae 50 grams.
Its preparation method carries out according to the following steps:
Said herbal medicine is mixed the back, and to add concentration be 75% ethanol 4000ml, and room temperature is dipping 36 hours down, filters, and is standby behind the filtrate recycling ethanol; The water (3000ml) that adds 5 times of medicinal residues weight in the medicinal residues decocts 3 times, and each 1 hour, collecting decoction, filter, filtrate and above-mentioned standby filtrate merging are concentrated into relative density and are 1.10 clear paste under 50 ℃, and then adding the water (600ml) of 3 times of clear paste weight, mixing left standstill 24 hours, getting supernatant filters, filtrate adds water to 1000ml again, stirs evenly fill, sterilize, promptly make the product of the present invention of oral liquid formulations.
Embodiment 2:
Composition of raw materials: Agkistrodon 100 grams, rhizoma sparganic 50 grams, Rhizoma Curcumae 50 grams, Stigma Croci 20 grams, Radix Ginseng 20 grams, the Radix Astragali 100 grams, Herba Hedyotidis Diffusae 100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 50 grams, Radix Trichosanthis 50 grams, Herba Violae 50 grams.
The step of its preparation method is identical with embodiment 1, is 95% but add concentration of ethanol; Dip time is 24 hours; Be that to be concentrated into relative density under 60 ℃ be 1.13 clear paste when concentrated; Time of repose is 36 hours.
Embodiment 3:
Composition of raw materials: Agkistrodon 100 grams, rhizoma sparganic 100 grams, Rhizoma Curcumae 100 grams, Stigma Croci 20 grams, Radix Ginseng 20 grams, the Radix Astragali 100 grams, Herba Hedyotidis Diffusae 90 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 100 grams, Radix Trichosanthis 50 grams, Herba Violae 50 grams.
The step of its preparation method is identical with embodiment 2.
Embodiment 4:
Composition of raw materials: Agkistrodon 100 grams, rhizoma sparganic 80 grams, Rhizoma Curcumae 80 grams, Stigma Croci 20 grams, Radix Ginseng 50 grams, the Radix Astragali 100 grams, Herba Hedyotidis Diffusae 80 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 80 grams, Radix Trichosanthis 80 grams, Herba Violae 50 grams.
The step of its preparation method is identical with embodiment 1, is 50% but add concentration of ethanol; Dip time is 48 hours; Be that to be concentrated into relative density under 70 ℃ be 1.14 clear paste when concentrated; Time of repose is 48 hours.
Embodiment 5:
Composition of raw materials: Agkistrodon 50 grams, rhizoma sparganic 50 grams, Rhizoma Curcumae 50 grams, Stigma Croci 20 grams, Radix Ginseng 30 grams, the Radix Astragali 80 grams, Herba Hedyotidis Diffusae 80 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 80 grams, Radix Trichosanthis 50 grams, Herba Violae 80 grams.
Its preparation method is identical with embodiment 4.
Embodiment 6:
Composition of raw materials: Agkistrodon 100 grams, rhizoma sparganic 100 grams, Rhizoma Curcumae 50 grams, Stigma Croci 20 grams, Radix Ginseng 20 grams, the Radix Astragali 100 grams, Herba Hedyotidis Diffusae 100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 60 grams, Radix Trichosanthis 60 grams, Herba Violae 60 grams.
Its preparation method is identical with embodiment 2.
Embodiment 7:
Composition of raw materials: Agkistrodon 80 grams, rhizoma sparganic 80 grams, Rhizoma Curcumae 50 grams, Stigma Croci 20 grams, Radix Ginseng 20 grams, the Radix Astragali 80 grams, Herba Hedyotidis Diffusae 100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 80 grams, Radix Trichosanthis 80 grams, Herba Violae 80 grams.
Its preparation method is identical with embodiment 2.
Below be the checking example of using product of the present invention:
1, beam * *, man, 46 years old, admission number 56845.On May 12nd, 2008, the patient was with multiple nodositas hepatocarcinoma, and the companion liver is intrinsic, omentum minus capsule ascites forms and is admitted to hospital.AFP checks that quantitative＞1000ng/ml.2008 cooperated systemic chemotherapy in my the row TACE of section art May 20, and scheme is: the first, first day cisplatin 60mg+ of eight days gemcitabine 1.4g+ liquid iodophor carburetion 20ml, post-operative recovery is good, does not tell uncomfortable liver area.During leaving hospital, use product of the present invention, every day 3 times, a 20ml returned hospital and checks on the the 3rd, 6 month always.Spirit since patient's private prosecution is left hospital, sleep, diet are good, and defecation is normal, and body weight does not have significant change.
2, Wu * *, man, 58 years old, admission number 57046.The patient went into me and institute goes to a doctor on May 30th, 2008, B ultrasonic, CT show leftlobe of liver occupying lesion (size 8 * 7cm), AFP checks positive, quantitative 1306.1ng/ml, be diagnosed as primary hepatocarcinoma, in the descending liver caudal lobe of general anesthesia on June 11 RESECTION OF LIVER CANCER in 2008, operation smoothly, postoperative pathology shows that (liver caudal lobe) hepatocarcinoma (beam rope, agglomerate, glandular tube type mix) part is clear cell carcinoma, and post-operative recovery is good.Postoperative check AFP218.28ng/ml, recovery from illness is left hospital.Be the control recurrence, the band product of the present invention of leaving hospital, oral, every day 3 times, a 20ml.Returned institute check AFP on August 7th, 2008, quantitative 14.38ng/ml looks into CT, B ultrasonic is not seen recurrence.Take product of the present invention over one year, every day 3 times, a 20ml always.Do not have obvious abdominal distention stomachache, do not have feel sick, vomiting, no fear of cold generate heat, spirit, diet, sleep are all normal, defecation is no abnormal, body weight does not have significant change.
3, not *, man, 29 years old, admission number 48620.The patient was admitted to hospital on July 10th, 2006 because of primary hepatocarcinoma, and B ultrasonic, CT show that (9.5 * 7.6cm), AFP checks that quantitatively 3620.7ng/ml performed the operation on July 16th, 2006 to occupying lesion of right lobe.Postoperative AFP checks, quantitative 1284.2ng/ml, and (medication: cisplatin 60mg+ epirubicin 60mg+ iodized oil 20ml), postoperative AFP97.9ng/ml left hospital in JIUYUE 5 in 2006 in the descending TACE art of local anaesthesia in hospital on August 25th, 2006.In on March 9th, 2007 once more the TACE art (medication: cisplatin 30mg+ epirubicin 30mg+ iodized oil 20ml), May 9 in 2007 checked for the third time, the injection of suggestion row anhydrous alcohol, refusal is treated on May 17th, 2007 and is left hospital.Check on June 8th, 2007 CT prompting little low-density kitchen range of right lobe of liver and no significant change before February give the PEI art three times, check AFP, quantitative 463.33ng/ml, consider that other hidden focus exist in the liver, the capable again TACE art of suggestion, refusal is treated on July 5th, 2007 and is left hospital.JIUYUE in 2007 was returned institutes' check on the 17th, and AFP checks, quantitative 1108.2ng/ml, but B ultrasonic, CT examination are not found clear and definite relapse and metastasis sign, suggestion row interventional therapy, and the patient disagrees with and left hospital in 22nd in JIUYUE in 2007.December returned institute's check once more on the 17th in 2007, and AFP, quantitative 1970ng/ml, B ultrasonic show 2 of the substantive occupy-places of leftlobe of liver, and blood is for abundant.The other substantive occupying lesion of right kidney, blood is for abundant, consider recurrence, in leftlobe of liver recurrent on the 8th hepatocarcinoma excision+upper right abdominal cavity secondary liver cancer excision+hepatic flexure of colon excision January in 2008, operation is smooth, postoperative pathology shows (lobus sinister) hepatocellular carcinoma, (colon) hepatocellular carcinoma is invaded the intestinal serous coat, and postoperative AFP checks, quantitative 214ng/ml, post-operative recovery is well left hospital.Give product antineoplaston of the present invention, oral, every day 3 times, a 20ml.Returned institute's check the 8th time on July 27th, 2009, do not have obvious abdominal distention stomachache at present, do not have feel sick, vomiting, no fear of cold generate heat, spirit, diet, sleep are all normal, defecation is no abnormal, body weight does not have significant change.
4, poplar * *, man, 42 years old, admission number 56227.The patient went into me and institute goes to a doctor on April 2nd, 2008, and B ultrasonic, CT show occupying lesion of right lobe (size 3.5 * 2.8cm), splenomegaly.AFP checks, quantitative 133ng/ml, be diagnosed as primary hepatocarcinoma, in the descending right lobe of liver hepatocarcinoma of general anesthesia on April 17 excision+incisxal edge release fluoride uracil implantation+splenectomy+gastric fundus vein disconnection in 2008, operation is smooth, and postoperative pathology shows hepatocarcinoma (Liang Suoxing), and the companion observes nodular cirrhosis,, chronic spleen congestion.Post-operative recovery is good.Postoperative AFP checks, quantitative 21.6ng/ml, and recovery from illness is left hospital.Be control recurrence, during leaving hospital, give product of the present invention, oral, every day 3 times, a 20ml, more than a year since no obvious abdominal distention stomachache, do not have feel sick, vomiting, no fear of cold generate heat, spirit, diet, sleep are all normal, defecation is no abnormal, body weight does not have significant change.
5, Lee * *, man, 54 years old, admission number 55116.The patient is because of upper abdominal pain repeatedly 3 years, increases the weight of to carry out " gastric cancer radical correction " because of " gastric cancer " in January, 2008 in 7 months, and postoperative pathology shows: (gastric antrum) do not break up or poorly differentiated adenocarcinoma, invades the coat of the stomach holostrome.Duodenum stump fistula appearred on the 10th day in postoperative.Postoperative serious bone marrow depression occurs with docetaxel+DDP+5-FU scheme chemotherapy (docetaxel 95mg/ days * 1 day, 5-fluorouracil 0.9g/ days * 5 days, cisplatin 90mg * 1 day) course of treatment, alleviates through symptomatic treatment.So far, give product of the present invention after leaving hospital, oral, every day 3 times, a 20ml.Came institute's treatment on April 7th, 2008, duodenum stump fistula is healed, and April 28 began to give JM-216+xeloda scheme chemotherapy, and process is smooth, leaves hospital afterwards.The Hui Yuanfu that follows the doctor's advice controls, and does not have over one year and feels sick, vomits, and does not have stomachache, diarrhoea, weight increase 2kg,
6, Wu * *, man, 34 years old, admission number 56137.Patient's private prosecution Upper abdominal pain repeatedly occurs in no inducement of beginning in March, 2007, there is not obvious alleviation from the clothes antacid, carry out gastroscopy in March, 2008; get the specimen pathologic finding and show: stomach angle ulcer (adenocarcinoma); on April 3rd, 08 because of " gastric cancer " at my institute's row radical operation for carcinoma of stomach, operation is smooth, and postoperative pathology shows: signet-ring cell carcinoma in the gastric mucosa.On April 17th, 2008 began to give FOLFOX4 scheme chemotherapy one-period (concrete dosage is: intravenous drip calcium folinate 400mg * 2 days+intravenous injection 5-fluorouracil 0.75g * 2 days, intravenous drip 1165mg * 2 day+intravenous drip JM-216 150mg * 2 days), process is smooth, leaves hospital afterwards.Give product of the present invention during leaving hospital, oral, every day 3 times, a 20ml.Do not have the acid regurgitation belch during this time, do not have to feel sick, vomiting, no hematemesis, melena and diarrhoea, no fear of cold generates heat, spiritual appetite still can, large and small just normal, body weight does not have and alleviates.
7, Zhu * *, man, 45 years old, admission number 56572.The patient because of stomach at the bottom of signet-ring cell carcinoma carried out 6 cycles of chemotherapy scheme respectively on 19th on May 28th, 2008, June 20, July 11, August 4, August 27, JIUYUE: paclitaxel 270mg+ cisplatin 110mg+5-fluorouracil 3.0g, do not see obvious toxicity.On August 26th, 2008 CT examination: more preceding obvious absorption behind the cardia signet ring cell cancer chemotherapy at the bottom of the stomach, dwindle, take a turn for the better.On October 23rd, 2008 rebuild at the descending total gastrectomy of general anesthesia, esophagus jejunum Roux-en-Y, and postoperative pathology shows: 1, (stomach swell thing) poorly differentiated adenocarcinoma.Signet-ring cell carcinoma is main, and cytopathy changes after meeting chemotherapy.Cancerous cell fills the air and soaks into the coat of the stomach holostrome.3 days capable paclitaxel 270mg+ cisplatin (first day 30mg, second and third day 40mg)+first, second and third day 5-fluorouracil 1g of postoperative November (7,8,9 days), in 1 cycle of chemotherapy, process is smooth.Give product of the present invention during leaving hospital, oral, every day 3 times, a 20ml.The institute of following the doctor's advice back checks chemotherapy, patient's spirit, sleep, appetite can, two is just normal, body weight does not have significant change.
Brief summary: above tumor cases, after treatments such as operation, chemicals, patient's spirit, sleep, appetite, gastrointestinal function, body weight etc. all are affected, and slight chronic cancer pain often takes place, thereby influence patients ' life quality.Product of the present invention improves patient's spirit, sleep, appetite, gastrointestinal function etc. by whole conditioning, has pain relieving simultaneously, improves the function that immunity, control and prolongation are recurred, and improves patients ' life quality etc., thereby obtains clinical efficacy.
Claims (1)
1. the medicine of an adjuvant therapy of tumors, it is characterized in that the required proportioning raw materials of medicine of every preparation 1000ml oral liquid formulations is: Agkistrodon 50～100 grams, rhizoma sparganic 50～100 grams, Rhizoma Curcumae 50～100 grams, Stigma Croci 20 grams, Radix Ginseng 20～50 grams, the Radix Astragali 50～100 grams, Herba Hedyotidis Diffusae 80～100 grams, Herba Scutellariae Barbatae 50 grams, Herba Portulacae 50 grams, Radix Isatidis 50～100 grams, Radix Trichosanthis 50～80 grams, Herba Violae 50～80 grams;
Preparation technology is:
Above-mentioned raw materials is mixed the ethanol 4000ml that the back adds concentration 50～95% by proportioning, flooded 24～48 hours, filter, standby behind the filtrate recycling ethanol; The decocting that adds 5 times of medicinal residues weight in the medicinal residues boils 3 times, and each 1 hour, collecting decoction, filter, filtrate and above-mentioned standby filtrate merging are concentrated into relative density and are 1.10～1.14 clear paste under 50～70 ℃, the water mixing that adds 3 times of clear paste weight again, left standstill 24～48 hours, and got supernatant and filter, filtrate adds water to 1000ml, stir evenly, fill, sterilization gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101144860A CN101693097B (en) | 2009-10-22 | 2009-10-22 | Medicament for adjuvant therapy of tumors and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101144860A CN101693097B (en) | 2009-10-22 | 2009-10-22 | Medicament for adjuvant therapy of tumors and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101693097A CN101693097A (en) | 2010-04-14 |
| CN101693097B true CN101693097B (en) | 2011-04-13 |
Family
ID=42092124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101144860A Expired - Fee Related CN101693097B (en) | 2009-10-22 | 2009-10-22 | Medicament for adjuvant therapy of tumors and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101693097B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041290B (en) * | 2012-11-29 | 2014-04-09 | 宁国市中医肿瘤医院 | Traditional Chinese medicine for treating lung cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1236626A (en) * | 1998-05-21 | 1999-12-01 | 赵清涛 | Medicinal capsule for suppressing tumour and its preparing process |
| CN1628826A (en) * | 2004-09-03 | 2005-06-22 | 曾隆江 | Medicine for treating cancer |
-
2009
- 2009-10-22 CN CN2009101144860A patent/CN101693097B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1236626A (en) * | 1998-05-21 | 1999-12-01 | 赵清涛 | Medicinal capsule for suppressing tumour and its preparing process |
| CN1628826A (en) * | 2004-09-03 | 2005-06-22 | 曾隆江 | Medicine for treating cancer |
Non-Patent Citations (1)
| Title |
|---|
| 谢裕安等.中药制剂消癌胶囊对恶性肿瘤T细胞亚群的影响.《广西中医学院学报》.2000,第17卷(第1期),10，20. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101693097A (en) | 2010-04-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103623388B (en) | A kind of Chinese medicine preparation for the treatment of chronic gastritis and preparation method thereof | |
| CN103041317B (en) | A kind of Chinese medicine composition for the treatment of tumor and preparation method thereof | |
| CN103536638A (en) | Medicament for treating gastrointestinal dysfunction and preparation method thereof | |
| CN103585514B (en) | A kind of be used for the treatment of gastric cancer Chinese medicine composition, application and preparation | |
| CN101085242B (en) | Traditional Chinese medicine composition for treating oral cavity ulcer | |
| CN104225441A (en) | Traditional Chinese medicine composition for treating stomach trouble and preparation method of granules and capsules of traditional Chinese medicine composition | |
| CN101693097B (en) | Medicament for adjuvant therapy of tumors and preparation method thereof | |
| CN104107393A (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis | |
| CN106266973A (en) | Stomach function regulating cuticula pain relieving soup | |
| CN104840730A (en) | Pure traditional Chinese medicine preparation for treating hepatitis and preparation method thereof | |
| CN103845673A (en) | Medicine for treating upper gastrointestinal hemorrhage and preparation method thereof | |
| CN104840864B (en) | A kind of Chinese medicine preparation for the treatment of infantile spleen deficiency type diarrhoea | |
| CN103301309B (en) | Traditional Chinese herbal medicine for treating laryngocarcinoma and esophagus cancer | |
| CN105770354A (en) | Medicament for treating chronic nephritis and preparation method thereof | |
| CN104940837A (en) | Traditional Chinese medicine for treating gall-stone | |
| CN105169199A (en) | Traditional Chinese medicinal composition for treating functional dyspepsia with syndrome of liver-stomach disharmony | |
| CN104491316A (en) | Traditional Chinese medicine preparation for treating middle-warmer energy insufficiency type prostate hyperplasia | |
| CN104815049A (en) | Compound preparation prepared from natural taurine for treating chronic liver diseases and preparation method thereof | |
| CN104958487A (en) | Traditional Chinese medicine for treating gastrointestinal ulcer | |
| CN104784649A (en) | Traditional Chinese medicine decoction for treating scapulohumeral periarthritis | |
| CN105434862A (en) | Spleen-and-stomach strengthening powder for resisting side effects of chemotherapy | |
| CN104491823A (en) | Traditional Chinese medicine electuary for treating dysmenorrheal and preparation method of traditional Chinese medicine electuary | |
| CN102671144B (en) | Traditional Chinese medicine oral fluid for curing ronic cholecystitis and preparation method thereof | |
| CN103977243A (en) | Medicine for treating refractory uremic pruritus and preparation method thereof | |
| CN108969596A (en) | A kind of instant particles as Chinese medicine and preparation method thereof for treating mouth week eczema |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110413 Termination date: 20161022 |