CN101984940A - Sac-covered esophagus scaffold capable of loading medicaments and preparation method thereof - Google Patents
Sac-covered esophagus scaffold capable of loading medicaments and preparation method thereof Download PDFInfo
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- CN101984940A CN101984940A CN 201010532866 CN201010532866A CN101984940A CN 101984940 A CN101984940 A CN 101984940A CN 201010532866 CN201010532866 CN 201010532866 CN 201010532866 A CN201010532866 A CN 201010532866A CN 101984940 A CN101984940 A CN 101984940A
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- corrugated tube
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Abstract
The invention discloses a sac-covered esophagus scaffold capable of loading medicaments. The esophagus scaffold consists of two parts, namely an inner supporting tube and a medicament sac, wherein the inner supporting tube is a corrugated tube; a positioning tube with a relatively big caliber is extended at each end of the corrugated tube; the corrugated tube between the two positioning tubes is an effective part; the length of the effective part is greater than that of a nidus position; an effective part of the medicament sac, which is a corrugated tube, and a layer of elastic material wrapped outside the effective part of the medicament sac are sealed to form a cavity; and a medicament feeding tube communicated with the medicament sac is fixed on the upper tube wall of the effective part of the corrugated tube. The invention has the advantages that: the scaffold has certain axial flexibility, which contributes to the placement of the scaffold; the scaffold has good radial strength and can keep a good passage at the same time; after being loaded with medicaments, the scaffold has better elasticity and flexibility and good adhesion, which can reduce damage of the scaffold to the nidus position and prevent the scaffold from being displaced; and the scaffold also can fulfill the aim of preventing and treating esophagus cancerous fistula, thereby relieving patient's pain.
Description
Technical field
The present invention relates to digestive system interventional therapeutic technique field, be specifically related to a kind of medicine-carried and cover capsule Esophageal Stent and preparation method thereof, improved the medical effectiveness of Esophageal Stent.
Background technology
Esophageal fistula come off by stress ulcer, anastomosis staple behind malignant tumor of esophagus and the operation on esophagus mostly and the radiotherapy of esophageal carcinoma ulcer after perforation of esophagus cause.Traditional esophagus overlay film frame is the main method of treatment esophageal fistula, and this type of overlay film frame only is after esophageal fistula forms, and in order to remove rapidly patient's symptom, rebuilds the diet passage and a kind of palliative therapy method of taking.But this type of coated esophagus support can not play the effect of prevention before esophageal fistula forms, and can not slow down the lasting deterioration of this complication after it is implanted effectively.Therefore, but a kind of drug loading of design cover the capsule Esophageal Stent, to improving the postoperative success rate, prolong the patient and have great importance life cycle.
Summary of the invention
But what the object of the present invention is to provide a kind of drug loading covers the capsule Esophageal Stent, to solve the problem that traditional Esophageal Stent does not have prevention and treatment esophageal fistula.Stay pipe was prepared from outward in this support was fixed on capsule by sealing ring, it is by interior stay pipe and capsule two-layer composite dimerous, wherein interior stay pipe can be made into bellows-like structure, when making this Esophageal Stent have good radial strength can to keep better channels, have certain axial bending again and be beneficial to the placement of support, and can in capsule, inject the medicine that prevents and treat esophageal fistula through check valve, when capsule was subjected to pathological tissues extruding (or because of being subjected to film self elastic pressure), medicine oozed out in the capsule and is absorbed by the body.Injecting medicine in capsule both can be before this support implant into body, also can be after this support implant into body, the injection of liquid medicine makes this support have better elasticity, pliability and good attaching, can reduce the damage of this support to diseased region, and can prevent that it is subjected to displacement.In addition, the invention provides the above-mentioned preparation method of covering the capsule Esophageal Stent, solved that traditional coated esophagus support can only block up fistula and the problem that can not prevent and treat improves the postoperative success rate thereby reach, prolong patient's purpose of life cycle.
Purpose of the present invention is achieved through the following technical solutions:
But a kind of drug loading cover the capsule Esophageal Stent, this Esophageal Stent is made up of interior stay pipe and medicine bag two parts, stay pipe is a corrugated tube in described, the corrugated tube two ends are respectively extended one and are had the positioning pipe of caliber greatly, corrugated tube between two positioning pipes is an effective site, and the length of effective site is greater than the length of diseased region; Described medicine bag is the cavity that one deck elastomeric material of the effective site of corrugated tube and its outer wrap is sealed to form, and a drug-feeding tube that communicates with medicine bag is fixed at the tube wall place in corrugated tube effective site upper end.Positioning pipe can play localized effect, prevents that this support is shifted, and all has a pair of groove in two-port simultaneously, is convenient to fixedly elastomeric material.
Preferably, described corrugated tube effective site is than the long 20～40mm of diseased region, be that the upper and lower mouth of support all exceeds narrow section (diseased region) 10～20mm, support specification length (corrugated tube total length) is respectively 60,80,100,120mm, the preferred interior diameter of this support corrugated tube is 14～20mm, overall diameter is 18～24mm, be according to length of lesion and position different, select the support of different size.Distance between adjacent two crests of corrugated tube is at 6～10mm.
Preferably, the length of described positioning pipe is 10mm, and the length of the effective site of corrugated tube is 40～100mm.
Preferably, the material of described corrugated tube is latex rubber, silica gel or plastics, and they all have higher intensity, can keep passage unimpeded preferably.
Preferably, described plastics are polyester plastics, polrvinyl chloride or politef.
Preferably, described elastomeric material is a semipermeable membrane.
Preferably, described semipermeable membrane is mixed cellulose ester, acetate fiber or removes greasy pericystium, casing, chicken stomach or duck crop, above-mentioned semipermeable membrane all has better elastic, pliability and intensity, supports in the pipeline in protection, also can reduce support diseased region is damaged; Can be according to the different choice of medicine different semipermeable membranes.
Preferably, described positioning pipe is profile or a straight-tube shape at the bottom of interior receipts rim of a cup shape, toroidal, hemispherical, the rim of a cup ball.
Before the injection, elastomeric material is not attached to corrugated tube, behind the injection medicine, can make this stent diameter increase by 2～4mm, but it can not influence interior stay pipe diameter.Medicine in this esophagus capsule can inject before implant into body, also can inject after implant into body.
The preparation method of above-mentioned Esophageal Stent comprises the steps:
(1) preparation of interior stay pipe: at first, process the corrugated tube that two ends have positioning pipe, and respectively process a pair of groove in the junction of two positioning pipes and corrugated tube effective site, at drug-feeding tube of corrugated tube effective site upper end tube wall place processing, promptly make interior stay pipe then.
(2) preparation of medicine bag: by sealing ring with an elastomeric material (can be processed with ripple on it) sealing and fixing in the groove at corrugated tube two ends, form the medicine bag of a sealing between elastomeric material and the corrugated tube, but promptly make drug loading cover the capsule Esophageal Stent.
The present invention has following advantage and beneficial effect with respect to prior art:
(1) interior stay pipe is made bellows-like structure, make this support have the placement that certain axial bending is beneficial to support, simultaneously have good radial strength again and can keep good passage, after the drug loading, this support has better elasticity, pliability and good attaching, can reduce of the damage of this support, and can prevent that it is subjected to displacement diseased region.
(2) Esophageal Stent of the present invention can block up fistula and can prevent and treat again, utilize the fast characteristics of diseased region tumor tissue growth (or because of being subjected to film self elastic pressure), make its extruding Esophageal Stent, medicine is oozed out in the capsule to be discharged in the human body gradually, reach the purpose of prevention and treatment esophageal fistula, thereby alleviate patient's misery.
Description of drawings
Fig. 1 is the structural representation of the Esophageal Stent of the embodiment of the invention 1.
Fig. 2 is the A-A profile of Fig. 1.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further concrete detailed description the in detail, but embodiments of the present invention are not limited thereto, the technological parameter for not indicating especially can carry out with reference to routine techniques.
Embodiment 1
But a kind of drug loading cover the capsule Esophageal Stent, form by interior stay pipe 1 and medicine bag 2 two parts, adopting polrvinyl chloride (PVC) be the material of interior stay pipe 1, described in stay pipe 1 be bellows-like structure, between the two adjacent wave peaks apart from being about 8.5mm.Stent length specification (corrugated tube total length) is 80mm, the corrugated tube upper end is a straight-tube shape positioning pipe 4 for bell mouth shape positioning pipe 3, lower end, each long 10mm of two positioning pipes, the inside and outside diameter of last horn mouth 3 maximums is respectively 20,22mm, lower end straight tube 4 inside and outside diameters are respectively 18,20mm, be 60mm for corrugated tube effective site length in the middle of two positioning pipes, this place inside and outside diameter of corrugated tube maximum is respectively 16,20mm.The junction of two positioning pipes and corrugated tube effective site respectively is provided with a pair of groove 5, with sealing ring 6 will be that the semipermeable membrane of material is fixed between the groove at corrugated tube two ends and forms medicine bag 2 with casing (top oils and fats is removed in processing), at unidirectional drug-feeding tube 7 of corrugated tube effective site upper end tube wall place fixed installation, drug-feeding tube 7 communicates with medicine bag 2, before this support implant into body, in medicine bag 2, inject medicine by drug-feeding tube 7, this moment, overlay film place diameter can reach 22mm, when selecting this support for use, should make the upper and lower mouth of support all exceed narrow section (or diseased region) 10～20mm.Under X line perspective or insert under the gastroscope or two kinds of methods in conjunction with inserting.
But a kind of drug loading cover the capsule Esophageal Stent, be dimerous by interior stay pipe 1 and medicine bag 2, adopting polytetrafluoroethylene (PTFE) is the material of interior stay pipe 1, described in stay pipe 1 be bellows-like structure, between the two adjacent wave peaks apart from being about 8mm.Stent length specification (corrugated tube total length) is 100mm, the corrugated tube upper end is a bell mouth shape positioning pipe 3, the lower end is a straight-tube shape positioning pipe 4, each long 10mm of two positioning pipes, in last horn mouth 3 maximums, overall diameter is respectively 18,20mm, in the straight tube 4 in lower end, overall diameter is respectively 16,18mm, be that corrugated tube effective site length is 80mm in the middle of two positioning pipes, the imperial palace of this place's corrugated tube, overall diameter is respectively 14,18mm is (in the middle of this pipe with the identical 1mm that is of wall thickness at two ends, this place's corrugated tube maximum outside diameter comprises wall thickness, do not comprise wall thickness with minimum diameter, and be again undulatory, so differ 4mm).The junction of two positioning pipes and corrugated tube effective site respectively is provided with a pair of groove 5, with sealing ring 6 will be that the semipermeable membrane of material is fixed between the groove at corrugated tube two ends and forms medicine bag 2 with pericystium (top oils and fats is removed in processing), at unidirectional drug-feeding tube 7 of corrugated tube effective site upper end tube wall place fixed installation, drug-feeding tube 7 communicates with medicine bag 2.When selecting this support for use, should make the upper and lower mouth of support all exceed narrow section (or diseased region) 10～20mm.Under X line perspective or insert under the gastroscope or two kinds of methods in conjunction with inserting, under instrument monitors, in medicine bag 2, inject medicine then through drug-feeding tube 7, diameter can reach 20mm herein under the state that normally is not squeezed.
But a kind of drug loading cover the capsule Esophageal Stent, be dimerous by interior stay pipe 1 and medicine bag 2, adopting silica gel is the material of interior stay pipe 1, described in stay pipe 1 be bellows-like structure, between the two adjacent wave peaks apart from being about 10mm.Stent length specification (corrugated tube total length) is 120mm, the corrugated tube upper end is a straight-tube shape positioning pipe 4 for bell mouth shape positioning pipe 3, lower end, each long 10mm of two positioning pipes, the inside and outside diameter of last horn mouth 3 maximums is respectively 22,24mm, lower end straight tube 4 inside and outside diameters are respectively 20,22mm, be 100mm for corrugated tube effective site length in the middle of two positioning pipes, this place inside and outside diameter of corrugated tube maximum is respectively 18,22mm.The joining place of two positioning pipes and corrugated tube effective site respectively is provided with a pair of groove 5, with sealing ring 6 will be that the semipermeable membrane of material is fixed between the groove at corrugated tube two ends and forms medicine bag 2 with duck crop (top oils and fats is removed in processing), at unidirectional drug-feeding tube 7 of corrugated tube effective site upper end tube wall place fixed installation, drug-feeding tube 7 communicates with medicine bag 2.When selecting this support for use, should make the upper and lower mouth of support all exceed narrow section 10～20mm.Under X line perspective or insert under the gastroscope or two kinds of methods in conjunction with inserting, under instrument monitors, in medicine bag 2, inject medicine then through drug-feeding tube 7, diameter can reach 24mm herein under the state that normally is not squeezed.
But a kind of drug loading cover the capsule Esophageal Stent, be dimerous by interior stay pipe 1 and medicine bag 2, adopting latex rubber is the material of interior stay pipe 1, described in stay pipe 1 be bellows-like structure, between the two adjacent wave peaks apart from being about 7mm.The stent length specification is 90mm, the corrugated tube upper end is a straight-tube shape positioning pipe 4 for bell mouth shape positioning pipe 3, lower end, each long 10mm of two positioning pipes, the inside and outside diameter of last horn mouth 3 maximums is respectively 22,24mm, lower end straight tube 4 inside and outside diameters are respectively 20,22mm, be 70mm for corrugated tube effective site length in the middle of two positioning pipes, this place inside and outside diameter of corrugated tube maximum is respectively 18,22mm.The junction of two positioning pipes and corrugated tube effective site respectively is provided with a pair of groove 5, with sealing ring 6 will be that the semipermeable membrane of material is fixed between the groove at corrugated tube two ends and forms medicine bag with the acetate fiber, at unidirectional drug-feeding tube 7 of corrugated tube effective site upper end tube wall place fixed installation, drug-feeding tube 7 communicates with medicine bag 2, before this support implant into body, in medicine bag 2, inject medicine through drug-feeding tube 7, this moment, overlay film place diameter can reach 24mm, when selecting this support for use, should make the upper and lower mouth of support all exceed narrow section (or diseased region) 10～20mm.Under X line perspective or insert under the gastroscope or two kinds of methods in conjunction with inserting.
But a kind of drug loading cover the capsule Esophageal Stent, be dimerous by interior stay pipe 1 and medicine bag 2, adopting polyester plastics is the material of interior stay pipe 1, described in stay pipe 1 be bellows-like structure, between the two adjacent wave peaks apart from being about 6.6mm.The stent length specification is 60mm, the corrugated tube upper end is a straight-tube shape positioning pipe 4 for bell mouth shape positioning pipe 3, lower end, each long 10mm of two positioning pipes, the inside and outside diameter of last horn mouth 3 maximums is respectively 20,22mm, lower end straight tube 4 inside and outside diameters are respectively 18,20mm, be 40mm for corrugated tube effective site length in the middle of two positioning pipes, this place inside and outside diameter of corrugated tube maximum is respectively 16,20mm.The junction of two positioning pipes and corrugated tube effective site respectively is provided with a pair of groove 5, with sealing ring 6 will be that the semipermeable membrane of material is fixed between the groove at corrugated tube two ends and forms medicine bag 2 with the mixed cellulose ester, at unidirectional drug-feeding tube 7 of corrugated tube effective site upper end tube wall place fixed installation, drug-feeding tube 7 communicates with medicine bag 2, when selecting this support for use, should make the upper and lower mouth of support all exceed narrow section (or diseased region) 10～20mm.Under X line perspective or insert under the gastroscope or two kinds of methods in conjunction with inserting, under instrument monitors, in medicine bag 2, inject medicine then through drug-feeding tube 7, diameter should reach 22mm herein under the state that normally is not squeezed.
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (10)
1. but a drug loading covers the capsule Esophageal Stent, it is characterized in that, this Esophageal Stent is made up of interior stay pipe and medicine bag two parts, stay pipe is a corrugated tube in described, the corrugated tube two ends are respectively extended one and are had the positioning pipe of caliber greatly, corrugated tube between two positioning pipes is an effective site, and the length of effective site is greater than the length of diseased region; Described medicine bag is the cavity that one deck elastomeric material of the effective site of corrugated tube and its outer wrap is sealed to form, and a drug-feeding tube that communicates with medicine bag is fixed at the tube wall place in corrugated tube effective site upper end.
2. Esophageal Stent according to claim 1 and 2 is characterized in that, described corrugated tube effective site is than the long 20～40mm of diseased region, and the distance between adjacent two crests is at 6～10mm.
3. Esophageal Stent according to claim 2 is characterized in that, the interior diameter of described corrugated tube is 14～20mm, and overall diameter is 18～24mm.
4. Esophageal Stent according to claim 1 is characterized in that, the length of described positioning pipe is 10mm, and the length of the effective site of corrugated tube is 40～100mm.
5. Esophageal Stent according to claim 3 is characterized in that, the material of described corrugated tube is latex rubber, silica gel or plastics.
6. Esophageal Stent according to claim 5 is characterized in that, described plastics are polyester plastics, polrvinyl chloride or politef.
7. Esophageal Stent according to claim 1 is characterized in that, described elastomeric material is a semipermeable membrane.
8. Esophageal Stent according to claim 7 is characterized in that, described semipermeable membrane is mixed cellulose ester, acetate fiber or removes greasy pericystium, casing, chicken stomach or duck crop.
9. according to claim 1 or 4 described Esophageal Stents, it is characterized in that described positioning pipe is profile or a straight-tube shape at the bottom of interior receipts rim of a cup shape, toroidal, hemispherical, the rim of a cup ball.
10. according to the preparation method of any described Esophageal Stent of claim 1～9, it is characterized in that, comprise the steps:
(1) preparation of interior stay pipe: at first, process the corrugated tube that two ends have positioning pipe, and respectively establish a pair of groove in the junction of two positioning pipes and corrugated tube effective site, at drug-feeding tube of corrugated tube effective site upper end tube wall place processing, promptly make interior stay pipe then.
(2) preparation of medicine bag: by sealing ring with an elastomeric material sealing and fixing in the groove at corrugated tube two ends, form the medicine bag of a sealing between elastomeric material and the corrugated tube, but promptly make drug loading cover the capsule Esophageal Stent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010532866 CN101984940A (en) | 2010-11-03 | 2010-11-03 | Sac-covered esophagus scaffold capable of loading medicaments and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010532866 CN101984940A (en) | 2010-11-03 | 2010-11-03 | Sac-covered esophagus scaffold capable of loading medicaments and preparation method thereof |
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| CN101984940A true CN101984940A (en) | 2011-03-16 |
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| CN 201010532866 Pending CN101984940A (en) | 2010-11-03 | 2010-11-03 | Sac-covered esophagus scaffold capable of loading medicaments and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429751A (en) * | 2011-09-15 | 2012-05-02 | 中国人民解放军第三军医大学第一附属医院 | Medical cavity stent with medicament storage cavity |
| CN103330607A (en) * | 2013-06-27 | 2013-10-02 | 河南科技大学 | Self-retracting intraesophageal bracket capable of carrying radiation elements for partial radiotherapy |
| CN103340706A (en) * | 2013-06-27 | 2013-10-09 | 河南科技大学 | Self-stretching intra-esophageal stent capable of carrying local chemotherapy drugs |
| CN109998744A (en) * | 2019-04-08 | 2019-07-12 | 吉林大学中日联谊医院 | A kind of titanium alloy medicament-release blood vessel stent |
| CN110167491A (en) * | 2016-11-09 | 2019-08-23 | 波士顿科学国际有限公司 | Bracket with displacement capacity |
| CN110186922A (en) * | 2019-06-25 | 2019-08-30 | 西安交通大学医学院第一附属医院 | A kind of experimental provision and method monitoring colon Migtating motor complex |
| CN113303945A (en) * | 2021-07-13 | 2021-08-27 | 上海市东方医院（同济大学附属东方医院） | Esophagus support device with drug loading and shaping functions |
| CN109172073B (en) * | 2018-09-03 | 2023-11-21 | 上海市第一人民医院 | Electrostatic spinning nanofiber membrane for controlling release of growth factors and esophageal tectorial membrane memory stent |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429751A (en) * | 2011-09-15 | 2012-05-02 | 中国人民解放军第三军医大学第一附属医院 | Medical cavity stent with medicament storage cavity |
| CN102429751B (en) * | 2011-09-15 | 2014-02-26 | 中国人民解放军第三军医大学第一附属医院 | Medical cavity stent with medicament storage cavity |
| CN103330607A (en) * | 2013-06-27 | 2013-10-02 | 河南科技大学 | Self-retracting intraesophageal bracket capable of carrying radiation elements for partial radiotherapy |
| CN103340706A (en) * | 2013-06-27 | 2013-10-09 | 河南科技大学 | Self-stretching intra-esophageal stent capable of carrying local chemotherapy drugs |
| CN103330607B (en) * | 2013-06-27 | 2015-07-01 | 河南科技大学 | Self-retracting intraesophageal bracket capable of carrying radiation elements for partial radiotherapy |
| CN110167491A (en) * | 2016-11-09 | 2019-08-23 | 波士顿科学国际有限公司 | Bracket with displacement capacity |
| CN109172073B (en) * | 2018-09-03 | 2023-11-21 | 上海市第一人民医院 | Electrostatic spinning nanofiber membrane for controlling release of growth factors and esophageal tectorial membrane memory stent |
| CN109998744A (en) * | 2019-04-08 | 2019-07-12 | 吉林大学中日联谊医院 | A kind of titanium alloy medicament-release blood vessel stent |
| CN110186922A (en) * | 2019-06-25 | 2019-08-30 | 西安交通大学医学院第一附属医院 | A kind of experimental provision and method monitoring colon Migtating motor complex |
| CN110186922B (en) * | 2019-06-25 | 2021-07-23 | 西安交通大学医学院第一附属医院 | Experimental device and method for monitoring colon transitional compound movement |
| CN113303945A (en) * | 2021-07-13 | 2021-08-27 | 上海市东方医院（同济大学附属东方医院） | Esophagus support device with drug loading and shaping functions |
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Application publication date: 20110316 |