CN102824198B - One can/directly paste blood vessel covered - Google Patents
One can/directly paste blood vessel covered Download PDFInfo
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- CN102824198B CN102824198B CN201110157160.3A CN201110157160A CN102824198B CN 102824198 B CN102824198 B CN 102824198B CN 201110157160 A CN201110157160 A CN 201110157160A CN 102824198 B CN102824198 B CN 102824198B
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- blood vessel
- directly paste
- vessel covered
- covered
- overlay film
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Abstract
The invention provides one can/directly paste blood vessel covered, described artificial blood vessel's overlay film surface-coated has adhesiveness embolism materials and poly-N-isopropyl acrylamide to be mixed to receive-----rice gel to be coated with <i>---</iGreatT. GreaT.GT layer.Described can/directly paste the liquid adhesive embolism materials release that blood vessel covered receiving-----rice gel is coated with in <i>---</iGreatT. GreaT.GT layer after, artificial blood vessel's overlay film and tunica intima are held tightly together, and the aneurysm of shutoff simultaneously, aneurysm and blood flow are completely cut off.Provided by the invention can/directly paste blood vessel covered perform the operation use time, simple to operate, cheap, safe and reliable, be applicable to the pathological changes such as intracranial aneurysm, carotid-cavernous fistula, arteriovenous fistula, breast and abdominal aortic aneurysm, very large function can be played at medical domain.
Description
Technical field
The present invention relates to one can/directly paste overlay film and preparation method thereof, and comprise the foley's tube that carrying directly can paste overlay film.Relate to specifically a kind of be used for the treatment of the pathological changes pipes such as intracranial aneurysm, carotid-cavernous fistula, arteriovenous fistula, peripheral arterial tumor, breast and abdominal aortic aneurysm, tracheal fistula, esophageal fistula and biliary tract fistula directly can paste overlay film.
Background technology
Along with the development of guided Interventional Technique, the application of overlay film frame in blood vessel or non-vascular disease is increasingly extensive, is placed to the place such as human body artery tumor or fistula mouth, can rapidly shutoff aneurysm or fistula, aneurysm or fistula are disappeared, thus reaches anatomy healing aneurysm or fistula.And along with the progress of overlay film frame manufacturing process, overlay film frame used also constantly develops, and is improved, and makes it more convenient in the application, to reach better therapeutic effect.
The overlay film frame of current use mostly is metal film coated support, is divided into the metal film coated support of balloon-expandable and the metal film coated support of self-expansion type.The metal film coated support of balloon-expandable is made up of internal metal rack, sacculus and artificial overlay film, and the metal film coated support of self-expansion type is made up of self-inflated internal metal rack and artificial overlay film.Because internal metal rack mostly is precious metal, and manufacturing process is complicated, and therefore metal film coated support is expensive.And metal film coated support insert human body after can produce the complication such as endothelialization delay, restenosis.Therefore look for that a kind of cheap, processing technology is simple and the product can curing the diseases such as intracranial aneurysm seems particularly important, simultaneously also to technical development and the progressive meaning having this important in this field.
Summary of the invention
The invention provides a kind of can/directly paste blood vessel covered and it preparation method and a kind ofly comprise this kind of blood vessel covered foley's tube, can be used for Ink vessel transfusing and also can be used in non-vascular.The present invention utilizes the characteristic of temperature sensitivity nanogel, makes even application after containing nano-gel microspheres can directly paste blood vessel covered at the outer surface structure of artificial blood vessel's overlay film when low temperature.
The invention provides one can/directly paste blood vessel covered, comprise artificial blood vessel's overlay film, it is characterized in that, described artificial blood vessel's overlay film surface-coated has embolism materials and poly-N-isopropyl acrylamide to be mixed and made into nanogel coating.
In above-mentioned overlay film, described gel layer is made up of nano-gel microspheres.
Present invention also offers above-mentioned can/directly paste blood vessel covered manufacture method, comprise the following steps:
Step 1, prepares poly-N-isopropyl acrylamide;
Step 2, is mixed and made into nano-gel microspheres by liquid embolic material and described poly-N-isopropyl acrylamide;
Step 3, is evenly coated in the outer surface of artificial blood vessel's overlay film and makes it dry by described nano-gel microspheres.
In above-mentioned overlay film and preparation method thereof, described embolism materials is liquid adhesive embolism materials.
In above-mentioned overlay film and preparation method thereof, described adhesiveness embolism materials can be the compound of 2-methyl styrene base-isobutyl alpha-cyanoacrylate glue, isobutyl alpha-cyanoacrylate etc. containing isobutyl alpha-cyanoacrylate structure.
In the preparation method of above-mentioned overlay film, operative temperature when being mixed with described poly-N-isopropyl acrylamide by liquid embolic material in step 2 is 10-30 DEG C.
Present invention also offers one and can directly paste blood vessel covered system, described foley's tube comprises sacculus and conduit, concrete, and the outside of described sacculus wraps above-mentioned can directly paste blood vessel covered, and balloon tip is connected with conduit.
One of the present invention can/directly paste blood vessel covered, advantage is:
1) provided by the present invention can/the nanogel coating of directly pasting blood vessel covered outer surface has the characteristic of pyrocondensation cold expanding, when a little more than human body temperature, nanogel coating shrinkage, liquid adhesive embolism materials is discharged, then artificial blood vessel's overlay film and tunica intima are held tightly together, and the aneurysm of shutoff simultaneously, aneurysm and blood flow are completely cut off, simplifies the operation course.
2) provided by the present invention can/directly paste blood vessel covered perform the operation use time, simple to operate and cheap.
3) provided by the present invention can/directly paste blood vessel coveredly to carry out in operation, in the daily life of postoperative rehabilitation and sufferer, all very safe, reliable.
4) provided by the present invention can/directly paste and blood vessel covered there is very large application surface, removing is applicable to outside intracranial aneurysm, is also applicable to the pathological changes such as carotid-cavernous fistula, arteriovenous fistula, breast and abdominal aortic aneurysm.
To sum up, the present invention a kind of can/directly paste that blood vessel covered preparation method provides can/directly paste and blood vessel covered there is simple to operate, cheap, safe characteristic, very large function can be played at medical domain.
Accompanying drawing explanation
Fig. 1 be the present invention carry can/directly paste the structural representation of blood vessel covered foley's tube;
Fig. 2 be the present invention can/directly paste and blood vessel coveredly deliver to target vessel place and cover the structural representation at aneurysm mouth place;
Fig. 3 be the present invention can/directly to paste blood vessel covered stay Ink vessel transfusing and shutoff aneurysm time structural representation.
Detailed description of the invention
Disclosed in this invention be a kind of can/directly paste blood vessel covered and it preparation method and a kind ofly comprise this kind of blood vessel covered therapy system.Based on NIPA (NIPAM) monomer, synthesis poly-N-isopropyl acrylamide (PNIPAM).Subsequently, when low temperature (10-30 DEG C), the embolism materials such as 2-methyl styrene base-isobutyl alpha-cyanoacrylate glue (Glubran glue) are joined in PNIPAM, form nano-gel microspheres, then be coated in the outer surface of artificial blood vessel's overlay film equably, just construct after drying of the present invention can directly paste blood vessel covered.
Below by specific embodiment, to the present invention can/directly paste and blood vessel coveredly carry out detailed and concrete introduction, to make better to understand the present invention, but following specific embodiment does not limit the scope of the invention.
Embodiment 1
Step 1, gets NIPAM monomer polymerization and becomes nanoscale PNIPAM gel;
Step 2, under the condition of 15 DEG C, joins in PNIPAM by Glubran glue, forms the nano-gel microspheres containing Glubran glue;
Step 3, is then coated in the outer surface of artificial blood vessel's overlay film equably by the nano-gel microspheres of gained, after dry, structure obtains containing can directly pasting of Glubran gel coating blood vessel covered.
Gained can/directly paste blood vessel covered, reliable in quality, there is not flaw in blood vessel covered surface.
Wherein, 2-methyl styrene base-isobutyl alpha-cyanoacrylate (the Glubran glue adopted in the present embodiment, NBCA-MS) namely Italian glue is a kind of liquid adhesive embolism materials produced by Italian GEM company, that increase 2-methyl styrene forms on the basis of conventional classical embolism materials isobutyl alpha-cyanoacrylate (NBCA), comparing its major advantage with NBCA is that polymerization time is extended to 60-90s by original 15-40s, for fully, even dispersion thromboembolism brain AVMs provides valuable time window, thus the risk that the microtubular that in the past causes due to thromboembolism glue premature polymerization can not extract can be avoided.
Embodiment 2
Step 1, gets NIPAM monomer polymerization and becomes nanoscale PNIPAM gel;
Step 2, under the condition of 15 DEG C, joins in PNIPAM by isobutyl alpha-cyanoacrylate, forms the nano-gel microspheres containing isobutyl alpha-cyanoacrylate;
Step 3, is then coated in the outer surface of artificial blood vessel's overlay film equably by the nano-gel microspheres of gained, after dry, structure obtains containing can directly pasting of isobutyl alpha-cyanoacrylate coating blood vessel covered.
Gained can/directly paste blood vessel covered, reliable in quality, there is not flaw in blood vessel covered surface.
When preparation can directly be pasted blood vessel covered, under 10 DEG C, 15 DEG C, 25 DEG C equitemperatures, adopt other compounds containing isobutyl alpha-cyanoacrylate structure to prepare nano-gel microspheres as embolism materials and other conditions are constant when, it is same that to obtain can directly pasting of reliable in quality blood vessel covered.Illustrate the present invention can directly paste blood vessel covered preparation method can effectively prepare described can directly paste blood vessel covered.
The present invention is blood vessel covered is used for the treatment of the pathological changes such as intracranial aneurysm, carotid-cavernous fistula, arteriovenous fistula, breast and abdominal aortic aneurysm in actual applications, we are to treat carotid aneurysm model and by reference to the accompanying drawings, to explain effectiveness and the practicality of the overlay film proving gained of the present invention.
Can/directly paste blood vessel covered treatment carotid aneurysm model embodiment in, removing use gained of the present invention can directly paste blood vessel covered outside, also use sacculus.Described sacculus can be made up of two cavitys: guidewire lumen and fluid injection chamber, whole foley's tube is divided into catheter proximal end, catheter body and distal end of catheter.Catheter proximal end is connecting device, and it has injection port, can connect syringe.Distal end of catheter be provided with described can directly paste blood vessel covered.The inner chamber of conduit is guidewire lumen, and be the passage that seal wire is come in and gone out, far-end is the inlet port of seal wire, and near-end is the outlet of seal wire; The outer wall of distal end of catheter has the aperture that distal end of catheter fluid injection chamber is communicated with sacculus.The tube wall being positioned at the wire leading pipe at hollow sacculus position is embedded with gauge point.
First, say that the method preparation provided is blood vessel covered containing can directly pasting of Glubran gel coating according to the present invention, used blood vessel covered be conventional medical blood vessel overlay film in medical procedure.
As shown in Figure 1, the nano-gel microspheres containing Glubran glue directly can be pasted blood vessel covered 1 and be compressed on sacculus 2, sacculus 2 is connected with conduit 3.
As shown in Figure 2, while lasting brine ice washing pipe, the blood vessel covered system that blood vessel covered 1, sacculus 2 and conduit 3 form to be delivered in target vessel 4 and to cover the position of aneurysm 5.Then in sacculus 2, inject the warm water (about 40 DEG C) containing contrast agent by conduit 3, make its Filled Balloon 2, strut blood vessel covered.
In Fig. 3, about 10, can/directly paste blood vessel covered reach Human Physiology temperature after, Glubran glue is released, and rapidly by target vessel and to be blood vessel coveredly bonded together, after withdrawing from the sacculus 2 in Fig. 2, blood vessel covered 1 just stays target vessel 4 interior also shutoff aneurysm 5, reaches the object of curing carotid aneurysm.
Adopt provided by the invention can/directly paste blood vessel covered treat shutoff as other pathological changes such as arteriovenous fistula, peripheral arterial tumor, breast and abdominal aortic aneurysms time, obtain good curative effect equally, reach the success of cure diseases.
Known by above-mentioned experiment, the present invention a kind of can/directly paste blood vessel covered method and can effectively cure the pathological changes such as intracranial aneurysm, carotid-cavernous fistula, arteriovenous fistula, breast and abdominal aortic aneurysm, and simple to operate in implementation process of performing the operation, and low cost, method is also safe and reliable.In clinical medicine, gather around and hold out broad prospects.Meanwhile, also greatly will accelerate this field medical advance, there is important scientific meaning and practical value.
Be described in detail specific embodiments of the invention above, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, equalization conversion done without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (5)
1. can directly paste blood vessel covered for one kind, comprise artificial blood vessel's overlay film, it is characterized in that, described artificial blood vessel's overlay film surface-coated has embolism materials and poly-N-isopropyl acrylamide to be mixed and made into nanogel coating, described embolism materials is liquid adhesive embolism materials, and operative temperature when described liquid adhesive embolism materials mixes with described poly-N-isopropyl acrylamide is 10-30 DEG C.
2. according to claim 1ly can directly paste blood vessel covered, it is characterized in that, described gel coat is made up of nano-gel microspheres.
3. according to claim 1 can directly paste blood vessel covered, it is characterized in that, described adhesiveness embolism materials is 2-methyl styrene base-isobutyl alpha-cyanoacrylate glue, isobutyl alpha-cyanoacrylate and other contain the compound of isobutyl alpha-cyanoacrylate structure.
4. can directly paste a blood vessel covered preparation method, it is characterized in that, step is as follows:
Step 1, prepares poly-N-isopropyl acrylamide;
Step 2, is mixed and made into nano-gel microspheres by liquid adhesive embolism materials and described poly-N-isopropyl acrylamide;
Step 3, is evenly coated in the outer surface of artificial blood vessel's overlay film and makes it dry by described nano-gel microspheres;
Wherein, operative temperature when described liquid adhesive embolism materials mixes with described poly-N-isopropyl acrylamide is 10-30 DEG C.
5. carrying can directly paste a blood vessel covered foley's tube, comprises sacculus and conduit, it is characterized in that, the outside of described sacculus wraps has the right can directly paste blood vessel covered described in requirement 1, and balloon tip is connected with conduit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110157160.3A CN102824198B (en) | 2011-06-13 | 2011-06-13 | One can/directly paste blood vessel covered |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110157160.3A CN102824198B (en) | 2011-06-13 | 2011-06-13 | One can/directly paste blood vessel covered |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102824198A CN102824198A (en) | 2012-12-19 |
| CN102824198B true CN102824198B (en) | 2016-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110157160.3A Expired - Fee Related CN102824198B (en) | 2011-06-13 | 2011-06-13 | One can/directly paste blood vessel covered |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2857350A1 (en) * | 2013-09-10 | 2015-04-08 | ESPCI Innov | Use of nanoparticles for gluing gels |
| CN105498074B (en) * | 2015-12-25 | 2017-08-08 | 李雷 | vascular wall repair system |
| CN108601930B (en) * | 2016-02-08 | 2021-12-14 | 祥丰医疗私人有限公司 | Drug eluting balloon |
| US10792477B2 (en) | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
| CN109925018B (en) * | 2019-01-30 | 2021-03-23 | 张韬 | Serial plugging chain segment for intratumoral embolism and aneurysm plugging system adopting same |
| CN110934661B (en) * | 2019-11-27 | 2023-01-03 | 张海军 | Degradable patch for treating aneurysm and conveying method thereof |
| CN114712034A (en) * | 2021-01-05 | 2022-07-08 | 上海微创心脉医疗科技(集团)股份有限公司 | Covered stent |
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| US6827735B2 (en) * | 2000-03-03 | 2004-12-07 | Cook Incorporated | Endovascular device having a stent |
| DE69633224T2 (en) * | 1995-02-14 | 2005-09-15 | Corvita Corp., Miami | Endovascular stent with locking ring |
| EP1177780B1 (en) * | 2000-08-02 | 2008-03-26 | Hector Daniel Barone | Multi-component endoluminal graft assembly |
| CN101690831A (en) * | 2009-07-31 | 2010-04-07 | 华中科技大学 | Temperature-sensitive nano-gel vascular embolic materials, preparation method and application thereof |
| CN101972180A (en) * | 2010-10-22 | 2011-02-16 | 上海索康医用材料有限公司 | Bifurcated vessel implant and preparation method thereof |
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Patent Citations (5)
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| DE69633224T2 (en) * | 1995-02-14 | 2005-09-15 | Corvita Corp., Miami | Endovascular stent with locking ring |
| US6827735B2 (en) * | 2000-03-03 | 2004-12-07 | Cook Incorporated | Endovascular device having a stent |
| EP1177780B1 (en) * | 2000-08-02 | 2008-03-26 | Hector Daniel Barone | Multi-component endoluminal graft assembly |
| CN101690831A (en) * | 2009-07-31 | 2010-04-07 | 华中科技大学 | Temperature-sensitive nano-gel vascular embolic materials, preparation method and application thereof |
| CN101972180A (en) * | 2010-10-22 | 2011-02-16 | 上海索康医用材料有限公司 | Bifurcated vessel implant and preparation method thereof |
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| CN102824198A (en) | 2012-12-19 |
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