CN109925018A - Embolism series connection blocks segment and using its aneurysm plugging system in tumor - Google Patents
Embolism series connection blocks segment and using its aneurysm plugging system in tumor Download PDFInfo
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- CN109925018A CN109925018A CN201910096109.2A CN201910096109A CN109925018A CN 109925018 A CN109925018 A CN 109925018A CN 201910096109 A CN201910096109 A CN 201910096109A CN 109925018 A CN109925018 A CN 109925018A
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Abstract
Embolism series connection blocks segment and using its aneurysm plugging system in a kind of tumor.The aneurysm plugging system includes embolism series connection closure segment and supply unit in tumor, wherein embolism is made of with series connection closure segment closure unit, connecting line and development telltale mark in tumor, each unit that blocks is fixedly connected by connecting line, and development telltale mark is located at interval of on a certain number of closure units.The system is it is possible to prevente effectively from the problem of metal class blocks the artifact that instrument generates under X-ray after closure and is unable to judge accurately tumor mouth marginal position, simultaneously, using the closure unit of flexible material, it can be under the premise of keeping blocking unit entirety compliance, the size of unit volume is blocked by adjusting, the aneurysm of different bores is adapted to, and then shortens blocking time, reduces ray and takes in dosage.
Description
Technical field
The present invention relates to surgical medical instruments, block segment more particularly to a kind of series connection of embolism in tumor and use its
Aneurysm plugging system.
Background technique
Aneurysm is the lesion or damage due to arterial wall, forms the table of arterial wall limitation or diffusivity expansion or bulging
It is existing, it is main performance with dilatancy, pulsation lump, can occurs at any position of arterial system, and it is dynamic with limbs trunk
Arteries and veins, aorta, arteria carotis, entocranial artery are relatively conventional.Its therapeutic modality mainly includes surgical intervention mode and interventional therapy side
Formula.Surgical intervention mode mainly includes the repairing of artery cut, aortic patch inhibits and artery end to end anastomosis, due to needing to cut
Superficial skin tissue, exposure arteries, operation wound is big, and amount of bleeding is more, and the time is long, very unfavorable to the recovery of patient.
Interventional treatments mainly include overlay film type artificial endovascular stent implantation, Coil embolization, gel embolism, plugging device bolt
Plug etc..Pass through interventional therapy, it is only necessary to puncture in skin surface into arteries and corresponding instrument be conveyed by conduit
To aneurysm diseased region, aneurysm closing or closure completely are avoided moving by the method for stent expansion, instrument embolism
Arteries and veins blood travels further into tumor mouth, blood flow direction back to normal.Interventional therapy risk is relatively small, performs the operation safer, avoids
Patient's surgery wound bring complication, substantially improves patient's prognosis.
Interventional technique at this stage, treating aneurysmal instrument by embolization processes is mainly Coil embolization and gel bolt
Plug.Wherein, Coil embolization due to main material be platinum spring ring, it is not only expensive, and due to platinum height do not transmit
Linearly, certain artifact can be generated in various imageological examinations, and then influences the judgement of doctor, reduce operative effect.And it is right
In gel embolism method, since it has a solidification process, be only suitable for carry out encephalic compared with thin vessels embolism, and for compared with
The embolism of large aneurysm, solidification effect and curing time greatly limit the size of aneurysm embolization, therefore, gel embolism
There are certain restrictions for adaptation of methods disease.
Summary of the invention
In view of this, blocking segment the main purpose of the present invention is to provide a kind of series connection of embolism in tumor and using its
Aneurysm plugging system, at least be partially solved at least one of above-mentioned technical problem.
To achieve the goals above, it as one aspect of the present invention, provides embolism series connection in a kind of tumor and blocks chain
Section, which is characterized in that including single at least one closure using the closure concatenated several closure units of unit connecting line, and setting
Development telltale mark in member and/or closure unit connecting line；
Wherein, the closure unit is made of polymer biological porous material.
As another aspect of the present invention, a kind of aneurysm plugging system is additionally provided, which is characterized in that the artery
Tumor plugging system includes embolism series connection closure segment and supply unit in tumor, in which:
It is that embolism series connection blocks segment in tumor as described above that embolism series connection, which blocks segment, in the tumor；
The supply unit includes delivery conduit and push rod, and delivery conduit is for accommodating embolism series connection envelope in the tumor
Stifled segment, push rod enter for embolism in the tumor to be pushed out the delivery conduit with series connection closure segment when needed
Blood vessel.
Based on the above-mentioned technical proposal it is found that aneurysm plugging system of the invention have compared with the existing technology it is following beneficial
Effect:
It is possible to prevente effectively from metal class blocks the artifact that instrument generates under X-ray after closure and is unable to judge accurately tumor mouth
The problem of marginal position, meanwhile, it, can be in the premise for keeping blocking unit entirety compliance using the closure unit of flexible material
Under, the size of unit volume is blocked by adjusting, and is adapted to the aneurysm of different bores, and then shorten blocking time, is reduced ray
Take in dosage.
Detailed description of the invention
Fig. 1 is the overall structure diagram of aneurysm plugging system of the invention.
In upper figure, appended drawing reference meaning is as follows:
1, series connection blocks unit
1-1, it blocks unit 1-2, block unit series line 1-3, development telltale mark
2, supply unit
2-1, conduit 2-2, push rod
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
Attached drawing, the present invention is described in further detail.
The present invention uses aneurysm embolization processes, while using organic-biological material as filler main body, in filler
Between placed locating development label, not only solved the development orientation problem of packing material, but also to effectively prevent developing material close
It is quasi- that positioning is greatly improved while guaranteeing filling effect, improving charging efficiency in artifact interference problem caused by collection stacks
True property, reduces the risk of operation, and more traditional Coil embolization and gel embolism have incomparable advantage.
Specifically, the invention discloses a kind of series connection of embolism in tumor to block segment, which is characterized in that including using closure
The concatenated several closure units of unit connecting line, and at least one is set and blocks unit and/or blocks on unit connecting line
Develop telltale mark；
Wherein, unit is blocked to be made of polymer biological porous material.
Wherein, the pore wall thickness for blocking unit is 1~300 μm, and porosity is 5%~95%, preferably 10%~90%；
Preferably, the material for blocking unit is degradable polymer biomaterial, further preferably polylactic acid
(PLA), poly lactide-glycolide acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), polycaprolactone
(PCL), polylactic acid-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA), Huo Zheshang
State the two of them in substance or two or more mixtures；
Preferably, the material for blocking unit is degradable natural biomaterial and its material that spreads out, further preferably egg
Two of them in white matter, collagen sponge, gelatin, chitosan, fibrin, cellulose and its derivates or above-mentioned substance
Or two or more mixture；
Preferably, block unit material be inertia biomaterial, further preferably poly-N-isopropyl acrylamide,
Polyethylene or polytetrafluoroethylene (PTFE).
Wherein, it can be cylindric, spherical, oval spherical or coniform for blocking the outer profile of unit.
Wherein, section maximum gauge of the unit under unexpanded original state is blocked no more than for conveying it into phase
Answer the diameter of the delivery conduit inner cavity of vessel position；Preferably, the section maximum gauge range for blocking unit is 1~10mm.
Wherein, surface or material internal in unit are blocked and contains vascular wall adhesion material, preferably alpha-cyanoacrylate
Isobutyl ester or derivatives thereof；Preferably, the doping content of vascular wall adhesion material is 5%~50%, preferably doping content
It is 10%~30%；Preferably, the vascular wall adhesion material of doping is graininess, particle size range is 0.1~100 μm, into
Preferably, granularity is 1~10 μm to one step.
Wherein, blocking unit connecting line is biological absorbable flexible pliable material, further preferably polylactic acid
(PLA), poly lactide-glycolide acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), polycaprolactone
(PCL), polylactic acid-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA), Yi Jishang
State the two of them in substance or two or more mixtures；Preferably, blocking unit connecting line is degradable natural biology
Material and its derivative, further preferably protein, collagen sponge, gelatin, chitosan, fibrin, cellulose and its spread out
Two of them or two or more mixtures in biology or above-mentioned substance；Preferably, it is raw for inertia to block unit connecting line
Object material, further preferably poly-N-isopropyl acrylamide, polyethylene or polytetrafluoroethylene (PTFE)；Connect preferably, blocking unit
The cross sectional shape of wiring is round, ellipse or parallelogram.
Preferably, embolism is blocked in segment with series connection in a tumor, a plurality of closure unit connecting line of use is cut
Face shape can be same or different.
Preferably, the cross-section major axis length for blocking unit connecting line can be 0.01~3mm.
Preferably, adjacent two length for blocking the closure unit connecting line between unit can be 0.1~20mm.
Wherein, develop telltale mark material be selected from one of platinum, gold, palladium, thallium, platinumiridio, tantalum；As excellent
Choosing, the development telltale mark in the form of coating or inlay form with closure unit combine；Preferably, inlaying the aobvious of form
Shadow telltale mark is designed as circular or coniform；Preferably, the development telltale mark for inlaying form is solid or hollow shape
Shape is located at and blocks inside unit, and outer surface is coated by closure unit；Preferably, development telltale mark is located at equidistantly
Be spaced apart from each other on a certain number of closure units.
The invention also discloses a kind of aneurysm plugging systems, using porous organic-biological material as filler main body, preparation
Unit connection will be blocked at closure unit, and using flexible series line, unit is blocked and is transported to along mating supply unit conduit
Aneurysm site is pushed out distal catheter mouth into aneurysm for unit is blocked by push rod, after blocking unit contact blood
It is expanded to predetermined size, realizes aneurysmal closure, it is final to restore former artery normal blood flow.
In a preferred embodiment, aneurysm plugging system of the invention includes embolism series connection closure unit in tumor
And supply unit.Embolism blocks unit with series connection and is made of closure unit, closure unit connecting line and development telltale mark in tumor.
Supply unit is made of the curved delivery conduit of head end, plug unit push chamber, contrast agent, seal wire push chamber, push rod.
Wherein, embolism series connection closure unit in tumor includes to block unit, closure unit connecting line and development positioning to mark
Note is made of wherein blocking unit polymer biological porous material, and pore wall thickness is 1~300 μm, porosity 5%-
95%.
Polymer biological porous material chooses the good polymer material of biocompatibility, and biocompatibility has as follows
Feature: low cytotoxicity, low irritability, low irritant, low systemic toxicity, hereditary-less toxicity and carcinogenicity.More preferably, the material
Material has good coagulating effectiveness, enables aneurysm plugging effect more preferably.Blocking unit material therefor can be degradable polymer
Biomaterial, including but not limited to polylactic acid (PLA), poly lactide-glycolide acid (PLGA), polyglycolic acid (PGA),
Polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer
(PEVA), polyvinyl alcohol (PVA) and two of them or two or more mixtures；Closure unit material therefor can be can
Degrade natural biologic material and its derived material, including but not limited to albumen, collagen sponge, gelatin, chitosan, fibrin,
Cellulose and its derivates or in which two kinds and two or more mixtures；Blocking unit material can be inertia biomaterial,
Including but not limited to poly- N. N-isopropylacrylamide, polyethylene, polytetrafluoroethylene (PTFE).
The section for blocking the unit direction parallel with catheter section is prototype, block unit can be it is cylindric, spherical or
Oval spherical, coniform, the closure unit being serially connected each other can select identical or different shape according to actual needs
Shape, can be the combination of one or two kinds of and two or more shapes, and the identical closure unit of shape, and geometric dimension can also be with
It is same or different.However, each closure unit in same train is under unexpanded original state, wherein it is each block it is single
The section maximum gauge of member cannot be greater than the delivery conduit intracavity diameter of supply unit.Each closure unit section is maximum straight
Diameter range is 1~10mm.During aneurysmal closure, not similar shape can be selected according to different aneurysm shape features
Shape, various sizes of closure unit are blocked so that the bulk density for blocking unit reaches optimum state, and block unit it
Between gap be minimized degree.
Unit is blocked to the adhesiveness of vascular wall to improve, and improves the fixed effect for blocking unit in aneurysm wall, it is excellent
Selection of land, can block unit in be doped into vascular wall adhesion material, it is preferable that can adulterate isobutyl alpha-cyanoacrylate and
Its derivative.The doping ratio of vascular wall adhesion material can be according to aneurysmal size and the shape and ratio used for blocking unit
Surface area is adjusted, and the content of selectable doping is 5%-50%, and preferably doping content is 10%-30%.The blood of doping
Tube wall adhesion material is graininess, and particle size range is 0.1~100 μm, it is preferable that granularity is 1~10 μm.
The connecting line blocked between unit is the good polymer flexibility material of biocompatibility, and biocompatibility has
Following features: low cytotoxicity, low irritability, low irritant, low systemic toxicity, hereditary-less toxicity and carcinogenicity.Connecting line
Material can be biological absorbable flexible pliable material, including but not limited to polylactic acid (PLA), poly lactic-co-glycolic acid
Copolymer (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid-caprolactone copolymer
(PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA) and two of them or two or more mixtures；
The material of connecting line can be degradable natural biomaterial and its derivative, including but not limited to protein, collagen sponge, bright
Glue, chitosan, fibrin, cellulose and its derivates or in which two kinds and two or more mixtures；The material of connecting line
It can be inertia biomaterial, including but not limited to poly-N-isopropyl acrylamide, polyethylene, polytetrafluoroethylene (PTFE).
Connecting line can be prepared into different sections according to the different requirements for blocking units for the push performance of connecting line
Shape, mostly round, ellipse or parallelogram, it is preferable that its cross-section major axis length is 0.01~3mm.Adjacent two block
The length of connecting line between unit is 0.1~20mm.Can according to block the shape of unit, size selection different cross section shape,
The connecting line of different cross section length realizes the different best match effects blocked under cell configuration and different closure unit sizes,
The push performance being optimal.
To improve the quantity blocked unit in aneurysm and blocking volume, and observation in real time blocks whether unit is still located at
It is pushed at aneurysm tumor mouth, on blocking unit in such a way that telltale mark is developed in addition, carries out development confirmation.Development
Marker material is one of platinum, gold, palladium, thallium, platinumiridio, tantalum.The telltale mark that develops, which is located at, to be blocked on unit, with table
Bread covers or inlays form and closely combines with plug unit.Using the developing mark of surface cladding form, with closure unit
Shape is consistent, can be designed as circular or coniform according to the face shaping for blocking unit；It is fixed using inserted development
Position label, can be various solid or hollow shapes, it is desirable that development telltale mark, which is located at, to be blocked inside unit, and outer surface is blocked
Unit is coated.Generally in the first closure unit in distal end as the first developing mark, in the identical closure unit of each geomery
In the plugging system being made into, at interval of a certain number of closure units, placement positioning developing mark is positioned by developing under X-ray
The observation of label, confirmation come into the quantity and aneurysmal closure volume of the closure unit in aneurysm, and according to development
Telltale mark judges to block whether unit aneurysm is clogged completely.Thus kind method determines plugging effect, more traditional bullet
Spring coil locating development label, has significant advantage, can not only determine block-up position, and it is possible to prevente effectively from due to gold
Belong to bulk density it is excessive and caused by artifact, whether completely enclosed to accurately identify aneurysm mouth, whether artery knurl complete
Embolism.
In aneurysm plugging system, matching used supply unit includes conduit and push rod, which is, for example, to include
Plastic thin wall of the head end of stainless steel braided wires with certain curved plastic thin wall conduit or with certain degree of hardness and intensity
Pipe.Stainless steel braided wires are mainly that conduit provides certain hardness support, and improves the buckle resistance energy of plastic catheter, it is ensured that are led
Pipe has corresponding pushability and good torsion control property.Plastic thin wall conduit material used be preferably TPU, PVC, PE, PP,
One of PA, PEBAX, TPE, PC.
The push rod of supply unit can be stainless steel disc spring screw rod, and push rod outer diameter and supply unit catheter diameter one
It causes.The push rod of supply unit can the plastic catheter for plastic catheter or with stainless steel braided wires and push rod outer diameter and conveying
Unit catheter diameter is consistent.
Explanation is further elaborated to technical solution of the present invention with attached drawing combined with specific embodiments below.
The present invention describes a kind of aneurysm plugging system, and Fig. 1 is the overall structure diagram of the aneurysm plugging system.
As shown in Figure 1, the aneurysm plugging system includes that series connection blocks unit 1 and 2 two parts of supply unit.Series connection blocks unit
It blocks unit 1-1, block unit series line 1-2, development telltale mark 1-3.Supply unit includes conduit 2-1, push rod 2-2.
Series connection blocks 1 part of unit, will block unit 1-1 by series line 1-2 and be coupled according to equidistant, locating development label
1-3 is located at the inside for blocking unit 1-1 or is coated on the outer surface for blocking unit 1-1, and equidistant arrangement, as entire envelope
The developing mark of stifled unit, and can be confirmed block the closure volume that unit has entered in aneurysm at any time.In surgical procedure,
Under ray, after there is suitable curved delivery conduit 2-1 to be placed on tumor oral area position head end, unit will be blocked one by one by push rod
It is pushed out catheter lumen, is made it into aneurysm, keeps rapid water swelling in its blood aobvious by real-time monitoring to predetermined volume
The position shadow telltale mark 1-3, determine entered in aneurysm closure unit 1-1 volume, it is ensured that block unit total volume and
Aneurysmal prediction volume matches.Finally, after entire aneurysm being blocked completely, matched supply unit 2 is withdrawn into body
Outside, aneurysmal closure is completed.
Embodiment 1
A kind of aneurysm plugging system blocks unit with series connection by embolism in tumor and its supply unit forms.Wherein, in tumor
Embolism blocks unit with series connection and is made of closure unit, closure unit connecting line and development telltale mark.Blocking unit is to use
Cylindric collagen sponge, initial closure unit cylinder are having a size of diameter of section 2.5mm, length 2.5mm, material porosity
50%, hole wall average thickness is 100 μm.It blocks unit to be connected in series by chitin fiber, the adjacent spacing blocked between unit
For 2.5mm, it is 11 that every string, which blocks element number, is coated with platinum development with its the 1st, 6, the 11 closure unit outer surface in distal end
Telltale mark, platinum locating development are located at envelope labeled as annular shape, outer diameter 2.5mm, wall thickness 0.1mm, length 1mm
The center of stifled unit, and be fitted close with unit is blocked.The series connection blocks the conveying that the supply unit that unit matches is 8F and leads
Pipe, the i.e. internal diameter of delivery conduit are 2.5mm, and delivery conduit material of main part is PEBAX 7233, include 6 bursts of stainless steel braided wires,
The curved part of conduit head end is PEBAX 7233, welds together with stainless steel braided wires PRBAX catheter main body, further increases
Head end reaches the pushability and flexibility of aneurysm mouth by blood vessel.
Embodiment 2
A kind of aneurysm plugging system blocks unit with series connection by embolism in tumor and its supply unit forms.Wherein, in tumor
Embolism blocks unit with series connection and is made of closure unit, closure unit connecting line and development telltale mark.Blocking unit is to use
Cylindric collagen sponge and ellipsoid fibrin, having a size of diameter of section 1.5mm, length is initial closure unit cylinder
1.5mm, material porosity are 20%, and hole wall average thickness is 150 μm.Ellipsoid fibrin be long axis 2mm, short axle 1.5mm,
Material porosity is 20%, and hole wall average thickness is 150 μm.Unit is blocked to be gone here and there by poly lactide-glycolide acid (PLGA)
Join, the adjacent spacing blocked between unit is 1.5mm, and it is 13 that every string, which blocks element number, with distal end its 1st, 7,13
A closure unit inner surface is inlaid with tantalum development telltale mark, and locating development is labeled as spherical, outer diameter 0.5mm, is located at envelope
The center of stifled unit.Every outer surface for blocking unit is coated with isobutyl alpha-cyanoacrylate, and coating layer thickness is 5 μm.The series connection
The delivery conduit that the supply unit that unit matches is 5F is blocked, i.e. the internal diameter of delivery conduit is 1.5mm, delivery conduit main body material
Material is PEBAX, includes 6 bursts of stainless steel braided wires, the curved part of conduit head end is PEBAX 7233, with stainless steel braided wires
PRBAX catheter main body welds together, and further increases head end by blood vessel, reaches the pushability and flexibility of aneurysm mouth.
Particular embodiments described above has carried out further in detail the purpose of the present invention, technical scheme and beneficial effects
Describe in detail bright, it should be understood that the above is only a specific embodiment of the present invention, is not intended to restrict the invention, it is all
Within the spirit and principles in the present invention, any modification, equivalent substitution, improvement and etc. done should be included in protection of the invention
Within the scope of.
Claims (10)
1. embolism blocks segment with series connection in a kind of tumor, which is characterized in that including concatenated several using unit connecting line is blocked
Unit is blocked, and at least one is set and blocks unit and/or blocks the development telltale mark on unit connecting line；
Wherein, the closure unit is made of polymer biological porous material.
2. embolism blocks segment with series connection in tumor according to claim 1, which is characterized in that the hole wall for blocking unit
With a thickness of 1~300 μm, porosity is 5%~95%, preferably 10%~90%；
Preferably, the material for blocking unit is degradable polymer biomaterial, further preferably polylactic acid
(PLA), poly lactide-glycolide acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), polycaprolactone
(PCL), polylactic acid-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA), Huo Zheshang
State the two of them in substance or two or more mixtures；
Preferably, the material for blocking unit is degradable natural biomaterial and its material that spreads out, further preferably egg
Two of them in white matter, collagen sponge, gelatin, chitosan, fibrin, cellulose and its derivates or above-mentioned substance
Or two or more mixture；
Preferably, it is described block unit material be inertia biomaterial, further preferably poly-N-isopropyl acrylamide,
Polyethylene or polytetrafluoroethylene (PTFE).
3. embolism blocks segment with series connection in tumor according to claim 1, which is characterized in that the closure unit is cylinder
Shape, spherical, ellipse is spherical or coniform；
The section maximum gauge of the unit under unexpanded original state that block is no more than for conveying it into corresponding blood
The diameter of the delivery conduit inner cavity of pipe position；
Preferably, the section maximum gauge range for blocking unit is 1~10mm.
4. embolism blocks segment with series connection in tumor according to claim 1, which is characterized in that surface in the closure unit
Or material internal contains vascular wall adhesion material, preferably isobutyl alpha-cyanoacrylate or derivatives thereof；
Preferably, the doping content of vascular wall adhesion material is 5%~50%, preferably doping content is 10%~30%；
Preferably, the vascular wall adhesion material of doping is graininess, particle size range is 0.1~100 μm, further preferably
Ground, granularity are 1~10 μm.
5. embolism blocks segment with series connection in tumor according to claim 1, which is characterized in that the closure unit connecting line
For biological absorbable flexible pliable material, further preferably polylactic acid (PLA), poly lactide-glycolide acid
(PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid-caprolactone copolymer (PLC),
Ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA) and the two of them or two or more in above-mentioned substance
Mixture；
Preferably, the closure unit connecting line is degradable natural biomaterial and its derivative, further preferably egg
Two of them in white matter, collagen sponge, gelatin, chitosan, fibrin, cellulose and its derivates or above-mentioned substance or
Two or more mixtures；
Preferably, the closure unit connecting line be inertia biomaterial, further preferably poly-N-isopropyl acrylamide,
Polyethylene or polytetrafluoroethylene (PTFE)；
Preferably, the cross sectional shape for blocking unit connecting line is round, ellipse or parallelogram；
Preferably, embolism is blocked in segment with series connection in a tumor, a plurality of closure unit connecting line of use
Cross sectional shape it is identical or different；
Preferably, the cross-section major axis length for blocking unit connecting line is 0.01~3mm；
Preferably, the length of the adjacent two closure unit connecting lines blocked between unit is 0.1~20mm.
6. embolism blocks segment with series connection in tumor according to claim 1, which is characterized in that the development telltale mark
Material is selected from one of platinum, gold, palladium, thallium, platinumiridio, tantalum；
Preferably, the development telltale mark is in the form of coating or inlays form and combines with the closure unit；
Preferably, the development telltale mark for inlaying form is designed as annular shape or coniform；
Preferably, the development telltale mark for inlaying form is solid or hollow shape, it is located inside the closure unit,
Its outer surface is coated by the closure unit；
It is spaced apart from each other on a certain number of closure units at equal intervals preferably, the development telltale mark is located at.
7. a kind of aneurysm plugging system, which is characterized in that the aneurysm plugging system includes embolism series connection closure in tumor
Segment and supply unit, in which:
It is that embolism series connection blocks in tumor as claimed in any one of claims 1 to 5 that embolism series connection, which blocks segment, in the tumor
Segment；
The supply unit includes delivery conduit and push rod, and delivery conduit blocks chain for accommodating embolism series connection in the tumor
Section, push rod enter blood for embolism in the tumor to be pushed out the delivery conduit with series connection closure segment when needed
Pipe.
8. aneurysm plugging system according to claim 7, which is characterized in that the delivery conduit is plastic catheter or band
The plastic catheter of stainless steel braided wires, the further preferably head end comprising stainless steel braided wires have certain curved plastics thin
Wall conduit；
Preferably, the material of plastic thin wall conduit used is selected from TPU, PVC, PE, PP, PA, PEBAX, TPE or PC.
9. aneurysm plugging system according to claim 7, which is characterized in that the push rod of the supply unit is variable
Curved stainless steel disc spring screw rod.
10. aneurysm plugging system according to claim 7, which is characterized in that the outer diameter of the push rod with it is described defeated
Send the internal diameter of the delivery conduit in unit consistent.
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