CN104873303B - The anti-interior leakage stent graft system of attached sponge structure - Google Patents

The anti-interior leakage stent graft system of attached sponge structure Download PDF

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Publication number
CN104873303B
CN104873303B CN201410817691.4A CN201410817691A CN104873303B CN 104873303 B CN104873303 B CN 104873303B CN 201410817691 A CN201410817691 A CN 201410817691A CN 104873303 B CN104873303 B CN 104873303B
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layer
interior leakage
coating layer
sponge structure
shaped supporting
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Expired - Fee Related
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CN201410817691.4A
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Chinese (zh)
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CN104873303A (en
Inventor
包俊敏
董健
宋超
袁良喜
张雷
周建
景在平
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Second Military Medical University SMMU
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Second Military Medical University SMMU
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Priority to CN201410817691.4A priority Critical patent/CN104873303B/en
Publication of CN104873303A publication Critical patent/CN104873303A/en
Priority to US15/537,429 priority patent/US11007047B2/en
Priority to PCT/CN2015/097972 priority patent/WO2016095864A1/en
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Abstract

The present invention relates to a kind of anti-interior leakage holder botanical systems of attached sponge structure, for preventing and kill off the interior leakage other than being leaked in II types in advance, which is characterized in that including:The metal net shaped supporting layer to match with arteries shape;The coating layer being covered on metal net shaped supporting layer;And it is distributed in the spongy layer on the outside of coating layer, spongy layer is filled between arterial vascular inner wall and coating layer under the action of natural resiliency and is formed by gap.The anti-interior leakage holder of the attached sponge structure of the present invention can avoid the generation leaked in other types in addition to being leaked in II types.

Description

The anti-interior leakage stent graft system of attached sponge structure
Technical field
The present invention relates to a kind of anti-interior leakage holders of attached sponge structure, belong to medical instruments field.
Background technology
Aneurysm is that most common initiation disables and lethal one of vascular diseases, it is seen that in any artery of whole body, with The elderly is common.Aneurysm can there are many size, form and distribution, Audit Report special committee of vascular surgery association (the Ad Hoc Committee on Reporting Standards of the Society for Vascular Surgery) Defining aneurysm is:Arteries diameter is more than that the permanent limitation of natural arterial caliber 50% is expanded, in order to which clinic is determined Plan and classified and standardized.
Earliest about attempting to treat aneurysmal record derived from 3rd century of Christian era, up to 1888, Matas et al. was completed The aneurysm neoplasty of first case truly ligatures bifurcated artery in the tumor intracavitary of arteria brachialis tumor.Nineteen fifty-one, Dubost etc. completes first case aneurysm suture and neoplasty, they cut off the abdominal aneurvsm of a patient, and have selected one The aorta pectoralis of the 20 years old donator of cadaver in position is transplanted in abdominal aortic aneurysms body, the patient is postoperative as alloplast It has survived 8 years.It repairs aneurysmal open surgery gradually to improve and optimize in subsequent 40 years, but its peri-operation period is dead It dies rate and is still up to 5%.1991, Parodi et al. is reported for the first time repaired aortic aneurysm using artificial endovascular stent compound Experience.Food and Drug Admistraton (FDA) ratify endovascular graft object clinical application after, aneurysm (including peripheral arterial tumor and Aortic aneurysm) it experienced from open bypass differentiation of the prosthetic to Endovascular repair.
Compared with conventional therapy, the diseases such as endovascular graft treatment aneurysm, artery dissection are carried out using overlay film frame Disease has many advantages, such as that operation wound is small, post-operative recovery is fast, the hospital stays is short, but its distinctive complication --- interior leakage, at present It can not also avoid completely.Interior leakage is one of postoperative most important complication of inner cavity insulation, and incidence is up to 45%.Interior leakage presses it Mechanism can be divided into I-V types.Wherein, the generation leaked in II types does not have correlation with stent graft, does not repeat.Below Interior leakage type in addition to being leaked in II types is briefly introduced, and leakage refers to due to holder overlay film and anchorage zone Wall of Artery in I types Docile is bad, and blood flow is caused to be leaked out in aneurysm cavity through overlay film frame proximal part or distal end, incidence about 10%, often It can be found in Photographg.Because the presence leaked in I types can cause high pressure in aneurysm cavity, aneurysm continuous enlargement even to have generation The risk of rupture, so needing to immediately treat in art.It is generally believed that proximal landing zone [explaining this concept] < 10mm and/or tumor Neck angulation【Explain this concept】60 ° of >, the interior leakage incidence of I types will be significantly raised, and wherein anchorage zone, which refers to the close of tumor chamber, distally has The normal blood vessels wall of one section of sufficient length is adequately sticked with ensureing that intravascular stent and its have, and the vascular wall of such segment length is fixed Justice is anchorage zone (landing zone, LZ), including proximally and distally LZ;Tumor neck angulation refers to tumor neck central axes and aorta master Formed angle between dry central axes.Currently, being for leaking general processing mode in the I types that are found in art:Balloon expandable plus use Stent graft, bare bracket or the embolization technique for utilizing cyanoacrylate, Onyx glue, spring ring, Fibrin Glue of short section. Although these technologies can handle leakage in most of I types, in some cases will be extremely difficult, such as:Abdominal aneurvsm proximal end Anchorage zone is too short, and influence arteria renalis blood supply is possible in proximal end plus with short section graft.The summaries such as Maldonado above-mentioned side at present Method handles the effect leaked in I types:Cyanoacrylate suppository success rate is 92.3%, and proximal end short section graft is 80%, bullet Spring coil is 75%.Leakage refers to existing defects on overlay film frame wall, fault location of the Endovascular blood through overlay film frame wall in type III It leaks out in aneurysm cavity and is formed by interior leakage.Leakage is another form leaked in type III in IV types, its main feature is that implantation overlay film Endovascular blood flow is leaked from the diffusivity of overlay film frame in holder one month.Leakage is also known as leakage in " internal tension " in V-type, refer to Inner cavity insulation is postoperative, and intravascular radiography or CT arteriographies do not find that leakage exists in apparent, but pressure increases in aneurysm, The case where tumor chamber expands.
When above-mentioned interior leakage occurs, which kind of processing mode no matter is taken, the problem of there is only success rates, there is also a large amount of The problem of increasing operating time and medical expense, and operating time extends so that patient's art risk, postoperative infection incidence Increase, high medical expense brings the financial burden of great number to patient, while occupying more social resources.
Invention content
To solve the above problems, the present invention has redesigned the holder used in endovascular graft, to avoid except in II types The generation leaked in other types other than leakage.
Present invention employs following technical solutions:
<Structure one>
A kind of anti-interior leakage holder of attached sponge structure, for preventing and kill off the interior leakage other than being leaked in II types in advance, which is characterized in that packet It includes:
The metal net shaped supporting layer to match with arteries shape;
The coating layer being covered on metal net shaped supporting layer;And
The spongy layer being distributed on the outside of coating layer, spongy layer are filled in arterial vascular inner wall under the action of natural resiliency It is formed by gap between coating layer.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, the thickness range of spongy layer is 1mm-5mm.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, the material of spongy layer is poly (glycolide-lactide) PGLA.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, edge of the spongy layer without departing from the end of metal net shaped supporting layer and coating layer.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, spongy layer is made of the material that can adsorb the haemocytes such as coagulation factor and blood platelet in blood.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, there is equally distributed diamond sunk, and a longer diagonal line and blood flow for diamond shape on spongy layer Direction is consistent.
<Structure two>
A kind of anti-interior leakage holder of attached sponge structure, for preventing and kill off the interior leakage other than being leaked in II types in advance, which is characterized in that packet It includes:
The metal net shaped supporting layer to match with arteries shape;
The coating layer being covered on metal net shaped supporting layer;And
The elastic network(s) compartment being distributed on the outside of coating layer, elastic network(s) compartment are filled in arterial blood under the action of natural resiliency It is formed by gap between the inner wall and overlay film of pipe.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, elastic network(s) compartment is composed of multiple polyhedral ribs.
In addition, the anti-interior leakage holder of the attached sponge structure of the present invention, can also have the feature that:
Wherein, polyhedron is double pyrometric cone columns.
Invention effect
The anti-interior leakage holder of attached sponge structure according to the present invention, due to additionally using spongy layer on the outside of coating layer, and And spongy layer is filled between inner wall and coating layer under the action of natural resiliency and is formed by gap so that blood flow cannot be straight It connects and pours tumor chamber, blood clotting can occur after a period of time has passed for the blood in sponge, to completely enclose tumor chamber, make It obtains tumor chamber and enters stable state.Since the present invention is also provided with spongy layer outside coating layer, elastic mesh actually also may be used To regard a kind of sponge of microstructure rule as.Therefore other than the generation that can be good at preventing to leak in I types, additionally it is possible to Prevent the generation leaked in III, IV and V-type.
Description of the drawings
Fig. 1 is the overall structure diagram of the anti-interior leakage holder of the attached sponge structure of the present invention;
Fig. 2 is the internal structure schematic diagram of the anti-interior leakage holder of the attached sponge structure of the present invention;
Fig. 3 is the cross-sectional view of the anti-interior leakage holder of the attached sponge structure of the present invention;
Fig. 4 is the schematic diagram at the anti-interior leakage stenter to implant blood vessel of the attached sponge structure of the present invention;
Fig. 5 is the diagrammatic cross-section at BB ' in Fig. 4;
Fig. 6, which is the sponge surface of the anti-interior leakage holder of the attached sponge structure of the present invention, has the schematic diagram of network;
Fig. 7 is that the surface of the anti-interior leakage holder of the attached sponge structure of the present invention is covered with the schematic diagram of elastic network(s) compartment;
Fig. 8 is the basic component units schematic diagram of the network of the anti-interior leakage holder of the attached sponge structure of the present invention;
Fig. 9 is long axis of the elastic network(s) compartment in holder of the network of the anti-interior leakage holder of the attached sponge structure of the present invention Partial section view on direction;
Figure 10 is the schematic diagram of the staggered pattern of the monomer of elastic mesh.
Specific implementation mode
Due to causing to be leaked in I types, i.e., since holder overlay film and anchorage zone Wall of Artery docile are bad, cause blood flow through overlay film Holder proximal part or distal end leak out to that there are many reason in aneurysm cavity, attached sponge structure of the invention it is anti-in leak holder pair Leakage all has the effect of prevention in I types caused by a variety of causes.Only to be drawn by arteriosclerosis plaque in specific implementation mode Holder overlay film and anchorage zone Wall of Artery docile it is bad for illustrate.
Illustrate the specific implementation mode of the present invention below in conjunction with attached drawing.
<Embodiment one>
Fig. 1 is the overall structure diagram of the anti-interior leakage holder of the attached sponge structure of the present invention, and Fig. 2 is the attached sea of the present invention The internal structure schematic diagram of the anti-interior leakage holder of continuous structure.As depicted in figs. 1 and 2, the anti-interior leakage holder 10 of attached sponge structure has There are metal net shaped supporting layer 11, coating layer 12 and spongy layer 13.Metal net shaped supporting layer 11 is located at innermost layer, and coating layer 12 covers It is placed on its outer layer, spongy layer 13 is located at the outer layer of coating layer 12.
12 common material of coating layer is terylene, also known as ethylene terephthalate.The material that spongy layer uses is poly- second Lactide, chemical name abbreviation PGLA.Poly (glycolide-lactide) material has the function of adsorbing the haemocytes such as coagulation factor and blood platelet. Spongy layer 13 is fixedly connected with coating layer by modes such as stickups.Spongy layer is integrally covered in the outside of holder, but both ends are not Both ends beyond metal net shaped supporting layer preferably inwardly bounce back a bit relative to the both ends of metal net shaped supporting layer again.
Fig. 3 is the cross-sectional view of the anti-interior leakage holder of the attached sponge structure of the present invention, and Fig. 4 is the attached sponge structure of the present invention It is anti-in schematic diagram at leakage stenter to implant blood vessel, Fig. 5 is the diagrammatic cross-section at BB ' in Fig. 4.Such as Fig. 3, Fig. 4 and Fig. 5 institute Show, when the anti-interior leakage holder 10 of attached sponge structure is implanted into the blood vessel of aneurysm point, the arterial blood near tumor chamber 16 There are arteriosclerosis plaques 15 on the vascular wall of pipe 14, and arteriosclerosis plaque 15 is prominent into vascular wall, by attached sponge structure It is anti-in leakage holder 10 metal net shaped supporting layer 11 and coating layer 12 jack up, seam is formed between coating layer 12 and blood vessel Gap can be filled among gap since spongy layer 13 has elasticity, and since sponge has porous structure.Blood exists It is greatly reduced by the flow velocity in the gap of sponge filling, simultaneously because the effect of the coagulation factor in blood, when by one section Between after sponge filling gap in remaining blood can solidify, to by gap closing.
There are one harmful effect in the presence of gap, precisely due to be constantly at gap blood flow impact it Under, the endothelial cell in blood vessel can not grow into the inside of holder so that the edge of holder cannot be covered by endothelial cell into And it joins together with blood vessel endothelium.After the anti-interior leakage holder 10 of the attached sponge structure of implantation the present embodiment, at gap Blood flow velocity decline so that epithelial cell of the holder gap nearby on vascular wall has the sufficient time gradually to grow into attached sponge knot Stent inner surface, is finally completely covered, joins together with the blood vessel endothelium at both ends by the inner surface of the anti-interior leakage holder 10 of structure.From And so that holder enters stable state, tumor intracavitary will not be re-filled with blood, and the blood clotting posterior tuberosity chamber that tumor intracavitary retains can be into Enter stable state, and then endotheli ocytosis, grow into tumor chamber so that tumor chamber is not susceptible to rupture.
As shown in Figure 1, the directions A Digital arteries blood flow direction, one end close to the directions A is proximal part, one end far from the directions A For distal end.The length of spongy layer 13 without departing from the upper and lower ends of metal net shaped supporting layer and coating layer edge, this be in order to It prevents sponge from being stretched out from the edge of the anti-interior leakage holder 10 of attached sponge structure, causes blood flow herein to solidify, thrombus is formed, in blood Into vascular embolization among blood vessel under the impact of stream.
The PGLA materials biodegradable time there are many influence factor, therefore can there are many methods adjusted, here only A kind of method is provided:It is adjusted by the ratio of both monomers of adjusting glycolide and lactide in polymerization, with glycolide Molar ratio in the copolymer increases, and the degradation speed of PGLA increases, and works as glycolide:Lactide=50:When 50, degradation time is 50-60 days, work as glycolide:Lactide=85:When 15, degradation time is 150 days.Interior leak blood coagulation is grown into again to fibroblast Time to the completion of fibrosis generally can be completed in two weeks, to ensure to have the sufficient time to make aneurysm cavity and I types It inside leaks into stable state, degradation time is advisable between 50-150 days, in this way will not and shadow too short due to PGLA degradation times Ring the closing leaked in I types.
The effect of embodiment one
According to the anti-interior leakage holder of the attached sponge structure in embodiment one, the anti-interior leakage of attached sponge structure according to the present invention Holder, due to additionally using spongy layer on the outside of coating layer, and spongy layer be filled under the action of natural resiliency inner wall with It is formed by gap between coating layer, when having artery sclerosis block on vascular wall, flexible spongy layer can will be passive Arteries and veins hardens the block metal net shaped supporting layer propped and is formed by gap filling between coating layer and blood vessel so that blood flow is not Can be directly into tumor chamber, the blood in sponge can solidify after a period of time has passed, to completely enclose tumor chamber so that tumor Chamber enters stable state.Spongiotic grid plays the role of three aspects, is on the one hand physical barrier so that blood is here Flow velocity slow down significantly, be on the other hand chemical action to promote blood coagulation, PGLA can adsorb coagulation factor and blood platelet etc. Haemocyte further promotes blood coagulation;Meanwhile network also acts as the matrix of fibrosis formation.
In addition, due to spongy layer length without departing from metal net shaped supporting layer and coating layer upper and lower ends edge, because This can prevent sponge from being stretched out from the edge of the anti-interior leakage holder 10 of attached sponge structure, cause blood flow herein to solidify, form blood Bolt enters vascular embolization among blood vessel under the impact of blood flow.
The method for implantation of the anti-interior leakage holder 10 of attached sponge structure:
The anti-interior leakage holder 10 of attached sponge structure is mounted on bracket conveyer, vascular lesion is transported to by conveyer Place makes conveyer gradually uniformly exit with the holder from swollen characteristic, and then the anti-interior leakage of attached sponge structure by release device Holder 10 closes the blood flow of tumor intracavitary, then withdraws from transport system so that holder is permanently disposed on lesion, reaches sealing blood vessels tumor The purpose of tumor chamber.
In surgical procedure, enter master from parteriole in human body using DSA (Digital subtraction angiograph) monitoring conveyers Artery finally reaches the overall process of tumor chamber.
<Embodiment two>
In the present embodiment two, to structure same as the previously described embodiments, this variation, which is given, to be identically numbered, and is saved Identical explanation.
Fig. 6, which is the sponge surface of the anti-interior leakage holder of the attached sponge structure of the present invention, has the schematic diagram of network;Such as Shown in Fig. 6, attached sponge structure it is anti-in the spongy layer of leakage holder 20 there is evenly distributed network 23, in network 23 With diamond groove 231.23 one side of network can save the material used in sponge, on the other hand due to diamond groove 231 have certain space, these spaces are possible to just accommodate lower artery sclerosis block after the implantation, simultaneously as sponge table Face is not to be covered completely by flat sponge, and artery sclerosis block only needs to jack up the stupefied side of protrusion between diamond groove 23, therefore Artery sclerosis block jacks up the also very little of the power used in sponge, compares sponge completely substantial in embodiment one, holder pair conversely speaking, The pressure of artery sclerosis block and vascular wall is smaller, to the stimulation of blood vessel also smaller.
<Embodiment three>
In the present embodiment three, to structure same as the previously described embodiments, this variation, which is given, to be identically numbered, and is saved Identical explanation.
Fig. 7 is that the surface of the anti-interior leakage holder of the attached sponge structure of the present invention is covered with the schematic diagram of elastic network(s) compartment, such as Shown in Fig. 7, elastic network(s) compartment 31 is covered in the outermost layer of the anti-interior leakage holder 30 of attached sponge structure.Fig. 8 is the attached sea of the present invention The basic component units schematic diagram of the network of the anti-interior leakage holder of continuous structure, as shown in figure 8, basic group of elastic network(s) compartment It is the prismatic by double pyrometric cone columns at internal and cylinder is hollow at unit 131.Basic component units are by PGLA material systems At.
Fig. 9 is the schematic diagram of the network of the anti-interior leakage holder of the attached sponge structure of the present invention, as shown in figure 9, multiple Basic component units 131 are laminated together to form elastic mesh piece 132.The center of the long axis and holder of basic component units 131 Axis is vertical, and head and the tail connection forms single layer, and as shown in Figure 10, Figure 10 is cut by the part that the section of the picture perpendicular to Fig. 9 obtains Face figure is staggered to form the elastic mesh of multi-layer intercrossed structure between multiple single layers in the junction of two basic component units 131 Layer 31.Elastic network(s) compartment 31 forms cylindrical be enclosed in outside the anti-interior leakage holder of attached sponge structure.
Due to the shape that the shape of the basic component units of elastic network(s) compartment is double pyrometric cone columns, and double pyrometric cone columns The long axis direction of long axis direction and holder is perpendicular, therefore double pyrometric cone columns are in the length perpendicular to holder applied by vascular wall It is more prone to deformation after the power of axis direction, so that spongy layer leaked in the I types between closed supports and arterial wall Filling has more strict effect.Certainly, elastic network(s) compartment can also be combined by other shapes of multiple polyhedral ribs and At.Such as hexahedron or tetrahedron.Preferably with double pyrometric cone columns employed in the embodiment of the present invention, i.e. enneahedron In one kind.
Certainly, the long axis direction of the long axis direction and entire holder of the double pyrometric cone columns used in above example is perpendicular It is the preferred embodiment of the present invention, the long axis direction of double pyrometric cone columns may be set to be it with the long axis direction of entire holder Its angle, only if it were not for parallel, angle between the two is better closer to vertical angle effect.
In above three embodiments, since spongy layer is integrally covered in the outside of holder, for proximal part and far Leakage all has the effect of prevention in the I types at heart end.
In addition, since the present invention is also provided with spongy layer outside coating layer, elastic mesh can also actually be regarded as A kind of sponge of microstructure rule.Therefore other than the generation that can be good at preventing to leak in I types, additionally it is possible to prevent III The generation leaked in IV types, since leakage refers to that rupture occurs for coating layer on holder and the interior leakage that causes in type III, and tradition branch Coating layer rupture posterior tuberosity chamber on frame will be communicated directly with the blood flow in blood vessel, and without any barrier, and the present invention is being added After spongy layer, even if coating layer ruptures, between the blood in tumor chamber and blood vessel also between across one layer of spongy layer, due to Spongy layer is porous structure, and blood flow velocity when entering in porous structure can be greatly reduced, therefore can effectively prevent blood Tumor chamber quickly is poured, causes the rupture of tumor chamber, meanwhile, blood in spongy layer is remained in due to flows decrease, and sponge Structure can adsorb coagulation factor and blood platelet so that the blood penetrated into sponge structure forms blood clot, therefore by one Spongy layer and the blood clot of its solidified inside play the effect of thoroughly closing tumor chamber after the section time.As a same reason, due to sea The presence of continuous layer makes IV, leaks in V-type and also can effectively be prevented.
In addition, the coating layer of the present invention can also be covered in the inside of metal net shaped supporting layer, to elastic network(s) compartment with Metal net shaped supporting layer is directly connected to, and such lamination order can also reach the technique effect of the present invention.

Claims (4)

1. the anti-interior leakage stent graft system of attached sponge structure, is bonded to prevent and kill off in advance in intra-arterial for being arranged with Wall of Artery Interior leakage in II types other than leakage, which is characterized in that including:
The metal net shaped supporting layer to match with arteries shape;
The coating layer being covered on the metal net shaped supporting layer;And
The spongy layer being distributed on the outside of the coating layer, the spongy layer are filled in the arterial blood under the action of natural resiliency It is formed by gap between the inner wall of pipe and the coating layer,
Wherein, the thickness range of the spongy layer is 1mm-5mm,
The material of the spongy layer is the poly (glycolide-lactide) PGLA that degradation time is 50-150 days,
There is equally distributed diamond sunk, and a longer diagonal line for the diamond shape and blood flow side on the spongy layer To consistent,
Edge of the length of the spongy layer without departing from the upper and lower ends of the metal net shaped supporting layer and the coating layer.
2. the anti-interior leakage stent graft system of attached sponge structure according to claim 1, it is characterised in that:
Wherein, the both ends of the spongy layer bounce back relative to the inward at both ends of the metal net shaped supporting layer.
3. the anti-interior leakage stent graft system of attached sponge structure according to claim 1, it is characterised in that:
Wherein, the spongy layer is made of the material that can adsorb coagulation factor and blood platelet in blood.
4. a kind of anti-interior leakage stent graft system of attached sponge structure, special for preventing and kill off the interior leakage other than being leaked in II types in advance Sign is, including:
The metal net shaped supporting layer to match with arteries shape;
The coating layer being covered on the metal net shaped supporting layer;And
The elastic network(s) compartment being distributed on the outside of the coating layer, the elastic network(s) compartment are filled in dynamic under the action of natural resiliency It is formed by gap between the inner wall of arteries and veins blood vessel and the coating layer,
Wherein, the elastic network(s) compartment is composed of the rib of multiple double pyrometric cone columns, and internal and cylinder is hollow, by PGLA Material is made,
The long axis direction of the long axis direction and the metal net shaped supporting layer of double pyrometric cone columns is perpendicular.
CN201410817691.4A 2014-12-19 2014-12-19 The anti-interior leakage stent graft system of attached sponge structure Expired - Fee Related CN104873303B (en)

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CN201410817691.4A CN104873303B (en) 2014-12-19 2014-12-19 The anti-interior leakage stent graft system of attached sponge structure
US15/537,429 US11007047B2 (en) 2014-12-19 2015-12-18 Endoleak preventing stent graft system
PCT/CN2015/097972 WO2016095864A1 (en) 2014-12-19 2015-12-18 Endoleak-preventing stent graft system

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WO2016095864A1 (en) * 2014-12-19 2016-06-23 中国人民解放军第二军医大学 Endoleak-preventing stent graft system
CN111700712A (en) * 2020-05-21 2020-09-25 普霖医疗科技(广州)有限公司 Branch covered stent
CN115192283B (en) * 2022-09-19 2022-12-27 艾柯医疗器械(北京)股份有限公司 Stent conveying system and stent system comprising same

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