CN101984821A - Bactericidal composition containing fluazinam and tebuconazole and application thereof - Google Patents
Bactericidal composition containing fluazinam and tebuconazole and application thereof Download PDFInfo
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- CN101984821A CN101984821A CN2010102287883A CN201010228788A CN101984821A CN 101984821 A CN101984821 A CN 101984821A CN 2010102287883 A CN2010102287883 A CN 2010102287883A CN 201010228788 A CN201010228788 A CN 201010228788A CN 101984821 A CN101984821 A CN 101984821A
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- tebuconazole
- fluazinam
- bactericidal composition
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Abstract
The invention relates to a bactericidal composition containing fluazinam and tebuconazole and application thereof. The bactericidal composition contains fluazinam and tebuconazole in a weight ratio of 1-60:1-40. The bactericidal composition can be used for preventing and controlling diseases in crops such as cereal crops, melons and fruits or vegetables and the like, has wide application range, good effect, low cost, fewer residues, and is safe to human, livestock, environment and the like.
Description
(1) technical field
The present invention relates to a kind of bactericidal composition and purposes, relate in particular to a kind of bactericidal composition that contains fluazinam and Tebuconazole and uses thereof.
(2) background technology
Fluazinam (Fluazinam) is the phenyl amines protective fungicide, and its mechanism of action is a mitochondria phosphorous oxide acidylate uncoupler, promptly gives sprouting, mycelia breakthrough, growth and sporulation by the inhibition spore and suppresses infecting of pathogen.The fluazinam fungicidal spectrum is wide, and effect is better than the GPF (General Protection False bactericide.Applicable crops is wide in grape, apple, pears, oranges and tangerines, wheat, soybean, potato, tomato, cucumber, paddy rice, tea, lawn etc., and is very effective to interlink spore genus, Botrytis, Phytophthora, Plasmopara, Sclerotinia and Venturia bacterium.Botrytis cinerea to anti-benzimidazole type and dicarboximide class biocide agent also has good result.Resistance of rainwater washing against, the lasting period is long.Except bactericidal activity, fluazinam also has certain acaricidal activity, engraves mite, kamisawa tetranychus etc. as citrus red mite, China pink.
But fluazinam does not have systemic activity and therapeutic action, can't enter in the plant corpus by plant surface, though a lot of pathogens there is bactericidal activity preferably, really not ideal in the practical application of field.
Tebuconazole (Tebuconazole) is a kind of triazole bactericidal agent, and its mechanism of action is the sterol demethylation, promptly passes through to suppress the biosynthesis of wheat sterol, kill pathogenic bacteria, thus prevent infecting of pathogen.Have treatment and protective effect preferably.Tebuconazole is widely used, and can be used for the control as wheat, barley, oat, rye, paddy rice, corn, peanut, soybean and crop pests such as other oil crop, tomato, potato, Chinese sorghum, grape, asparagus, mango, pears, peach, apple, banana, tea tree and various vegetables thereof.
But because of factors such as Tebuconazole price and the good controls of tool, the abuse of Tebuconazole list agent in recent years phenomenon is more serious, has caused the generation of resistance, if can not effectively resolve this problem, will be subjected to very big influence the service life of Tebuconazole.
(3) summary of the invention
One of purpose of the present invention is to overcome above-mentioned deficiency, but a kind of low delaying drug resistance applied widely, effective, residual is provided and increases the bactericidal composition that contains fluazinam and Tebuconazole in service life.
Two of purpose of the present invention is to provide a kind of purposes that contains the bactericidal composition of fluazinam and Tebuconazole.
The object of the present invention is achieved like this:
A kind of bactericidal composition that contains fluazinam and Tebuconazole, described composition contains fluazinam and Tebuconazole, and the weight ratio of described fluazinam and Tebuconazole is 1～60: 1～40.
The optimization weight ratio of described fluazinam and Tebuconazole is 4～30: 8～40.
The weight ratio of described fluazinam and Tebuconazole is 1: 1,1: 4,1: 8,1: 16,1: 20,4: 1,8: 1,12: 1 or 16: 1.
Described combination dosage form is any one formulation that allows on the agricultural chemicals.
Described combination dosage form is wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
Described fluazinam and the Tebuconazole mass percent in composition is 1～90%.
A kind of purposes that contains the bactericidal composition of fluazinam and Tebuconazole is used for the medicine as cereal crop, melon and fruit or vegetable crop disease.
Be used for medicine as pear scab.
Compared with prior art, the invention has the beneficial effects as follows:
(1) present composition synergistic effect of doing well in certain ratio range, the bactericidal effect of composition have had than single agent and have significantly improved, and have reduced agricultural chemicals using dosage and cost simultaneously, have reduced residually, have also alleviated the harmful effect to environment;
(2) the mechanism of action difference of two kinds of active components among the present invention, the application of composition can delay or overcome the resistance of pathogen, prolongs the service life of product;
(3) present composition scope of application increases, be applicable to the disease of crops such as control cereal crop, various melon and fruit, vegetables, crop pests such as paddy rice, wheat, tomato, banana, apple, pears particularly are as rice blast, wheat powdery mildew, early blight of tomato, alternaria leaf spot of apple, pear scab etc.
(4) embodiment
Clearer in order to be purpose of the present invention, technical scheme and advantage, the present invention describes with following instantiation, but the present invention is not limited to these examples.
The present composition is an active ingredient with fluazinam and Tebuconazole, finds through the indoor bioassay test, and antagonistic drug venereal disease evil had obvious role in synergism after both were composite, specifically was illustrated with following biologicall test example.
The example of measuring in kind: the composite toxicity test of fluazinam and Tebuconazole to pear scab
1, subjects: pear scab
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T1156.2-2006 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC
50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T1156.2-2006 ", according to Sun﹠amp; The co-toxicity coefficient method (CTC) of Johnson (1960) is estimated the synergistic effect of pharmacy mix, and promptly CTC≤80 are antagonism, and 80＜CTC＜120 are summation action, and CTC 〉=120 are synergistic effect.
The percentage composition of A medicament in toxicity index * 100 mixtures of the theoretical toxicity index (TTI) of mixture=medicament A
The percentage composition of B medicament in the toxicity index of+medicament B * 100 mixtures
5, result and analysis
The toxicity test that makes up the pear scab bacterium that is mixed of fluazinam, Tebuconazole and the two different proportion thereof the results are shown in Table 1, and " fluorine: penta " is writing a Chinese character in simplified form of " fluazinam: Tebuconazole " in the table 1.
Table 1 fluazinam and Tebuconazole are mixed to the toxicity test result of pear cucumerinum
Indoor biometrics is the result show: fluazinam and Tebuconazole are mixed with 1: 1,1: 4,1: 8,1: 16,1: 20,4: 1,8: 1,12: 1 and 16: 1 ratios pear cucumerinum is all shown synergistic effect, and be wherein better with the synergistic effect of 1: 1,1: 4 and 1: 16.Therefore, only from the synergy virulence relatively, can look 1: 1,1: 4 and 1: 16 is the best proportioning that fluazinam and Tebuconazole are mixed.As for which kind of ratio being mixed in the production reality, still needing and take all factors into consideration decision in conjunction with synergy virulence, Financial cost, processing technology and toxicity etc.
The present composition can claim to be fit to agricultural with the preparation of known method and go up any one formulation of using, and wherein reasonable formulation has missible oil, water dispersible granules, aqueous emulsion, suspending agent and wetting powder, below describes with instantiation.
Embodiment 1:
Fluazinam 2.5g, Tebuconazole 2.5g, what thing 3g of phenethyl phenol polyethenoxy ether institute, this sulfoacid calcium of alkyl 1g, sorbitol polyoxyethylene ether 1.5g, polyvinyl alcohol-acetic acid polyethylene and ethylene copolymers 0.5g, reduction are supplied 100g than 0.5g, ethylene glycol 10g, organic silicone 0.2g, rhodamine toner 0.1g, water, mix, grind through sand mill, stir again, make the present composition 75% suspension seed-coating agent.
Embodiment 2:
With fluazinam 10g, Tebuconazole 40g, sodium methylene bis-naphthalene sulfonate 4.5g, sodium lignin sulfonate 3g, kaolin add, ethylene glycol 5g, xanthans 0.5g, kaolin supplies 100g, after mixing, through comminution by gas stream, granulation, make the present composition 50% water dispersible granules again.
Embodiment 3:
With fluazinam 8g, Tebuconazole 12g, dodecyl sodium sulfate 5g, polyoxyethylene nonylphenol ether 3g, sodium methylene bis-naphthalene sulfonate 2g, xanthans 0.2g propane diols 5g, suitable quantity of water, to mix through wet grinding, homogenizing makes the present composition 20% suspending agent.
Embodiment 4:
Fluazinam 3g, Tebuconazole 48g, dodecyl sodium sulfate 4.5g, sodium lignin sulfonate 3g, white carbon 5g, kaolin are added to 100g, mix making the present composition 51% wetting powder through comminution by gas stream.
Embodiment 5:
With fluazinam 2g, Tebuconazole 18g, dimethylbenzene 10g, alkylaryl formaldehyde resin APEO 10g, alkylphenol polyoxyethylene phosphate 1g, ethylene glycol 4g, xanthans 0.1g, organic silicone 0.1g, suitable quantity of water, the preparation oil phase, the preparation water, under high shear, add in the oil phase with the even aqueous phase of oil phase or with water, shear and make the present composition 20% aqueous emulsion.
Application Example:
The preparation that utilizes the foregoing description to make is prevented and treated the pear scab test of pesticide effectiveness.
1, test is handled: this test medicine consumption is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent, 25% Tebuconazole wetting powder and clear water blank.
2, test method: test and Selection is carried out in the serious theatre of pear scab over the years, tests each age fruit tree of hanking and is no less than 2, repeats 4 times.Investigation method and evaluating drug effect are undertaken by GB/T17980.24-2000.
3, result of the test such as following table:
Annotate: a is illustrated on α=0.05 level significantly, and b is illustrated on α=0.05 level variant, c be illustrated in have on α=0.05 level not remarkable.
Field control effectiveness test shows that fluazinam and Tebuconazole bactericidal composition have good preventive effect to pear scab, and control efficiency is better than single agent kind.
Claims (8)
1. bactericidal composition that contains fluazinam and Tebuconazole, it is characterized in that: described composition contains fluazinam and Tebuconazole, and the weight ratio of described fluazinam and Tebuconazole is 1～60: 1～40.
2. the bactericidal composition that contains fluazinam and Tebuconazole according to claim 1 is characterized in that: the weight ratio of described fluazinam and Tebuconazole is 4～30: 8～40.
3. the bactericidal composition that contains fluazinam and Tebuconazole according to claim 1 is characterized in that: the weight ratio of described fluazinam and Tebuconazole is 1: 1,1: 4,1: 8,1: 16,1: 20,4: 1,8: 1,12: 1 or 16: 1.
4. according to claim 1 or 2 or 3 described bactericidal compositions, it is characterized in that: described combination dosage form is any one formulation that allows on the agricultural chemicals.
5. the bactericidal composition that contains fluazinam and Tebuconazole according to claim 4 is characterized in that: described combination dosage form is wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
6. the bactericidal composition that contains fluazinam and Tebuconazole according to claim 1 is characterized in that: described fluazinam and the Tebuconazole mass percent in composition is 1～90%.
7. the purposes of the bactericidal composition that contains fluazinam and Tebuconazole described in the claim 1 is characterized in that: be used for the medicine as cereal crop, melon and fruit or vegetable crop disease.
8. the purposes that contains the bactericidal composition of fluazinam and Tebuconazole according to claim 7 is characterized in that: be used for the medicine as pear scab.
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| CN 201010228788 CN101984821B (en) | 2010-07-15 | 2010-07-15 | Bactericidal composition containing fluazinam and tebuconazole and application thereof |
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| CN101984821A true CN101984821A (en) | 2011-03-16 |
| CN101984821B CN101984821B (en) | 2013-06-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070180A (en) * | 2013-02-05 | 2013-05-01 | 潘登 | Multifunctional rice seed treating agent |
| WO2016203154A1 (en) * | 2015-06-19 | 2016-12-22 | Phyteurop S.A. | Process for treating perennial plant wood diseases |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108739823A (en) * | 2018-06-21 | 2018-11-06 | 陕西上格之路生物科学有限公司 | Application of the bactericidal composition of containing fluazinam in prevention head blight and bakanae disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119693A (en) * | 2010-01-08 | 2011-07-13 | 南京华洲药业有限公司 | Synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof |
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- 2010-07-15 CN CN 201010228788 patent/CN101984821B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119693A (en) * | 2010-01-08 | 2011-07-13 | 南京华洲药业有限公司 | Synergetic antibacterial composition containing fluazinam and tebuconazole and use thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070180A (en) * | 2013-02-05 | 2013-05-01 | 潘登 | Multifunctional rice seed treating agent |
| WO2016203154A1 (en) * | 2015-06-19 | 2016-12-22 | Phyteurop S.A. | Process for treating perennial plant wood diseases |
| FR3037479A1 (en) * | 2015-06-19 | 2016-12-23 | Phyteurop S A | PROCESS FOR TREATING WOOD DISEASES OF PERENNIAL PLANTS |
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| CN101984821B (en) | 2013-06-05 |
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Owner name: JIANGYIN SULI CHEMICALS CO., LTD. Free format text: FORMER OWNER: JIANGYIN SULI TECHNOLOGY CO., LTD. Effective date: 20120730 |
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