CN101983680A - Traditional Chinese medicine composition for treating infertility and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infertility and preparation method thereof Download PDFInfo
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- CN101983680A CN101983680A CN2010105348465A CN201010534846A CN101983680A CN 101983680 A CN101983680 A CN 101983680A CN 2010105348465 A CN2010105348465 A CN 2010105348465A CN 201010534846 A CN201010534846 A CN 201010534846A CN 101983680 A CN101983680 A CN 101983680A
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Abstract
The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating infertility and a preparation method thereof. The invention is characterized in that the traditional Chinese medicine composition is prepared by the following traditional Chinese medicine raw materials by parts by weight: 40-60 parts of epimedium, 35-65 parts of wolfberry fruit, 40-60 parts of Chinese yam and 45-55 parts of cistanche. The composition has good curative effect on infertility, no toxic or side effect is produced, and safety is high.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, particularly a kind of Chinese medicine composition for the treatment of infertility and preparation method thereof.
Background technology
The infertility normal couple at child-bearing age that makes a comment or criticism has normality life after marriage, 1 year or longer time, do not practise contraception, and also fertility, married couple takes place by sterile person 15%, and wherein the sickness rate of male infertility accounts for 30%.The fertility primary condition be have normal sexual function and have can with the bonded eupyrene sperm of ovum.Therefore, no matter be that the sexual organ dissects or physiological defect, or the hypothalamic pituitary gonadal axis insufficiency of accommodation, can cause sterile.
The traditional Chinese medical science is the marrow of Chinese traditional culture, also is very important achievement in the Chinese history development.And for the diagnoses and treatment of male infertility this respect, the traditional Chinese medical science has abundant research treatment experience.In just record once of traditional Chinese medical science ancient books " dialectical record ": " all men can not give birth to six diseases, six diseases what is meant by? smart cold, two weakness of QIs, three abundant expectoration, four mutually fire contain, five is smart rare, six stagnation of QIs ".
Summary of the invention
The object of the present invention is to provide Chinese medicine composition of a kind of infertility and preparation method thereof.Its therapeutic effect is good, and is safe.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
The present invention also aims to the application of this Chinese medicine composition in the medicine of preparation treatment infertility.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of infertility is characterized in that:
Raw material of Chinese medicine medicine by following weight parts is formulated: Herba Epimedii 40-60 part, Fructus Lycii 35-65 part, Rhizoma Dioscoreae 40-60 part, Herba Cistanches 45-55 part.
Described a kind of weight portion for the treatment of the Chinese medicine composition of infertility is: 50 parts of Herba Epimedii, 50 parts of Fructus Lycii, 50 parts of Rhizoma Dioscoreaes, 50 parts of Herba Cistanches.
Described a kind of weight portion for the treatment of the Chinese medicine composition of infertility is: 40 parts of Herba Epimedii, 35 parts of Fructus Lycii, 40 parts of Rhizoma Dioscoreaes, 45 parts of Herba Cistanches.
Described a kind of weight portion for the treatment of the Chinese medicine composition of infertility is: 60 parts of Herba Epimedii, 65 parts of Fructus Lycii, 60 parts of Rhizoma Dioscoreaes, 55 parts of Herba Cistanches.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), above 4 the flavor raw materials in, Herba Epimedii is ground into coarse powder, Fructus Lycii and Rhizoma Dioscoreae fragmentation, Herba Cistanches is ground into fine powder, and is standby;
3), add the 65-85% ethanol that the 6-10 of Fructus Lycii weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered merging filtrate, recovery ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4), thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, the limit edged stirs, precipitation adds ethanol elution 3-5 time, the total ethanol consumption be the thick paste amount 6-10 doubly, place a moment, the merging supernatant, standby;
5), add the 65-85% ethanol that the 6-10 of Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filter, the supernatant that filtrate and step 4) obtain merges, and reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6), add the 65-85% ethanol that the 8-12 of Rhizoma Dioscoreae weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered merging filtrate, recovery ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7), the thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, with step 2) the Herba Cistanches fine powder mixing that obtains, drying is ground into fine powder, mixing is made described Chinese medicine composition.
Described fine powder all can pass through 100 mesh sieves, wherein is no less than 95% and can passes through 120 mesh sieves.
In the above-mentioned preparation method, the best thickening temperature of step 3), step 5) and step 6) is 60 ℃.
Preparation of the present invention is peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation unguentum etc., more preferably capsule.
Preparation of the present invention is determined usage and dosage according to patient's situation in use.Every of this medicament specification contains active ingredient 0.35g, an oral 2-3 grain, and 2 times on the 1st, serveing on 3 months was 1 course of treatment.
Chinese medicine composition of the present invention is Herba Epimedii, Fructus Lycii, Rhizoma Dioscoreae, Herba Cistanches, is clinical treatment experience and verification experimental verification and prescription, Herba Epimedii [function cures mainly] kidney invigorating and YANG supporting, expelling wind and removing dampness.Control the sexual impotence erectile problem, dribbling urination, the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless." book on Chinese herbal medicine is just ": Fructus Lycii, highly seasoned and pure, so the energy nourishing YIN has sun in the moon, so can QI invigorating.Compendium of Material Medica is summarized Rhizoma Dioscoreae five big functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".. " book on Chinese herbal medicine converges and says ": Herba Cistanches, support the gate of vitality, nourishing kidney gas, the medicine of replenishing vital essence and blood is also.
The specific embodiment
Below by the specific embodiment that provides the present invention is described clearly further, but not as a limitation of the invention.
Embodiment 1
Described a kind of weight portion for the treatment of the Chinese medicine composition of infertility is: 50 parts of Herba Epimedii, 50 parts of Fructus Lycii, 50 parts of Rhizoma Dioscoreaes, 50 parts of Herba Cistanches.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), above 4 the flavor raw materials in, Herba Epimedii is ground into coarse powder, Fructus Lycii and Rhizoma Dioscoreae fragmentation, Herba Cistanches is ground into fine powder, and is standby;
3), add the 65-85% ethanol that the 6-10 of Fructus Lycii weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered merging filtrate, recovery ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4), thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, the limit edged stirs, precipitation adds ethanol elution 3-5 time, the total ethanol consumption be the thick paste amount 6-10 doubly, place a moment, the merging supernatant, standby;
5), add the 65-85% ethanol that the 6-10 of Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filter, the supernatant that filtrate and step 4) obtain merges, and reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6), add the 65-85% ethanol that the 8-12 of Rhizoma Dioscoreae weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered merging filtrate, recovery ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7), the thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, with step 2) the Herba Cistanches fine powder mixing that obtains, drying is ground into fine powder, mixing is made described Chinese medicine composition.
Embodiment 2
Described a kind of weight portion for the treatment of the Chinese medicine composition of infertility is: 40 parts of Herba Epimedii, 35 parts of Fructus Lycii, 40 parts of Rhizoma Dioscoreaes, 45 parts of Herba Cistanches.
Preparation method is with embodiment 1
Embodiment 3
Described a kind of weight portion for the treatment of the Chinese medicine composition of infertility is: 60 parts of Herba Epimedii, 65 parts of Fructus Lycii, 60 parts of Rhizoma Dioscoreaes, 55 parts of Herba Cistanches.
Preparation method is with embodiment 1
More than the prescription effect of three embodiment be more significant prescription, but so long as comparatively significantly curative effect, Herba Epimedii 40-60 part, Fructus Lycii 35-65 part, Rhizoma Dioscoreae 40-60 part, Herba Cistanches 45-55 part all can be arranged by following prescription proportioning.
The umber of Chinese medicine component can be got gram (g), kilogram (kg), ton (t)
In order to show the therapeutic effect of medicine of the present invention, the present invention has carried out clinical trial:
A kind of clinical experiment for the treatment of anginal Chinese medicine composition proposed by the invention is as follows: select age 22-32 year patient 45 examples, 26 years old mean age, the course of disease 1 year-5 years, average course of disease 3 years.The patient did not accept other treatment before this treatment.3 months is a course of treatment, carries out symptom score after 3 months.Among the 45 routine patients, 15 examples (being called the treatment group) take capsule of the present invention (specification: the 0.35g/ grain), each 2-3 grain, every day 2 times; 15 examples (being called contrast A group) are regularly taken clomiphene; 15 examples (be called contrast B group) injection chorionic-gonadotropin hormone, during the patient discontinue the habit of smoking and drinking, be careful in one's diet and have a rest.
Therapeutic outcome:
After treating 3 months skies, therapeutic effect relatively sees Table 1.
Table 1 capsule for treating of the present invention is the effect comparison after 28 days
| Group | The N number | Effectively | 3 months effective (%) | Side effect |
| The treatment group | 15 | 14 | 93.3% | 0 |
| Contrast A group | 15 | 12 | 80% | 11 |
| Contrast B group | 15 | 14 | 93.3% | 8 |
By table 1 as seen, the effective percentage that uses the made capsular treatment group of the present invention is apparently higher than contrast A group, and the effective percentage of treatment group equals to contrast the B group, and the side effect example is several then to be zero, and side effect all appears in contrast A group and contrast B group.The result shows the good effect of using the made capsular treatment group of the present invention, has no side effect.
In addition, use the made capsule of the present invention, medical expense is starkly lower than matched group.
Claims (5)
1. treat Chinese medicine composition of infertility and preparation method thereof for one kind, it is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated:
Herba Epimedii 40-60 part, Fructus Lycii 35-65 part, Rhizoma Dioscoreae 40-60 part, Herba Cistanches 45-55 part.
2. according to described a kind of Chinese medicine composition for the treatment of infertility of claim 1 and preparation method thereof, it is characterized in that: 50 parts of Herba Epimedii, 50 parts of Fructus Lycii, 50 parts of Rhizoma Dioscoreaes, 50 parts of Herba Cistanches.
3. according to described a kind of Chinese medicine composition for the treatment of infertility of claim 1 and preparation method thereof, it is characterized in that: 40 parts of Herba Epimedii, 35 parts of Fructus Lycii, 40 parts of Rhizoma Dioscoreaes, 45 parts of Herba Cistanches.
4. according to described a kind of Chinese medicine composition for the treatment of infertility of claim 1 and preparation method thereof, it is characterized in that: 60 parts of Herba Epimedii, 65 parts of Fructus Lycii, 60 parts of Rhizoma Dioscoreaes, 55 parts of Herba Cistanches.
5. according to the described a kind of preparation method for the treatment of the Chinese medicine composition of infertility of claim 1-4, comprise the steps:
1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), above 4 the flavor raw materials in, Herba Epimedii is ground into coarse powder, Fructus Lycii and Rhizoma Dioscoreae fragmentation, Herba Cistanches is ground into fine powder, and is standby;
3), add the 65-85% ethanol that the 6-10 of Fructus Lycii weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filtered merging filtrate, recovery ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.10-1.30;
4), thick paste that step 3) is obtained adds ethanol (concentration of alcohol 95%) eluting, the limit edged stirs, precipitation adds ethanol elution 3-5 time, the total ethanol consumption be the thick paste amount 6-10 doubly, place a moment, the merging supernatant, standby;
5), add the 65-85% ethanol that the 6-10 of Herba Epimedii coarse powder weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 2-4 time was extracted 1-2 hour at every turn, filter, the supernatant that filtrate and step 4) obtain merges, and reclaims ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
6), add the 65-85% ethanol that the 8-12 of Rhizoma Dioscoreae weight doubly measures, heating (65 ℃ of temperature) reflux, extract, 1-3 time was extracted 1-2 hour at every turn, filtered merging filtrate, recovery ethanol, and in 50-70 ℃ of thick paste that is concentrated into relative density 1.30-1.32;
7), the thick paste that obtains of thick paste that step 4) is obtained and step 3) merges, with step 2) the Herba Cistanches fine powder mixing that obtains, drying is ground into fine powder, mixing is made described Chinese medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105348465A CN101983680A (en) | 2010-11-08 | 2010-11-08 | Traditional Chinese medicine composition for treating infertility and preparation method thereof |
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| CN2010105348465A CN101983680A (en) | 2010-11-08 | 2010-11-08 | Traditional Chinese medicine composition for treating infertility and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510934A (en) * | 2014-11-24 | 2015-04-15 | 三穗民族中西医结合诊所 | Male infertility treatment drug |
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2010
- 2010-11-08 CN CN2010105348465A patent/CN101983680A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510934A (en) * | 2014-11-24 | 2015-04-15 | 三穗民族中西医结合诊所 | Male infertility treatment drug |
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Application publication date: 20110309 |