CN104510934A - Male infertility treatment drug - Google Patents

Male infertility treatment drug Download PDF

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Publication number
CN104510934A
CN104510934A CN201410678589.0A CN201410678589A CN104510934A CN 104510934 A CN104510934 A CN 104510934A CN 201410678589 A CN201410678589 A CN 201410678589A CN 104510934 A CN104510934 A CN 104510934A
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parts
radix
semen
male infertility
fructus
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印和平
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SANSUI NATIONAL TRADITIONAL CHINESE AND WESTERN MEDICINE COMBINED CLINIC
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SANSUI NATIONAL TRADITIONAL CHINESE AND WESTERN MEDICINE COMBINED CLINIC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane

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Abstract

The invention discloses a male infertility treatment drug comprising the following raw material medicines by weight: 12-17 parts of dodder, 12-17 parts of semen astragali complanati, 12-17 parts of fructus broussonetiae, 12-17 parts of dogwood, 12-17 parts of rhizoma alismatis, 12-17 parts of Chinese angelica, 12-17 parts of schisandra propinqua, 12-17 parts of farfugium japonicum, 16-23 parts of salvia miltiorrhiza, 16-23 parts of poria cocos, 16-23 parts of radix morindae officinalis, 27-32 parts of Chinese yam, 9-14 parts of Chinese chive seed, 12-17 parts of smallflower microtis, 7-13 parts of epimedium, 16-23 parts of prepared rhizome of rehmannia, 12-17 parts of barbary wolfberry fruit and polygonatum humile Fisch. ex Maxim. The male infertility treatment drug can be used for male sterility in clinic, and has the characteristics of good curative effect and little side effect.

Description

A kind of medicine for the treatment of male infertility
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of male infertility.
Background technology
Male infertility incidence rate is about 10%.Wherein simple wife's side factor is about 50%, and simple bridegroom's or husband's side factor is about 30%, and men and women total about 20%.Clinically male sterility is divided into sexual dysfunction and normal two classes of sexual function, it is sterile that the latter can be further divided into azoospermia, oligospermatism, azoospermia, asthenospermia disease and sperm count normality according to semen analysis result.
Male infertility is except congenital deformity of testis and dysplasia, and external potential hazard is Briefs, often easily out in the cold.
The contraction of scrotum is to regulate the temperature of testis lower than body temperature about 2 degree, just testis only reaches optimum state lower than body temperature about 2 degree secretions being conducive to testosterone.Testosterone is the important substance promoting spermatogenesis.The Briefs of current trend close-fitting vest, general design is above all double-deck, scrotum and penis is bundled together, of a specified duration cause hip under long-term in the environment of hot humid, become the hotbed that virus and bacteria grows.Under hip, long hot humid is the potential danger of the common andropathys such as triggering male prostatitis, varicocele, seminal vesiculitis, eczema scrotum.Prostatitis, varicocele and seminal vesiculitis are male infertility common diseases.
The etiological classification of male sterility can according to being divided into absolute sterility (azoospermia) and relative sterility (the few or motility of sperm of sperm quantity is low etc.) fertility, primary sterility and secondary sterility can be divided into by clinical manifestation, property after property before testis, testicular and testis can be divided into by sexual organ's diseased region.
For the treatment of male infertility, comprise several as follows:
Drug therapy: conventional chorionic-gonadotropin hormone, clomiphene.
Operative treatment: active treatment sexual dysfunction, keeps normal sexual life.Blocking for congenital absence of the vas deferentia, semen deposition pipeline should positive operative treatment with vasoligation person.
Keep semen deposition pipeline unobstructed: active treatment sexual dysfunction, keeps normal sexual life.Blocking for congenital absence of the vas deferentia, semen deposition pipeline should positive operative treatment with vasoligation person.
Improve sperm function: person actively should give antibiotic therapy urogenital tract infection; Vitamin E, vitamin C and zinc preparation all can improve sperm function.For immune infertility person, adopt condom can eliminate and lower the stimulation of sperm antigen to women.The heavy dose of method such as short application use and Sperm washing artificial insemination of immunosuppressant, helpful to treatment immune infertility.
Artificial insemination: comprise the insemination of donor sperm artificial and husband's sperm artificial insemination two large classes.In recent years, external artificial auxiliary procreation technology obtained develop rapidly, and especially in endochylema, monosperm injection art has been used for the treatment of oligospermatism, azoospermia and azoospermia, achieves good effect.
Traditional Chinese medical herbal treatment: (containing prostatitis, seminal vesiculitis, epididymis deferentitis), immunity male infertility are infected for the varicocele of 1 degree, seminal fluid, adopt Chinese medicine Coryza Treated by Syndrome Differentiation, or blood circulation promoting and blood stasis dispelling, or liver heat removing and kidney replenishing, or the kidney invigorating and essence nourishing, or soothing the liver tune punching.
In treatment male infertility, medically have accumulated many invaluable experiences, also there is certain curative effect.But the medicine circulated in market, has unsatisfactory part more, or onset is slow, or side effect is large or costly etc., and operative treatment adds the health of patient and psychological misery in another degree.
Summary of the invention
The object of the present invention is to provide a kind of good effect, the medicine of the treatment male infertility that side effect is little.
Medicine of the present invention is prepared by the crude drug of following weight proportion:
Semen Cuscutae 12-17 part, Semen Astragali Complanati 12-17 part, Fructus Broussonetiae 12-17 part, Fructus Corni 12-17 part, Rhizoma Alismatis 12-17 part, Radix Angelicae Sinensis 12-17 part, Radix seu Caulis Schisandrae Sinensis 12-17 part. Coniogramme japonica (Thunb.) Diels 12-17 part, Radix Salviae Miltiorrhizae 16-23 part, Poria 16-23 part, bar halberd 16-23 part, Rhizoma Dioscoreae 27-32 part, Semen Allii Tuberosi 9-14 part, Herba Microtis taiwanianae 12-17 part, Herba Epimedii 7-13 part, Radix Rehmanniae Preparata 16-23 part, Fructus Lycii 12-17 part, golden bamboo root tail 15-20 part.
The preferred weight proportioning of above-mentioned raw materials medicine is:
Semen Cuscutae 15 parts, Semen Astragali Complanati 15 parts, Fructus Broussonetiae 15 parts, Fructus Corni 15 parts, Rhizoma Alismatis 15 parts, Radix Angelicae Sinensis 15 parts, Radix seu Caulis Schisandrae Sinensis 15 parts. Coniogramme japonica (Thunb.) Diels 15 parts, Radix Salviae Miltiorrhizae 20 parts, Poria 20, bar halberd 20 parts, Rhizoma Dioscoreae 30 parts, Semen Allii Tuberosi 12 parts, Herba Microtis taiwanianae 15 parts, Herba Epimedii 10 parts, 20 parts, Radix Rehmanniae Preparata, Fructus Lycii 15 parts, golden bamboo root tail 15-20 part.
The present invention compared with prior art, there is obvious beneficial effect, as can be known from the above technical solutions: the present invention selects Semen Cuscutae, Semen Astragali Complanati, Fructus Broussonetiae, Fructus Corni, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix seu Caulis Schisandrae Sinensis, Coniogramme japonica (Thunb.) Diels, Radix Salviae Miltiorrhizae, Poria, Ba Ji, Rhizoma Dioscoreae, Semen Allii Tuberosi, Herba Microtis taiwanianae, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Lycii, golden bamboo root tail to be raw material, treat male infertility by the synergism between each medicine, main manifestations is dizziness and tinnitus, soreness of the waist and knees, spiritlessness and weakness, impotence and premature ejaculation.Its good effect, side effect are little, and medication is convenient and swift.Clinical 105 examples use, total effective rate 96.2%, cure rate 59.0%.
Detailed description of the invention
The beneficial effect of medicine of the present invention is set forth further below by way of test example.
test example:the clinical observation of medicine of the present invention
Clinical data:
All cases 105 example.
Diagnostic criteria:
" disease of tcm Standardization of diagnosis and curative effect "
Therapeutic Method:
Every day, potion, was decocted in water for oral dose, and generally took medicine 3-6 month.
Criterion of therapeutical effect:
Cure: after treatment, its wife is conceived or Sperm recovery indices has reached normally, clinical symptoms and sign disappear.
Effective: Sperm recovery indices is obviously dismissed close to normal, clinical symptoms and sign or substantially disappears.
Invalid: Sperm recovery indices has no change, clinical symptoms and sign and is not improved.
Therapeutic outcome:
105 routine patients are through Drug therapy of the present invention, and cure 62 examples, effective 39 examples, invalid 4 examples, total effective rate is 96.2%, cure rate 59.0%.
embodiment 1
Take Semen Cuscutae 17g, Semen Astragali Complanati 17g, Fructus Broussonetiae 17g, Fructus Corni 12g, Rhizoma Alismatis 12g, Radix Angelicae Sinensis 12g, Radix seu Caulis Schisandrae Sinensis 17g. Coniogramme japonica (Thunb.) Diels 17g, Radix Salviae Miltiorrhizae 23g, Poria 16g, bar halberd 16g, Rhizoma Dioscoreae 27g, Semen Allii Tuberosi 14g, Herba Microtis taiwanianae 17g, Herba Epimedii 13g, Radix Rehmanniae Preparata 16g, Fructus Lycii 12g, gold bamboo root tail 15-20g, cleaning, decocts with water and get final product.
embodiment 2
Take Semen Cuscutae 12g, Semen Astragali Complanati 12g, Fructus Broussonetiae 12g, Fructus Corni 17g, Rhizoma Alismatis 17g, Radix Angelicae Sinensis 17g, Radix seu Caulis Schisandrae Sinensis 12g. Coniogramme japonica (Thunb.) Diels 12g, Radix Salviae Miltiorrhizae 16g, Poria 23g, bar halberd 23g, Rhizoma Dioscoreae 32g, Semen Allii Tuberosi 9g, Herba Microtis taiwanianae 12g, Herba Epimedii 7g, Radix Rehmanniae Preparata 23g, Fructus Lycii 17g, golden bamboo root tail 15-20g, cleans, decocts with water and get final product.
embodiment 3
Take Semen Cuscutae 14g, Semen Astragali Complanati 14g, Fructus Broussonetiae 14g, Fructus Corni 14g, Rhizoma Alismatis 14g, Radix Angelicae Sinensis 14g, Radix seu Caulis Schisandrae Sinensis 14g. Coniogramme japonica (Thunb.) Diels 14g, Radix Salviae Miltiorrhizae 21g, Poria 21g, bar halberd 21g, Rhizoma Dioscoreae 28g, Semen Allii Tuberosi 10g, Herba Microtis taiwanianae 14g, Herba Epimedii 9g, Radix Rehmanniae Preparata 21g, Fructus Lycii 14g, golden bamboo root tail 15-20g, cleans, decocts with water and get final product.
embodiment 4
Take Semen Cuscutae 15g, Semen Astragali Complanati 15g, Fructus Broussonetiae 15g, Fructus Corni 15g, Rhizoma Alismatis 15g, Radix Angelicae Sinensis 15g, Radix seu Caulis Schisandrae Sinensis 15g. Coniogramme japonica (Thunb.) Diels 15g, Radix Salviae Miltiorrhizae 20g, Poria 20, bar halberd 20g, Rhizoma Dioscoreae 30g, Semen Allii Tuberosi 12g, Herba Microtis taiwanianae 15g, Herba Epimedii 10g, Radix Rehmanniae Preparata 20g, Fructus Lycii 15g, golden bamboo root tail 15-20g, cleans, decocts with water and get final product.

Claims (2)

1. treat a medicine for male infertility, be made up of the crude drug of following weight proportioning: Semen Cuscutae 12-17 part, Semen Astragali Complanati 12-17 part, Fructus Broussonetiae 12-17 part, Fructus Corni 12-17 part, Rhizoma Alismatis 12-17 part, Radix Angelicae Sinensis 12-17 part, Radix seu Caulis Schisandrae Sinensis 12-17 part. Coniogramme japonica (Thunb.) Diels 12-17 part, Radix Salviae Miltiorrhizae 16-23 part, Poria 16-23 part, bar halberd 16-23 part, Rhizoma Dioscoreae 27-32 part, Semen Allii Tuberosi 9-14 part, Herba Microtis taiwanianae 12-17 part, Herba Epimedii 7-13 part, Radix Rehmanniae Preparata 16-23 part, Fructus Lycii 12-17 part, golden bamboo root tail 15-20 part.
2. the medicine for the treatment of male infertility as claimed in claim 1, is characterized in that: be made up of the crude drug of following weight proportioning: Semen Cuscutae 15 parts, Semen Astragali Complanati 15 parts, Fructus Broussonetiae 15 parts, Fructus Corni 15 parts, Rhizoma Alismatis 15 parts, Radix Angelicae Sinensis 15 parts, Radix seu Caulis Schisandrae Sinensis 15 parts. Coniogramme japonica (Thunb.) Diels 15 parts, Radix Salviae Miltiorrhizae 20 parts, Poria 20, bar halberd 20 parts, Rhizoma Dioscoreae 30 parts, Semen Allii Tuberosi 12 parts, Herba Microtis taiwanianae 15 parts, Herba Epimedii 10 parts, 20 parts, Radix Rehmanniae Preparata, Fructus Lycii 15 parts, golden bamboo root tail 15-20 part.
CN201410678589.0A 2014-11-24 2014-11-24 Male infertility treatment drug Pending CN104510934A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050028475A (en) * 2003-09-18 2005-03-23 (주)에이지아이 Composition for prophylaxis and treatment of lowering male reproductive function
CN101983680A (en) * 2010-11-08 2011-03-09 西安谦坤商务咨询管理有限公司 Traditional Chinese medicine composition for treating infertility and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050028475A (en) * 2003-09-18 2005-03-23 (주)에이지아이 Composition for prophylaxis and treatment of lowering male reproductive function
CN101983680A (en) * 2010-11-08 2011-03-09 西安谦坤商务咨询管理有限公司 Traditional Chinese medicine composition for treating infertility and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李郑生: "补肾生精汤治疗男性不育症105例", 《河南中医学院学报》 *

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