CN101983239A - 使用聚酮化物合酶制备二元羧酸 - Google Patents

使用聚酮化物合酶制备二元羧酸 Download PDF

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Publication number
CN101983239A
CN101983239A CN2009801110665A CN200980111066A CN101983239A CN 101983239 A CN101983239 A CN 101983239A CN 2009801110665 A CN2009801110665 A CN 2009801110665A CN 200980111066 A CN200980111066 A CN 200980111066A CN 101983239 A CN101983239 A CN 101983239A
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China
Prior art keywords
pks
host cell
domain
module
diacid
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CN2009801110665A
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English (en)
Chinese (zh)
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莱昂纳德·卡茨
杰弗里·L·福特曼
杰伊·D·科斯林
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University of California San Diego UCSD
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University of California San Diego UCSD
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Publication of CN101983239A publication Critical patent/CN101983239A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyamides (AREA)
  • Polyesters Or Polycarbonates (AREA)
CN2009801110665A 2008-03-28 2009-03-30 使用聚酮化物合酶制备二元羧酸 Pending CN101983239A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4058408P 2008-03-28 2008-03-28
US61/040,584 2008-03-28
PCT/US2009/038831 WO2009121066A1 (en) 2008-03-28 2009-03-30 Producing dicarboxylic acids using polyketide synthases

Publications (1)

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CN101983239A true CN101983239A (zh) 2011-03-02

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CN2009801110665A Pending CN101983239A (zh) 2008-03-28 2009-03-30 使用聚酮化物合酶制备二元羧酸

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US (2) US8569023B2 (https=)
EP (1) EP2254995A4 (https=)
JP (1) JP2011516045A (https=)
CN (1) CN101983239A (https=)
BR (1) BRPI0909839A2 (https=)
WO (1) WO2009121066A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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CN104011216A (zh) * 2011-06-30 2014-08-27 英威达技术有限责任公司 用于生产尼龙-7、尼龙-7,7和聚酯的生物转化工艺
CN104126012A (zh) * 2011-12-21 2014-10-29 英威达技术有限责任公司 用于生产尼龙-7、尼龙-7,7和聚酯的生物转化工艺
CN105085242A (zh) * 2014-05-25 2015-11-25 山东方明药业集团股份有限公司 一种优质丙酮二羧酸及丙酮二羧酸酯的合成方法
WO2025140469A1 (en) * 2023-12-28 2025-07-03 Westlake University Bioengineering of modular polyketide synthases

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BRPI0909839A2 (pt) 2008-03-28 2017-06-13 Univ California produção de ácidos dicarboxílicos usando policetídeo sintases
BRPI0909059A2 (pt) 2008-04-29 2019-09-24 Univ California produção de biocombustíveis usando sintases de policetídeo.
EP2383260A3 (en) * 2010-04-30 2011-12-28 Dipharma Francis S.r.l. Process for the preparation of statins
ITMI20100753A1 (it) * 2010-04-30 2011-10-31 Dipharma Francis Srl Procedimento per la preparazione di statine
BR112013007441A2 (pt) 2010-09-28 2017-07-04 Univ California produção de alfa-olefinas usando sintases de policetídeo
US9334514B2 (en) * 2010-10-29 2016-05-10 The Regents Of The University Of California Hybrid polyketide synthases
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
WO2012071439A1 (en) * 2010-11-22 2012-05-31 The Regents Of The University Of California Host cells and methods for producing diacid compounds
CA2868113A1 (en) 2011-03-22 2012-09-27 Opx Biotechnologies, Inc. Microbial production of chemical products and related compositions, methods and systems
JP6058650B2 (ja) 2011-06-17 2017-01-11 インビスタ テクノロジーズ エス．アー．エール．エル． 廃棄流中のモノマー含有量を増大させるためのヒドロラーゼの使用
DE102011110945A1 (de) 2011-08-15 2013-02-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt
DE102011110946A1 (de) 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
US9102960B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US9102958B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
EP2735328A1 (en) * 2012-11-27 2014-05-28 PARI Pharma GmbH Fluid reservoir for an aerosol generation device, combination of fluid reservoir and primary fluid package, and aerosol generation device for use with the fluid reservoir
BR112015013413A2 (pt) 2012-12-14 2017-11-14 Invista Tech Sarl método para biosintetizar um produto e hospedeiro recombinante
WO2014105790A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
EP2938733A2 (en) 2012-12-31 2015-11-04 Invista North America S.a.r.l. Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation
WO2014105797A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
WO2014105788A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
EP2938734A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via aromatic compounds
WO2014105793A1 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage
WO2014105805A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN106795534A (zh) 2014-06-16 2017-05-31 英威达技术有限责任公司 用于生物合成化合物的方法、试剂和细胞
EP3155111A1 (en) 2014-06-16 2017-04-19 Invista Technologies S.à r.l. Process for producing glutarate and glutaric acid methyl ester
WO2015195611A2 (en) 2014-06-16 2015-12-23 Invista Technologies S.À.R.L. Methods, reagents and cells for biosynthesizing compound
US9816117B2 (en) 2014-06-16 2017-11-14 Invista North America S.A.R.L. Methods, reagents and cells for biosynthesizing compounds
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3305401B1 (en) * 2015-06-08 2023-12-20 IHI Corporation Reactor
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
US12241101B2 (en) * 2018-08-10 2025-03-04 Kyowa Hakko Bio Co., Ltd. Microorganism producing polyunsaturated fatty acid and method for producing polyunsaturated fatty acid

Family Cites Families (8)

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CA2171629A1 (en) 1993-09-20 1995-03-30 Chaitan Khosla Recombinant production of novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
ATE286133T1 (de) 1995-07-06 2005-01-15 Univ Leland Stanford Junior Zellfreie synthese von polyketiden
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
WO2000031247A2 (en) 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
BRPI0909839A2 (pt) * 2008-03-28 2017-06-13 Univ California produção de ácidos dicarboxílicos usando policetídeo sintases

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104011216A (zh) * 2011-06-30 2014-08-27 英威达技术有限责任公司 用于生产尼龙-7、尼龙-7,7和聚酯的生物转化工艺
CN104126012A (zh) * 2011-12-21 2014-10-29 英威达技术有限责任公司 用于生产尼龙-7、尼龙-7,7和聚酯的生物转化工艺
CN105085242A (zh) * 2014-05-25 2015-11-25 山东方明药业集团股份有限公司 一种优质丙酮二羧酸及丙酮二羧酸酯的合成方法
WO2025140469A1 (en) * 2023-12-28 2025-07-03 Westlake University Bioengineering of modular polyketide synthases

Also Published As

Publication number Publication date
US20110014667A1 (en) 2011-01-20
WO2009121066A1 (en) 2009-10-01
BRPI0909839A2 (pt) 2017-06-13
US8569023B2 (en) 2013-10-29
EP2254995A1 (en) 2010-12-01
US9040282B2 (en) 2015-05-26
EP2254995A4 (en) 2011-05-25
JP2011516045A (ja) 2011-05-26
US20140030789A1 (en) 2014-01-30

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Application publication date: 20110302