CN101972478B - 抗体治疗 - Google Patents

抗体治疗 Download PDF

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Publication number
CN101972478B
CN101972478B CN2010105006839A CN201010500683A CN101972478B CN 101972478 B CN101972478 B CN 101972478B CN 2010105006839 A CN2010105006839 A CN 2010105006839A CN 201010500683 A CN201010500683 A CN 201010500683A CN 101972478 B CN101972478 B CN 101972478B
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China
Prior art keywords
antibody
cea
fragment
mab
hmn
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Expired - Fee Related
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CN2010105006839A
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Chinese (zh)
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CN101972478A (zh
Inventor
D·M·高登伯
H·J·汉森
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Immunomedics Inc
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Immunomedics Inc
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Priority claimed from PCT/US2002/032307 external-priority patent/WO2004032962A1/en
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Publication of CN101972478A publication Critical patent/CN101972478A/zh
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K38/19Cytokines; Lymphokines; Interferons
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    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN2010105006839A 2002-10-08 2003-10-08 抗体治疗 Expired - Fee Related CN101972478B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US41653102P 2002-10-08 2002-10-08
US60/416,531 2002-10-08
US60/416531 2002-10-08
PCT/US2002/032307 WO2004032962A1 (en) 2002-10-08 2002-10-11 Combination therapy with class iii anti-cea monoclonal antibodies and therapeutic agents
USPCT/US02/32307 2002-10-11
US46716103P 2003-05-02 2003-05-02
US60/467,161 2003-05-02
US60/467161 2003-05-02

Related Parent Applications (1)

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CN2003801053839A Division CN1878562B (zh) 2002-10-08 2003-10-08 抗体治疗

Publications (2)

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CN101972478A CN101972478A (zh) 2011-02-16
CN101972478B true CN101972478B (zh) 2012-10-31

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US (8) US7803372B2 (https=)
EP (1) EP1572131B1 (https=)
JP (2) JP4790413B2 (https=)
KR (1) KR20050065587A (https=)
CN (1) CN101972478B (https=)
AU (1) AU2003282752A1 (https=)
CA (1) CA2501616C (https=)
IL (3) IL167901A (https=)
WO (1) WO2004032857A2 (https=)

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CN101972478B (zh) * 2002-10-08 2012-10-31 免疫医疗公司 抗体治疗
EP1746157A4 (en) * 2004-04-27 2009-02-18 Chugai Pharmaceutical Co Ltd PROCESS FOR PLASMA CELL PROGRAMMING
BRPI0511187A (pt) * 2004-05-20 2007-12-04 Zymogenetics Inc método para tratar cáncer em um indivìduo
WO2006084075A2 (en) * 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Adam-9 modulators
US7601355B2 (en) * 2005-06-01 2009-10-13 Northwestern University Compositions and methods for altering immune function
RU2423381C2 (ru) 2005-07-25 2011-07-10 Трабьон Фармасьютикалз, Инк. Снижение количества в-клеток с использованием cd37-специфических и cd20-специфических связывающих молекул
WO2007111714A2 (en) 2005-11-28 2007-10-04 Zymogenetics, Inc. Il-21 antagonists
US20090226444A1 (en) 2005-12-21 2009-09-10 Micromet Ag Pharmaceutical antibody compositions with resistance to soluble cea
NZ573646A (en) 2006-06-12 2012-04-27 Wyeth Llc Single-chain multivalent binding proteins with effector function
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
DK2164514T3 (en) 2007-05-21 2017-02-27 Alderbio Holdings Llc Antibodies to IL-6 and its use
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