CN101970662A - 带有修饰碱基的寡核苷酸作为抗病毒剂的应用 - Google Patents

带有修饰碱基的寡核苷酸作为抗病毒剂的应用 Download PDF

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CN101970662A
CN101970662A CN2008801234555A CN200880123455A CN101970662A CN 101970662 A CN101970662 A CN 101970662A CN 2008801234555 A CN2008801234555 A CN 2008801234555A CN 200880123455 A CN200880123455 A CN 200880123455A CN 101970662 A CN101970662 A CN 101970662A
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modified
compound
oligonucleotide
nucleobases
oligonucleotides
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Chinese (zh)
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马特·萨尔玛
安德烈斯·梅利茨
马蒂·卡拉尔森
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Baltic Technology Development Ltd
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Baltic Technology Development Ltd
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN2008801234555A 2007-11-05 2008-11-05 带有修饰碱基的寡核苷酸作为抗病毒剂的应用 Pending CN101970662A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98554807P 2007-11-05 2007-11-05
US60/985,548 2007-11-05
US5768508P 2008-05-30 2008-05-30
US61/057,685 2008-05-30
PCT/FI2008/050633 WO2009060122A2 (en) 2007-11-05 2008-11-05 Use of oligonucleotides with modified bases as antiviral agents

Publications (1)

Publication Number Publication Date
CN101970662A true CN101970662A (zh) 2011-02-09

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CN2008801234555A Pending CN101970662A (zh) 2007-11-05 2008-11-05 带有修饰碱基的寡核苷酸作为抗病毒剂的应用

Country Status (10)

Country Link
US (1) US20110171287A1 (enExample)
EP (1) EP2212420A2 (enExample)
JP (1) JP5710977B2 (enExample)
CN (1) CN101970662A (enExample)
AU (1) AU2008324066A1 (enExample)
BR (1) BRPI0819191A2 (enExample)
CA (1) CA2704549A1 (enExample)
MX (1) MX2010004983A (enExample)
WO (1) WO2009060122A2 (enExample)
ZA (1) ZA201003234B (enExample)

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CN113069551A (zh) * 2014-08-19 2021-07-06 西北大学 蛋白质/寡核苷酸核-壳纳米颗粒治疗剂

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Publication number Priority date Publication date Assignee Title
CN113069551A (zh) * 2014-08-19 2021-07-06 西北大学 蛋白质/寡核苷酸核-壳纳米颗粒治疗剂

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WO2009060122A2 (en) 2009-05-14
JP2011502501A (ja) 2011-01-27
US20110171287A1 (en) 2011-07-14
EP2212420A2 (en) 2010-08-04
AU2008324066A1 (en) 2009-05-14
BRPI0819191A2 (pt) 2017-03-21
CA2704549A1 (en) 2009-05-14
MX2010004983A (es) 2010-07-29
WO2009060122A3 (en) 2009-06-25
JP5710977B2 (ja) 2015-04-30
ZA201003234B (en) 2011-06-29

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Application publication date: 20110209