CN101962665B - 提高轮枝拟青霉gz中虫草菌素产量的方法 - Google Patents
提高轮枝拟青霉gz中虫草菌素产量的方法 Download PDFInfo
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- CN101962665B CN101962665B CN 201010243545 CN201010243545A CN101962665B CN 101962665 B CN101962665 B CN 101962665B CN 201010243545 CN201010243545 CN 201010243545 CN 201010243545 A CN201010243545 A CN 201010243545A CN 101962665 B CN101962665 B CN 101962665B
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- cordycepin
- 30min
- paecilomyces varioti
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- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 title claims abstract description 32
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 16
- 241000082085 Verticillium <Phyllachorales> Species 0.000 title abstract 2
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- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 7
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- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 claims description 36
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 1
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- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- 241000930385 Paecilomyces verticillatus Species 0.000 description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 2
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- 230000002051 biphasic effect Effects 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- WIBFFTLQMKKBLZ-SEYXRHQNSA-N n-butyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCC WIBFFTLQMKKBLZ-SEYXRHQNSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
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- 241000894006 Bacteria Species 0.000 description 1
- 241001264174 Cordyceps militaris Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
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- 238000010168 coupling process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
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- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
3 | 8% | 116±1.0mg/L | 224% |
Claims (4)
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CN101962665B true CN101962665B (zh) | 2012-12-26 |
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CN101942394A (zh) * | 2010-09-28 | 2011-01-12 | 贵州大学 | 轮枝拟青霉菌株及其用途 |
CN102220397A (zh) * | 2011-04-14 | 2011-10-19 | 贵州大学 | 一种提高虫草菌素产量的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1472330A (zh) * | 2003-06-23 | 2004-02-04 | 贵州大学 | 一种提高虫草菌素含量的方法 |
CN101531968A (zh) * | 2008-05-04 | 2009-09-16 | 贵州大学 | 红曲协同发酵提高蛹虫草子实体和虫草菌素产量的方法 |
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2010
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1472330A (zh) * | 2003-06-23 | 2004-02-04 | 贵州大学 | 一种提高虫草菌素含量的方法 |
CN101531968A (zh) * | 2008-05-04 | 2009-09-16 | 贵州大学 | 红曲协同发酵提高蛹虫草子实体和虫草菌素产量的方法 |
Non-Patent Citations (2)
Title |
---|
前体物质与真菌激发子对虫草菌素产量的影响;李祝等;《食品科学》;20080630;第29卷(第6期);273-275 * |
李祝等.前体物质与真菌激发子对虫草菌素产量的影响.《食品科学》.2008,第29卷(第6期),273-275. |
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Inventor after: Xiao Yang Inventor after: Li Zhu Inventor after: Ren Xiuxiu Inventor after: Chen Qing Inventor after: Zhou Lihong Inventor after: Liu Wujuan Inventor before: Li Zhu Inventor before: Ren Xiuxiu Inventor before: Xiao Yang Inventor before: Chen Qing Inventor before: Zhou Lihong Inventor before: Liu Wujuan |
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Free format text: CORRECT: INVENTOR; FROM: LI ZHU REN XIUXIU XIAO YANG CHEN QING ZHOU LIHONG LIU WUJUAN TO: XIAO YANG LI ZHU REN XIUXIU CHEN QING ZHOU LIHONG LIU WUJUAN |
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Effective date of registration: 20140515 Address after: 550025 Huaxi, Guiyang, Guizhou University (North) Technology Department Patentee after: Guizhou University Patentee after: Guizhou Province Product Quality Supervision and Inspection Institute Address before: 550025 Huaxi, Guiyang, Guizhou University (North) Technology Department Patentee before: Guizhou University |
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