CN101940672B - Medicament for curing gout and preparation method thereof - Google Patents
Medicament for curing gout and preparation method thereof Download PDFInfo
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- CN101940672B CN101940672B CN2010102664691A CN201010266469A CN101940672B CN 101940672 B CN101940672 B CN 101940672B CN 2010102664691 A CN2010102664691 A CN 2010102664691A CN 201010266469 A CN201010266469 A CN 201010266469A CN 101940672 B CN101940672 B CN 101940672B
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Abstract
The invention discloses a medicament for curing gout and a preparation method thereof. The medicament is prepared from the following traditional Chinese medicaments in part by weight: 10 to 20 parts of pseudo-ginseng root, 25 to 35 parts of Chinese rhubarb, 5 to 15 parts of red flower, 10 to 20 parts of sargentgloryvine stem, 10 to 20 parts of rhizoma alismatis, 10 to 20 parts of bidentate achyranthes and 10 to 20 parts of corydalis tuber. In the invention, the pseudo-ginseng, the Chinese rhubarb and the like are used as the main ingredients to cure the gout. Compared with other traditional Chinese medicinal formula, the medicament has more reliable curing effects, is safe and has no obvious side and toxic effects. The medicament has remarkable treatment effects on symptoms such as gout caused by hyperuricacidemia, remarkable reduction effect on gouty arthritis and remarkable relief effect on gouty tophus. The medicament has the effects of invigorating blood circulation, removing obstruction in channels, clearing heat and promoting diuresis.
Description
Technical field
The present invention relates to Chinese patent drug technique field, specifically a kind of medicine for the treatment of gout and preparation method thereof.
Background technology
Gout claims " hyperuricemia " again, is a kind of because of the purine metabolism obstacle, makes uric acid accumulation and the disease that causes.The definition of gout is to have a kind of metabolism that is called the material of purine that disorder has taken place in the human body, the synthetic increase of uric acid (the oxidative metabolism product of purine) or discharge reduce, cause hyperuricemia, when the blood uric acid excessive concentration, uric acid promptly is deposited in joint, soft tissue, cartilage and the kidney with the form of sodium salt, causes the foreign body inflammatory reaction of tissue.And multiselect colchicine on the present gout clinical treatment, medicines such as ibuprofen, indometacin and allopurinol, objectively side effect is obvious, and a part of patient can't be interdependent to treating, then use traditional Chinese medical herbal treatment.The Chinese prescription of treatment gout is of a great variety, but outstanding less of therapeutic effect.
Summary of the invention
The purpose of this invention is to provide good gout medicine of a kind of therapeutic effect and preparation method thereof.
Medicine of the present invention is made up of the Chinese medicine of following weight proportion:
Radix Notoginseng 10-20 part Radix Et Rhizoma Rhei 25-35 part Flos Carthami 5-15 part Caulis Sargentodoxae 10-20 part
Rhizoma Alismatis 10-20 part Radix Achyranthis Bidentatae 10-20 part Rhizoma Corydalis 10-20 part
The drug weight proportioning is preferably:
Radix Notoginseng 16-18 part Radix Et Rhizoma Rhei 29-31 part Flos Carthami 9-11 part Caulis Sargentodoxae 14-16 part
Rhizoma Alismatis 11-13 part Radix Achyranthis Bidentatae 9-11 part Rhizoma Corydalis 11-13 part.
Preparation method: (capsule)
(1) Radix Notoginseng is pulverized to fine powder, sieve, standby;
(2) Radix Et Rhizoma Rhei is pulverized and is coarse powder, extracts 2 times with mass concentration 70% alcohol heating reflux, and each 1.5 hours, extracting solution filtered, and merging filtrate reclaims ethanol and concentrates thick extractum;
(3) Rhizoma Corydalis is pulverized and is coarse powder, extracts 2 times with mass concentration 80% alcohol heating reflux, and each 1 hour, extracting solution filtered, and merging filtrate reclaims ethanol and concentrates thick extractum;
(4) Flos Carthami, Caulis Sargentodoxae, Rhizoma Alismatis, Radix Achyranthis Bidentatae decoct with water secondary, and merge extractive liquid, filters, and filtrate decompression is condensed into thick extractum;
(5) above-mentioned thick extractum and Radix Notoginseng fine powder mixing, drying is pulverized, and sieves, and incapsulates, and makes finished product.
The medicament composing prescription of the present invention also method of available prior art is made the medicine of other dosage form, as tablet, pill, granule or the like.
In the medicine of the present invention, Radix Notoginseng contains nearly 10～13% total saponins, is mainly the ginsenoside's class and the distinctive arasaponin effective constituents of Radix Notoginseng of dammarane type, and the kind of saponin reaches tens of kinds in the Radix Notoginseng, and that known content is the highest is the ginsenoside Rg
1, other has Rb
1Deng, arasaponin is the composition of tool feature in the Radix Notoginseng, wherein with Panax Notoginseng saponin R
1Content is maximum.Radix Notoginseng contains special aminoacid--dencichine again, and in addition, Radix Notoginseng also contains flavone component, micro-volatile oil, resin and oils and fats and protein.Discover that Radix Notoginseng has blood vessel dilating, brings high blood pressure down, microcirculation improvement, blood flow increasing, prevention and treatment heart and brain tissues ischemia, anoxia; Promote protein, ribonucleic acid (RNA), DNA (deoxyribonucleic acid) (DNA) to synthesize building body; Promote the blood cell metabolism, the balance adjustment blood cell; The enhancing human body immunity function; Hemostasis, blood circulation promoting and blood stasis dispelling; Antiinflammatory; Two-ways regulation blood glucose, blood fat reducing, cholesterol, the arteriosclerotic effect of inhibition.
Radix Et Rhizoma Rhei contains anthraquinone derivatives, glycosides compound, tannin class, organic acid, volatile oil etc.Discover Radix Et Rhizoma Rhei have rush down down, diuresis; Effects such as hypercholesterolemia reducing, triglyceride, low density lipoprotein, LDL, very low density lipoprotein (VLDL) and lipid peroxide.
Rhizoma Corydalis contains kind surplus the alkaloid 10, wherein through what identify dextrorotation corydaline (Rhizoma Corydalis first element), Tetrahydropalmatine (tetrahydropalmatine), protopine etc. is arranged.Discover that Rhizoma Corydalis has analgesic activity.
The present invention is a main component with Radix Notoginseng, Radix Et Rhizoma Rhei, Rhizoma Corydalis etc., the treatment gout; Observe in clinical practice for many years, the Most patients state of an illness and clinical indices are obviously improved, and it is more reliable to compare other Chinese medicine preparation curative effect, and the no obvious toxic-side effects of safety.Symptoms such as the gout that the present invention causes hyperuricemia, gouty arthritis and tophus have the obvious treatment effect, to reducing blood uric acid tangible effect are arranged, and are obvious to the gouty arthritis mitigation.The present invention has the effect of promoting blood circulation to remove obstruction in the collateral, clearing away heat-damp and promoting diuresis.
Clinical efficacy of the present invention is as follows:
One, clinical data: observe this institute outpatient service patient with gout totally 213 examples, male's 192 examples wherein, women's 21 examples, 30～40 years old 51 age example, 41～50 years old 93 example, 51～60 years old 66 example, 3 examples more than 61 years old.The maximum 81 years old, reckling 31 years old.
Exclusion standard:
1. anemia of pregnant woman and women breast-feeding their children.
2. allergic constitution and multiple drug allergy person.
3. merge serious liver and hemopoietic system, serious primary disease such as hormonal system and psychotic.
4. not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment and safety judgement person.
5. the age is person below 9 years old.
Two, Therapeutic Method:
With capsule 0.35g/ grain of the present invention, each 4, one day three times, warm water takes, and 30 days was 1 course of treatment, finishes to judge curative effect the course of treatment.
Three, observation index:
1. lab testing contrast before and after the treatment.
2. sx such as arthralgia, redness or disappearance.
Observation item: blood uric acid
Result: produce effects 53 examples, effective 135 examples, invalid 25 examples, treatment effective percentage 88.3%.
The specific embodiment
Embodiment 1:
The raw material of getting it filled: (unit of weight: kilogram)
Radix Notoginseng 15, Radix Et Rhizoma Rhei 25, Flos Carthami 5, Caulis Sargentodoxae 10, Rhizoma Alismatis 10, Radix Achyranthis Bidentatae 10, Rhizoma Corydalis 10.
Preparation by the following method:
(1) Radix Notoginseng is pulverized to fine powder, sieve, standby;
(2) Radix Et Rhizoma Rhei is pulverized and is coarse powder, extracts 2 times with mass concentration 70% alcohol heating reflux, and each 1.5 hours, extracting solution filtered, and merging filtrate reclaims ethanol and concentrates thick extractum;
(3) Rhizoma Corydalis is pulverized and is coarse powder, extracts 2 times with mass concentration 80% alcohol heating reflux, and each 1 hour, extracting solution filtered, and merging filtrate reclaims ethanol and concentrates thick extractum;
(4) Flos Carthami, Caulis Sargentodoxae, Rhizoma Alismatis, Radix Achyranthis Bidentatae decoct with water secondary, and merge extractive liquid, filters, and filtrate decompression is condensed into thick extractum;
(5) above-mentioned thick extractum and Radix Notoginseng fine powder mixing, drying is pulverized, and sieves, and incapsulates, and makes finished product.
Embodiment 2:
The raw material of getting it filled: (unit of weight: kilogram)
Radix Notoginseng 17, Radix Et Rhizoma Rhei 30, Flos Carthami 10, Caulis Sargentodoxae 15, Rhizoma Alismatis 12, Radix Achyranthis Bidentatae 10, Rhizoma Corydalis 12.
Press the method preparation of embodiment 1.
Embodiment 3:
The raw material of getting it filled: (unit of weight: kilogram)
Radix Notoginseng 18, Radix Et Rhizoma Rhei 30, Flos Carthami 10, Caulis Sargentodoxae 20, Rhizoma Alismatis 15, Radix Achyranthis Bidentatae 15, Rhizoma Corydalis 20.
Press the method preparation of embodiment 1.
Embodiment 4:
The raw material of getting it filled: (unit of weight: kilogram)
Radix Notoginseng 16, Radix Et Rhizoma Rhei 35, Flos Carthami 15, Caulis Sargentodoxae 15, Rhizoma Alismatis 20, Radix Achyranthis Bidentatae 20, Rhizoma Corydalis 15.
Press the method preparation of embodiment 1.
Embodiment 5:
The raw material of getting it filled: (unit of weight: kilogram)
Radix Notoginseng 10, Radix Et Rhizoma Rhei 30, Flos Carthami 10, Caulis Sargentodoxae 15, Rhizoma Alismatis 15, Radix Achyranthis Bidentatae 15, Rhizoma Corydalis 12.
Press the method preparation of embodiment 1.
Claims (3)
1. medicine for the treatment of gout is characterized in that it is the medicine of being made by the Chinese medicine of following weight proportion:
Radix Notoginseng 10-20 part Radix Et Rhizoma Rhei 25-35 part Flos Carthami 5-15 part Caulis Sargentodoxae 10-20 part
Rhizoma Alismatis 10-20 part Radix Achyranthis Bidentatae 10-20 part Rhizoma Corydalis 10-20 part.
2. medicine for the treatment of gout is characterized in that it is the medicine of being made by the Chinese medicine of following weight proportion:
Radix Notoginseng 16-18 part Radix Et Rhizoma Rhei 29-31 part Flos Carthami 9-11 part Caulis Sargentodoxae 14-16 part
Rhizoma Alismatis 11-13 part Radix Achyranthis Bidentatae 9-11 part Rhizoma Corydalis 11-13 part.
3. by the process for preparing medicine of the described treatment gout of claim 1, it is characterized in that carrying out according to the following steps:
(1) Radix Notoginseng is pulverized to fine powder, sieve, standby;
(2) Radix Et Rhizoma Rhei is pulverized and is coarse powder, extracts 2 times with mass concentration 70% alcohol heating reflux, and each 1.5 hours, extracting solution filtered, and merging filtrate reclaims ethanol and concentrates thick extractum;
(3) Rhizoma Corydalis is pulverized and is coarse powder, extracts 2 times with mass concentration 80% alcohol heating reflux, and each 1 hour, extracting solution filtered, and merging filtrate reclaims ethanol and concentrates thick extractum;
(4) Flos Carthami, Caulis Sargentodoxae, Rhizoma Alismatis, Radix Achyranthis Bidentatae decoct with water secondary, and merge extractive liquid, filters, and filtrate decompression is condensed into thick extractum;
(5) above-mentioned thick extractum and Radix Notoginseng fine powder mixing, drying is pulverized, and sieves, and incapsulates, and makes finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102664691A CN101940672B (en) | 2010-08-30 | 2010-08-30 | Medicament for curing gout and preparation method thereof |
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| CN2010102664691A CN101940672B (en) | 2010-08-30 | 2010-08-30 | Medicament for curing gout and preparation method thereof |
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| CN101940672A CN101940672A (en) | 2011-01-12 |
| CN101940672B true CN101940672B (en) | 2011-11-09 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105148120A (en) * | 2015-10-14 | 2015-12-16 | 王艳娣 | Traditional Chinese medicine for effective prevention and cure of male hyperuricemia accompanied with gout |
| CN106421523B (en) * | 2016-10-28 | 2019-08-30 | 扬州大学 | A kind of Chinese medicine compound prescription for treating gout |
| CN114432324A (en) * | 2021-12-13 | 2022-05-06 | 吉林省道地参茸有限公司 | New application of triterpenoid saponin compound in treating hyperuricemia and gout |
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| CN100335094C (en) * | 2001-12-30 | 2007-09-05 | 湖南三九唯康药业有限公司 | Notoginseng pain relieving plaster and its preparation method |
| CN1506105A (en) * | 2002-12-12 | 2004-06-23 | 张存志 | Chinese patent medicine for preventing and treating post-operation blood stasis and its prepn process |
| CN1241586C (en) * | 2003-05-26 | 2006-02-15 | 江苏康缘药业股份有限公司 | Chinese medicine composition and preparing method thereof |
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Effective date of registration: 20180521 Address after: 310000 West Lake international science and technology building, 391, Xihu District two road, Hangzhou, Zhejiang, C910 Patentee after: HANGZHOU HUADONG MEDICINE GROUP NEW MEDICINE RESEARCH INSTITUTE CO., LTD. Address before: No. 21, Jiefang village, Kunming, Yunnan Province Co-patentee before: Zhang Xianghua Patentee before: Kunming Kidney Disease Research Institute Co-patentee before: Lv Menyang |
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Address after: Hangzhou City, Zhejiang province 310011 Moganshan Road No. 866 Patentee after: HANGZHOU HUADONG MEDICINE GROUP NEW MEDICINE RESEARCH INSTITUTE CO., LTD. Address before: No. two Wen 391 Road, Xihu District, Hangzhou, West Lake international science and technology building, C910 Patentee before: HANGZHOU HUADONG MEDICINE GROUP NEW MEDICINE RESEARCH INSTITUTE CO., LTD. |
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Application publication date: 20110112 Assignee: Hangzhou Huadi Pharmaceutical Technology Co.,Ltd. Assignor: Hangzhou Huadong Medicine Group Biopharmaceutical Co.,Ltd. Contract record no.: X2021330000100 Denomination of invention: The invention relates to a drug for treating gout and a preparation method thereof Granted publication date: 20111109 License type: Common License Record date: 20210820 |