CN101940538B - Xenon-containing cosmetics and preparation method thereof - Google Patents
Xenon-containing cosmetics and preparation method thereof Download PDFInfo
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- CN101940538B CN101940538B CN201010275306XA CN201010275306A CN101940538B CN 101940538 B CN101940538 B CN 101940538B CN 201010275306X A CN201010275306X A CN 201010275306XA CN 201010275306 A CN201010275306 A CN 201010275306A CN 101940538 B CN101940538 B CN 101940538B
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Abstract
The invention relates to xenon-containing cosmetics. The cosmetics containing lipotropy-grease ingredients are taken as a carrier, and 0.01-3 volumes of xenon is dissolved in 1 volume of carrier. The preparation method of the xenon-containing cosmetics comprises the following steps of: absorbing the carrier by using an injector at normal temperature, then adding xenon into the injector, sealing the injector, powerfully shaking the injector for more than 30 min at least, moving an injector piston while dissolving the xenon in the carrier in order to complement the reduced volume of the xenon when dissolving. According to scale change of the injector, the dissolved quantity of the xenon can be read. After the xenon is dissolved into the cosmetics, the penetrability of the cosmetics can be effectively enhanced, thus the cosmetics has better use effect.
Description
Technical field: the present invention relates to a kind of cosmetics and preparation method thereof, is a kind of cosmetics that contain xenon and preparation method thereof.
Background technology: adopt the things chitosan polymer of natural origin to increase the infiltration and the therapeutic effect of cosmetics usually, the characteristics of this polymer are to form secondary or physical bond, the concentration of electrophilic center and nucleophilic center is provided, but effect are not remarkable.In treatment cosmetics hypersensitive; Adopt widely and add the method that contains glucose corticosteroid ointment; But this method is accompanied by severe complications, for example reduces immunity, produces superinfection; Cause skin malnutrition, cause acne, dermatitis, hirsutism, ichthyosis, cutaneous pigmentation etc.Cosmetics generally all contain oil substances; Fat-body in the oil substances has the good curing effect to the deep layer of skin; The atomic diameter of fat-body is generally between the 100-400 micron; But the microvascular diameter of skin is about 5 microns, and therefore, fat-body can not be through the blood capillary deep layer that penetrates to the skin.
Summary of the invention: the deficiency to above-mentioned prior art the invention provides a kind of cosmetics that contain xenon and preparation method thereof.
Be to realize above-mentioned purpose, the technical scheme that the present invention adopts is: containing the cosmetics of xenon, is carrier in the cosmetics with lipophilic class-lubricant component of containing, the xenon of dissolving 0.01-3 volumes in the 1 volume carrier.
The method for preparing that contains the cosmetics of xenon; At normal temperatures and pressures, adopt syringe to suck carrier, in syringe, add xenon then; The closed injection device; At least strongly rock syringe more than 30 minutes, along with syringe piston is moved in the dissolving of xenon in carrier, the minimizing of volume when dissolving with additional xenon.Scale according to syringe changes, and can read the meltage of xenon.
After xenon is dissolved in cosmetics, can effectively improve the permeability of cosmetics, thereby make the result of use of cosmetics better.
The specific embodiment:
Used carrier can be a liquid condition, like solution, and aerosol, foam, water droplet, suspension, emulsion, gel, liquid ointment or other are suitable for the liquid condition of skin or mucosa absorption; Also can be solid shape or software shape, as: powder, granule, suppository, solid ointment or other are suitable for the solid, shaped body of skin or mucosa absorption.The composition of carrier is natural and mixture sintetics.
Embodiment 1:
The cosmetics that adopt contain following ingredients: avocado oil, triglycerides, sodium polyacrylate, simethicone, tridecyl alcohol polyethers, polydimethylsiloxane.The Sudan of extra adding lipophilic class dyestuff black is as visual labelling in used reagent.Get 2 parts of mentioned reagent, each 100 milliliters.A copy of it does not add xenon, is labeled as reagent one.Another part is labeled as reagent two; At normal temperatures and pressures, with 800 milliliter injection devices, suck 100 milliliters of reagent two; Add 300 milliliters of xenons then; The closed injection device acutely rocked 40 minutes, and xenon is dissolved in the reagent two (carrier among following each embodiment all according to said method adds xenon) fully.Remove two kinds of reagent then, be coated in the skin surface of the arm area of human body, the area of coating is 1cm
2In 20 minutes, carry out continual observation, confirm the flow area of two kinds of reagent and the absorption area of skin, the result of observation finds that the overflow sexuality of two pairs of skins of reagent will be higher than reagent one 50%.Skin about forearm is done 5 groups of same experiments, and the result who draws is that the overflow sexuality of two pairs of skins of reagent on average is higher than reagent one 32%.In addition, through extremely all removing with the conscientious scouring of filter paper, the skin that discovery reagent two applied has been dyed black after removing all reagent from skin, and the skin that reagent one applies does not have variable color, and this just explains that reagent two has goed deep into the top layer of skin.In sum, the cosmetics that add xenon make cosmetics have better penetration, thereby reach better therapeutic.
Embodiment 2:
Carry out clinical experiment; 24 female volunteers have been participated in this experiment, and their age, their skin all demonstrated aging in various degree because of the age between 45-58 year; But they did not carry out any surgical operation in nearly 6 months, and did not suffer from dermatitis or other anaphylaxis dermatosis.The cosmetic emulsion that adopts contains following ingredients: borage oil, Semen Lini oil, glyceryl stearate, glycerol, stearic acid, green tea extract.Used cosmetics have preserves moisture, and improves the effect of skin-nourishing and anti aging effect.Show that used cosmetic emulsion is harmless, and do not have stimulation and anaphylaxis through microbiologic analysis, chemical analysis, virusology experiment parameter result.According to the method for embodiment 1,28 milliliters xenons are joined in these cosmetics of 100 milliliters, be labeled as reagent two, these cosmetics that do not add xenon are labeled as reagent one.The women who participates in experiment is divided into 6 groups, and every group 4 people, one day twice of every group of participant are coated with at right facial skin and put reagent two on the skin, and left face is coated with puts reagent one on the skin, uses altogether 30 days.Obtain a result like following table: (participant was by system marking in 5 fens, and 1 is minimum, and 5 for the highest, makes even and divide equally)
| Parameter | Reagent one | Reagent two |
| Improve skin texture | 4 | 5 |
| The comfort level of using | 4 | 5 |
| Inviscid, no glossy | 4 | 5 |
| Moistening effect | 3 | 5 |
| Non-pigment is calm | 3 | 5 |
| The effect of improving to skin elasticity | 3 | 5 |
| The effect of improving to the little wrinkle of skin | 2 | 4 |
| Improve the cutis laxa state | 2 | 4 |
| Total points | 25 | 38 |
Can reach a conclusion according to above result: the cosmetics that contain xenon can strengthen the result of use of cosmetics.
Embodiment 3:
Select for use milk card Neil with automatic tanning effects and DOVE milky lotion as carrier.In 100 milliliters of card Neils, add 28 milliliters of xenons, be labeled as reagent 2-1.In 100 milliliters of DOVE milky lotion, add 24 milliliters of xenons, be labeled as reagent 2-1.The card Neil that does not add xenon is labeled as reagent 1-1, and the DOVE milky lotion that does not add xenon is labeled as reagent 1-2.Above four kinds of reagent are coated with the skin surface of putting on the skin at forearm respectively, and area is 3cm
2Result such as following table:
Can leave from above result, xenon can be quickened the action time of cosmetics.
Embodiment 4:
Selecting content for use is that the sulphur ointment of 10% sulfur is a carrier, this sulphur ointment by sulfur, vaseline, emulsifying agent and water by the known proportion proportioning.The xenon that in 100 milliliters sulphur ointment, adds 100 milliliters is labeled as reagent two, and what do not add xenon is labeled as reagent one.14 patients that suffer from comedo and acne have participated in experiment, are divided into two groups to them, every group of each 7 people.There are 8 to suffer from Perioral Dermatitis among the patient who participates in testing, every group of each 4 people.Sulphur ointment every day is coated with the skin affected part of putting the patient on the skin three times.The patient treatment effect of using reagent one is with usual the same, and comedo and acne takes a turn for the better after 5-7 days.Use the patient of reagent two promptly to embody effect in 2-3 days in use.Suffer among the patient of Perioral Dermatitis, use the patient of reagent one to embody effect at 5-6 days, and use the patient of reagent two promptly to embody effect at 2-3 days.This shows that the result of use of sulphur ointment that added the xenon after-acceleration has been strengthened therapeutical effect.
Embodiment 5:
Select for use the dermopathic emulsion of a kind of treatment (main component is: terbinafine HCl, benzyl alcohol, water, isopropyl palmitate, sodium hydroxide, Polysorbate, Span60, hexadecanol/spermol, hexadccyl palmitate, stearic acid hexadecane alcohol ester etc.) to be carrier; In 100 milliliters of these emulsions, add 25 milliliters of xenons; Be labeled as reagent two, what do not add xenon is labeled as reagent one.9 because of anaphylaxis contact dermatitis causes that the patient of beriberi has participated in experiment, and wherein 5 patients use two, 4 patients of reagent to use reagent one.Sooner or later respectively putting a reagent on the skin treats impaired local skin.After using 7 days, use 4 people of reagent one to find: the affected area erythema of shank and foot damaged skin has reduced, but is not clearly, new erythema do not occur, does not find that macule reduces, the commentaries on classics of also not getting better of peeling.Use 5 people of reagent two to find: the erythema of affected area obviously reduces, and new erythema do not occur, and macule, pimple and decortication have all obviously reduced.After using 14 days, use 4 people of reagent one to find: the erythema of affected area reduces, and macule also reduces to some extent, and it is not obvious that decortication reduces, and still there is breach in heel.Use 5 people of reagent two to find: foot and shank epidermis are the normal colour of skin, and macule obviously reduces, and heel does not have breach.This shows, add this emulsion of xenon, can significantly shorten treatment cycle.
Claims (4)
1. xenon is characterized in that as the application of penetrating agent in cosmetics: the cosmetics with lipophilic class-lubricant component of containing are carrier, and the xenon of dissolving 0.01-3 volumes after xenon is dissolved in cosmetics, can improve the permeability of cosmetics in the 1 volume carrier; The method for preparing of these cosmetics is: at normal temperatures and pressures; Adopt syringe to suck carrier; In syringe, add xenon then, the closed injection device rocks syringe more than 30 minutes at least strongly; Along with syringe piston is moved in the dissolving of xenon in carrier, the minimizing of volume when dissolving with additional xenon.
2. xenon as claimed in claim 1 is characterized in that as the application of penetrating agent in cosmetics: xenon is in dissolved state or dispersity in carrier.
3. xenon as claimed in claim 1 is characterized in that as the application of penetrating agent in cosmetics: used carrier can be a liquid condition, also can be solid shape.
4. xenon as claimed in claim 1 is characterized in that as the application of penetrating agent in cosmetics: the composition of carrier is natural and mixture sintetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010275306XA CN101940538B (en) | 2010-09-08 | 2010-09-08 | Xenon-containing cosmetics and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010275306XA CN101940538B (en) | 2010-09-08 | 2010-09-08 | Xenon-containing cosmetics and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101940538A CN101940538A (en) | 2011-01-12 |
| CN101940538B true CN101940538B (en) | 2012-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010275306XA Expired - Fee Related CN101940538B (en) | 2010-09-08 | 2010-09-08 | Xenon-containing cosmetics and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1255065A (en) * | 1997-03-10 | 2000-05-31 | 迈克尔·乔治夫 | Medicinal preparation containing lipophilicity inert gas |
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2010
- 2010-09-08 CN CN201010275306XA patent/CN101940538B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1255065A (en) * | 1997-03-10 | 2000-05-31 | 迈克尔·乔治夫 | Medicinal preparation containing lipophilicity inert gas |
Non-Patent Citations (1)
| Title |
|---|
| 曹伟、李章万、刘进、张文胜.《GC-MS测定氙再不同浓度脂肪乳下的分配系数》.《华西药学杂志》.2007,第22卷(第4期),423－425页. * |
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| CN101940538A (en) | 2011-01-12 |
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