CN101925576B - κ-选择性阿片受体拮抗剂 - Google Patents

κ-选择性阿片受体拮抗剂 Download PDF

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Publication number
CN101925576B
CN101925576B CN2009801026504A CN200980102650A CN101925576B CN 101925576 B CN101925576 B CN 101925576B CN 2009801026504 A CN2009801026504 A CN 2009801026504A CN 200980102650 A CN200980102650 A CN 200980102650A CN 101925576 B CN101925576 B CN 101925576B
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disorder
pharmaceutically acceptable
alcohol
compound
acceptable salt
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Chinese (zh)
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CN101925576A (zh
Inventor
N·迪亚斯比佐
D·L·麦金兹
C·H·米奇
C·佩德雷加尔-特尔塞罗
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Eli Lilly and Co
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2009801026504A 2008-01-22 2009-01-13 κ-选择性阿片受体拮抗剂 Active CN101925576B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP08380012 2008-01-22
EP08380012.8 2008-01-22
US3912108P 2008-03-25 2008-03-25
US61/039121 2008-03-25
US61/039,121 2008-03-25
PCT/US2009/030811 WO2009094260A1 (en) 2008-01-22 2009-01-13 Kappa selective opioid receptor antagonist

Publications (2)

Publication Number Publication Date
CN101925576A CN101925576A (zh) 2010-12-22
CN101925576B true CN101925576B (zh) 2013-02-06

Family

ID=40876972

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801026504A Active CN101925576B (zh) 2008-01-22 2009-01-13 κ-选择性阿片受体拮抗剂

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US (2) US7709522B2 (enExample)
EP (1) EP2252581B1 (enExample)
JP (1) JP5345637B2 (enExample)
KR (1) KR101172170B1 (enExample)
CN (1) CN101925576B (enExample)
AR (1) AR070158A1 (enExample)
AU (1) AU2009206653B2 (enExample)
BR (1) BRPI0907382B8 (enExample)
CA (1) CA2713025C (enExample)
CO (1) CO6290644A2 (enExample)
CY (1) CY1113071T1 (enExample)
DK (1) DK2252581T3 (enExample)
DO (1) DOP2010000222A (enExample)
EA (1) EA017484B1 (enExample)
EC (1) ECSP10010365A (enExample)
ES (1) ES2388708T3 (enExample)
HR (1) HRP20120558T1 (enExample)
IL (1) IL206038A (enExample)
JO (1) JO2797B1 (enExample)
MA (1) MA32751B1 (enExample)
MX (1) MX2010007849A (enExample)
MY (1) MY163014A (enExample)
NZ (1) NZ586225A (enExample)
PE (1) PE20091317A1 (enExample)
PL (1) PL2252581T3 (enExample)
PT (1) PT2252581E (enExample)
SI (1) SI2252581T1 (enExample)
TN (1) TN2010000306A1 (enExample)
TW (1) TWI422369B (enExample)
UA (1) UA100715C2 (enExample)
WO (1) WO2009094260A1 (enExample)
ZA (1) ZA201003908B (enExample)

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NZ586225A (en) * 2008-01-22 2012-05-25 Lilly Co Eli Kappa selective opioid receptor antagonist
UY31604A1 (es) * 2008-01-22 2009-08-31 Compuestos tricíclicos y uso de los mismos
EP2757881A4 (en) 2011-09-15 2014-11-12 Univ Kansas KAPPA OPIATE RECEPTOR EFFECTORS AND USES THEREOF
EP2758134B1 (en) 2011-09-19 2019-05-29 Carmel - Haifa University Economic Corporation Ltd. Buprenorphine for the treatment of acute suicidality
US9512105B2 (en) 2011-12-09 2016-12-06 Research Triangle Institute 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA
US9283196B1 (en) 2013-01-30 2016-03-15 MediSynergics, LLC Cycloalkyl-diamines for CNS disorders
CA2911231C (en) * 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US10316021B2 (en) * 2016-11-28 2019-06-11 Pfizer Inc. Heteroarylphenoxy benzamide kappa opioid ligands
KR102656163B1 (ko) 2017-03-17 2024-04-08 더 스크립스 리서치 인스티튜트 카파 오피오이드 수용체 길항제 및 그와 관련된 제품 및 방법
JP6480616B1 (ja) 2018-02-08 2019-03-13 有限会社 ディオン光学技研 照準スコープ
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN114195693A (zh) * 2020-09-17 2022-03-18 广东东阳光药业有限公司 一种酰胺化合物的晶型及其制备方法
CN114591211B (zh) * 2020-12-04 2025-10-21 广东东阳光药业股份有限公司 一种酰胺化合物的共晶及其制备方法
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
BR112023023030A2 (pt) 2021-05-04 2024-02-15 Janssen Pharmaceuticals Inc Composições e métodos para o tratamento de depressão
CA3247733A1 (en) * 2022-01-10 2023-07-13 Janssen Pharmaceuticals, Inc. Compositions and methods of treating depression
MX2024008618A (es) * 2022-01-10 2024-09-25 Janssen Pharmaceuticals Inc Composiciones y métodos para el tratamiento de la depresión.
IL315415A (en) * 2022-03-07 2024-11-01 Janssen Pharmaceuticals Inc The compositions containing eticarpant
CA3254365A1 (en) 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. POLYMORPHIC FORMS OF ATICAPRANT INTENDED FOR USE IN THE TREATMENT OF MAJOR DEPRESSION
CA3254503A1 (en) * 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. PURE FORMS OF CRYSTALLINE ATICAPRANT
JP7176142B1 (ja) 2022-03-09 2022-11-21 直迪 清瀬 各アルコール飲用者において飲用し得るアルコール飲料の種類に対応する飲用量の上限値に関する情報を提供するシステム

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1681498A (zh) * 2002-09-19 2005-10-12 伊莱利利公司 作为阿片受体拮抗剂的二芳基醚

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US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
CA2372040C (en) * 1999-05-12 2008-12-02 Francois Jenck Imidazodiazepine derivative
CA2425124A1 (en) * 2000-10-05 2002-04-11 Hanns Mohler Selective anxiolytic therapeutic agents
AU2002231206A1 (en) * 2000-12-21 2002-07-01 The Mclean Hospital Corporation Treatment of depression
US6974824B2 (en) 2001-01-08 2005-12-13 Research Triangle Institute Kappa opioid receptor ligands
US7119196B2 (en) * 2002-03-28 2006-10-10 Wisys Technology Foundation, Inc. Anxiolytic agents with reduced sedative and ataxic effects
CA2518194A1 (en) 2003-03-07 2004-09-23 Eli Lilly And Company 6-substituted nicotinamide derivatives as opioid receptor antagonists
ATE406360T1 (de) * 2003-03-07 2008-09-15 Lilly Co Eli Antagonisten der opioidrezeptoren
US7196100B2 (en) * 2003-12-12 2007-03-27 Eli Lilly And Company Opioid receptor antagonists
EP1699783B1 (en) * 2003-12-22 2012-07-25 Eli Lilly And Company Opioid receptor antagonists
CA2559207A1 (en) * 2004-03-12 2005-09-29 The Mclean Hospital Corporation Salvinorin derivatives and uses thereof
ATE475640T1 (de) * 2004-03-12 2010-08-15 Lilly Co Eli Antagonisten des opioidrezeptors
ATE399164T1 (de) * 2004-03-12 2008-07-15 Lilly Co Eli Antagonisten des opioidrezeptors
EP1735268B1 (en) * 2004-03-15 2012-02-15 Eli Lilly And Company Opioid receptor antagonists
ES2318472T3 (es) * 2004-03-15 2009-05-01 Eli Lilly And Company Derivados de 5-(5-(aminoetil)-indol-1-ilmetil)-benzamida y compuestos relacionados como antagonistas del receptor opioide para el tratamiento de la obesidad.
US8551986B2 (en) * 2005-12-08 2013-10-08 The Mclean Hospital Corporation Treatment of sequelae of psychiatric disorders
RS51211B (sr) 2006-04-04 2010-12-31 Emodis Gmbh. Primena formulacija koje sadrže kapa-opioid receptor-agoniste za tretman disocijativnih poremećaja
US8633175B2 (en) 2006-08-09 2014-01-21 Glaxosmithkline Llc Compounds as antagonists or inverse agonists at opioid receptors
WO2008021851A2 (en) 2006-08-09 2008-02-21 Smithkline Beecham Corporation Novel compounds as antagonists or inverse agonists for opioid receptors
KR20090051778A (ko) 2006-09-08 2009-05-22 화이자 프로덕츠 인코포레이티드 다이아릴 에터 유도체 및 이의 용도
NZ586225A (en) * 2008-01-22 2012-05-25 Lilly Co Eli Kappa selective opioid receptor antagonist

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1681498A (zh) * 2002-09-19 2005-10-12 伊莱利利公司 作为阿片受体拮抗剂的二芳基醚

Also Published As

Publication number Publication date
KR20100095639A (ko) 2010-08-31
TWI422369B (zh) 2014-01-11
EA017484B1 (ru) 2012-12-28
MA32751B1 (fr) 2011-11-01
US20090186873A1 (en) 2009-07-23
SI2252581T1 (sl) 2012-09-28
DOP2010000222A (es) 2015-11-15
US8173695B2 (en) 2012-05-08
MX2010007849A (es) 2010-08-09
DK2252581T3 (da) 2012-07-16
JP5345637B2 (ja) 2013-11-20
CN101925576A (zh) 2010-12-22
BRPI0907382B1 (pt) 2020-03-10
UA100715C2 (ru) 2013-01-25
ES2388708T3 (es) 2012-10-17
CA2713025A1 (en) 2009-07-30
KR101172170B1 (ko) 2012-08-07
HK1146822A1 (en) 2011-07-15
IL206038A (en) 2013-11-28
US20100197669A1 (en) 2010-08-05
WO2009094260A1 (en) 2009-07-30
AU2009206653A1 (en) 2009-07-30
PE20091317A1 (es) 2009-09-03
TN2010000306A1 (en) 2011-11-11
ZA201003908B (en) 2011-11-30
HRP20120558T1 (hr) 2012-10-31
EP2252581A1 (en) 2010-11-24
EP2252581B1 (en) 2012-06-20
JO2797B1 (en) 2014-03-15
ECSP10010365A (es) 2010-08-31
IL206038A0 (en) 2010-11-30
MY163014A (en) 2017-07-31
CO6290644A2 (es) 2011-06-20
US7709522B2 (en) 2010-05-04
JP2011524850A (ja) 2011-09-08
EA201070877A1 (ru) 2010-12-30
AR070158A1 (es) 2010-03-17
BRPI0907382A2 (pt) 2015-07-21
BRPI0907382B8 (pt) 2021-05-25
CY1113071T1 (el) 2016-04-13
TW200936129A (en) 2009-09-01
CA2713025C (en) 2012-12-04
NZ586225A (en) 2012-05-25
PT2252581E (pt) 2012-08-31
PL2252581T3 (pl) 2012-10-31
AU2009206653B2 (en) 2013-07-18

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