JP5345637B2 - κ選択的オピオイド受容体アンタゴニスト - Google Patents

κ選択的オピオイド受容体アンタゴニスト Download PDF

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Publication number
JP5345637B2
JP5345637B2 JP2010543182A JP2010543182A JP5345637B2 JP 5345637 B2 JP5345637 B2 JP 5345637B2 JP 2010543182 A JP2010543182 A JP 2010543182A JP 2010543182 A JP2010543182 A JP 2010543182A JP 5345637 B2 JP5345637 B2 JP 5345637B2
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disorder
ethanol
pharmaceutically acceptable
acceptable salt
depression
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JP2011524850A5 (enExample
JP2011524850A (ja
Inventor
ヌリア・ディアス・ブエソ
デイビッド・リー・マッキンジー
チャールズ・ハワード・ミッチ
コンセプシオン・ペドレガル−テルセロ
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イーライ リリー アンド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010543182A 2008-01-22 2009-01-13 κ選択的オピオイド受容体アンタゴニスト Active JP5345637B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08380012 2008-01-22
US3912108P 2008-03-25 2008-03-25
US61/039,121 2008-03-25
PCT/US2009/030811 WO2009094260A1 (en) 2008-01-22 2009-01-13 Kappa selective opioid receptor antagonist

Publications (3)

Publication Number Publication Date
JP2011524850A JP2011524850A (ja) 2011-09-08
JP2011524850A5 JP2011524850A5 (enExample) 2012-02-23
JP5345637B2 true JP5345637B2 (ja) 2013-11-20

Family

ID=40876972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010543182A Active JP5345637B2 (ja) 2008-01-22 2009-01-13 κ選択的オピオイド受容体アンタゴニスト

Country Status (32)

Country Link
US (2) US7709522B2 (enExample)
EP (1) EP2252581B1 (enExample)
JP (1) JP5345637B2 (enExample)
KR (1) KR101172170B1 (enExample)
CN (1) CN101925576B (enExample)
AR (1) AR070158A1 (enExample)
AU (1) AU2009206653B2 (enExample)
BR (1) BRPI0907382B8 (enExample)
CA (1) CA2713025C (enExample)
CO (1) CO6290644A2 (enExample)
CY (1) CY1113071T1 (enExample)
DK (1) DK2252581T3 (enExample)
DO (1) DOP2010000222A (enExample)
EA (1) EA017484B1 (enExample)
EC (1) ECSP10010365A (enExample)
ES (1) ES2388708T3 (enExample)
HR (1) HRP20120558T1 (enExample)
IL (1) IL206038A (enExample)
JO (1) JO2797B1 (enExample)
MA (1) MA32751B1 (enExample)
MX (1) MX2010007849A (enExample)
MY (1) MY163014A (enExample)
NZ (1) NZ586225A (enExample)
PE (1) PE20091317A1 (enExample)
PL (1) PL2252581T3 (enExample)
PT (1) PT2252581E (enExample)
SI (1) SI2252581T1 (enExample)
TN (1) TN2010000306A1 (enExample)
TW (1) TWI422369B (enExample)
UA (1) UA100715C2 (enExample)
WO (1) WO2009094260A1 (enExample)
ZA (1) ZA201003908B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11168958B2 (en) 2018-02-08 2021-11-09 DEON Optical Design Corporation Sighting scope

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TWI422369B (zh) * 2008-01-22 2014-01-11 Lilly Co Eli κ選擇性類鴉片受體拮抗劑
KR20100130596A (ko) * 2008-01-22 2010-12-13 다케다 야쿠힌 고교 가부시키가이샤 부신 피질 자극 호르몬 방출 인자 길항 작용을 갖는 3 환식 화합물 및 이를 함유하는 약학 조성물
WO2013040321A1 (en) 2011-09-15 2013-03-21 University Of Kansas Kappa opioid receptor effectors and uses thereof
WO2013042054A1 (en) 2011-09-19 2013-03-28 Carmel - Haifa University Economic Corporation Ltd. Buprenorphine for the treatment of acute suicidality
CA2858752C (en) 2011-12-09 2019-12-31 Research Triangle Institute 1-substituted 4-arylpiperazines as kappa opioid receptor antagonists
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
US9283196B1 (en) 2013-01-30 2016-03-15 MediSynergics, LLC Cycloalkyl-diamines for CNS disorders
JP2016519161A (ja) * 2013-05-24 2016-06-30 アルカームス ファーマ アイルランド リミテッド モルファン及びモルフィナン類似物及び使用の方法
US10316021B2 (en) * 2016-11-28 2019-06-11 Pfizer Inc. Heteroarylphenoxy benzamide kappa opioid ligands
EP3596069B1 (en) 2017-03-17 2022-07-13 The Scripps Research Institute Kappa opioid receptor antagonists and products and methods related thereto
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN114195693A (zh) * 2020-09-17 2022-03-18 广东东阳光药业有限公司 一种酰胺化合物的晶型及其制备方法
CN114591211B (zh) * 2020-12-04 2025-10-21 广东东阳光药业股份有限公司 一种酰胺化合物的共晶及其制备方法
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
JP2024516297A (ja) 2021-05-04 2024-04-12 ヤンセン ファーマシューティカルズ，インコーポレーテッド うつ病の治療のための組成物及び方法
MX2024008618A (es) * 2022-01-10 2024-09-25 Janssen Pharmaceuticals Inc Composiciones y métodos para el tratamiento de la depresión.
JP2025503649A (ja) * 2022-01-10 2025-02-04 ヤンセン ファーマシューティカルズ，インコーポレーテッド うつ病の治療のための組成物及び方法
EP4489748A1 (en) * 2022-03-07 2025-01-15 Janssen Pharmaceuticals, Inc. Pure forms of crystalline aticaprant
JP2025508069A (ja) * 2022-03-07 2025-03-21 ヤンセン ファーマシューティカルズ，インコーポレーテッド アチカプラントを含む組成物
WO2023170550A1 (en) 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. Polymorph forms of aticaprant for use in treating major depressive disorder
JP7176142B1 (ja) 2022-03-09 2022-11-21 直迪 清瀬 各アルコール飲用者において飲用し得るアルコール飲料の種類に対応する飲用量の上限値に関する情報を提供するシステム

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US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
EP1178990B1 (en) * 1999-05-12 2003-01-29 F. Hoffmann-La Roche Ag Imidazodiazepine derivative
EP1337859A1 (en) * 2000-10-05 2003-08-27 Hanns Mohler Selective anxiolytic therapeutic agents
WO2002049643A1 (en) * 2000-12-21 2002-06-27 The Mclean Hospital Corporation Treatment of depression
US6974824B2 (en) 2001-01-08 2005-12-13 Research Triangle Institute Kappa opioid receptor ligands
BR0308918A (pt) * 2002-03-28 2005-01-04 Wisys Technology Found Inc Agentes ansiolìticos com efeitos sedativos e atáxicos reduzidos
PL212616B1 (pl) * 2002-09-19 2012-10-31 Lilly Co Eli Eter diarylowy i kompozycja farmaceutyczna zawierajaca ten eter
BRPI0407616A (pt) 2003-03-07 2006-02-14 Lilly Co Eli composto, composição farmacêutica, método para bloquear uma combinação de receptor de mu, capa, delta (heterodìmero) deste em mamìferos, método para tratar ou prevenir obesidade e doenças relacionadas, uso de um composto, e método de suprimir o apetite em um paciente em necessidade deste"
WO2004080996A1 (en) * 2003-03-07 2004-09-23 Eli Lilly And Company Opioid receptor antagonists
JP2007516256A (ja) * 2003-12-12 2007-06-21 イーライ リリー アンド カンパニー オピオイド受容体拮抗物質
CN1894240A (zh) * 2003-12-22 2007-01-10 伊莱利利公司 阿片受体拮抗剂
US7381750B2 (en) * 2004-03-12 2008-06-03 Eli Lilly And Company Amino-phenoxymethyl-benzamide opioid receptor antagonists
ATE399164T1 (de) * 2004-03-12 2008-07-15 Lilly Co Eli Antagonisten des opioidrezeptors
AU2005222640A1 (en) * 2004-03-12 2005-09-29 The Mclean Hospital Corporation Salvinorin derivatives and uses thereof
ES2318472T3 (es) * 2004-03-15 2009-05-01 Eli Lilly And Company Derivados de 5-(5-(aminoetil)-indol-1-ilmetil)-benzamida y compuestos relacionados como antagonistas del receptor opioide para el tratamiento de la obesidad.
CA2557794A1 (en) * 2004-03-15 2005-10-06 Eli Lilly And Company Opioid receptor antagonists
US8551986B2 (en) * 2005-12-08 2013-10-08 The Mclean Hospital Corporation Treatment of sequelae of psychiatric disorders
CA2646899C (en) 2006-04-04 2014-05-06 Holger Lars Hermann Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders
JP5362565B2 (ja) 2006-08-09 2013-12-11 スミスクライン ビーチャム コーポレーション オピオイド受容体のアンタゴニストまたはインバースアゴニストである新規化合物
US20100222345A1 (en) 2006-08-09 2010-09-02 Caroline Jean Diaz Novel compounds as antagonists or inverse agonists for opioid receptors
KR20090051778A (ko) 2006-09-08 2009-05-22 화이자 프로덕츠 인코포레이티드 다이아릴 에터 유도체 및 이의 용도
TWI422369B (zh) * 2008-01-22 2014-01-11 Lilly Co Eli κ選擇性類鴉片受體拮抗劑

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11168958B2 (en) 2018-02-08 2021-11-09 DEON Optical Design Corporation Sighting scope

Also Published As

Publication number Publication date
MA32751B1 (fr) 2011-11-01
US20100197669A1 (en) 2010-08-05
ECSP10010365A (es) 2010-08-31
HK1146822A1 (en) 2011-07-15
KR20100095639A (ko) 2010-08-31
AU2009206653A1 (en) 2009-07-30
CA2713025A1 (en) 2009-07-30
TN2010000306A1 (en) 2011-11-11
EP2252581A1 (en) 2010-11-24
BRPI0907382B1 (pt) 2020-03-10
IL206038A (en) 2013-11-28
DK2252581T3 (da) 2012-07-16
DOP2010000222A (es) 2015-11-15
TW200936129A (en) 2009-09-01
CN101925576B (zh) 2013-02-06
IL206038A0 (en) 2010-11-30
PE20091317A1 (es) 2009-09-03
MX2010007849A (es) 2010-08-09
EA201070877A1 (ru) 2010-12-30
TWI422369B (zh) 2014-01-11
EA017484B1 (ru) 2012-12-28
NZ586225A (en) 2012-05-25
US20090186873A1 (en) 2009-07-23
EP2252581B1 (en) 2012-06-20
PL2252581T3 (pl) 2012-10-31
PT2252581E (pt) 2012-08-31
AR070158A1 (es) 2010-03-17
CY1113071T1 (el) 2016-04-13
KR101172170B1 (ko) 2012-08-07
CO6290644A2 (es) 2011-06-20
US7709522B2 (en) 2010-05-04
AU2009206653B2 (en) 2013-07-18
UA100715C2 (ru) 2013-01-25
HRP20120558T1 (hr) 2012-10-31
CA2713025C (en) 2012-12-04
MY163014A (en) 2017-07-31
BRPI0907382B8 (pt) 2021-05-25
JO2797B1 (en) 2014-03-15
CN101925576A (zh) 2010-12-22
ZA201003908B (en) 2011-11-30
ES2388708T3 (es) 2012-10-17
BRPI0907382A2 (pt) 2015-07-21
SI2252581T1 (sl) 2012-09-28
WO2009094260A1 (en) 2009-07-30
US8173695B2 (en) 2012-05-08
JP2011524850A (ja) 2011-09-08

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