CN101919392B - Bactericidal composition containing famoxadone and JS399-19 - Google Patents
Bactericidal composition containing famoxadone and JS399-19 Download PDFInfo
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- CN101919392B CN101919392B CN 201010268145 CN201010268145A CN101919392B CN 101919392 B CN101919392 B CN 101919392B CN 201010268145 CN201010268145 CN 201010268145 CN 201010268145 A CN201010268145 A CN 201010268145A CN 101919392 B CN101919392 B CN 101919392B
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- phenylancryic acetate
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Abstract
The invention discloses a bactericidal composition containing famoxadone and JS399-19, the composite comprises the active ingredients of the famoxadone and the JS399-19, and the weight ratio of the famoxadone to the JS399-19 is 10:1-1:40. The bactericidal composition can be prepared into the formulations of water dispersible granules, wettable powder, suspension and dispersible oil suspension and be used for preventing and treating alternaria mali and leaf spot of fruit tree crops, blight of melon crops, sheath blight, gibberellic disease and rust disease of cereal crops; and the bactericidal composition has reasonable components, good bactericidal effect, few medication times and low medication cost, and the activities and the bactericidal effects of all the components are not superposed simply, but have the significant synergy, thereby being capable of retarding the production of resistance, having good safety to the crops and being in line with the safety requirements of pesticide preparations.
Description
Technical field
The present invention relates to a kind of spot defoliation, leaf spot for control fruit tree kind crop, the fusarium wilt of melon crop, the microbicide compositions of the banded sclerotial blight of cereal crop, head blight and rust, it is by the composite microbicide compositions of Huo Cheng Fen famoxadone and 2-cyano-3-amino-3-phenylancryic acetate.
Background technology
The English common name famoxadone of famoxadone, molecular formula C
22H
18N
2O
4, chemical name 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1,3-azoles quinoline-2,4-diketone.Be a kind of new and effective, wide-spectrum bactericide, its mechanism of action is that inhibitor of energy is the mitochondria electron transfer inhibitor; Cromoci oxidoreductase among the complex III there is inhibitory action.The bactericide inhibitory action that multiple inhibition is breathed is (IC relatively
50, ppb): JE874 (4.5); ICIA 5504 (170.0); BAS 490F (75.0); SSF-126 (3500.0); it has protection, treat, root out, infiltration, systemic activity; with the phenyl amide series bactericidal agent without handing over resistance, suitable crop such as wheat, barley, pea, beet, rape, grape, potato, melon, capsicum, tomato, fruit tree etc.Be mainly used in preventing and treating important disease in Ascomycetes, Basidiomycetes, the oomycetes subclass such as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight etc.Have lipophilicity, spray on the crop leaf after, easily adhere to, not by the rain drop erosion special efficacy, but because the single dose use cost is higher, and action site is comparatively single, germ easily produces resistance, and the resistance of existing correlation report, single dose is used and is had certain risk.
2-cyano-3-amino-3-phenylancryic acetate belongs to 2-cyanoacrylate bactericide; structural formula is 2-cyano group-3-amino-3-aminoacrylic acid ethyl ester; it is a kind of novel structure; the new type bactericide of mode of action uniqueness; multiple pathogen all had higher bactericidal activity; especially the reaping hook mushroom is caused that bakanae disease of rice that head blight, fusarium moniliforme cause, the cucurbits fusarium wilt that Fusarium oxysporum causes are effective, have protective effect and therapeutic action.Be absorbed by root, at blade upwards transporting arranged, towards the blade bottom and interlobate transporting relatively poor.But its independent use is easily developed immunity to drugs, and conductivity is general, and is active general to higher fungi.
Fruit tree kind crop such as alternaria leaf spot of apple, sigatoka, melon crop such as watermelon blight, cereal crop such as rice sheath blight disease, wheat scab, rust are the common frdquently encountered disease evils, and it usually makes crushing disaster.In actual use, 2-cyano-3-amino-3-phenylancryic acetate has very high bactericidal activity to lower fungus disease such as wheat scab, rust etc., but it exists fungicidal spectrum wideless, and conductivity is general, and the independent defective that easily develops immunity to drugs of use.Famoxadone is as a kind of wide-spectrum bactericide, have protection, treat, root out, infiltration, systemic activity, but control exists pathogen that it is easily produced resistance, the high shortcoming of use cost separately.Therefore ， carries out rational mixture Jiang famoxadone and 2-cyano-3-amino-3-phenylancryic acetate, is expected to have synergistic effect, improves its control efficiency, reduces spraying times and dosage, and the resistance of slowing down germ Dui famoxadone and 2-cyano-3-amino-3-phenylancryic acetate produces, and reduces the effect of cost accounting.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, bactericidal effect is good, and drug cost is low, be difficult for developing immunity to drugs, the spot defoliation, the leaf spot that are used for control fruit tree kind crop, the fusarium wilt of melon crop, the agricultural bactericidal composition of the banded sclerotial blight of cereal crop, head blight and rust.
In order to overcome the defective of existing unitary agent, technical scheme of the present invention is to solve like this:
The present invention contain as the first active component De famoxadone with as the 2-cyano-3-amino-3-phenylancryic acetate of the second active component, wherein the weight ratio of the first active component and the second active component is 10: 1～1: 40.The cumulant of the first active component and the second active component (gross weight) is 5%～80% of described composition total weight, is preferably 10%～50%.
According to method known in those skilled in the art, can be mixed with the upper any formulation that allows of agricultural during the microbicide compositions practical application of Han famoxadone of the present invention and 2-cyano-3-amino-3-phenylancryic acetate, but preparation formulation such as water dispersible granules, wetting powder, suspending agent dispersed oil suspending agent.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and finish the present invention very much.Dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate; Wetting agent is selected from alkyl sulfate, alkylsulfonate, naphthalene sulfonate; Disintegrant is selected from ammonium sulfate, urea, sucrose, glucose; Binding agent is selected from diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family; Filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay.
To wetting powder, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate; Wetting agent is selected from alkyl sulfate, alkylsulfonate, naphthalene sulfonate; Filler is selected from ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay.
To suspending agent, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, TERSPERSE 2425 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt); Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: sorbitan monostearate), emulsifier T-60 (common name: the sorbitan monostearate APEO), agricultural newborn 1601# (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), TERSPERSE 4894 emulsifier is selected from Nongru-700 # (common name:; Wetting agent is selected from alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500; Thickener is selected from xanthans, polyvinyl alcohol, bentonite; Preservative is selected from formaldehyde, benzoic acid, Sodium Benzoate; Defoamer such as organic silicon defoamer; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride.
But to the dispersed oil suspending agent, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), TERSPERSE 2425; Emulsifier is selected from the serial emulsifier of BY (castor oil polyoxyethylene ether) (BY-110, BY-125, BY-140), Nongru-700 #, farming breast 2201, this dish-60#, Tween-60 #, agricultural newborn 1601#, TERSPERSE 4894; Wetting agent is selected from alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol polyoxyethylene phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500; Thickener is selected from white carbon, polyvinyl alcohol, bentonite, aluminium-magnesium silicate; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride; Stabilizing agent is selected from epoxidized soybean oil, epoxychloropropane, triphenyl phosphate; Dispersion medium is selected from soybean oil, rapeseed oil, little wheat oil, methyl oleate, diesel oil, machine oil, mineral oil.
Component of the present invention is reasonable, and bactericidal effect is good, has reduced the medication number of times, drug cost is low, and its active and bactericidal effect is not the simple superposition of each composition activity, but significant synergistic effect is arranged, slow down the generation of resistance, good to crop safety, meet the security requirement of pesticidal preparations.The present invention is to spot defoliation, the leaf spot of fruit tree kind crop, the fusarium wilt of melon crop, and the banded sclerotial blight of cereal crop, head blight and rust have preferably control efficiency.
Embodiment
In order to prevent and treat the diseases such as alternaria leaf spot of apple in the agricultural production, sigatoka, cucumber fusarium axysporum, wheat scab, rust, rice sheath blight disease, the compositions such as inventor Yi famoxadone and 2-cyano-3-amino-3-phenylancryic acetate have carried out mutual composite synergy research, and concrete grammar is:
1) the former medicine of Alternaria mali (Alternariaalternataf.sp.mali) the test medicine 2-cyano-3-amino-3-phenylancryic acetate former medicine of former Yao ， famoxadone that adopts the Jiangsu pesticide research the to produce former medicine that adopts farmingization company of Du Pont to produce.Test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single dose and each Mixed Pharmacy are arranged respectively following 5 variable concentrations gradients: 2-cyano-3-amino-3-phenylancryic acetate is 1.50 μ g/ml, 3.0 μ g/ml, 6.0 μ g/ml, 12.0 μ g/ml, 24 μ g/ml; Famoxadone is 1.25 μ g/ml, 2.5 μ g/ml, 5 μ g/ml, 10 μ g/ml, 20 μ g/ml; Famoxadone and 2-cyano-3-amino-3-phenylancryic acetate binary mixture mixture concentration gradient are 1.0 μ g/ml, 2.0 μ g/ml, 4.0 μ g/ml, 8.0 μ g/ml, 16 μ g/ml, establish the clear water contrast; Repeat 3 times.Adopting the mycelial growth rate method, with cultured pathogen, is the card punch of 5cm with diameter under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; Check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value by inhibiting rate and the logarithm value of series concentration
50Value, and calculate relative coefficient of synergism.
The Wadley method: estimate the synergistic effect of pharmacy mix according to coefficient of synergism (SR), both SR＜0.5 was antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.The coefficient of synergism of mixture (SR value) calculates by following formula:
In the formula: X
1---the EC of mixture
50Theoretical value, unit be the milligram every liter (mg/L)
P
A---the percentage composition of A in the mixture, unit are percentage (%)
P
B---the percentage composition of B in the mixture, unit are percentage (%)
The EC of A in the A---mixture
50Value, unit is every liter (mg/L) of milligram
The EC of B in the B---mixture
50Value, unit is every liter (mg/L) of milligram
The coefficient of synergism of SR---mixture;
X
1---mixture EC
50Theoretical value, unit is every liter (mg/L) of milligram;
X
2---mixture EC
50Measured value, unit are every liter (mg/L) of milligram.
Table 1 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are mixed to the Toxicity Determination result of Alternaria mali
2) sigatoka bacterium (Sigatoka disease of banana).Test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single dose and each Mixed Pharmacy are arranged respectively following 5 variable concentrations gradients: 2-cyano-3-amino-3-phenylancryic acetate is 1.0 μ g/ml, 2.0 μ g/ml, 4 μ g/ml, 8 μ g/ml, 16 μ g/ml; Famoxadone is 0.75 μ g/ml, 1.5 μ g/ml, 3.0 μ g/ml, 6.0 μ g/ml, 12.0 μ g/ml; Famoxadone and 2-cyano-3-amino-3-phenylancryic acetate binary mixture mixture concentration gradient are 0.5 μ g/ml, 1.0 μ g/ml, 2.0 μ g/ml, 4.0 μ g/ml, 8.0 μ g/ml, establish the clear water contrast; Repeat 3 times.Adopting the mycelial growth rate method, with cultured pathogen, is the card punch of 5cm with diameter under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; Check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value by inhibiting rate and the logarithm value of series concentration
50Value, and calculate relative coefficient of synergism.
Table 2 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are mixed to the Toxicity Determination result of sigatoka bacterium
3) cucumber fusarium axysporum (Fusarium oxysporum f.sp.cucumerinum).Test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single dose and each Mixed Pharmacy are arranged respectively following 5 variable concentrations gradients: 2-cyano-3-amino-3-phenylancryic acetate is 0.3 μ g/ml, 0.6 μ g/ml, 1.2 μ g/ml, 2.4 μ g/ml, 4.8 μ g/ml; Famoxadone is 0.2 μ g/ml, 0.4 μ g/ml, 0.8 μ g/ml, 1.60 μ g/ml, 3.2 μ g/ml; Famoxadone and 2-cyano-3-amino-3-phenylancryic acetate binary mixture mixture concentration gradient are 0.175 μ g/ml, 0.35 μ g/ml, 0.7 μ g/ml, 1.4 μ g/ml, 2.8 μ g/ml, establish the clear water contrast; Repeat 3 times.Adopting the mycelial growth rate method, with cultured pathogen, is the card punch of 5cm with diameter under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; Check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value by inhibiting rate and the logarithm value of series concentration
50Value, and calculate relative coefficient of synergism.
Table 3 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are mixed to the Toxicity Determination result of cucumber fusarium axysporum
4) fusarium graminearum (Gibberella sanbinetti).Test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single dose and each Mixed Pharmacy are arranged respectively following 5 variable concentrations gradients: 2-cyano-3-amino-3-phenylancryic acetate is 0.2 μ g/ml, 0.4 μ g/ml, 0.8 μ g/ml, 1.6 μ g/ml, 3.2 μ g/ml; Famoxadone is 0.1 μ g/ml, 0.2 μ g/ml, 0.4 μ g/ml, 0.8 μ g/ml, 1.6 μ g/ml; Famoxadone and 2-cyano-3-amino-3-phenylancryic acetate binary mixture mixture concentration gradient are 0.075 μ g/ml, 0.15 μ g/ml, 0.3 μ g/ml, 0.6 μ g/ml, 1.2 μ g/ml, establish the clear water contrast; Repeat 3 times.Adopting the mycelial growth rate method, with cultured pathogen, is the card punch of 5cm with diameter under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; Check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value by inhibiting rate and the logarithm value of series concentration
50Value, and calculate relative coefficient of synergism.
Table 4 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are mixed to the Toxicity Determination result of fusarium graminearum
5) wheat rust germ (PuuciniagraminisPers.f.sp.triticiErikss.et.Hem).Test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single dose and each Mixed Pharmacy are arranged respectively following 5 variable concentrations gradients: 2-cyano-3-amino-3-phenylancryic acetate is 0.2 μ g/ml, 0.4 μ g/ml, 0.8 μ g/ml, 1.6 μ g/ml, 3.2 μ g/ml; Famoxadone is 0.15 μ g/ml, 0.3 μ g/ml, 0.6 μ g/ml, 1.2 μ g/ml, 2.4 μ g/ml; Famoxadone and 2-cyano-3-amino-3-phenylancryic acetate binary mixture mixture concentration gradient are 0.125 μ g/ml, 0.25 μ g/ml, 0.5 μ g/ml, 1.0 μ g/ml, 2.0 μ g/ml, establish the clear water contrast; Repeat 3 times.Adopting the mycelial growth rate method, with cultured pathogen, is the card punch of 5cm with diameter under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; Check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value by inhibiting rate and the logarithm value of series concentration
50Value, and calculate relative coefficient of synergism.
Table 5 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are mixed to the Toxicity Determination result of wheat rust germ
6) rice sheath blight disease germ (Rhizoctonia solani).Test method is with reference to " the agricultural industry criteria NY/T1156.6-2006 of the People's Republic of China (PRC) ".At first single dose and each Mixed Pharmacy are arranged respectively following 5 variable concentrations gradients: 2-cyano-3-amino-3-phenylancryic acetate is 0.25 μ g/ml, 0.5 μ g/ml, 1.0 μ g/ml, 2.0 μ g/ml, 4.0 μ g/ml; Famoxadone is 0.2 μ g/ml, 0.4 μ g/ml, 0.8 μ g/ml, 1.60 μ g/ml, 3.2 μ g/ml; Famoxadone and 2-cyano-3-amino-3-phenylancryic acetate binary mixture mixture concentration gradient are 0.15 μ g/ml, 0.3 μ g/ml, 0.6 μ g/ml, 1.2 μ g/ml, 2.4 μ g/ml, establish the clear water contrast; Repeat 3 times.Test target bacterium is to pick up from the from up to down Rhizoctonia solani Kuhn blade of 4 leaves～6 leaf positions of field, washes the sheath blight fungus sporangium of vacuum side of blade with 4 ℃ of distilled water, and (concentration is controlled at every milliliter 1 * 10 to be made into suspension
5Individual～1 * 10
7Individual sporangium), deposit under 4 ℃ for subsequent use; Be inoculated in vacuum side of blade with ready fresh sporangia suspension drop 10 μ L.4 of every blade inoculations, every processing are no less than 5 leaves.The protectiveness test is the 24h inoculation after chemicals treatment, and the therapeutic test is the 24h inoculation before processing.Ware lid on the inoculation bonnet places climatic cabinate or the humidistat of illumination is arranged, the continuous illumination in every day/dark 12h alternately, temperature is 17 ℃～22 ℃, cultivates under the condition of relative moisture more than 90%.Depending on processing and the measurement of blank incidence and record scab diameter, unit is millimeter (mm), calculates control efficiency.
Table 6 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are mixed to the Toxicity Determination result of Rhizoctonia solani Kuhn
Can find out that from table 1-6 famoxadone and 2-cyano-3-amino-3-phenylancryic acetate are composite, it is that 10: 1～1: 40 o'clock coefficient of synergism is all greater than 1.5 that alternaria leaf spot of apple, sigatoka, cucumber fusarium axysporum, wheat scab, rust, Rhizoctonia solani Kuhn are all had very high synergistic effect ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate weight ratio.Below in conjunction with example of formulations content of the present invention is described further.
Example of formulations 1:
Take by weighing 10% famoxadone, 70% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 2% diatomite, 5% glucose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is namely mixed, ultra micro air-flow crushing, mixing, granulation step are produced 80% famoxadone 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules.
Example of formulations 2
Take by weighing 6% famoxadone, 60% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 1%K-12,1% carboxymethyl cellulose, 3% urea, diatomite and add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is namely mixed, ultra micro air-flow crushing, mixing, granulation step are produced 66% famoxadone 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules.
Example of formulations 3:
Take by weighing 2% famoxadone, 40% 2-cyano-3-amino-3-phenylancryic acetate, 4%TERSPERSE 2700,2% dispersing agent NNO, 2% Nekal BX (nekal), 1%K-12,3% corn starch, 3% sulphur ammonium, attapulgite and add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is namely mixed, ultra micro air-flow crushing, mixing, granulation step are produced 42% famoxadone 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules.
Example of formulations 4:
Take by weighing 1.8% famoxadone, 76% 2-cyano-3-amino-3-phenylancryic acetate, 4%Morwet D-425 (alkyl naphthalene sulfonic acid condensation polymer sodium salt, Akzo Nobel N.V. produces), 3% dispersing agent NNO, 2% Nekal BX, 2%K-12,3% wheaten starch, 5% sucrose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is namely mixed, ultra micro air-flow crushing, mixing, granulation step are produced 77.8% famoxadone 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules.
Example of formulations 5
Take by weighing 5% famoxadone, 25% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 4894,2%TERSPERSE 2500,3%TERSPERSE 2425,0.2% xanthans, 3% white carbon, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 30% famoxadone 2-cyano-3-amino-3-phenylancryic acetate suspending agent behind the sand mill sand milling.
Example of formulations 6:
Take by weighing 10% famoxadone, 30% 2-cyano-3-amino-3-phenylancryic acetate, 2%NNO, 2%TERSPERSE 2500,1% emulsifier T-60,3% Nongru-700 #, 0.1% xanthans, 3% white carbon, 5% propane diols, 0.5% formaldehyde, 0.3% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 40% famoxadone 2-cyano-3-amino-3-phenylancryic acetate suspending agent behind the sand mill sand milling.
Example of formulations 7:
Take by weighing 10% famoxadone, 15% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 4894,1%TERSPERSE 2500,1%TERSPERSE 2425,0.2% xanthans, 3% white carbon, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 25% famoxadone 2-cyano-3-amino-3-phenylancryic acetate suspending agent behind the sand mill sand milling.
Example of formulations 8:
Take by weighing 30% famoxadone, 3% 2-cyano-3-amino-3-phenylancryic acetate, 4%TERSPERSE 4894,1.5%TERSPERSE 2500,0.5%TERSPERSE 2425,0.2% xanthans, 3% white carbon, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 33% famoxadone 2-cyano-3-amino-3-phenylancryic acetate suspending agent behind the sand mill sand milling.
Example of formulations 9
Take by weighing 4% famoxadone, 1% 2-cyano-3-amino-3-phenylancryic acetate, 4% calcium lignosulfonate, 2% Nekal BX, 1%K-12,5% White Carbon black, kaolin and add to 100% weight portion.Above-mentioned raw materials makes 5% famoxadone 2-cyano-3-amino-3-phenylancryic acetate wetting powder through mixing behind the air-flow crushing.
Example of formulations 10
Take by weighing 5% famoxadone, 45% 2-cyano-3-amino-3-phenylancryic acetate, 4% calcium lignosulfonate, 3%TERSPERSE2700,2% Nekal BX, 2%K-12,3% White Carbon black, fine particle calcium carbonate and add to 100% weight portion.Above-mentioned raw materials makes 50% famoxadone 2-cyano-3-amino-3-phenylancryic acetate wetting powder through mixing behind the air-flow crushing.
Example of formulations 11
Take by weighing 5% famoxadone, 60% 2-cyano-3-amino-3-phenylancryic acetate, 4% calcium lignosulfonate, 4% dispersing agent NNO, 2% Nekal BX, 2%K-12,5% White Carbon black, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 65% famoxadone 2-cyano-3-amino-3-phenylancryic acetate wetting powder through mixing behind the air-flow crushing.
Example of formulations 12
Take by weighing 6% famoxadone, 24% 2-cyano-3-amino-3-phenylancryic acetate, 4% calcium lignosulfonate, 3%TERSPERSE2700,2% Nekal BX, 2%K-12,3% White Carbon black, fine particle calcium carbonate and add to 100% weight portion.Above-mentioned raw materials makes 30% famoxadone 2-cyano-3-amino-3-phenylancryic acetate wetting powder through mixing behind the air-flow crushing.
Example of formulations 13
Take by weighing 3% famoxadone, 12% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 2425,4% this dish-60#, 3% Tween-60 #, 1%TERSPERSE 2500,0.5% white carbon, 5% propane diols, 1% epoxychloropropane, methyl oleate and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 15% famoxadone 2-cyano-3-amino-3-phenylancryic acetate dispersed oil suspending agent behind the sand mill sand milling.
Example of formulations 14
Take by weighing 3% famoxadone, 24% 2-cyano-3-amino-3-phenylancryic acetate, 3% dispersing agent NNO, 3% farming breast 2201,4%BY-125,1%TERSPERSE 2500,1% aluminium-magnesium silicate, 3% propane diols, 15% epoxidized soybean oil, soybean oil adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 27% famoxadone 2-cyano-3-amino-3-phenylancryic acetate dispersed oil suspending agent behind the sand mill sand milling.
Example of formulations 15
Take by weighing 2% famoxadone, 24% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 2425,2% this dish-60#, 2% Tween-60 #, 5%BY-110,1%TERSPERSE 2500,0.5% white carbon, 5% propane diols, 20% epoxidized soybean oil, methyl oleate and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 26% famoxadone 2-cyano-3-amino-3-phenylancryic acetate dispersed oil suspending agent behind the sand mill sand milling.
Example of formulations 16
Take by weighing 2% famoxadone, 12% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 2425,3%TERSPERSE 4894,3% this dish-60#, 2% Tween-60 #, 1%TERSPERSE 2500,0.5% bentonite, 5% ethylene glycol, 3% triphenyl phosphate, rapeseed oil and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 14% famoxadone 2-cyano-3-amino-3-phenylancryic acetate dispersed oil suspending agent behind the sand mill sand milling.
Example of formulations 17
Take by weighing 5% famoxadone, 10% 2-cyano-3-amino-3-phenylancryic acetate, 3%TERSPERSE 2425,2% this dish-60#, 2% Tween-60 #, 5%BY-125,1%TERSPERSE 2500,0.5% white carbon, 5% propane diols, 20% epoxidized soybean oil, methyl oleate and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 15% famoxadone 2-cyano-3-amino-3-phenylancryic acetate dispersed oil suspending agent behind the sand mill sand milling.
Biological example 1 control alternaria leaf spot of apple field control effectiveness test
Test arrangement is in area just outside a city gate, Liquan County town, test medicine 66% famoxadone 2-cyano-3-amino-3-phenylancryic acetate (6%+60%) WDG is provided by Shanggezhilu Biosciences Co., Ltd., Shaanxi, contrast medicament 25% 2-cyano-3-amino-3-phenylancryic acetate SC (commercial), 10% famoxadone SC (self-control), apple variety: Fuji; Test is carried out field control effectiveness test with reference to " field control effectiveness test criterion () GB/T 17980.124-2004 bactericidal agent for preventing and treating alternaria leaf spot of apple ".In for the first time dispenser on July 25th, 09, for the second time dispenser on August 10, the residential quarter of test medicine, contrast medicament and blank are processed and are adopted random district group to arrange, and two strains investigation is selected in every residential quarter, 2 young sprouts are fixed in every strain minute all directions, its whole blades of periodic investigation record total number of sheets, the sick numbers of sheets at different levels, repeat for 4 times, investigation state of an illness radix before the dispenser, altogether dispenser twice, 10 days investigation prevention effects before each dispenser and after the last dispenser.
Stage division (take blade as unit):
0 grade: without scab;
1 grade: lesion area accounts for below 10% of whole leaf area;
3 grades: lesion area accounts for the 11%-25% of whole leaf area;
5 grades: lesion area accounts for the 26%-40% of whole leaf area;
7 grades: lesion area accounts for the 41%-65% of whole leaf area;
9 grades: lesion area accounts for more than 66% of whole leaf area.
The drug effect computational methods:
In the formula: CK
0, CK
1Be respectively the forward and backward disease index of blank district dispenser; PT
0, PT
1Be respectively the forward and backward disease index of chemicals treatment district dispenser.
Table 7 control alternaria leaf spot of apple field control effectiveness test
As can be seen from Table 7 ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate can effectively preventing after composite alternaria leaf spot of apple, control efficiency all is better than the single dose with concentration, in the test Drug level to the target crop safety.
Biological example 2 is prevented and treated the sigatoka field control effectiveness test
The Institute of Plant Protection, Zhangzhou City is entrusted in test, test medicine 27% famoxadone 2-cyano-3-amino-3-phenylancryic acetate (3%+24%) but the dispersed oil suspending agent provided by Shanggezhilu Biosciences Co., Ltd., Shaanxi, contrast medicament 25% 2-cyano-3-amino-3-phenylancryic acetate SC (commercial), 10% famoxadone SC (self-control), banana variety: Zhang any of several broadleaf plants No. 8; Prevent and treat the sigatoka field control effectiveness test and carry out field control effectiveness test with reference to " field control effectiveness test criterion () GB/T17980.95-2004 bactericidal agent for preventing and treating sigatoka ".The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, two strains investigation is selected in every residential quarter, every strain banana is down investigated 10 leaves (not opening lobus cardiacus disregards) from top, records total number of sheets, the sick numbers of sheets at different levels, repeat for 4 times, be administered to for the first time for the first time dispenser on June 20th, 09, for the second time dispenser on July 10, investigation state of an illness radix before the dispenser, altogether dispenser twice, 7 days investigation prevention effects before each dispenser and after the last dispenser.
Stage division (take blade as unit):
0 grade: without scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area.
Table 8 is prevented and treated the sigatoka field control effectiveness test
As can be seen from Table 8 ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate can effectively preventing after composite sigatoka, control efficiency all is better than the single dose with concentration, in the test Drug level to the target crop safety.Biological example 3 control cucumber fusarium axysporum field control effectiveness tests
Experimental field in Xingping City Ma Wei town, test medicine 30% famoxadone 2-cyano-3-amino-3-phenylancryic acetate (5%+25%) suspending agent is provided by Shanggezhilu Biosciences Co., Ltd., Shaanxi, contrast medicament 25% 2-cyano-3-amino-3-phenylancryic acetate SC (commercial), 10% famoxadone SC (self-control), cucumber variety: Tianjin spring No. 4; Control cucumber fusarium axysporum field control effectiveness test carries out field control effectiveness test with reference to " field control effectiveness test criterion () GB/T 17980.113-2004 bactericidal agent for preventing and treating cucumber fusarium axysporum ".The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange residential quarter area 30m
2, 4 repetitions, in dispenser on May 20 in 09 year, investigation diseased plant strain number and total strain number before the medicine, the classical symptom that whether all plant have fusarium wilt in the 10 investigation residential quarters behind the medicine records the morbidity strain number of fusarium wilt and investigates total strain number.
The drug effect computational methods
Diseased plant rate (the %)=diseased plant number * total strain number of 100/ investigation
Control efficiency (%)=(blank district diseased plant rate-treatment region diseased plant rate) * 100/ blank district diseased plant rate
The field control effectiveness test of table 9 control cucumber fusarium axysporum
As can be seen from Table 9 ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate can effectively preventing after composite cucumber fusarium axysporum, control efficiency all is better than the single dose with concentration, in the test Drug level to the target crop safety.Biological example 4 is prevented and treated the wheat scab test of pesticide effectiveness
Experimental field press down together in the Mei County, test medicine 50% famoxadone 2-cyano-3-amino-3-phenylancryic acetate (5%+45%) wetting powder is provided by Shanggezhilu Biosciences Co., Ltd., Shaanxi, contrast medicament 25% 2-cyano-3-amino-3-phenylancryic acetate SC (commercial), 10% famoxadone SC (self-control), wheat breed: west farming 9871; Prevent and treat the wheat scab field control effectiveness test and carry out field control effectiveness test with reference to " field control effectiveness test criterion () NY/T 1464.15-2007 bactericidal agent for preventing and treating wheat scab ".The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange residential quarter area 30m
2, repeat for 4 times, be administered on May 8th, 09 for the first time, be administered to May 20 for the second time, 5 samplings of every residential quarter diagonal, every some investigation 150 fringes, the percentage that accounts for whole fringe area with withered fringe area comes classification, records sick spike numbers at different levels and total spike number.
Stage division (take blade as unit):
0 grade: full fringe is anosis;
1 grade: withered fringe area accounts for below 1/4 of full fringe area;
3 grades: withered fringe area accounts for 1/4～1/2 of full fringe area;
5 grades: withered fringe area accounts for 1/2～3/4 of full fringe area;
7 grades: withered fringe area accounts for more than 3/4 of full fringe area;
The drug effect computational methods:
Disease tassel yield by formula (1) calculates D=Nd * 100/N (1)
D---disease tassel yield in the formula, the % of unit; The sick spike number N---of Nd---investigates total spike number
Disease index by formula (2) calculates X=∑ (Ni * i) * 100/ (N * 7) (2)
The X-disease index; Ni---sick spike numbers at different levels; I---relative level numerical value; N---investigates total spike number
Control efficiency is calculated by (3)
Control efficiency (%)=(X1-X2) * 100/X1 (3)
In the formula: P---control efficiency (%); X1---blank district disease index; X2---blank district disease index
Table 10 is prevented and treated the wheat scab field control effectiveness test
As can be seen from Table 10 ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate can effectively preventing after composite wheat scab, control efficiency all is better than the single dose with concentration, in the test Drug level to the target crop safety.Biological example 5 is prevented and treated the wheat rust field control effectiveness test
Test is selected in osiery town, Chenggu County, test wheat breed river wheat 30, test medicine 14% famoxadone 2-cyano-3-amino-3-phenylancryic acetate (2%+12%) but the dispersed oil suspending agent provided by Shanggezhilu Biosciences Co., Ltd., Shaanxi, contrast medicament 25% 2-cyano-3-amino-3-phenylancryic acetate SC (commercial), 10% famoxadone SC (self-control) prevents and treats the wheat rust field control effectiveness test and carries out field control effectiveness test with reference to " field control effectiveness test criterion () GB/T 17980.23-2000 bactericidal agent for preventing and treating Cereal Rust ".The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange residential quarter area 30m
2Repeat for 4 times, be administered to for the first time on February 20th, 09, be administered to for the second time and carried out March 8, investigation state of an illness radix before the dispenser, every residential quarter is selected representational 5 sampling surveys at random, every some investigation 20 strains, every strain investigation three leaves in top (if having boot leaf then to comprise boot leaf), the percentage classification that accounts for whole leaf area with lesion area on the every leaf.
Stage division (take blade as unit):
0 grade: anosis;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-25% of whole leaf area;
5 grades: lesion area accounts for the 26%-50% of whole leaf area;
7 grades: lesion area accounts for the 51%-75% of whole leaf area;
9 grades: lesion area accounts for more than 76% of whole leaf area.
Table 11 is prevented and treated the wheat rust field control effectiveness test
As can be seen from Table 11 ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate can effectively preventing after composite wheat rust, control efficiency all is better than the single dose with concentration, in the test Drug level to the target crop safety
Biological example 6 is prevented and treated the rice sheath blight disease field control effectiveness test
Test is selected in osiery town, Chenggu County, test water rice varieties gold excellent 725, test medicine 30% famoxadone 2-cyano-3-amino-3-phenylancryic acetate (5%+25%) suspending agent is provided by Shanggezhilu Biosciences Co., Ltd., Shaanxi, contrast medicament 25% 2-cyano-3-amino-3-phenylancryic acetate SC (commercial), 10% famoxadone SC (self-control) prevents and treats the rice sheath blight disease field control effectiveness test and carries out field control effectiveness test with reference to " field control effectiveness test criterion () GB/T 17980.26-2000 bactericidal agent for preventing and treating rice sheath blight disease ".The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange residential quarter area 30m
2, repeat for 4 times, be administered on June 20th, 2010 for the first time, second inferior to July 10, investigation state of an illness radix before the dispenser, altogether dispenser twice, 7 days investigation prevention effects before each dispenser and after the last dispenser.Every residential quarter is got 4 investigation at random, looks into two strains at every, and whole sheet leaves are investigated in every strain.
Stage division (take blade as unit):
0 grade: without scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-10% of whole leaf area;
5 grades: lesion area accounts for the 11%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
Table 12 is prevented and treated the rice sheath blight disease field control effectiveness test
As can be seen from Table 12 ， famoxadone and 2-cyano-3-amino-3-phenylancryic acetate can effectively preventing after composite rice sheath blight disease, control efficiency all is better than the single dose with concentration, in the test Drug level to the target crop safety.
Comprehensively above-mentioned, the present invention prevents and treats spot defoliation, leaf spot, the fusarium wilt of melon crop, the banded sclerotial blight of cereal crop, head blight, the rust of fruit tree kind crop, component is reasonable, and bactericidal effect is good, reduces the medication number of times, drug cost is low, and its activity and bactericidal effect are not the simple superposition of each composition activity, but significant synergistic effect is arranged, and slow down the generation of resistance, good to crop safety, meet the security requirement of pesticidal preparations.
Claims (5)
1. a bactericidal composition that contains famoxadone and 2-cyano-3-amino-3-phenylancryic acetate is characterized in that the bactericidal composition active component is,
A) a property one-tenth alive divides famoxadone;
B) the second active component 2-cyano-3-amino-3-phenylancryic acetate;
The weight ratio of the first active component and the second active component is 10:1 ~ 1:40.
2. the bactericidal composition of Han famoxadone according to claim 1 and 2-cyano-3-amino-3-phenylancryic acetate, it is characterized in that: the cumulant of the first active component and the second active component is 5%～80% of described composition total weight.
3. the bactericidal composition of Han famoxadone according to claim 2 and 2-cyano-3-amino-3-phenylancryic acetate, it is characterized in that: the cumulant of the first active component and the second active component is 10%～50% of described composition total weight.
4. the bactericidal composition of Han famoxadone according to claim 1 and 2-cyano-3-amino-3-phenylancryic acetate is characterized in that: but described combination dosage form is water dispersible granules, wetting powder, suspending agent dispersed oil suspending agent.
5. the bactericidal composition of Han famoxadone claimed in claim 1 and 2-cyano-3-amino-3-phenylancryic acetate is in spot defoliation, the leaf spot of control fruit tree kind crop, the fusarium wilt of melon crop, the application in the banded sclerotial blight of cereal crop, head blight and the rust.
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