CN101917992A - 用于治疗运动障碍的pde7抑制剂的用途 - Google Patents

用于治疗运动障碍的pde7抑制剂的用途 Download PDF

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Publication number
CN101917992A
CN101917992A CN200880017058XA CN200880017058A CN101917992A CN 101917992 A CN101917992 A CN 101917992A CN 200880017058X A CN200880017058X A CN 200880017058XA CN 200880017058 A CN200880017058 A CN 200880017058A CN 101917992 A CN101917992 A CN 101917992A
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CN
China
Prior art keywords
activity
inhibiting
alkyl
pde7
compound
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Pending
Application number
CN200880017058XA
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English (en)
Chinese (zh)
Inventor
J·E·伯格曼
N·S·卡特沙尔
G·A·德莫普洛斯
V·A·弗洛里奥
G·盖塔纳里斯
P·格雷
J·霍曼
R·安鲁斯特
曾红葵
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Omeros Corp
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Omeros Medical Systems Inc
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Publication date
Application filed by Omeros Medical Systems Inc filed Critical Omeros Medical Systems Inc
Priority to CN201510082785.6A priority Critical patent/CN104758291B/zh
Publication of CN101917992A publication Critical patent/CN101917992A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880017058XA 2007-03-27 2008-03-27 用于治疗运动障碍的pde7抑制剂的用途 Pending CN101917992A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510082785.6A CN104758291B (zh) 2007-03-27 2008-03-27 用于治疗运动障碍的pde7抑制剂的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92049607P 2007-03-27 2007-03-27
US60/920,496 2007-03-27
PCT/US2008/058530 WO2008119057A2 (en) 2007-03-27 2008-03-27 The use of pde7 inhibitors for the treatment of movement disorders

Related Child Applications (1)

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CN201510082785.6A Division CN104758291B (zh) 2007-03-27 2008-03-27 用于治疗运动障碍的pde7抑制剂的用途

Publications (1)

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CN101917992A true CN101917992A (zh) 2010-12-15

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CN200880017058XA Pending CN101917992A (zh) 2007-03-27 2008-03-27 用于治疗运动障碍的pde7抑制剂的用途
CN201510082785.6A Active CN104758291B (zh) 2007-03-27 2008-03-27 用于治疗运动障碍的pde7抑制剂的用途

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Country Status (11)

Country Link
US (3) US20080260643A1 (cg-RX-API-DMAC7.html)
EP (1) EP2139475B1 (cg-RX-API-DMAC7.html)
JP (2) JP5580192B2 (cg-RX-API-DMAC7.html)
CN (2) CN101917992A (cg-RX-API-DMAC7.html)
AU (1) AU2008230710B2 (cg-RX-API-DMAC7.html)
CA (1) CA2681650C (cg-RX-API-DMAC7.html)
ES (1) ES2533206T3 (cg-RX-API-DMAC7.html)
MX (1) MX2009010450A (cg-RX-API-DMAC7.html)
NZ (1) NZ580413A (cg-RX-API-DMAC7.html)
RU (1) RU2449790C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008119057A2 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207275B2 (en) 2010-11-08 2021-12-28 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US11464785B2 (en) 2010-11-08 2022-10-11 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
CN117100245A (zh) * 2017-01-05 2023-11-24 诺克特丽克丝健康公司 不宁腿综合征或过度活跃神经治疗

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US8637528B2 (en) * 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
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FR2943673B1 (fr) 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione
FR2944206B1 (fr) 2009-04-09 2012-12-28 Sanofi Aventis Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
FR2944282B1 (fr) 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207275B2 (en) 2010-11-08 2021-12-28 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US11464785B2 (en) 2010-11-08 2022-10-11 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
CN117100245A (zh) * 2017-01-05 2023-11-24 诺克特丽克丝健康公司 不宁腿综合征或过度活跃神经治疗

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AU2008230710B2 (en) 2014-04-10
CA2681650A1 (en) 2008-10-02
JP2014198718A (ja) 2014-10-23
BRPI0809244A2 (pt) 2014-09-23
US20110091388A1 (en) 2011-04-21
MX2009010450A (es) 2009-11-23
RU2449790C2 (ru) 2012-05-10
AU2008230710A1 (en) 2008-10-02
JP5943964B2 (ja) 2016-07-05
JP2010522768A (ja) 2010-07-08
CA2681650C (en) 2016-11-22
WO2008119057A2 (en) 2008-10-02
ES2533206T3 (es) 2015-04-08
HK1139861A1 (en) 2010-09-30
JP5580192B2 (ja) 2014-08-27
CN104758291B (zh) 2020-03-03
RU2009138966A (ru) 2011-05-10
EP2139475A4 (en) 2012-03-07
US20080260643A1 (en) 2008-10-23
EP2139475B1 (en) 2014-12-17
US20190183824A1 (en) 2019-06-20
CN104758291A (zh) 2015-07-08
EP2139475A2 (en) 2010-01-06
WO2008119057A3 (en) 2008-11-20
NZ580413A (en) 2012-11-30

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Application publication date: 20101215