CN101912539A - Chinese medicinal composition for treating cervical spondylotic radiculopathy and preparation method thereof - Google Patents
Chinese medicinal composition for treating cervical spondylotic radiculopathy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating cervical spondylotic radiculopathy and a preparation method thereof. The preparation method of the composition of the invention comprises a step of preparing active ingredients from pseudo-ginseng root, Chinese angelica, safflower, artificial calculus bovis, astragalus, root of kudzu vine, white paeony root and the like serving as raw traditional Chinese medicinal materials. The Chinese medicinal composition of the invention has the effects of activating blood circulation to dissipate blood stasis, warming meridians, promoting the restoration consciousness and relieving pain and can be used for blood stasis obstruction syndrome of cervical spondylotic radiculopathy and syndromes such as stiffness and pain of neck and shoulder, scurrying pain of upper limb of the diseased side and the like. The Chinese medicinal composition of the invention has the advantages of stable therapeutic effect, no toxic or side effect, suitability for long-term taking and total effective rate of over 95.0 percent and is an ideal medicament for treating the cervical spondylotic radiculopathy.
Description
[technical field]
The invention belongs to the Chinese medicine technical field of pharmaceuticals.More specifically, the present invention relates to be used for the treatment of the Chinese medicine composition of cervical spondylotic radiculopathy, also relate to the preparation method of described Chinese medicine composition.
[background technology]
It is common clinical, frequently-occurring disease that neck pushes away disease.Stretch before and after the head bend and left and right sides rotation, lateral bending, when rotatablely moving, the suffered heavy stress of cervical vertebra changes thereupon, and is overworked for a long time if the cervical region posture is bad, and soft-tissue strains such as musculi colli ligament then easily take place.When incidence wound or the damp that is affected by the cold, internal injury, neck bone degeneration of joint, inflammatory stimulus etc., then can cause trachelism, destroyed the cervical muscle equilibrium stress.If the cervical region activity exceeds normal range, the rotation of neck bone joint, displacement just may take place in head under slight external force effect, cervical intervertebral disk also can be subjected to the influence of this external carbuncle and the degeneration of intervertebral disc is taken place, even vertebral pulp takes place deviate from from the rear, compressing or stimulate spinal nerves and clinical symptoms occurs.Cause that thus osteoarthropathy of cervical vertebra reason changes, cause the cervical vertebra anatomical position to change, make cervical spinal instability, if compressing or inflammatory stimulus cervical nerves root then can cause cervical spondylotic radiculopathy.
It is a kind of cervical spondylosis of high incidence wherein that the spondylotic radiculopathy neck pushes away disease, is that the spondylotic radiculopathy neck pushes away disease.Cervical spondylotic radiculopathy mainly is because vertebral pulp is given prominence to and deviate from, the little hyperosteogeny in rear, uncovertebral joint bony spur form with and adjacent three joints (articulatio intercentralis, uncovertebral joint, little joint, rear) loosening all can causing to spinal nerve root with displacement stimulate and compressing.The main clinical manifestation of this disease is a neck and shoulder pain, and cervical region is ached behind the occipitalia, develops into gradually pain in arm or finger fiber crops pain to occur, and the Ipsilateral upper limb feels that heavy, grip goes down, and occurs holding thing sometimes and falls.
At present doctor trained in Western medicine pushes away two kinds of disease employing non-operative treatment and operative treatments to the spondylotic radiculopathy neck.Methods such as the main using cervical vertebra traction of non-operative treatment, partial closure, physical therapy, acupuncture.Although these methods have application, its effect is slow, curative effect is not very high, patient suffering.Adopt operative treatment to develop complications, dangerous higher.
At present, the vast medical worker of China actively excavates abundant motherland's medical science resource, has carried out big quantity research for solution treatment spondylotic radiculopathy neck pushes away disease.
CN 03112032.6 discloses a kind of medicament that is used for the treatment of cervical spondylosis and preparation method thereof, and this medicament is made with former medicines of plurality of Chinese such as Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygiis.
CN 01116015.2 discloses a kind of herbal mixture oral formulations that is used for the treatment of myeloid form and cervical spondylotic radiculopathy and prolapse of lumbar intervertebral disc, and it mainly is made up of 20 flavor Chinese medicines such as Semen Persicae, Flos Carthami, Olibanum, Myrrha, Radix Angelicae Sinensis, Scorpio, Eupolyphaga Seu Steleophaga.The applicant thinks, the expansible blood vessel of this prescription, microcirculation improvement, releasing smooth muscle and skeletal muscle spasm, anti-inflammatory response, anti-immunoreation, trophic nerve cell promote the recovery of injured nerve cell function, thereby improve nervous system and General Symptoms simultaneously.
CN 201010139801.8 discloses a kind of Chinese medicine preparation, promptly is used for the treatment of Liver and kidney two void, and cold-damp hinders the bone-strengthening and muscle-relaxing medicine of the cervical spondylotic radiculopathy due to the network.It mainly is made up of kinds of traditional Chinese medicines such as Herba Epimedii, Radix Rehmanniae Preparata, Herba Pyrolae, Rhizoma Drynariae, Herba Cistanches.This Chinese medicine preparation has the curative effect height, and toxic and side effects is little, total obvious effective rate 64.58%, and total effective rate 95%, to Liver and kidney two void, the cold dampness accumulation pattern cervical spondylosis has better curative effect, and is safe and reliable.
CN 200710014555.1 discloses a kind of Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy.This Chinese medicine composition is formulated by kinds of traditional Chinese medicines such as the Radix Angelicae Dahuricae, Radix Aconiti Kusnezoffii Preparata, Radix Angelicae Pubescentis, Radix Dipsaci, Radix Achyranthis Bidentataes.This traditional Chinese medicine composition for treating cervical spondylotic radiculopathy has obtained significant effect, and stable curative effect has no side effect, total effective rate 92.3%.
CN 200710014557.0 discloses a kind of Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy.This Chinese medicine composition is formulated by kinds of traditional Chinese medicines such as the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Puerariae, the Radix Paeoniae Albas.This traditional Chinese medicine composition for treating cervical spondylotic radiculopathy has obtained significant effect, and stable curative effect shortens treatment time, and no pain has no side effect, total effective rate 94.3%.
CN 200710015402.9 discloses a kind of Chinese medicine composition that is used for the treatment of cervical spondylopathy.This Chinese medicine composition is formulated by kinds of traditional Chinese medicines such as the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparatas.This traditional Chinese medicine composition for treating cervical spondylotic radiculopathy has obtained significant effect, and stable curative effect has no side effect, total effective rate 92.3%.
CN 200910075468.6 discloses a kind of medicine that is used for the treatment of cervical spondylotic radiculopathy.It is formulated with kinds of traditional Chinese medicines such as the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Chrysanthemi, Spica Prunellae, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longaes.This medicine has invigorating the kidney and strengthening the bones, blood nourishing acupuncture-stimulating, expelling wind and removing dampness, the effect of relieving spasm to stop pain, the curative effect that is used for the treatment of cervical spondylotic radiculopathy really, rapidly, taking convenience, safety.
[summary of the invention]
[technical problem that will solve]
The purpose of this invention is to provide a kind of Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy.
Another object of the present invention provides a kind of preparation method of described Chinese medicine composition.
[technical scheme]
The present invention is achieved through the following technical solutions.
The present invention relates to a kind of Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy.Described Chinese medicine composition is formed by effective ingredient or effective ingredient and at pharmaceutically acceptable carrier, it is characterized in that described effective ingredient made by following raw material medicaments:
Radix Notoginseng 10-50 weight portion Radix Angelicae Sinensis 10-50 weight portion
Rhizoma Chuanxiong 10-50 weight portion Flos Carthami 10-50 weight portion
Rhizoma Gastrodiae 10-50 weight portion Cortex Cinnamomi 6-35 weight portion
Artificial Calculus Bovis 3-16 weight portion Radix Astragali 3-10 weight portion
Radix Puerariae 2-5 weight portion Radix Paeoniae Alba 2-6 weight portion.
A preferred embodiment of the invention, described effective ingredient is made by following raw material medicaments:
Radix Notoginseng 15-40 weight portion Radix Angelicae Sinensis 15-40 weight portion
Rhizoma Chuanxiong 15-40 weight portion Flos Carthami 15-40 weight portion
Rhizoma Gastrodiae 15-40 weight portion Cortex Cinnamomi 10-28 weight portion
Artificial Calculus Bovis 4-12 weight portion Radix Astragali 4-8 weight portion
Radix Puerariae 3-5 weight portion Radix Paeoniae Alba 3-6 weight portion.
According to another kind of preferred implementation of the present invention, described effective ingredient is made by following raw material medicaments:
Radix Notoginseng 20-35 weight portion Radix Angelicae Sinensis 20-35 weight portion
Rhizoma Chuanxiong 20-35 weight portion Flos Carthami 20-35 weight portion
Rhizoma Gastrodiae 20-35 weight portion Cortex Cinnamomi 12-24 weight portion
Artificial Calculus Bovis 5-10 weight portion Radix Astragali 5-8 weight portion
Radix Puerariae 3-4 weight portion Radix Paeoniae Alba 3-5 weight portion.
According to another kind of preferred implementation of the present invention, it is granule, capsule, tablet, pill or oral liquid.
The invention still further relates to the described preparation method that is used for the treatment of the Chinese medicine composition of cervical spondylotic radiculopathy.This method comprises the steps:
A, take by weighing 10-50 weight portion Radix Angelicae Sinensis, 10-50 weight portion Rhizoma Chuanxiong and 6-35 weight portion Cortex Cinnamomi, soaked after the mixing 1-3 hour, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 1-3 hour down at temperature 50-60 ℃, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 10-50 weight portion Radix Notoginseng and 10-50 weight portion Rhizoma Gastrodiae powder are broken into fine powder, then with they mixings, soaked again 1-3 hour, decocted then 1-2 hour, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 1-3 time again with after 10-50 weight portion Flos Carthami mixes, each 0.5-3 hour, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, carry out concentrating under reduced pressure again until the clear paste at temperature 50-60 ℃ following relative density 1.10-1.30, drying under reduced pressure is ground into fine powder then, add 3-16 weight portion artificial Calculus Bovis, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 3-10 weight portion Radix Astragali, 2-5 weight portion Radix Puerariae and 2-6 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 2-4 time, each 1-2 hour, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at temperature 50-60 ℃ following relative density 1.10-1.30, and drying under reduced pressure is ground into fine powder then;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, make described Chinese medicine composition.
A preferred embodiment of the invention, when soaking or decoct with water, the weight that makes water is 2-5 with the ratio of former medicine weight: 1 at every turn at every turn.
According to another kind of preferred implementation of the present invention, at step D) fine powder mixture 75% alcohol granulation that obtains, under temperature 30-40 ℃, carry out drying again, make described Chinese medicinal composition granules.
According to another kind of preferred implementation of the present invention, described concentrating under reduced pressure is concentrating of carrying out under pressure 0.1-1.0MPa.
According to another kind of preferred implementation of the present invention, described drying under reduced pressure is the drying of carrying out under pressure 0.01-0.5MPa.
According to another kind of preferred implementation of the present invention, described fine powder is a granularity 60-120 purpose powder.
Below the present invention will be described in more detail.
The present invention relates to a kind of Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy.Described Chinese medicine composition is formed by effective ingredient or effective ingredient and at pharmaceutically acceptable carrier, it is characterized in that described effective ingredient made by following raw material medicaments:
Radix Notoginseng 10-50 weight portion Radix Angelicae Sinensis 10-50 weight portion
Rhizoma Chuanxiong 10-50 weight portion Flos Carthami 10-50 weight portion
Rhizoma Gastrodiae 10-50 weight portion Cortex Cinnamomi 6-35 weight portion
Artificial Calculus Bovis 3-16 weight portion Radix Astragali 3-10 weight portion
Radix Puerariae 2-5 weight portion Radix Paeoniae Alba 2-6 weight portion.
According to the present invention, should be meant conventional medicine carrier in pharmaceutical field at pharmaceutically acceptable carrier, for example diluent, excipient and water etc., filler such as starch, sucrose, lactose, microcrystalline Cellulose etc.; Binding agent such as cellulose derivative, alginate, gelatin and polyvinylpyrrolidone; Wetting agent such as glycerol; Disintegrating agent such as carboxymethyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate and sodium bicarbonate; Absorption enhancer such as quaternary ammonium compound; Surfactant such as hexadecanol, sodium lauryl sulphate; Absorption carrier such as kaolin and soap clay; Lubricant such as Pulvis Talci, calcium stearate and magnesium, micropowder silica gel and Polyethylene Glycol; Other adjuvant such as flavouring agent, sweeting agent etc.
Described effective ingredient should be appreciated that be that every flavor Chinese crude drug contains in the drug composition in the present invention the treatment cervical spondylotic radiculopathy is had the composition of active treatment effect.
The source and the pharmacological action of every flavor Chinese crude drug of mentioning in the drug composition in the present invention are as follows.
Radix Notoginseng is the root of panax araliaceae plant, nature and flavor temperature, sweet in the mouth, little hardship.Function cures mainly dissipating blood stasis hemostasis, subduing swelling and relieving pain.It is used for various inside and outside hemorrhage, breast ventral spine pains, tumbling and swelling.
When the dry root that is classified as umbelliferae angelica, nature and flavor temperature, sweet in the mouth, suffering are returned liver, the heart, spleen channel.Function cure mainly enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.It is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Rhizoma Chuanxiong is a samphire Rhizoma Chuanxiong rhizome, and nature and flavor suffering, temperature are returned liver, gallbladder, pericardium channel.Function cures mainly blood-activating and qi-promoting, wind-expelling pain-stopping.It is used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Flos Carthami is the dried floral of feverfew Flos Carthami, nature and flavor temperature, acrid in the mouth.Function cures mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.
Rhizoma Gastrodiae is the dry tuber of the orchid family Gastrodia plant Rhizoma Gastrodiae, embellishes but not dry, and the master goes into Liver Channel, no matter be longer than the disease deficiency and excess of suppressing the hyperactive liver to relieve the wind syndrome, all liver-wind stirring up internallys, the vertigo, is key medicine.The headache, dizzy of blood deficiency liver-wind stirring up internally be can treat, infantile convulsion, epilepsy, tetanus also can be used for.Wind-expelling pain-stopping.Dizzy, the migraine and general headache that is used for that wind-phlegm causes, numb limbs and tense tendons, hemiplegia.
Cortex Cinnamomi is for being the cinnamomic bark of canella, the big heat of nature and flavor, acrid in the mouth, sweet.Function cures mainly and mends that fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.
The Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, and nature and flavor are sweet, and tepor is returned lung, spleen, liver, kidney channel.Effect cures mainly benefiting QI for strengthening the superficies, arresting sweating takes off, holds in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is used for the treatment of that the deficiency of vital energy is weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle are difficultly burst, burst for a long time do not hold back, blood deficiency and yellow complexion, interior-heat are quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Radix Puerariae is the dry root of legume pueraria lobata or Radix Puerariae rattan, and the sweet suffering of nature and flavor is flat, returns spleen, stomach warp.Function cures mainly only temperature of yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness.Cure the wound that cold, warm headache stiffness of the nape, dysphoria with smothery sensation are quenched one's thirst, had loose bowels, dysentery, skin eruption are saturating, hypertension, angina pectoris, deafness.
The Radix Paeoniae Alba is the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae, the nature and flavor picric acid, and liver, spleen channel are returned in cold.Function cures mainly nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing receipts antiperspirant, the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
The artificial Calculus Bovis is Fel Bovis seu Bubali or artificial light brown or the golden yellow powder of making that extract of Fel Sus domestica warp.Its main component has bilirubin, cholic acid, cholesterol, inorganic salt etc., and nature and flavor are sweet, cool, GUIXIN, Liver Channel.Function with cure mainly clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, endogenous wind stopping, detoxifcation.It is used for that calentura coma, wind-phlegm fan, infantile convulsion are twitched, epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Preferably, described effective ingredient is made by following raw material medicaments:
Radix Notoginseng 15-40 weight portion Radix Angelicae Sinensis 15-40 weight portion
Rhizoma Chuanxiong 15-40 weight portion Flos Carthami 15-40 weight portion
Rhizoma Gastrodiae 15-40 weight portion Cortex Cinnamomi 10-28 weight portion
Artificial Calculus Bovis 4-12 weight portion Radix Astragali 4-8 weight portion
Radix Puerariae 3-5 weight portion Radix Paeoniae Alba 3-6 weight portion.
More preferably, described effective ingredient is made by following raw material medicaments:
Radix Notoginseng 20-35 weight portion Radix Angelicae Sinensis 20-35 weight portion
Rhizoma Chuanxiong 20-35 weight portion Flos Carthami 20-35 weight portion
Rhizoma Gastrodiae 20-35 weight portion Cortex Cinnamomi 12-24 weight portion
Artificial Calculus Bovis 5-10 weight portion Radix Astragali 5-8 weight portion
Radix Puerariae 3-4 weight portion Radix Paeoniae Alba 3-5 weight portion.
The present invention relates to a kind of preparation method that is used for the treatment of the Chinese medicine composition of cervical spondylotic radiculopathy.This method comprises the steps:
A, take by weighing 10-50 weight portion Radix Angelicae Sinensis, 10-50 weight portion Rhizoma Chuanxiong and 6-35 weight portion Cortex Cinnamomi, soaked after the mixing 1-3 hour, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 1-3 hour down at temperature 50-60 ℃, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by.
Distillation extraction is a kind of method of utilizing effective ingredient in the steam extraction medical material, it is the extracting method that the those of ordinary skill in pharmaceutical technology field is known, the equipment that distillation extraction uses also is the equipment that the those of ordinary skill in pharmaceutical technology field is known, and for example the experiment type plants essential oil of Shanghai square source plant equipment company limited production extracts equipment.
The cyclodextrin molecular structure is formed by connecting by α-1,4 glycosidic bond by 6 above glucoses, is tubbiness.Form the hydrophobicity cavity in the bucket, can absorb the hydrophobic small molecules material or the group of a certain size and shape, form stable non-covalent complex.Beta-schardinger dextrin-is one of best enclose material of known effect.In the beta-cyclodextrin inclusion compound technology, saturated water solution method is the method that a kind of those skilled in the art know, to treat that enclose material or its solution add in the saturated beta-schardinger dextrin-aqueous solution, postcooling makes its crystallization in the reasonable time of under agitation the process, filter, drying can obtain described clathrate.
B; respectively 10-50 weight portion Radix Notoginseng and 10-50 weight portion Rhizoma Gastrodiae powder are broken into fine powder; then with they mixings; soaked again 1-3 hour; decocted then 1-2 hour; the cooling back filters and obtains filtrate and medicinal residues; these medicinal residues with in steps A) medicinal residues that obtain merge; decoct with water 1-3 time again with after 10-50 weight portion Flos Carthami mixes; each 0.5-3 hour; filter; this merging filtrate and the filtrate that obtains previously; steps A) the distillation remaining aqueous solution that obtains merges; carry out concentrating under reduced pressure again until the clear paste at temperature 50-60 ℃ following relative density 1.10-1.30, drying under reduced pressure is ground into fine powder then; add 3-16 weight portion artificial Calculus Bovis; steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously.
In this step, described pulverizing is to use pulverizer with Radix Notoginseng or be ground into fine powder, granularity 60-120 purpose powder for example, the pulverizer that uses during pulverizing is a normally used pulverizer in this medical technical field, for example the 30B Chinese herbal medicine Highefficientpulverizer group of Changzhou Pu Naier drying equipment company limited production.
Described concentrating under reduced pressure is concentrating of carrying out under pressure 0.1-1.0MPa.The equipment that described concentrating under reduced pressure uses is normally used equipment in this medical technical field, for example the vacuum decompressioning and concentrating tank of Wuxi City Haidah chemical machinery company limited production.
Described drying under reduced pressure is the drying of carrying out under pressure 0.01-0.5MPa.The equipment that described drying under reduced pressure uses is normally used equipment in this medical technical field, for example the vacuum drying oven of the grand industry in Tianjin light industry and machinery company limited production.
C, take by weighing the 3-10 weight portion Radix Astragali, 2-5 weight portion Radix Puerariae and 2-6 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 2-4 time, each 1-2 hour, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at temperature 50-60 ℃ following relative density 1.10-1.30, and drying under reduced pressure is ground into fine powder then.
The equipment that drying under reduced pressure and pulverizing are used is equipment as previously described.
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, make described Chinese medicine composition.
When implementing Chinese medicine composition preparation method of the present invention, when soaking or decoct with water, the weight that makes water is 2-5 with the ratio of former medicine weight: 1 at every turn at every turn.
Preferably, the weight that makes water is 2-4 with the ratio of former medicine weight: 1, and more preferably, the weight that makes water is 3-4 with the ratio of former medicine weight: 1.
According to another kind of preferred implementation of the present invention, at step D) fine powder mixture 75% alcohol granulation that obtains, under temperature 30-40 ℃, carry out drying again, make described Chinese medicinal composition granules.
When implementing Chinese medicine composition preparation method of the present invention, described concentrating under reduced pressure is concentrating of carrying out under pressure 0.1-1.0MPa.Preferably, the pressure of described concentrating under reduced pressure is 0.2-0.8MPa.More preferably, the pressure of described concentrating under reduced pressure is 0.4-0.6MPa.
Described drying under reduced pressure is the drying of carrying out under pressure 0.01-0.5MPa.Preferably, described drying under reduced pressure pressure is 0.02-0.4MPa.More preferably, described drying under reduced pressure pressure is 0.05-0.2MPa.
According to another kind of preferred implementation of the present invention, described fine powder is a granularity 60-120 purpose powder.
The product that Chinese medicine composition of the present invention obtains through above-mentioned preparation process, can with make various dosage forms at pharmaceutically acceptable carrier or excipient composition, for example granule, capsule, tablet, pill or oral liquid, wherein can select according to different dosage form at pharmaceutically acceptable carrier or excipient, employed these carriers or excipient all are to determine easily for the those of ordinary skill in pharmaceutical technology field, also are conspicuous.
[beneficial effect]
Chinese medicine composition of the present invention has blood circulation promoting and blood stasis dispelling, and the effect of warming the meridian understand things pain-stopping can be used for the cervical spondylotic radiculopathy syndrome of static blood blocking collaterals, and disease is seen stiff, the pain of neck and shoulder part, Ipsilateral upper limbs walloping aches etc.Chinese medicine composition of the present invention has been obtained significant effect in the treatment cervical spondylotic radiculopathy, stable curative effect has no side effect, and is suitable for taking for a long time.Total effective rate through clinical verification treatment cervical spondylotic radiculopathy reaches more than 95.0%, is a kind of medicine of ideal treatment cervical spondylotic radiculopathy therefore.
[specific embodiment]
Embodiment 1: the preparation of granule of the present invention
A, take by weighing 10 weight portion Radix Angelicae Sinensis, 30 weight portion Rhizoma Chuanxiongs and 35 weight portion Cortex Cinnamomis, soaked after the mixing 1 hour, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil of collecting beta-schardinger dextrin-and water enclose, stirred 1 hour down for 60 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 10 weight portion Radix Notoginseng and 30 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 1 hour, decocted then 2 hours, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 3 times again with after 50 weight portion Flos Carthamis mix, each 1 hour, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 0.1MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.01Pa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.10-1.15 of temperature, add 3 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 3 weight portion Radixs Astragali, 5 weight portion Radix Puerariaes and 3 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 2 times, each 2 hours, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.10-1.15 of temperature under pressure 0.1MPa, carry out drying under reduced pressure then under pressure 0.01Pa, is ground into fine powder;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, reuse 75% ethanol is made granule, carries out drying, packing under 30 ℃ of temperature.
Embodiment 2: the preparation of granule of the present invention
A, take by weighing 50 weight portion Radix Angelicae Sinensis, 10 weight portion Rhizoma Chuanxiongs and 6 weight portion Cortex Cinnamomis, soaked after the mixing 2 hours, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 3 hours down for 50 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 50 weight portion Radix Notoginseng and 10 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 2 hours, decocted then 1.5 hours, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 2 times again with after 30 weight portion Flos Carthamis mix, each 2 hours, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 1.0MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.5MPa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.15-1.20 of temperature, add 9 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 10 weight portion Radixs Astragali, 3 weight portion Radix Puerariaes and 2 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 3 times, each 1.5 hours, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.15-1.20 of temperature under pressure 1.0MPa, carry out drying under reduced pressure then under pressure 0.5MPa, is ground into fine powder;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, reuse 75% ethanol is made granule, carries out drying, packing under 35 ℃ of temperature.
Embodiment 3: the preparation of granule of the present invention
A, take by weighing 30 weight portion Radix Angelicae Sinensis, 50 weight portion Rhizoma Chuanxiongs and 20 weight portion Cortex Cinnamomis, soaked after the mixing 3 hours, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 2 hours down for 55 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 30 weight portion Radix Notoginseng and 50 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 3 hours, decocted then 1 hour, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 1 time again with after 10 weight portion Flos Carthamis mix, each 3 hours, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 0.5MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.03MPa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.20-1.25 of temperature, add 16 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and 1 weight portion dextrin, mix homogeneously;
C, take by weighing the 6 weight portion Radixs Astragali, 2 weight portion Radix Puerariaes and 6 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 4 times, each 1 hour, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.20-1.25 of temperature under pressure 0.5MPa, carry out drying under reduced pressure then under pressure 0.03MPa, is ground into fine powder;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, reuse 75% ethanol is made granule, carries out drying, packing under 40 ℃ of temperature.
Embodiment 4: the preparation of capsule of the present invention
A, take by weighing 50 weight portion Radix Angelicae Sinensis, 10 weight portion Rhizoma Chuanxiongs and 6 weight portion Cortex Cinnamomis, soaked after the mixing 2 hours, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 3 hours down for 50 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 50 weight portion Radix Notoginseng and 10 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 2 hours, decocted then 1.5 hours, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 2 times again with after 30 weight portion Flos Carthamis mix, each 2 hours, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 1.0MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.5MPa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.15-1.20 of temperature, add 9 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 10 weight portion Radixs Astragali, 3 weight portion Radix Puerariaes and 2 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 3 times, each 1.5 hours, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.15-1.20 of temperature under pressure 1.0MPa, carry out drying under reduced pressure then under pressure 0.5MPa, is ground into fine powder;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, reuse 75% ethanol is made granule, carries out drying under 35 ℃ of temperature, incapsulates then.
Embodiment 5: the preparation of tablet of the present invention
A, take by weighing 10 weight portion Radix Angelicae Sinensis, 30 weight portion Rhizoma Chuanxiongs and 35 weight portion Cortex Cinnamomis, soaked after the mixing 1 hour, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil of collecting beta-schardinger dextrin-and water enclose, stirred 1 hour down for 60 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 10 weight portion Radix Notoginseng and 30 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 1 hour, decocted then 2 hours, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 3 times again with after 50 weight portion Flos Carthamis mix, each 1 hour, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 0.1MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.01Pa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.10-1.15 of temperature, add 3 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 3 weight portion Radixs Astragali, 5 weight portion Radix Puerariaes and 3 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 2 times, each 2 hours, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.10-1.15 of temperature under pressure 0.1MPa, drying under reduced pressure under pressure 0.01Pa is ground into fine powder then;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, make wet granular with preparation tablet excipient starch commonly used again, tabletting then, drying, packing.
Embodiment 6: the preparation of pill of the present invention
A, take by weighing 30 weight portion Radix Angelicae Sinensis, 50 weight portion Rhizoma Chuanxiongs and 20 weight portion Cortex Cinnamomis, soaked after the mixing 3 hours, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 2 hours down for 55 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 30 weight portion Radix Notoginseng and 50 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 3 hours, decocted then 1 hour, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 1 time again with after 10 weight portion Flos Carthamis mix, each 3 hours, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 0.5MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.03MPa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.20-1.25 of temperature, add 16 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and 1 weight portion dextrin, mix homogeneously;
C, take by weighing the 6 weight portion Radixs Astragali, 2 weight portion Radix Puerariaes and 6 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 4 times, each 1 hour, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.20-1.25 of temperature under pressure 0.5MPa, carry out drying under reduced pressure then under pressure 0.03MPa, is ground into fine powder;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, add refined honey again and make pill.
Embodiment 7: the preparation of oral liquid of the present invention
A, take by weighing 50 weight portion Radix Angelicae Sinensis, 10 weight portion Rhizoma Chuanxiongs and 6 weight portion Cortex Cinnamomis, soaked after the mixing 2 hours, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 3 hours down for 50 ℃ in temperature, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 50 weight portion Radix Notoginseng and 10 weight portion Rhizoma Gastrodiae powders are broken into fine powder, then with they mixings, soaked again 2 hours, decocted then 1.5 hours, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 2 times again with after 30 weight portion Flos Carthamis mix, each 2 hours, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, under pressure 1.0MPa, carry out concentrating under reduced pressure again until clear paste, under pressure 0.03MPa, carry out drying under reduced pressure then, be ground into fine powder at 55 ℃ of following relative density 1.15-1.20 of temperature, add 9 weight portion artificial Calculus Boviss, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 10 weight portion Radixs Astragali, 3 weight portion Radix Puerariaes and 2 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 3 times, each 1.5 hours, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at 55 ℃ of following relative density 1.15-1.20 of temperature under pressure 1.0MPa, carry out drying under reduced pressure then under pressure 0.03MPa, is ground into fine powder;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, add correctives Mel and diluent water again and make oral liquid.
Below further specify the effect of Chinese medicine composition of the present invention by clinical trial.
Test example 1: granule clinical trial of the present invention
The purpose of this test example is the curative effect of research granule treatment of the present invention cervical spondylotic radiculopathy and to the safety of human body.
(1) case is selected:
The Western medicine diagnose standard
1, neck and shoulder pain does not stiffly relax, companion one or both sides upper limb string pain, numbness, triceps tendon hyporeflexia, or the atrophy of a certain longue meat is arranged, backache, chest pain (heart district), migraine, or scalp pain, or vertigo, vomiting and nausea, blurred vision.
2, push other pain spot of cervical spine or Ipsilateral intervertebral foramina and Ipsilateral upper limb radiating pain occurs, the pressure head test, brachial plexus nerve tractive (+), the upper limb tendon reflex is normal or low, Hough Man (+).
3, X ray examination: vertebral articulations hypertrophy or physiological curve change, narrowing of intervertebral space, intervertebral foramina distortion etc.
4, through the physics and chemistry inspection, except other diseases (as rheumatoid arthritis etc.).
Differential diagnosis in tcm: syndrome of static blood blocking collaterals
Ipsilateral shoulder back is stiff, pain, companion's Ipsilateral brachialgia, upper limb numbness or dizziness.Dark or the ecchymosis of tongue, white, the deep and stringy pulse or heavy of tongue.
(2) test case standard
1, includes standard in
1. meet above-mentioned Western medicine diagnose and differential diagnosis in tcm person.
2. meet the spondylotic radiculopathy in the arthralgia pain type of cervical spondylosis.
3. the age is 18-70 year patient.
2, exclusion standard
1. age＜18 year old＞70 years old
2. gestation, women breast-feeding their children and prepare pregnant person
3. severe cardiac, brain, liver, kidney, hemopoietic system serious disease, diabetes and psychotic are arranged
4. allergic constitution person
5. paralytic and non-cervical spondylosis cause dizzy, SPONDYLOPATHY OF VERTEBRAL ARTERY TYPE.
(3) grouping and contrast Therapeutic Method
(1) random packet after each hospital distributes case, is sticked the neck relaxation grain respectively No. 1, No. 2 by curative and contrast medicine, sends out medicine then and uses.
(2) 300 examples are organized in treatment, the each 6g of the embodiment of the invention 1 granule, every day three times.
(3) matched group 125 examples are according to national drug standards WS
3The granule of-722 (Z-150)-2004 (Z) preparation, each 10g, every day three times.
(4) one months was 1 course of treatment
(5) inactive other treated this sick medicine and method in the course of treatment
(4) observation index
(A) safety indexes
1, general physical examination and unexpected untoward reaction can occur
2, hematuria is just conventional
3, electrocardiogram, liver function (ALT), renal function (BnN.Cr).(will do 1/3 at least)
(B) health giving quality observation index
1, related symptoms
2, cervical region movable function and other sign are checked
3, hemorheology: in the treatment group, do 30 examples
4, microcirculation inspection: in the treatment group, do 30 examples
(5), curative effect determinate standard
Clinic control: symptom and relevant sign disappearance, symptom integral are more than 90%.
Produce effects: symptom and sign obviously improves, symptom integral reduces 70-89%.
Effectively: symptom and sign makes moderate progress, symptom integral reduces 30-69%.
Invalid: symptom and sign do not have improve or increase the weight of, symptom integral reduces＜30%.
(6), result of the test
A, total effects
Table 1: total effects result
By The above results as can be seen, medicine of the present invention has blood circulation promoting and blood stasis dispelling, the effect of warming the meridian understand things pain-stopping, can be used for the cervical spondylotic radiculopathy syndrome of static blood blocking collaterals, stable curative effect, the total effective rate of treatment cervical spondylotic radiculopathy reaches more than 95.0%, has no side effect, being suitable for taking for a long time, is a kind of medicine of ideal treatment cervical spondylotic radiculopathy therefore.
B, safety evaluation
1,4 routine patients have mild nausea in the treatment group, and drug withdrawal is not done other processing and spontaneous remission.
2,115 routine patients have carried out an inspection such as just routine examination of hematuria, electrocardiogram, liver function, renal function routine in the treatment group, and security inspection the results are shown in table 2.
Table 2: security inspection result (example)
| ? | Routine blood test | Routine urinalysis | Just conventional | Liver function | Renal function | Electrocardiogram |
| Before the treatment | 115? | 115? | 115? | 115? | 115? | 115? |
| After the treatment | 115? | 115? | 115? | 115? | 115? | 115? |
[0187]Table 2 is the result show, every inspections such as routine blood test that 115 patients of treatment group carry out before and after treatment all belong to normally.
C, model case
Case 1: Mr. Wang, man, 43 years old.
This patient's neck shoulder stiffness pain with side upper limb numbness half a year, increased the weight of for two weeks, and pain is from the hands radiation left of back neck and shoulder part, and morning, time-out pain was heavier.Have a medical check-up: back neck and shoulder part tenderness is extensive, and the left side is heavy than the right side, the other tenderness (+) of C456 left side vertebra, and intervertebral foramina squeeze test (+), brachial plexus nerve distraction test (+), two shoulder joint activities are normal, and two upper limb muscular strengths are normal, and tongue is dark, white and thin fur, deep and hesitant pulse.Have a blood test, urine, electrocardiogram, liver function, renal function, throat vertebra X-ray film shows that it is straight that cervical vertebra side position physiology curvature becomes, C4-6 vertebral body trailing edge hyperosteogeny.Tcm diagnosis is a neck and shoulder pain, congestion resistance network card, and Western medicine diagnose is cervical spondylotic radiculopathy (moderate), takes the Chinese medicine granules of the embodiment of the invention 1 preparation, each 6 grams, day clothes three times.
The week back check of taking medicine, neck and shoulder part pain begins to alleviate, and stiff sense and local tenderness are also alleviated, and intervertebral foramina squeeze test, brachial plexus nerve distraction test are all the same.
Back check around taking medicine, the conscious neck and shoulder part pain of patient, stiff, pain and numbness disappear substantially, radiation pain does not appear, other pain relief, intervertebral foramina squeeze test and the brachial plexus nerve distraction test feminine gender of pressing of vertebra, the tongue blackout is red, normal pulse, check blood, urine, just no abnormality seen, the cervical vertebra X-ray film shows, cervical vertebra side position physiology curvature has become directly, and efficacy determination is a clinic control.
Case 2: Mrs Meng, woman, 59 years old.
This patient's left upper extremity and left hand finger tip numbness, the back cervical region discomfort of aching reaches 1 year, and from left side shoulder and left upper extremity radiated pain, characteristic of disease shows effect repeatedly, haves a medical check-up: back neck and shoulder part tenderness is extensive, and the left side is heavier.The cervical vertebra functional activity is obstructed, pressure head test (+), and the other tenderness (+) of left side vertebra, intervertebral foramina squeeze test (+), brachial plexus nerve distraction test (+), the upper limb muscular strength is normal, no upper limb amyotrophy, tongue ecchymosis, deep and hesitant pulse.Have a blood test, urine, electrocardiogram, liver function, renal function, throat vertebra X-ray film shows, the extensive degenerative change of cervical vertebra, it is straight that cervical vertebra side position physiology curvature becomes, clinical diagnosis is a cervical spondylotic radiculopathy, meet congestion resistance network card, take the Chinese medicine granules of the embodiment of the invention 2 preparations, each 6 grams, day clothes three times.
After taking medicine, upper limb numbness, neck and shoulder part radiation pain all began to alleviate when a week, and sign is not seen obvious improvement, continues to take described Chinese medicine granules.
Back check around taking medicine, patient's neck and shoulder part pain, upper limb numbness, the complete obiteration of radiation pain symptom, the pressure head test is turned out cloudy with brachial plexus nerve distraction test sign, the intervertebral foramina squeeze test is all positive, and nail fold microcirculation index obviously descends, and it is flat that the tongue arteries and veins changes, check blood, urine, just no abnormality seen, the cervical vertebra X-ray film shows that cervical vertebra side position physiology curvature has become directly, and efficacy determination is a clinic control.
Claims (10)
1. Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy, it is formed by effective ingredient or effective ingredient and at pharmaceutically acceptable carrier, it is characterized in that described effective ingredient made by following raw material medicaments:
Radix Notoginseng 10-50 weight portion Radix Angelicae Sinensis 10-50 weight portion
Rhizoma Chuanxiong 10-50 weight portion Flos Carthami 10-50 weight portion
Rhizoma Gastrodiae 10-50 weight portion Cortex Cinnamomi 6-35 weight portion
Artificial Calculus Bovis 3-16 weight portion Radix Astragali 3-10 weight portion
Radix Puerariae 2-5 weight portion Radix Paeoniae Alba 2-6 weight portion.
2. Chinese medicine composition according to claim 1 is characterized in that described effective ingredient made by following raw material medicaments:
Radix Notoginseng 15-40 weight portion Radix Angelicae Sinensis 15-40 weight portion
Rhizoma Chuanxiong 15-40 weight portion Flos Carthami 15-40 weight portion
Rhizoma Gastrodiae 15-40 weight portion Cortex Cinnamomi 10-28 weight portion
Artificial Calculus Bovis 4-12 weight portion Radix Astragali 4-8 weight portion
Radix Puerariae 3-5 weight portion Radix Paeoniae Alba 3-6 weight portion.
3. Chinese medicine composition according to claim 1 is characterized in that described effective ingredient made by following raw material medicaments:
Radix Notoginseng 20-35 weight portion Radix Angelicae Sinensis 20-35 weight portion
Rhizoma Chuanxiong 20-35 weight portion Flos Carthami 20-35 weight portion
Rhizoma Gastrodiae 20-35 weight portion Cortex Cinnamomi 12-24 weight portion
Artificial Calculus Bovis 5-10 weight portion Radix Astragali 5-8 weight portion
Radix Puerariae 3-4 weight portion Radix Paeoniae Alba 3-5 weight portion.
4. Chinese medicine composition according to claim 1 is characterized in that it is granule, capsule, tablet, pill or oral liquid.
5. a preparation method that is used for the treatment of the Chinese medicine composition of cervical spondylotic radiculopathy is characterized in that this method comprises the steps:
A, take by weighing 10-50 weight portion Radix Angelicae Sinensis, 10-50 weight portion Rhizoma Chuanxiong and 6-35 weight portion Cortex Cinnamomi, soaked after the mixing 1-3 hour, then at temperature 98-100 ℃ of following distillating extracting oil, the volatile oil beta-cyclodextrin inclusion compound of collecting, stirred 1-3 hour down at temperature 50-60 ℃, place cooling, be ground into fine powder after the cold drying; Distillation remaining aqueous solution and medicinal residues are stand-by;
B, respectively 10-50 weight portion Radix Notoginseng and 10-50 weight portion Rhizoma Gastrodiae powder are broken into fine powder, then with they mixings, soaked again 1-3 hour, decocted then 1-2 hour, the cooling back filters and obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, decoct with water 1-3 time again with after 10-50 weight portion Flos Carthami mixes, each 0.5-3 hour, filter, this merging filtrate and the filtrate that obtains previously, steps A) the distillation remaining aqueous solution that obtains merges, carry out concentrating under reduced pressure again until the clear paste at temperature 50-60 ℃ following relative density 1.10-1.30, drying under reduced pressure is ground into fine powder then, add 3-16 weight portion artificial Calculus Bovis, steps A) obtains Benexate Hydrochloride and dextrin, mix homogeneously;
C, take by weighing the 3-10 weight portion Radix Astragali, 2-5 weight portion Radix Puerariae and 2-6 weight portion Radix Paeoniae Alba mix homogeneously, decoct with water 2-4 time, each 1-2 hour, merge decoction liquor, filter, the filtrate that obtains is carried out concentrating under reduced pressure until the clear paste at temperature 50-60 ℃ following relative density 1.10-1.30, and drying under reduced pressure is ground into fine powder then;
D, with step B) mixture and the step C that obtain) the fine powder mixing that obtains, make described Chinese medicine composition.
6. method according to claim 5 is characterized in that when soaking or decoct with water at every turn at every turn, and the weight that makes water is 2-5 with the ratio of former medicine weight: 1.
7. method according to claim 5 is characterized in that at step D) fine powder mixture 75% alcohol granulation that obtains, under temperature 30-40 ℃, carry out drying again, make described Chinese medicinal composition granules.
8. method according to claim 5 is characterized in that described concentrating under reduced pressure is concentrating of carrying out under pressure 0.1-1.0MPa.
9. method according to claim 5 is characterized in that described drying under reduced pressure is the drying of carrying out under pressure 0.01-0.5MPa.
10. according to the described method of each claim in claim 5 or 7, it is characterized in that described fine powder is a granularity 60-120 purpose powder.
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| CN102600377A (en) * | 2012-04-07 | 2012-07-25 | 陈永胜 | Medicine for treatment of cervical disease and preparation method thereof |
| CN103156461A (en) * | 2013-03-14 | 2013-06-19 | 高长华 | Traditional Chinese medicine (TCM) pillow core capable of treating cervical spondylosis and lumbar spondylosis and preparation method thereof |
| CN109288973A (en) * | 2018-12-04 | 2019-02-01 | 河南中医药大学 | A kind of Chinese medicinal granule for treating nerve root cervical vertebra sickness |
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| CN102600377A (en) * | 2012-04-07 | 2012-07-25 | 陈永胜 | Medicine for treatment of cervical disease and preparation method thereof |
| CN103156461A (en) * | 2013-03-14 | 2013-06-19 | 高长华 | Traditional Chinese medicine (TCM) pillow core capable of treating cervical spondylosis and lumbar spondylosis and preparation method thereof |
| CN109288973A (en) * | 2018-12-04 | 2019-02-01 | 河南中医药大学 | A kind of Chinese medicinal granule for treating nerve root cervical vertebra sickness |
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| CN101912539B (en) | 2012-08-01 |
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