CN101912510A - Traditional Chinese medicine composition for promoting fracture healing at intermediate stage and preparation method thereof - Google Patents
Traditional Chinese medicine composition for promoting fracture healing at intermediate stage and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for promoting fracture healing at the intermediate stage, which is prepared from the following raw materials by weight: 50 parts of rhizoma drynariae, 40 parts of himalayan teasel root, 40 parts of eupolyphaga, 40 parts of malaytea scurfpea fruit, 120 parts of Chinese yam, 50 parts of prepared radix polygoni multiflori, 40 parts of dangshen, 40 parts of white paeony root, 26 parts of calcined pyritum, 35 parts of leech, 50 parts of calcined dragon's bones, 50 parts of earthworms, 25 parts of prepared frankincense, 25 parts of prepared myrrh, 30 parts of costustoot and 40 parts of radix achyranthis bidentatae. Through compatibility of the above medicines, the composition has the effects of activating blood and dissolving stasis, softening hardness to dissipate stagnation, removing stasis and promoting fresh blood production and joining sinews and bones. The composition can be used at the intermediate stage of fracture, can accelerate absorption of residual stasis and can quickly form callus to heal the fracture.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition that promotes union of fracture.
Background technology
At present,, but still there are many problems though the Chinese patent medicine of the suitable fracture healing in mid-term of selling on the market is various in style: the one, curative effect is not good enough; The 2nd, can only be used for slight wound and be not suitable for severe injury; The 3rd, the Chinese patent medicine that has has added the big crude drug of a class toxicity such as Cinnabaris, Radix Aconiti Kusnezoffii, Semen Strychni, Venenum Bufonis, Realgar, Semen Crotonis Pulveratum, Semen Pharbitidis, Resina garciniae, is prone to untoward reaction after the patient takes, and there is potential safety hazard in the serious harm Liver and kidney, is difficult for informal dress and obeys slowly.
In order to alleviate drug toxicity, people are sometimes by the usefulness that is decocted in water for oral dose, but the crude drug that has goes into to fry in shallow oil the back the smell is awful difficult clothes are not that everybody can both accept.Moreover synthetism good medicine that has such as Pyritum should not go into to fry in shallow oil again.
In view of above problem, under the Drug therapy principle in fracture mid-term instructs, reference analysis relevant at all times in a large number prescription, in conjunction with clinical experience and handed down from the older generations of the family experience have been developed into the present invention for many years.
Summary of the invention
The Chinese medicine composition and the preparation method that the purpose of this invention is to provide a kind of healing in mid-term that promotes to fracture.
For reaching above-mentioned purpose, Chinese medicine composition of the present invention is formed by following parts by weight of Chinese traditional medicine material combination:
50 parts of Rhizoma Drynariae, 40 parts of Radix Dipsacis, 40 parts of eupolyphaga, Fructus Psoraleae 40 portionings, Rhizoma Dioscoreae 120 portionings, 50 parts of Radix Polygoni Multiflori Preparatas, 40 parts of Radix Codonopsis, 40 parts of the Radix Paeoniae Albas, 26 parts of Pyritum (calcined)s, 35 parts of Hirudos, Os Draconis (calcined) 50 portionings, 50 parts of Pheretimas, 25 parts of Olibanum (processed)s, 25 parts of Myrrha (processed)s, 30 parts of the Radix Aucklandiae, 40 parts of Radix Achyranthis Bidentataes.
Utilize Chinese medicine composition of the present invention to prepare capsular method to be: with the broken fine powder of making more than fineness 120 orders of above-mentioned raw material of Chinese medicine medicated powder, fine powder is put in the baking box, temperature is controlled to heat about 170 degree and got final product in 5 minutes, in time stir therebetween and prevent coking, the outlet postcooling is encapsulated, one 0.4 gram.
Utilize Chinese medicine composition of the present invention prepare capsular method can also for: with above-mentioned raw material of Chinese medicine medicine to scale after the proportioning, make fine powder more than fineness 120 orders with Chinese medicine grinder, then the fine powder of making is encapsulated with the edible plastic bag, put in the pressure cooker and steamed 10 minutes, encapsulated the getting final product in back dried in taking-up, one 0.4 gram.
The capsule effective ingredient that above-mentioned two kinds of methods prepare does not have difference, and curative effect is the same.
The capsule using method that Chinese medicine composition of the present invention is made is: day clothes 2～3 times, be grown up one time 5, the child is cut down according to the circumstance.
Chinese medicine composition of the present invention also can add conventional adjuvant by other processing methods of pharmaceutics and make the granule of clinical acceptance, tablet, pill, oral solutions etc.
Medicine of the present invention is the overall Therapeutic Principle who has taked reinforcement and elimination in combination.Think, though be " damage one card is specially from blood wheel ", " the blood stasis of blood of not living then can not be gone, the stasis of blood do not go then bone can not connect ".Right in sick mid-term, if only brokenly simply do not mend, rapid wear QI and blood impairing the liver kidney then, made original just " limbs decrease in outer and QI and blood is hindered in interior, and battalion defends does not to some extent get used to, internal organs by discord " further increase the weight of damage.The unable spermatogenesis of deficient source of generating QI and blood is converted into QI and blood, and asthenia of qi and blood is not and alive, and then unable removing blood stasis with potent drugs finally causes permanent " the empty stasis of blood ", and " void " becomes the pathologic basis that influences union of fracture with " stasis of blood ".Here it is, and some fracture becomes the true cause that bone does not connect connects.So, sick to mid-term in broken dissipating blood stasis blood, must execute to mend, focus on accent the kidney invigorating liver spleen.Modern study thinks that the mechanism of union of fracture is: promptly have osteoclast, foreign-body giant cell and osteoblast to generate after the wound soon." break " medicine and enter foreign bodies such as hematoma clearance blood stasis, bone scraps and enter the condition that provides for " benefit " medicine, the latter occupies the hematoma position and enters fracture gap and form callus, makes knochenbruch continued access healing.The present invention has excited internal organs (mainly being Liver and kidney) function effectively by " breaking " and " benefits " two groups of crude drug reasonable compatibilities just, make broken two kinds of mechanism of bone and skeletonization accelerate formation simultaneously, and reaches the promotion union of fracture.
The mechanism of action of books invention is described according to pharmacology analysis below: in the side: Rhizoma Drynariae, Radix Dipsaci, eupolyphaga are monarch drug; Fructus Psoraleae, Rhizoma Dioscoreae, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Radix Paeoniae Alba, Pyritum are ministerial drug; Os Draconis, Pheretima, Olibanum, Myrrha, Hirudo, the Radix Aucklandiae are adjuvant drug; Radix Achyranthis Bidentatae makes for assistant.
Rhizoma Drynariae, eupolyphaga, Radix Dipsaci, Pyritum are all the reunion of fractured tendons and bones medicine: wherein Rhizoma Drynariae the kidney invigorating, synthetism, and the double GUFENG curative effect of dispelling cures mainly at bone; The Radix Dipsaci invigorating the liver and kidney, the energy relaxing muscles and tendons and activating QI and blood in the collateral of holding concurrently cures mainly at muscle, and two medicines phase 5 has the reunion of bone curative effect.Eupolyphaga removing blood stasis, the Pyritum blood and relieving pain that looses, two medicines are 5 blood circulation and removing stasis mutually, and reunion of bone power strengthens.Os Draconis and Pheretima, the former restrains, but tranquilizing mind, suppressing the hyperactive liver and subsiding YANG life, it is calcareous in a large number that research thinks that Os Draconis contain, and helps callus calcification maturation; Latter's tonneau, but collateral dredging is treated numbness, relieving convulsion, diuresis, vessel softening, but both mutually 5 blood pressure lowering, tranquilizing mind, remove irritated, the meridian dredging, diuresis.Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Polygoni Multiflori, Fructus Psoraleae all can the kidney invigorating, and Rhizoma Dioscoreae is held concurrently can the spleen reinforcing lung and yin nourishing, and Fructus Psoraleae also can enriching spleen-QI but warming YANG; The convenient vessel softening of Radix Polygoni Multiflori double energy tonifying liver laxation is mended and the oiliness clothes clothes slowly of should growing; Radix Achyranthis Bidentatae also can tonifying liver, but tonneau two just, has bone and muscle strengthening loose congestion, the descending effect of priming concurrently, so Radix Achyranthis Bidentatae promptly can be assistant and also can be and make.The mutual reinforcement between of Olibanum Myrrha is a usefulness, but granulation promoting is invigorated blood circulation, promoting the circulation of QI pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral.Hirudo 5 is with the Radix Aucklandiae, a removing blood stasis, and a promoting the circulation of QI pain relieving, the capable then blood of gas is lived; Research thinks that Hirudo has blood coagulation resisting function, can delay and hinder blood coagulation.But Radix Codonopsis 5 is with Radix Paeoniae Alba benefiting QI and nourishing blood, and Radix Codonopsis is apt to invigorating middle warmer gas, nourishing blood to promote the production of body fluid, the Radix Paeoniae Alba enrich blood yin fluid astringing, relieving spasm to stop pain; Radix Codonopsis 5 is with the Radix Aucklandiae, a QI invigorating, and a circulation of qi promoting, the Radix Aucklandiae is held concurrently can strengthening the spleen to promote digestion, can sharp all benefits and do not give birth to dull.The effect that full side plays blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, removing blood stasis tissue regeneration promoting, reunion of bone altogether.
Above-mentioned all medicine compatibilities have blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, removing blood stasis tissue regeneration promoting, the effect of reunion of bone.Be used to the mid-term of fracturing, can quicken residual blood stasis and absorb, form callus fast and make union of fracture.Being made into capsule in early days the nineties is applied to clinical, treatment all ages and classes, different parts, dissimilar fracture, all demonstrated beyond thought good result, surpass all similar commercially available Chinese patent medicines, institute controls the no disunion person of fracture, and taking convenience, safety are easy to accept, and do not see untoward reaction.The present invention not only is used to the treatment of fracturing mid-term, also can separately or cooperate related drugs be used to fracture later stage, fracture delayed union, bone does not connect connects and multiple difficult miscellaneous diseases.
Below by oral capsule clinical experiment data declaration of the present invention curative effect of the present invention.
One, physical data
Only with the part clinical data on February 5th, 11 days 1 March in 2008 as statistics.Totally 305 examples, wherein male 173 examples, women 132 examples; 298 examples of fracturing; Fracture delayed union 4 examples; Bone does not connect connects 3 examples; The oldest 78 years old, minimum 2 years old.The course of disease is the longest 640 days, and is the shortest 2 hours.
Two, diagnostic criteria
1, fracture: the dislocation and fracture trauma history is clear and definite, and local swelling pain, ecchymosis can have deformity, abnormal movement and bony crepitus.Type that X-ray film can clearly be fractured and direction of displacement.
2, fracture delayed union: general back about three months connectionists not yet that fracture that are grown up.Or exceed this position normal healing time person more than a times that fractures, still have abnormal movement.The X sheet shows: no callus or the useless osseous callus of using.
3, bone does not connect connects: adult bone by half year about connectionist not yet.Or exceed this position normal healing time of fracturing and still do not have connection more than 2～3 times.The X sheet shows: no callus, or original callus absorbs, and section becomes slick and sly or sclerosis because of bone absorption, the clear expansion of fracture gap.
Three, criterion of therapeutical effect
1, fracture
Produce effects: local tenderness, vertical kowtow pain and autonomous or passive abnormal movement all disappears; The X sheet shows that having the capacity callus crosses fracture line, and fracture line blurs, disappears or near the disappearance.
Effectively: local appearance and feel sx, vertical button pain of tenderness and abnormal movement all obviously alleviate; The X sheet shows that the broken ends of fractured bone seen that a certain amount of healthy callus is arranged.
Invalid: local symptom does not have improvement, the broken ends of fractured bone ring week property tenderness, vertical button pain and abnormal movement still exist; The X sheet shows that the broken ends of fractured bone does not have callus, or gives up on a small quantity and use osseous callus, even the broken ends of fractured bone has seen that the bone resorption phenomenon is arranged.
2, fracture delayed union
Produce effects: local clinical symptoms all disappears; The X sheet: existing healthy callus is crossed fracture line, fuzzy or approaching disappearance of fracture line.
Effectively: local clinical symptoms is existing obviously to be improved; The X sheet: the broken ends of fractured bone has been seen has a small amount of healthy callus to occur.
Invalid: local symptom and the no significant change of the preceding contrast of treatment; The X sheet does not also have the sign of being clearly better with contrast before the treatment.
3, bone does not connect connects
How to cause because bone does not connect connects, therefore, mainly rely on the performance of X line to determine curative effect by the operation internal fixation.
Produce effects: fracture line blurs, disappears or approaching the disappearance, existing on every side a large amount of healthy callus.
Effectively: fracture line shows fuzzy slightly, and slick and sly hardened pseudarthrosis face becomes crude, occurs a small amount of normal callus on every side.
Invalid: before the treatment with treatment after the no significant change of X sheet contrast.
Therapeutic Method: day 2 to 3 capsules of clothes, each 5 (1 0.4 gram)
Taboo: the anemia of pregnant woman prohibits clothes.
Above-mentioned patient is through 1 to 8 months treatment, result such as following table:
| Diagnostic criteria case load number | Produce effects (example) | Effectively (example) | Invalid (example) |
| Fracture 298 | 288? | 10? | 0? |
| Delayed union 4 | 4? | 0? | 0? |
| Bone does not connect connects 3 | 2? | 1? | 0? |
| Effective percentage % | 96.4? | 3.6? | 0? |
The specific embodiment
The specific embodiment of the present invention is not described in detail in this as described in the summary of the invention, and those skilled in the art can implement fully according to the content of description record.
Further specify therapeutic effect of the present invention below in conjunction with concrete model case.
Case one, Jiang, man, 72 years old, people from Jinan, Shandong.The local treatment of left side wrist traumatic injury first quarter moon swells and ache and does not feel any better, and Come examined on January 1st, 2009.Look into and see the unusual swelling of patient's hands, the nervous light of skin, refer to faint, carpal joint bend and stretch rotate limited.The X sheet shows: the failure that resets of left distal radius flexing type comminuted fracture, and external fixation improper use, and anti-fixing.Handle: reduction is fixed again.Oral capsule for treating of the present invention, oral 5, day clothes three times.Further consultation on January 13 in 2009 sees that the swelling of wrist hands eliminates substantially, each to telemechanical near normal.The para-position of X sheet is good to line.On January 8th, 2009, incoming call was fully recovered.
Case two, grandson, man, 34 years old, people from Changqing, Shandong.Right fracture of tibia and fibula is treated at local external fixation and not to be felt any better in nearly 4 months, and Come examined on April 12nd, 2008.Check: suffer from little tama, the dark violet light of skin, 3 relations of sufficient outward turning are obviously not normal, and fracture still has abnormal movement, and ring has tenderness in week, and the longitudinal axis tunks pain.The X sheet: 1/3 place's screw type fracture under in the right tibia, para-position less than 1/3 and interior one-tenth angle are big, do not see that callus occurs; The dislocation of the oblique type fracture of fibula epimere.Handle: after reduction is fixed again, oral capsule for treating of the present invention, 5 of every clothes, day clothes 3 times.Further consultation on May 31 in 2008 is seen and is held the rod walking, and the no abnormal activity of the broken ends of fractured bone encircles all tenderness and vertical button pain disappears, and color of the leather does not normally have swelling.Reach clinical cure through controlling 48 days.The X sheet shows that bit line is good, and fracture line is fuzzy, and the healthy callus of existing capacity is crossed fracture line.
Case three, teacher, woman, 35 years old, people from Jiangsu.On August 22nd, 2008, incoming call was stated: left chi is scratched bone epimere fracture before 1 year 09 months, so far nonunion behind the titanium plate internal fixation, after the wound at once by husband's operation (husband is certain orthopaedics hospital orthopedics director) of operating, got steel plate for me before 10 days, steel plate takes out the back and finds that bone has split again and few of external callus, it is upward fixing again just to have changed secondary new steel plate, and the husband regrets feeling guilty very much very much afterwards, again upper steel plate.Cannot online enquiries seek help.Check that network sends sheet and be strictly that bone does not connect connects.Oral capsule for treating of the present invention, every day three times, each 5, through controlling surplus bone connection recovery from illness in March.
Claims (3)
1. Chinese medicine composition of healing in mid-term that can promote to fracture is characterized in that it is formed by following parts by weight of Chinese traditional medicine material combination:
50 parts of Rhizoma Drynariae, 40 parts of Radix Dipsacis, 40 parts of eupolyphaga, Fructus Psoraleae 40 portionings, Rhizoma Dioscoreae 120 portionings, 50 parts of Radix Polygoni Multiflori Preparatas, 40 parts of Radix Codonopsis, 40 parts of the Radix Paeoniae Albas, 26 parts of Pyritum (calcined)s, 35 parts of Hirudos, Os Draconis (calcined) 50 portionings, 50 parts of Pheretimas, 25 parts of Olibanum (processed)s, 25 parts of Myrrha (processed)s, 30 parts of the Radix Aucklandiae, 40 parts of Radix Achyranthis Bidentataes.
2. the described Chinese medicine composition of claim 1 prepares capsular method, it is characterized in that, with all raw material of Chinese medicine medicines to scale after the proportioning, the above fine powder of fineness 120 orders is made in pulverizing, fine powder is put in the baking box, temperature is controlled at 170 degree heating and got final product in 5 minutes, in time stirs therebetween and prevents coking, the canned capsule of outlet postcooling.
3. the described Chinese medicine composition of claim 1 prepares capsular method, it is characterized in that, with all raw material of Chinese medicine medicines to scale after the proportioning, make fine powder more than fineness 120 orders with Chinese medicine grinder, then the fine powder of making is encapsulated with the edible plastic bag, put in the pressure cooker and steamed 10 minutes, take out and dry the canned capsule in back.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103099899A (en) * | 2012-12-10 | 2013-05-15 | 宋爱民 | Traditional Chinese medicine preparation externally used for treating traumatic synovitis of knee joint |
| CN105148019A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating fractures |
| CN105663440A (en) * | 2016-01-28 | 2016-06-15 | 张生禄 | Oral medicine for treating symptoms occurring in middle stage of fracture and soft tissue contusion |
| CN116211946A (en) * | 2023-03-22 | 2023-06-06 | 杨丽 | Application of traditional Chinese medicine composition in preparation of medicine for promoting fracture healing |
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| CN101172148A (en) * | 2006-11-03 | 2008-05-07 | 梁振兴 | Pharmaceutical composition for treating bone fracture, dislocation and soft tissue injury, and preparation method thereof |
| CN101224268A (en) * | 2008-01-10 | 2008-07-23 | 强繁英 | Chinese traditional medicine for treating bone fracture, postoperative bone nonunion and delayed union and preparing method thereof |
| CN101637589A (en) * | 2008-08-01 | 2010-02-03 | 梁振兴 | Chinese medicinal composition for treating early stage bone injuries and soft tissue injuries and preparation method thereof |
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| CN101172148A (en) * | 2006-11-03 | 2008-05-07 | 梁振兴 | Pharmaceutical composition for treating bone fracture, dislocation and soft tissue injury, and preparation method thereof |
| CN101224268A (en) * | 2008-01-10 | 2008-07-23 | 强繁英 | Chinese traditional medicine for treating bone fracture, postoperative bone nonunion and delayed union and preparing method thereof |
| CN101637589A (en) * | 2008-08-01 | 2010-02-03 | 梁振兴 | Chinese medicinal composition for treating early stage bone injuries and soft tissue injuries and preparation method thereof |
Non-Patent Citations (1)
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| 《新中医》 19801231 陈铁 骨折治疗经验（一） 6-9 1-3 , 第6期 2 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099899A (en) * | 2012-12-10 | 2013-05-15 | 宋爱民 | Traditional Chinese medicine preparation externally used for treating traumatic synovitis of knee joint |
| CN105148019A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating fractures |
| CN105663440A (en) * | 2016-01-28 | 2016-06-15 | 张生禄 | Oral medicine for treating symptoms occurring in middle stage of fracture and soft tissue contusion |
| CN116211946A (en) * | 2023-03-22 | 2023-06-06 | 杨丽 | Application of traditional Chinese medicine composition in preparation of medicine for promoting fracture healing |
| CN116211946B (en) * | 2023-03-22 | 2023-09-26 | 杨丽 | Application of traditional Chinese medicine composition in preparation of medicine for promoting fracture healing |
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