CN101912409A - Aerial fog disinfectant and preparation method thereof - Google Patents
Aerial fog disinfectant and preparation method thereof Download PDFInfo
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- CN101912409A CN101912409A CN 201010251816 CN201010251816A CN101912409A CN 101912409 A CN101912409 A CN 101912409A CN 201010251816 CN201010251816 CN 201010251816 CN 201010251816 A CN201010251816 A CN 201010251816A CN 101912409 A CN101912409 A CN 101912409A
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Abstract
The invention discloses an aerial fog disinfectant and a preparation method thereof. The preparation method mainly comprises the steps of preparing poly(hexamethylene biguanide) hydrochloride as a disinfection factor, dimethyl didecyl ammonium sulfide, propylene glycol as a solvent, ethanol, and the like into liquid disinfectant through a certain process and sealing the liquid disinfectant in a pressure-proof vessel and then filling a certain amount of propellant to ensure that the disinfectant is dispersed on the surface of an object in the form of fog. The invention is mainly used for spraying and disinfecting surfaces of hands, skin and ordinary objects to achieve convenient and rapid disinfection effect.
Description
Technical field
The present invention relates to disinfectant and preparation method, be specifically related to a kind of aerial fog disinfectant and preparation method.
Background technology
The disinfecting cleaning of human body skin surface and body surface is the problem that the common people and professional person are concerned about always, traditional method is directly to be immersed in the antiseptic solution or to reach the purpose of disinfection by wiping modes such as cotton swabs by will sterilize target skin or object, this method is on the less object of compare less sterilization area or volume, can reach reliable effect, but it is bigger for the sterilization area, or have the disinfection of the body surface of certain height, lean on artificial smear to be difficult to bear with high-quality finish.Soak in addition and spread upon under some certain conditions and use, not very convenient, especially layman's use, what they needed is a kind of a kind of disinfectant that need not smear fast of plug and play, also is the disinfectant that needs a kind of more convenient practicality for the operation of medical workers process certainly.People also adopt manual air-atomizing agent in actual use, as contain the disinfectant spray of ethanol and chlorohaxanpyridine acetate, but the atomizing effect of this dosage form is poor, can not uniformly spray, the sterilizing ability of chlorohaxanpyridine acetate is limited in addition, so overall result of use is not fine.
Summary of the invention
The objective of the invention is to: a kind of aerial fog disinfectant and preparation method are provided, and disinfectant solution diffuses to body surface with vaporific form, and is easy to use, and Disinfection Effect is good.
Technical solution of the present invention is: the aerial fog disinfectant fill is made in proportion by disinfectant solution and propellant in pressure vessel, and propellant is 5.0%～40.0% of a disinfectant solution quality; The mass percent of each component is in the disinfectant solution:
Hexamethylene 0.1%～8.0%
The two certain herbaceous plants with big flowers bases six of dimethyl are changed ammonium 0.1%～5.0%
Propylene glycol 1.0%～10.0%
Ethanol 5.0%～20.0%
Disodiumedetate 0.05%～0.5%
Spice 0.05%～1.0%
Deionized water 55.5%～93.7%.
A kind of as mentioned above aerial fog disinfectant, wherein the component hexamethylene is the main sterilization factors of disinfectant, this antibacterial broad-spectrum antiseptic, gram positive bacteria, gram negative bacteria, fungus and yeast are all had very strong kill capability, and its mass percent shared in disinfectant solution is 0.1%～8.0%.
A kind of as mentioned above aerial fog disinfectant, wherein the two certain herbaceous plants with big flowers base six change ammoniums of component dimethyl are quaternary cationic surfactant, and having good is bactericidal activity, and its mass percent shared in disinfectant solution is 0.1%～5.0%.
A kind of as mentioned above aerial fog disinfectant, wherein the component propylene glycol is a cosolvent, increases the sterilization factors solubility property, improves the penetration capacity of disinfection factor, its mass percent shared in disinfectant solution is 1.0%～10.0%.
A kind of as mentioned above aerial fog disinfectant, wherein component ethanol is organic solvent, plays filling liquid and froth breaking effect, its mass percent shared in disinfectant solution is 5.0%～20.%.
A kind of as mentioned above aerial fog disinfectant, wherein component disodiumedetate (EDTA-2Na) is the agent that boils together, and mainly is the hardness that reduces aqueous solution, increases the stability of compositions, its mass percent shared in disinfectant solution is 0.05%～0.5%.
A kind of as mentioned above aerial fog disinfectant, wherein component spice is auxiliary element, mainly is the abnormal smells from the patient that is used for improving compositions, and the abnormal smells from the patient end user mood of selecting for use the people west to like is more joyful, and its mass percent shared in disinfectant solution is 0.05%～1.0%.
A kind of as mentioned above aerial fog disinfectant, wherein the component propellant is third butane, dimethyl ether or compressed air, it mainly acts on is the pressure that increases in the packing container, is the power that disinfectant is dispersed.
The preparation method of this aerial fog disinfectant is a two-step method, and the first step is the preparation of disinfectant solution: (1), the deionized water that will accurately measure add reactor, add the disodiumedetate stirring and are warming up to 40 ℃; (2), stirring propylene glycol, the ethanol that will accurately measure down joins in the reactor; (3), while stirring the two certain herbaceous plants with big flowers bases six of hexamethylene, dimethyl that add accurately metering are changed ammonium, it is dissolved fully be uniformly dispersed; (4), add the spice stirring and refluxing 30 minutes of accurately metering, be cooled to 25 ℃; (5), check, qualified back is standby; The second step fill: (1), the disinfectant solution of first step preparation is delivered on the dosing filling machine requirement by packing container carry out quantitative filling; (2), the filling or the bottle interpolation valve of having irritated disinfectant solution sealed through sealing machine; (3), with quantitative propellant filling machine propellant is pressurizeed towards installing in the disinfectant solution tank that has sealed by formula ratio; (4), the air-tightness of checking the aerosol jar is guaranteed air tight.
Wherein, the volume of the filling of fill aerial fog disinfectant or bottle is 100ml～1000ml, is can, aluminium pot or polyester bottle, and pressure is 0.3～0.6mpa during room temperature.
The present invention is sealed in a certain amount of propellant of disinfectant solution filling in the withstand voltage container, be convenient to the sprinkling of loosing of waving of disinfectant, make disinfectant solution diffuse to body surface, be used for hands and skin, general body surface spraying disinfection with vaporific form, easy to operate, Disinfection Effect is good.
The specific embodiment
Further specify technical solution of the present invention below in conjunction with specific embodiment, these embodiment can not be interpreted as it is restriction to technical solution.
Embodiment 1:
The aerial fog disinfectant fill is made in proportion by disinfectant solution and propellant in pressure vessel, and propellant third butane is 5.0% of a disinfectant solution quality; The mass percent of each component is in the disinfectant solution: hexamethylene 0.1%, the two certain herbaceous plants with big flowers bases six of dimethyl are changed ammonium 0.1%, propylene glycol 1.0%, ethanol 5.0%, disodiumedetate 0.05%, spice 0.05%, deionized water 93.7%.
This aerial fog disinfectant prepares with two-step method, and the first step is the preparation of disinfectant solution: (1), the deionized water that will accurately measure add reactor, add the disodiumedetate stirring and are warming up to 40 ℃; (2), stirring propylene glycol, the ethanol that will accurately measure down joins in the reactor; (3), while stirring the two certain herbaceous plants with big flowers bases six of hexamethylene, dimethyl that add accurately metering are changed ammonium, it is dissolved fully be uniformly dispersed; (4), add the spice stirring and refluxing 30 minutes of accurately metering, be cooled to 25 ℃; (5), check, qualified back is standby; The second step fill: (1), the disinfectant solution of first step preparation is delivered on the dosing filling machine requirement by packing container 100ml carry out quantitative filling; (2), the filling or the bottle interpolation valve of having irritated disinfectant solution sealed through sealing machine; (3), with quantitative propellant filling machine propellant is pressurizeed towards installing in the disinfectant solution tank that has sealed by formula ratio 0.3mpa; (4), the air-tightness of checking the aerosol jar is guaranteed air tight.
Embodiment 2:
The preparation method of this aerial fog disinfectant is with embodiment 1, and the aerial fog disinfectant fill is made in proportion by disinfectant solution and propellant in 500ml, 0.45mpa pressure vessel, and the propellant dimethyl ether is 22.5% of a disinfectant solution quality; The mass percent of each component is in the disinfectant solution: hexamethylene 4.05%, the two certain herbaceous plants with big flowers bases six of dimethyl are changed ammonium 2.55%, propylene glycol 5.5%, ethanol 12.5%, disodiumedetate 0.275%, spice 0.525%, deionized water 74.6%.
Embodiment 3:
The preparation method of this aerial fog disinfectant is with embodiment 1, and the aerial fog disinfectant fill is made in proportion by disinfectant solution and propellant in 1000ml, 0.6mpa pressure vessel, and the propellant compressed air is 40.0% of a disinfectant solution quality; The mass percent of each component is in the disinfectant solution: hexamethylene 8.0%, the two certain herbaceous plants with big flowers bases six of dimethyl are changed ammonium 5.0%, propylene glycol 10.0%, ethanol 20.0%, disodiumedetate 0.5%, spice 1.0%, deionized water 55.5%.
The sample of embodiment 1 detects through provincial hygiene department, and spraying disinfection 0.5 minute is killed logarithm value＞3 to the Pseudomonas aeruginosa of artificial contamination on the cloth sheet, escherichia coli, staphylococcus aureus, Candida albicans.
The sample of embodiment 2 is adversary, skin spraying sterilization 1 minute, and its surperficial natural bacteria killed logarithm value＞1; To wood surface spraying disinfection 1 minute, its surperficial natural bacteria killed logarithm value＞1.
The sample of embodiment 3 is deposited 3 months effective ingredient hexamethylene, the two certain herbaceous plants with big flowers ammonium chloride rates of descent of dimethyl all less than 10% through 37 ℃, and stability meets the requirement of Ministry of Public Health " disinfection technology standard " version in 2002, and effect duration is 2 years.
Through check, the sample of embodiment 1-3 is to male and female chmice acute per os LD
50Be worth all greater than 5000mg/kg b.wt the nontoxic level in true border; To rabbit acute skin irritation reaction integrated value is 0, belongs to nonirritant; To rabbit damaged skin irritant reaction integrated value is 0, and disposable damaged skin irritant test stimulus intensity is a nonirritant; Dosage reaches 5000mg/kg b.wt, does not detect the male and female PCEMNR is caused the micronucleus effect.
Claims (4)
1. aerial fog disinfectant, it is characterized in that: the aerial fog disinfectant fill is made in proportion by disinfectant solution and propellant in pressure vessel, and propellant is 5.0%～40.0% of a disinfectant solution quality; The mass percent of each component is in the disinfectant solution:
Hexamethylene 0.1%～8.0%
The two certain herbaceous plants with big flowers bases six of dimethyl are changed ammonium 0.1%～5.0%
Propylene glycol 1.0%～10.0%
Ethanol 5.0%～20.0%
Disodiumedetate 0.05%～0.5%
Spice 0.05%～1.0%
Deionized water 55.5%～93.7%.
2. a kind of aerial fog disinfectant according to claim 1 is characterized in that: propellant is third butane, dimethyl ether or compressed air.
3. the preparation method of a kind of aerial fog disinfectant according to claim 1, it is characterized in that this preparation method is a two-step method, the first step is the preparation of disinfectant solution: (1), the deionized water that will accurately measure add reactor, add the disodiumedetate stirring and are warming up to 40 ℃; (2), stirring propylene glycol, the ethanol that will accurately measure down joins in the reactor; (3), while stirring the two certain herbaceous plants with big flowers bases six of hexamethylene, dimethyl that add accurately metering are changed ammonium, it is dissolved fully be uniformly dispersed; (4), add the spice stirring and refluxing 30 minutes of accurately metering, be cooled to 25 ℃; (5), check, qualified back is standby; The second step fill: (1), the disinfectant solution of first step preparation is delivered on the dosing filling machine requirement by packing container carry out quantitative filling; (2), the filling or the bottle interpolation valve of having irritated disinfectant solution sealed through sealing machine; (3), with quantitative propellant filling machine propellant is pressurizeed towards installing in the disinfectant solution tank that has sealed by formula ratio; (4), the air-tightness of checking the aerosol jar is guaranteed air tight.
4. the preparation method of a kind of aerial fog disinfectant according to claim 3 is characterized in that: the volume of the filling of aerial fog disinfectant or bottle is 100ml～1000ml, and pressure is 0.3～0.6mpa during room temperature.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010251816 CN101912409A (en) | 2010-08-12 | 2010-08-12 | Aerial fog disinfectant and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010251816 CN101912409A (en) | 2010-08-12 | 2010-08-12 | Aerial fog disinfectant and preparation method thereof |
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| CN101912409A true CN101912409A (en) | 2010-12-15 |
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| CN 201010251816 Pending CN101912409A (en) | 2010-08-12 | 2010-08-12 | Aerial fog disinfectant and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434799A (en) * | 2014-11-02 | 2015-03-25 | 卫国刚 | Polyhexamethylene guanidine spray and preparation method thereof |
| CN106359468A (en) * | 2015-07-22 | 2017-02-01 | 徐伟 | Shoe-foot deodorizing cleaning aerosol |
| CN111149804A (en) * | 2020-02-24 | 2020-05-15 | 江苏瑞丰科技实业有限公司 | Sterilizing and disinfecting spray |
| CN112244021A (en) * | 2020-09-15 | 2021-01-22 | 江苏瑞丰科技实业有限公司 | Efficient sterilization and mosquito repellent spray |
| CN112244036A (en) * | 2020-09-15 | 2021-01-22 | 江苏瑞丰科技实业有限公司 | Efficient sterilization and mite removal spray |
| CN113144260A (en) * | 2020-07-28 | 2021-07-23 | 燊洛施消毒用品(上海)有限公司 | Method for sterilizing space environment by using self-spraying hydrogen peroxide |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476761A (en) * | 2003-07-02 | 2004-02-25 | 刘瑞源 | Liquid disinfectant |
-
2010
- 2010-08-12 CN CN 201010251816 patent/CN101912409A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476761A (en) * | 2003-07-02 | 2004-02-25 | 刘瑞源 | Liquid disinfectant |
Non-Patent Citations (2)
| Title |
|---|
| 《医学理论与实践》 20090331 崔玉洁 聚六亚甲基双胍与双癸基二甲基氯化铵协同作用的研究 360-362 1-4 第22卷, 第3期 2 * |
| 《广西化工》 20000930 汪朝阳 方兴未艾的气雾剂 第33页 1-2 第29卷, 第3期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434799A (en) * | 2014-11-02 | 2015-03-25 | 卫国刚 | Polyhexamethylene guanidine spray and preparation method thereof |
| CN106359468A (en) * | 2015-07-22 | 2017-02-01 | 徐伟 | Shoe-foot deodorizing cleaning aerosol |
| CN111149804A (en) * | 2020-02-24 | 2020-05-15 | 江苏瑞丰科技实业有限公司 | Sterilizing and disinfecting spray |
| CN113144260A (en) * | 2020-07-28 | 2021-07-23 | 燊洛施消毒用品(上海)有限公司 | Method for sterilizing space environment by using self-spraying hydrogen peroxide |
| CN113274530A (en) * | 2020-07-28 | 2021-08-20 | 燊洛施消毒用品(上海)有限公司 | Disinfection method, disinfectant composition adopted by disinfection method and spray tank |
| CN112244021A (en) * | 2020-09-15 | 2021-01-22 | 江苏瑞丰科技实业有限公司 | Efficient sterilization and mosquito repellent spray |
| CN112244036A (en) * | 2020-09-15 | 2021-01-22 | 江苏瑞丰科技实业有限公司 | Efficient sterilization and mite removal spray |
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Open date: 20101215 |