CN101904922A - Plaster for treating pain caused by femoral head necrosis - Google Patents

Abstract

The invention relates to a plaster for treating pain caused by femoral head necrosis. The plaster is prepared from a traditional Chinese herbal medicine, a plaster substrate and a transdermal agent. The traditional Chinese herbal medicine comprises the following raw materials in part by weight: 3 to 5 parts of incised notopterygium rhizome, 2 to 3 parts of Chinese fevervine herb, 3 to 5 parts of williams elder twig, 3 to 10 parts of scandent schefflera stem and leaf, 1 to 2 parts of mealy fangji root, 1 to 2 parts of earthworm, 1 to 5 parts of leech and 1 to 3 parts of pseudoginseng root; the plaster substrate is prepared from the following raw materials in part by weight: 22 to 25 parts of hot melt adhesive and 22 to 35 parts of rosin; the use amount of the transdermal agent accounts for 5 to 7 percent of the total weight of the herb medicaments and the plaster substrate; and the transdermal agent adopts nitrogen copper. The plaster has the advantages of quick effect, good pain relieving effect, no toxic and side effect and easy application.

Description

A kind of treatment is because the plaster of the pain that femur head necrosis causes

Technical field

The present invention relates to a kind of treatment because the plaster of the pain that femur head necrosis causes belongs to Chinese medicine plaster.

Background technology

Chinese patent discloses a kind of " plaster for the treatment of femur head necrosis; Bone tuberculosis; Osteomyelitis; Osteoma "; And (number of patent application:201010101965.1); It is made up of Resina garciniae; Margarita; Cinnabaris; Sanguis Draxonis, Crinis Carbonisatus, Hirudo, Gecko, Aspongopus, Wu , TUBIECHONG, Agkistrodon, Zaocys, Semen Strychni, Caulis et Folium hedyotis hedyotideae, Caulis Spatholobi, Herba Aristolochiae Mollissimae, Rhizoma seu Herba Elatostematis stewardii, Herba speranskiae tuberculatae, Herba Centipedae, the Radix Linderae, Squama Manis, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Semen Sinapis, Flos Carthami, Radix Aconiti Kusnezoffii, Radix Aconiti, Oleum Terebinthinae, Borneolum Syntheticum, Moschus.

Include in the above-mentioned plaster and contain alkaloidal Chinese herbal medicine Radix Aconiti Kusnezoffii and Radix Aconiti, also include mercurous and Chinese herbal medicine Cinnabaris arsenic, in addition, Squama Manis is the state guarantee animal, and above-mentioned a few flavor medicines can cause following problem:

(1) described alkaloid Aconitum carmichjaelii Debx. class alkalescence medicine causes skin allergy easily, and use the skin many places also may cause the aconitine intoxicating phenomenon.

(2) Cinnabaris contains materials such as hydrargyrum and arsenic, and long-time use may cause toxicity in vivo to accumulate, and toxic reaction occurs.

(3) Squama Manis is the state guarantee animal, and medicine is difficult to buy.

Summary of the invention

Technical problem to be solved by this invention provides a kind of treatment of having rapid-action, good analgesic effect, having no side effect, be easy to stick because the plaster of the pain that femur head necrosis causes.

The technical solution adopted for the present invention to solve the technical problems:

The present invention is made by Chinese herbal medicine, plaster substrate and transdermal agent; Described Chinese herbal medicine comprises the crude drug of following portions by weight ratio:

Rhizoma Et Radix Notopterygii: 3-5

Herba Paederiae: 2-3

Ramulus Sambuci Williamsii: 3-5

Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): 3-10

Radix Stephaniae Tetrandrae: 1-2

Pheretima: 1-2

Hirudo: 1-5

Radix Notoginseng: 1-3;

Described plaster substrate is made by the raw material of following portions by weight ratio:

PUR: 22-25

Colophonium: 22-35;

The consumption of described transdermal agent accounts for the 5%-7% of described Chinese herbal medicine and plaster substrate gross weight; Described transdermal agent adopts nitrogen copper.

Chinese herbal medicine of the present invention also comprises the crude drug of following portions by weight ratio:

Concha Ostreae: 3-5

The Cortex Eucommiae: 1.2-3

Radix Achyranthis Bidentatae: 1.2-3

Radix Dipsaci: 1.2-3

Radix Salviae Miltiorrhizae: 1.2-3

Rhizoma Drynariae: 1.2-3

TUBIECHONG: 1.2-3

Fructus Zanthoxyli: 1-3

Nidus Vespae: 1-3

Borneolum Syntheticum: 5-25.

Beneficial effect of the present invention is as follows:

(1) because transdermal agent can make the rapid Transdermal absorption of effective ingredient, therefore rapid-action.

(2) good analgesic effect, effective percentage is 100%, cure rate reaches 76%.

(3) do not contain the big and alkaloidal Chinese herbal medicine of toxicity in this plaster composition, again owing to adopt the adhesive bandage lining, so this plaster has no side effect, and is easy to paste and cleaning.

The treatment mechanism of this plaster:

This plaster that is affixed on body surface tip that can excite nerve, by reflection, blood vessel dilating, promote local blood circulation, improve surrounding tissue nutrition, reach detumescence, antiinflammatory and aim of alleviating pain, medicine reaches subcutaneous tissue in the affected part by dermal osmosis simultaneously, produce the relative potence of drug level in the part, thus the stronger pharmacological action of performance.

In addition, because of this plaster has adopted pointed drug component, can pass through effects on neural system, blood flow effect, reach following effect: (1) is local to suppress the platelet excitement, and then avoids local thrombus to form, and improves the state of blood supply insufficiency, with reducing swelling and alleviating pain.Can regulate the human body function, improve body immunity.(2) excitement of stimulating osteoblast helps the generation of new bone, delays the speed of osteonecrosis.(3) localized degradation muscle ossifys, the loosen contracture of muscle, and then reduce: a, perstriction because of the rigid and issuable following phenomenon of muscle, be of value to the foundation of local vascular collateral circulation, and then improve the blood supply state, recover normal physiological status gradually, also ossify and " referred pain " of generation with regard to having removed muscle; B, nerve compression are of value to the normal conduction of neutral net, be of value to the rehabilitation of muscular tissue, also the nerve " radiating pain " that has produced with regard to having removed muscle to ossify.Therefore, this plaster has good reducing swelling and alleviating pain effect at the femur head necrosis patient.

Respectively distinguish the flavor of in this plaster pharmacology of Chinese herbal medicine:

One, the pharmacology of main medicine:

(1) Rhizoma Et Radix Notopterygii, Herba Paederiae, Ramulus Sambuci Williamsii and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) are traditional medications of Chinese traditional treatment all kinds of " arthromyodynia " pain, the Chinese herbal medicine modern study confirms, the compound action of these medicines, for smooth muscle spasm, pain due to all kinds of muscle contractures, and neuropathic pain, better pain relieving effect is all arranged, and avoid or alleviated gastrointestinal is stimulated.

(2) Radix Stephaniae Tetrandrae, Pheretima cooperate in the combination of this group medicine of Hirudo and Radix Notoginseng the Hirudo blood circulation promoting and blood stasis dispelling, stop the formation of thrombosis, the dual regulation that Radix Notoginseng has hemostasis to invigorate blood circulation to blood, and can assist Hirudo to invigorate blood circulation, and avoid bleeding, Radix Notoginseng still is good analgesic drug product in addition.But Radix Stephaniae Tetrandrae, Pheretima inducing diuresis to remove edema and the meridian dredging, modern study confirms that Radix Stephaniae Tetrandrae, Pheretima are woven with Degradation for partial groups, are good muscle relaxants.

Above-mentioned two groups of drug regimens have formed blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, soft perpendicular eliminating stagnation, unimpeded QI and blood, the mass action of invigorating function of kidney and strengthening bone.

Two, the pharmacology of auxiliary element:

Concha Ostreae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Radix Salviae Miltiorrhizae, Rhizoma Drynariae, Eupolyphaga Seu Steleophaga, Fructus Zanthoxyli, Nidus Vespae and Borneolum Syntheticum: these Chinese herbal medicine are traditional medication combinations of treatment fracture, modern Study of Medicinal Herbs confirms, medicines such as Concha Ostreae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Dipsaci, Radix Salviae Miltiorrhizae, Rhizoma Drynariae, but but the effect of invigorating function of kidney and strengthening bone is the excitement of supplement calcium stimulating osteoblast and osteoclast; The Fructus Zanthoxyli dispelling cold by warming the meridian; The Borneolum Syntheticum promoting the flow of QI in the collateral by warming the meridian; Nidus Vespae hard masses softening and resolving; These auxiliary elements cooperate with main medicine, have just formed the more complete drug regimen of the pain that the treatment femur head necrosis causes.

In addition, Colophonium is base starting material, has the effect of reducing swelling and alleviating pain again.

The specific embodiment

Embodiment (seeing the following form):

Annotate: in (1) above-mentioned table, the proportioning of denitrogenating outer other component of copper is a ratio of weight and number.

(2) proportioning of nitrogen copper is the percentage ratio that accounts for the gross weight of Chinese herbal medicine and substrate.

The preparation method of embodiment 1 is as follows:

1, the ratio requirement by embodiment 1 takes by weighing each raw material.

2, it is standby Borneolum Syntheticum to be ground into fine powder.

3, extract all the other medium-height grass the effective elements of the medicines:

(1) all the other Chinese herbal medicine powders are broken into granule, place for 95% ethanol one week of immersion, it is standby to filter rear filtrate.

(2) filtering residue is decocted with water 2 hours, it is standby to leach medicinal liquid.

(3) above-mentioned twice filtrate is mixed impurity such as after-filtration Deproteinization.

(4) above-mentioned (3) step gained filtrate is heated the concentrated medicament that is condensed into dense colloid state.

4, preparation plaster substrate (being carrier):

(1) Colophonium is melted the after-filtration decontamination in chaffy dish, and then the twice-cooked stir-frying fusing.

(2) in melting rosiny chaffy dish, add thermosol, make its complete consolute make plaster substrate.

5, preparation unguentum:

(1) in above-mentioned plaster substrate, add described concentrated medicament while stirring, make intermediate product.

When (2) temperature for the treatment of above-mentioned intermediate product is reduced to 60-70 ℃, add Borneolum Syntheticum and transdermal agent nitrogen copper while stirring, promptly get unguentum after treating to mix fully.

6, encapsulation:

Above-mentioned unguentum stand is applied on rice paper, after cooling, be encapsulated on the plaster cloth made from the adhesive bandage lining, in the plastic packaging bag of packing into then.

The applicant utilizes the plaster of embodiment 1 preparation that the patient who suffers from femur head necrosis has been carried out clinical treatment, and clinical efficacy is described as follows:

1, efficacy assessment standard:

(1) cure:

Used this plaster treatment 1-3 month, pain disappears, and joint motion is checked not recurrence of pain freely after half a year.

(2) effective:

Used this plaster treatment 1-3 month, pain is obviously alleviated, and range of motion increases.

(3) invalid:

Used this plaster treatment 1-3 month, pain can not alleviate, and range of motion does not improve.

2, case is selected:

Selecting patient 50 people altogether, all is the patient who is diagnosed as femur head necrosis through city-level to go to the hospital.

Model case illustrates:

(1) patient goes into business so-and-so, the man, and 60 years old:

Bilateral hip pain appears in patient's no obvious inducement before 8 years, be radioactivity, radiate to thigh, increase the weight of when movable, went to a doctor at that time in The First Hospital of Hebei Medical University, after the row double hip joint CT examination, be diagnosed as " bilateral femoral head ischemic necrosis ", the suggestion patient does replacement operation of artificial femoral head, does not agree.The back all gives Chinese medicine eliminating blood stasis and smoothing collaterals, blood circulation promoting and blood stasis dispelling, physiotherapy and symptomatic treatment to how tame hospital hospitalization.Heavy when light during the state of an illness, companion's intermittent claudication.Two hip pain increase the weight of to accompany intermittent claudication, when movable more so, difficulty in walking.Use this plaster external application for curing, onset after 30 minutes, pain symptom obviously alleviates, and continues to use this plaster treatment after 30 days, and pain disappears, and joint motion is flexible, checks after half a year, and pain is recurrence not.

(2) patient grandson so-and-so, the man, 49 years old:

The right hip pain of patient 13 years, left hip pain 6 years increased the weight of 3 days.Be admitted to hospital in 2010-06-11.Right hip pain appears in no obvious inducement before 13 years, is radioactivity, to the thigh radiation, increases the weight of when movable.Once went to a doctor at worker's hospital of our unit pain clinic, and gave partial closure's treatment, effect is undesirable.After go to a doctor in the Hebei First Academy of medical university, be diagnosed as " right side ischemic necrosis of femoral head " after the inspection of row double hip joint X-ray film, and the suggestion patient does femur head necrosis circulation art, agree.Left hip pain appears in no obvious inducement before 6 years, and symptom is with right hip, after economizing three institutes' row double hip joint X-ray films and checking, is diagnosed as " bilateral femoral head ischemic necrosis ", and is heavy when light during the state of an illness, companion's intermittent claudication.One all causes are suffered from cold, and afterwards pair hip pain are heavy a little in fatigue, do not deal with, and pain obviously increases the weight of.Use this plaster external application for curing, pain symptom obviously alleviates after 1 day, continues to use the pain disappearance after 30 days of this plaster treatment, and joint motion is flexible, checks after half a year, and pain is recurrence not.

3, the statistical disposition of treatment statistical test data:

Use this plaster to treat by the patient's (these patients all are diagnosed as the femur head necrosis patient through city-level to go to the hospital) who suffers from femur head necrosis to 50, treatment time is that 1-3 did not wait in individual month, clinical test results is: total effectively number is 50 people, the healing number is 38 people, and invalid number is 0 people.Therefore, effective percentage is 100%, and cure rate is 76%, and inefficiency is 0%.

4, conclusion

Use this plaster that 50 routine femur head necrosis patients are carried out clinical treatment observation, the result shows: this plaster is rapid-action, good analgesic effect, effective percentage is 100%, cure rate reaches 76%, and patient is consistent reflects: this plaster is easy to paste and cleaning, does not have uncomfortable reflection.

In addition, the applicant entrusts units concerned that the powder (pale brown toner end) of this plaster is carried out acute toxicity testing to mice, and the experiment situation is as follows:

The understanding of this laboratory observation is subjected to the reagent thing to irritate the acute toxicity of stomach to mice, and 20 are tried mouse stomach to being subjected to reagent thing 17.0g/kg (maximum stomach concentration 0.425g/ml, the maximum volume 40ml/kg of irritating), 14 days observing times.Experimental session is tried mice does not all have death, the appearance activity reduces, reposes after being tried the mice administration, abnormality do not occur, does not observe other acute toxic reaction.The result shows that mice is subjected to the reagent thing to irritate the maximum tolerated dose MTD＞17.0g/kg of stomach.

Claims (2)

1. a treatment is because the plaster of the pain that femur head necrosis causes, it is characterized in that it is made by Chinese herbal medicine, plaster substrate and transdermal agent; Described Chinese herbal medicine comprises the crude drug of following portions by weight ratio:

Rhizoma Et Radix Notopterygii: 3-5

Herba Paederiae: 2-3

Ramulus Sambuci Williamsii: 3-5

Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): 3-10

Radix Stephaniae Tetrandrae: 1-2

Pheretima: 1-2

Hirudo: 1-5

Radix Notoginseng: 1-3;

Described plaster substrate is made by the raw material of following portions by weight ratio:

PUR: 22-25

Colophonium: 22-35;

The consumption of described transdermal agent accounts for the 5%-7% of described Chinese herbal medicine and plaster substrate gross weight; Described transdermal agent adopts nitrogen copper.

2. a kind of treatment according to claim 1 is because the plaster of the pain that femur head necrosis causes is characterized in that described Chinese herbal medicine also comprises the crude drug of following portions by weight ratio:

Concha Ostreae: 3-5

The Cortex Eucommiae: 1.2-3

Radix Achyranthis Bidentatae: 1.2-3

Radix Dipsaci: 1.2-3

Radix Salviae Miltiorrhizae: 1.2-3

Rhizoma Drynariae: 1.2-3

TUBIECHONG: 1.2-3

Fructus Zanthoxyli: 1-3

Nidus Vespae: 1-3

Borneolum Syntheticum: 5-25.