CN101903387B - 8-苯氨基咪唑并吡啶和它们在制备抗癌剂和/或抗炎剂中的用途 - Google Patents
8-苯氨基咪唑并吡啶和它们在制备抗癌剂和/或抗炎剂中的用途 Download PDFInfo
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- CN101903387B CN101903387B CN200880122184.1A CN200880122184A CN101903387B CN 101903387 B CN101903387 B CN 101903387B CN 200880122184 A CN200880122184 A CN 200880122184A CN 101903387 B CN101903387 B CN 101903387B
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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Landscapes
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| US5402408P | 2008-05-16 | 2008-05-16 | |
| US61/054,024 | 2008-05-16 | ||
| PCT/US2008/087476 WO2009085980A1 (en) | 2007-12-19 | 2008-12-18 | 8-anilin0imidaz0pyridines and their use as anti-cancer and/or anti-inflammatory agents |
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| CN101903387A CN101903387A (zh) | 2010-12-01 |
| CN101903387B true CN101903387B (zh) | 2014-05-21 |
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| CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
| ES2529119T3 (es) | 2010-07-02 | 2015-02-17 | Gilead Sciences, Inc. | Compuestos heterocíclicos condensados como moduladores de canales iónicos |
| TWI510480B (zh) | 2011-05-10 | 2015-12-01 | Gilead Sciences Inc | 充當離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (enExample) | 2011-07-01 | 2018-04-28 | ||
| TWI549944B (zh) | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| HRP20190281T1 (hr) | 2011-09-14 | 2019-05-31 | Samumed, Llc | Indazol-3-karboksamidi i njihova uporaba kao inhibitora signalizacijskog puta wnt/b-katenin |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| KR101223245B1 (ko) * | 2012-09-12 | 2013-01-17 | 삼부기술 주식회사 | 영상이미지의 기준점 대비 도화하기 위한 대상 지형지물을 촬영하는 공간 영상도화 시스템 |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| US9943677B2 (en) | 2013-10-15 | 2018-04-17 | Radux Devices, LLC | Securing a medical device to a valve instrument |
| PE20161573A1 (es) | 2014-02-13 | 2017-01-19 | Incyte Corp | Ciclopropilamina como inhibidor de la lsd1 |
| TWI664164B (zh) | 2014-02-13 | 2019-07-01 | 美商英塞特控股公司 | 作為ｌｓｄ１抑制劑之環丙胺 |
| WO2015123408A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| WO2015123437A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| CN108358939A (zh) * | 2014-07-29 | 2018-08-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环化合物及其制备方法和用途 |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| MY191796A (en) | 2015-04-03 | 2022-07-15 | Incyte Corp | Heterocyclic compounds as lsd1 inhibitors |
| GB201511790D0 (en) * | 2015-07-06 | 2015-08-19 | Iomet Pharma Ltd | Pharmaceutical compound |
| US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
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2008
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- 2008-12-18 JP JP2010539814A patent/JP5710268B2/ja not_active Expired - Fee Related
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- 2008-12-18 KR KR1020107015816A patent/KR20100101666A/ko not_active Abandoned
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- 2008-12-18 AT AT08868471T patent/ATE513832T1/de active
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- 2008-12-18 RU RU2010129910/04A patent/RU2498985C2/ru not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2231662A1 (en) | 2010-09-29 |
| RU2010129910A (ru) | 2012-01-27 |
| ATE513832T1 (de) | 2011-07-15 |
| PT2231662E (pt) | 2011-09-12 |
| CA2704125A1 (en) | 2009-07-09 |
| CN101903387A (zh) | 2010-12-01 |
| RU2498985C2 (ru) | 2013-11-20 |
| PL2231662T3 (pl) | 2011-11-30 |
| AU2008343062A1 (en) | 2009-07-09 |
| ZA201003046B (en) | 2011-08-31 |
| DK2231662T3 (da) | 2011-08-29 |
| NZ585306A (en) | 2012-05-25 |
| AU2008343062B2 (en) | 2013-03-07 |
| US20100280063A1 (en) | 2010-11-04 |
| IL205490A (en) | 2015-09-24 |
| IL205490A0 (en) | 2010-12-30 |
| EP2231662B1 (en) | 2011-06-22 |
| US8293763B2 (en) | 2012-10-23 |
| JP2011507888A (ja) | 2011-03-10 |
| KR20100101666A (ko) | 2010-09-17 |
| WO2009085980A1 (en) | 2009-07-09 |
| JP5710268B2 (ja) | 2015-04-30 |
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