CN101903340B - 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 - Google Patents
取代的n-苯基联吡咯烷羧酰胺及其治疗用途 Download PDFInfo
- Publication number
- CN101903340B CN101903340B CN2008801212081A CN200880121208A CN101903340B CN 101903340 B CN101903340 B CN 101903340B CN 2008801212081 A CN2008801212081 A CN 2008801212081A CN 200880121208 A CN200880121208 A CN 200880121208A CN 101903340 B CN101903340 B CN 101903340B
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- China
- Prior art keywords
- methyl
- phenyl
- bipyrrolidine
- carboxylic acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *C(CCC1)N1C(CC1)CN1c(cc1)ccc1N Chemical compound *C(CCC1)N1C(CC1)CN1c(cc1)ccc1N 0.000 description 5
- LFMNOHYCZLVTQR-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(C1CC1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(C1CC1)=O LFMNOHYCZLVTQR-UHFFFAOYSA-N 0.000 description 1
- ZETKRQDDYKMOPO-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(C1C(C)(C)C1(C)C)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(C1C(C)(C)C1(C)C)=O ZETKRQDDYKMOPO-UHFFFAOYSA-N 0.000 description 1
- JVRCPBUFCJRHEI-HJWRWDBZSA-N CC(CN(C)C(/C=C\C(NC(C1CC1)=O)=C)=C)N1C(C)CCC1 Chemical compound CC(CN(C)C(/C=C\C(NC(C1CC1)=O)=C)=C)N1C(C)CCC1 JVRCPBUFCJRHEI-HJWRWDBZSA-N 0.000 description 1
- BTNJIWYZQYOUJA-STQMWFEESA-N CCC(C)(C)OC(N(CC1)C[C@H]1N1[C@@H](C)CCC1)=O Chemical compound CCC(C)(C)OC(N(CC1)C[C@H]1N1[C@@H](C)CCC1)=O BTNJIWYZQYOUJA-STQMWFEESA-N 0.000 description 1
- QQFAGVRJPSCEIU-UHFFFAOYSA-N CCC(C)N(C)C(CC1)CN1C(OC(C)(C)C)=O Chemical compound CCC(C)N(C)C(CC1)CN1C(OC(C)(C)C)=O QQFAGVRJPSCEIU-UHFFFAOYSA-N 0.000 description 1
- AVZBGWPCVDJMMY-UHFFFAOYSA-N CCCN(C)C(CC1)CN1c(cc1)ccc1N Chemical compound CCCN(C)C(CC1)CN1c(cc1)ccc1N AVZBGWPCVDJMMY-UHFFFAOYSA-N 0.000 description 1
- WFSAHCWIQYOYHH-WMZOPIPTSA-N C[C@@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1NC(c1ccc[o]1)=O Chemical compound C[C@@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1NC(c1ccc[o]1)=O WFSAHCWIQYOYHH-WMZOPIPTSA-N 0.000 description 1
- RAICQPFLQTZKOQ-HIFRSBDPSA-N C[C@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1N Chemical compound C[C@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1N RAICQPFLQTZKOQ-HIFRSBDPSA-N 0.000 description 1
- CFNGUJUWGIXAEI-UHFFFAOYSA-N Cc(cc(cc1)NC(C2CCOCC2)=O)c1N(CC1)CC1N(CCC1)C1N Chemical compound Cc(cc(cc1)NC(C2CCOCC2)=O)c1N(CC1)CC1N(CCC1)C1N CFNGUJUWGIXAEI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98059907P | 2007-10-17 | 2007-10-17 | |
| US60/980,599 | 2007-10-17 | ||
| PCT/US2008/079757 WO2009052062A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101903340A CN101903340A (zh) | 2010-12-01 |
| CN101903340B true CN101903340B (zh) | 2013-03-27 |
Family
ID=40247942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801212081A Expired - Fee Related CN101903340B (zh) | 2007-10-17 | 2008-10-14 | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8088808B2 (enExample) |
| EP (1) | EP2212283B1 (enExample) |
| JP (1) | JP5377503B2 (enExample) |
| KR (1) | KR20100072077A (enExample) |
| CN (1) | CN101903340B (enExample) |
| AT (1) | ATE525351T1 (enExample) |
| AU (1) | AU2008312635B2 (enExample) |
| BR (1) | BRPI0818581A2 (enExample) |
| CA (1) | CA2702467C (enExample) |
| CY (1) | CY1112083T1 (enExample) |
| DK (1) | DK2212283T3 (enExample) |
| ES (1) | ES2372332T3 (enExample) |
| HR (1) | HRP20110762T1 (enExample) |
| IL (1) | IL205001A (enExample) |
| MA (1) | MA31858B1 (enExample) |
| MX (1) | MX2010003949A (enExample) |
| MY (1) | MY151348A (enExample) |
| NZ (1) | NZ584690A (enExample) |
| PL (1) | PL2212283T3 (enExample) |
| PT (1) | PT2212283E (enExample) |
| RS (1) | RS52235B (enExample) |
| RU (1) | RU2477720C2 (enExample) |
| SI (1) | SI2212283T1 (enExample) |
| WO (1) | WO2009052062A1 (enExample) |
| ZA (1) | ZA201002115B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2477721C2 (ru) | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
| RS52235B (sr) * | 2007-10-17 | 2012-10-31 | Sanofi | Supstituisani n-fenil-bipirolidin karboksamidi i njihova terapeutska upotreba |
| ES2378011T3 (es) | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
| HRP20110953T1 (hr) | 2007-10-17 | 2012-01-31 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| JP5833105B2 (ja) | 2010-05-11 | 2015-12-16 | サノフイ | 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
| TW201206901A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| WO2011143163A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081382A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
| TW201206444A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| PH12013500027A1 (en) * | 2010-07-06 | 2017-10-25 | Astrazeneca Ab | Therapeutic agents 976 |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| JP2013232564A (ja) * | 2012-04-27 | 2013-11-14 | National Institute Of Advanced Industrial & Technology | 半導体装置および半導体装置の製造方法 |
| CN108250128A (zh) * | 2012-09-27 | 2018-07-06 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| BR112015016394A2 (pt) | 2013-01-10 | 2017-07-11 | Gruenenthal Gmbh | carboxamidas ii baseadas em pirazolil como inibidoras do canal crac |
| KR20150103751A (ko) | 2013-01-10 | 2015-09-11 | 그뤼넨탈 게엠베하 | Crac 채널 억제제로서의 피라졸릴계 카복스아미드 ｉ |
| EP3366683A1 (en) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| EP1556046A1 (en) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| US7951826B2 (en) | 2005-03-17 | 2011-05-31 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
| AU2006232871B9 (en) * | 2005-04-01 | 2011-11-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| JP5193033B2 (ja) * | 2005-07-01 | 2013-05-08 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
| WO2007048595A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| BRPI0707872A2 (pt) * | 2006-02-15 | 2011-05-10 | Sanofi Aventis | arildiidroisoquinolinonas substituÍdas por azaciclila, processo para sua preparaÇço e seu uso como medicamentos |
| ES2378011T3 (es) * | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
| RU2477721C2 (ru) | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
| HRP20110953T1 (hr) | 2007-10-17 | 2012-01-31 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
| RS52235B (sr) * | 2007-10-17 | 2012-10-31 | Sanofi | Supstituisani n-fenil-bipirolidin karboksamidi i njihova terapeutska upotreba |
-
2008
- 2008-10-14 RS RS20110522A patent/RS52235B/sr unknown
- 2008-10-14 PT PT08839959T patent/PT2212283E/pt unknown
- 2008-10-14 SI SI200830416T patent/SI2212283T1/sl unknown
- 2008-10-14 CA CA2702467A patent/CA2702467C/en not_active Expired - Fee Related
- 2008-10-14 RU RU2010119528/04A patent/RU2477720C2/ru not_active IP Right Cessation
- 2008-10-14 JP JP2010530049A patent/JP5377503B2/ja not_active Expired - Fee Related
- 2008-10-14 EP EP08839959A patent/EP2212283B1/en active Active
- 2008-10-14 DK DK08839959.7T patent/DK2212283T3/da active
- 2008-10-14 BR BRPI0818581-6A patent/BRPI0818581A2/pt not_active IP Right Cessation
- 2008-10-14 MX MX2010003949A patent/MX2010003949A/es active IP Right Grant
- 2008-10-14 KR KR1020107010769A patent/KR20100072077A/ko not_active Ceased
- 2008-10-14 WO PCT/US2008/079757 patent/WO2009052062A1/en not_active Ceased
- 2008-10-14 AT AT08839959T patent/ATE525351T1/de active
- 2008-10-14 HR HR20110762T patent/HRP20110762T1/hr unknown
- 2008-10-14 NZ NZ584690A patent/NZ584690A/en not_active IP Right Cessation
- 2008-10-14 AU AU2008312635A patent/AU2008312635B2/en not_active Ceased
- 2008-10-14 ES ES08839959T patent/ES2372332T3/es active Active
- 2008-10-14 PL PL08839959T patent/PL2212283T3/pl unknown
- 2008-10-14 CN CN2008801212081A patent/CN101903340B/zh not_active Expired - Fee Related
- 2008-10-14 MY MYPI20101299 patent/MY151348A/en unknown
-
2010
- 2010-03-15 US US12/724,028 patent/US8088808B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02115A patent/ZA201002115B/en unknown
- 2010-04-11 IL IL205001A patent/IL205001A/en not_active IP Right Cessation
- 2010-05-17 MA MA32850A patent/MA31858B1/fr unknown
-
2011
- 2011-11-18 US US13/299,574 patent/US8252824B2/en not_active Expired - Fee Related
- 2011-11-24 CY CY20111101151T patent/CY1112083T1/el unknown
Also Published As
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