CN101899041B - 葛根素的一种优势药用晶型固体物质及制备方法与用途 - Google Patents
葛根素的一种优势药用晶型固体物质及制备方法与用途 Download PDFInfo
- Publication number
- CN101899041B CN101899041B CN201010188779.6A CN201010188779A CN101899041B CN 101899041 B CN101899041 B CN 101899041B CN 201010188779 A CN201010188779 A CN 201010188779A CN 101899041 B CN101899041 B CN 101899041B
- Authority
- CN
- China
- Prior art keywords
- puerarin
- brilliant
- type
- solid matter
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
Description
实施例 | 反应溶剂 | HPLC纯度(%) | 回收率(%) |
2 | 丙酮 | 99.0 | 60 |
3 | 正丙醇 | 98.1 | 75 |
4 | 乙腈 | 99.1 | 88 |
5 | 四氢呋喃 | 98.8 | 71 |
6 | 苯 | 98.7 | 77 |
7 | 甲苯 | 98.6 | 80 |
8 | 二氯甲烷 | 98.5 | 88 |
9 | 正己烷 | 98.1 | 65 |
10 | 环己烷 | 99.3 | 55 |
11 | 二氧六环 | 98.5 | 63 |
12 | DMF | 99.4 | 78 |
13 | DMSO | 98.7 | 81 |
14 | 石油醚 | 98.1 | 80 |
15 | 吡啶 | 98.6 | 76 |
实施例 | 反应溶剂 | HPLC纯度(%) | 回收率(%) |
17 | 1∶1的甲醇-正丙醇 | 99.3 | 65 |
18 | 3∶1的丙酮-乙腈 | 98.5 | 77 |
19 | 3∶2的正丙醇-丙酮 | 99.6 | 84 |
20 | 2∶1的乙腈-四氢呋喃 | 98.1 | 84 |
21 | 4∶1的四氢呋喃-甲醇 | 98.7 | 86 |
22 | 1∶5的甲苯-二氧六环 | 99.9 | 87 |
23 | 1∶3的苯-二氯甲烷 | 98.2 | 89 |
24 | 5∶1的二氯甲烷-甲苯 | 98.4 | 90 |
25 | 1∶4的正己烷-苯 | 99.1 | 91 |
26 | 1∶5的环己烷-二氧六环 | 98.6 | 88 |
27 | 1∶8的DMF-环己烷 | 99.5 | 86 |
28 | 1∶1∶1的DMSO-吡啶-DMF | 98.1 | 84 |
29 | 1∶1∶1的正丙醇-丙酮-石油醚 | 98.8 | 87 |
30 | 1∶1∶1的甲醇-正丙醇-吡啶 | 99.5 | 89 |
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010188779.6A CN101899041B (zh) | 2009-05-31 | 2010-05-31 | 葛根素的一种优势药用晶型固体物质及制备方法与用途 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910085057.5 | 2009-05-31 | ||
CN200910085057 | 2009-05-31 | ||
CN201010188779.6A CN101899041B (zh) | 2009-05-31 | 2010-05-31 | 葛根素的一种优势药用晶型固体物质及制备方法与用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101899041A CN101899041A (zh) | 2010-12-01 |
CN101899041B true CN101899041B (zh) | 2015-01-21 |
Family
ID=43225000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201010188779.6A Active CN101899041B (zh) | 2009-05-31 | 2010-05-31 | 葛根素的一种优势药用晶型固体物质及制备方法与用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101899041B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105125512B (zh) * | 2015-09-09 | 2018-04-17 | 山东大学 | 一种晶v型葛根素片剂及其制备方法 |
CN108567769A (zh) * | 2017-03-09 | 2018-09-25 | 中国医学科学院药物研究所 | 葛根素在制备预防和/或治疗肺动脉高压及其并发症药物中的用途 |
CN109662963A (zh) * | 2017-10-15 | 2019-04-23 | 中国医学科学院药物研究所 | 晶v型葛根素在制备预防和/或治疗糖尿病肝脏损伤药物的用途 |
CN115581670A (zh) * | 2022-11-11 | 2023-01-10 | 中国药科大学 | 一种调控中药葛根总黄酮提取物溶出速率的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1129700A (zh) * | 1995-02-23 | 1996-08-28 | 赵爱平 | 葛根素及其提取方法和用途 |
CN1563029A (zh) * | 2004-03-23 | 2005-01-12 | 合肥工业大学 | 高纯葛根素的结晶纯化方法 |
CN1760201A (zh) * | 2005-10-21 | 2006-04-19 | 安徽农业大学 | 膜技术分离纯化葛根素的方法 |
-
2010
- 2010-05-31 CN CN201010188779.6A patent/CN101899041B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1129700A (zh) * | 1995-02-23 | 1996-08-28 | 赵爱平 | 葛根素及其提取方法和用途 |
CN1563029A (zh) * | 2004-03-23 | 2005-01-12 | 合肥工业大学 | 高纯葛根素的结晶纯化方法 |
CN1760201A (zh) * | 2005-10-21 | 2006-04-19 | 安徽农业大学 | 膜技术分离纯化葛根素的方法 |
Non-Patent Citations (1)
Title |
---|
电磁诱导对葛根素结晶速率、晶体形貌及纯度影响研究;谢慧明等;《农业工程学报》;20060731;第22卷(第7期);第220-222页 * |
Also Published As
Publication number | Publication date |
---|---|
CN101899041A (zh) | 2010-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101434593B (zh) | 黄芩素两种晶型物质、其制法和其药物组合物与用途 | |
CN101747305B (zh) | 硝克柳胺化合物晶v型、其制法和其药物组合物与用途 | |
CN101899041B (zh) | 葛根素的一种优势药用晶型固体物质及制备方法与用途 | |
CN104844591A (zh) | 盐酸托烷司琼晶ii型物质及制备方法和其组合物与用途 | |
CN101898962B (zh) | 大黄酸晶b型固体物质及制备方法与用途 | |
CN103012345B (zh) | 木犀草素α晶型物质、其制法和其药物组合物与用途 | |
CN101429185B (zh) | 槲皮素两种晶型物质、其制法和其药物组合物与用途 | |
CN110302386A (zh) | 包含柠檬苦素类化合物和磺酰脲类药物的组合产品 | |
CN101429184A (zh) | 木犀草素两种晶型物质、其制法和其药物组合物与用途 | |
CN113214207B (zh) | 橙皮素与甜菜碱共晶物a及制备方法和其组合物与用途 | |
CN103058976B (zh) | 槲皮素α晶型物质、其制法和其药物组合物与用途 | |
CN103099776A (zh) | 钩吻素子缓释制剂及其制备方法 | |
CN101899052B (zh) | 岩白菜素的b晶型固体物质及其制备方法与用途 | |
CN113214208A (zh) | 橙皮素与异烟酰胺共晶物及制备方法和其组合物与用途 | |
CN101906101B (zh) | 罗通定晶b型固体物质与制备方法与用途 | |
CN110327355A (zh) | 包含柠檬苦素类化合物和sglt-2抑制剂的组合产品 | |
CN113214206B (zh) | 橙皮素与甜菜碱共晶物b及制备方法和其组合物与用途 | |
CN107325136A (zh) | 一种乙酰天麻素化合物及其制备方法、药物组合物、制剂与应用 | |
CN104098567B (zh) | 二羟丙茶碱晶ii型物质及制备方法和其药物组合物与用途 | |
CN103788044B (zh) | 硝克柳胺化合物晶i型、其制法和其药物组合物与用途 | |
CN108239126A (zh) | 水杨酸甲酯乳糖苷晶ⅲ型固体物质及制备方法和其组合物与用途 | |
CN103030619B (zh) | 5-甲基-7-甲氧异黄酮的晶c型、其制法和其药物组合物与用途 | |
CN109988216A (zh) | 白桦脂醇晶d型物质及制备方法和其组合物与用途 | |
CN108239079A (zh) | 芒果苷晶ⅴ型物质及制备方法和其组合物与用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: PHARMACOLOGY INST. OF CAMS Effective date: 20141225 Owner name: SHANDONG YIKANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: PHARMACOLOGY INST. OF CAMS Effective date: 20141225 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Lv Yang Inventor after: Du Guanhua Inventor after: Gao Zhaolin Inventor after: Chang Ying Inventor after: Meng Fanrui Inventor before: Lv Yang Inventor before: Du Guanhua Inventor before: Chang Ying Inventor before: Meng Fanrui |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100050 XUANWU, BEIJING TO: 277500 ZAOZHUANG, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: LV YANG DU GUANHUA CHANG YING MENG FANRUI TO: LV YANG DU GUANHUA GAO ZHAOLIN CHANG YING MENG FANRUI |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20141225 Address after: 277500, 3288, Yikang Avenue, Tengzhou, Shandong, Zaozhuang Applicant after: SHANDONG YIKANG PHARMACEUTICAL CO., LTD. Applicant after: Institute of Materia Medica of Chinese Academy of Medical Sciences Address before: 100050 Beijing city Xuanwu District Xiannongtan Street No. 1 Applicant before: Institute of Materia Medica of Chinese Academy of Medical Sciences |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |