CN101897829A - Medicinal composition with function of alleviating visual fatigue and preparation method thereof - Google Patents

Abstract

The invention discloses a medicinal composition with function of alleviating visual fatigue and a preparation method thereof. The medicinal composition is prepared from radix rehmanniae preparata, cassia seed, medlar and chrysanthemum according to a certain weight proportion. The medicinal composition is prepared into oral liquid. The medicinal composition has the effect of alleviating the visual fatigue.

Description

A kind of pharmaceutical composition and preparation method thereof with asthenopia releasing function

Technical field

The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to field of health care food with asthenopia releasing function.

Background technology

Along with the development of scientific and technological cause, the improving constantly of people's living standard, TV, computer are generalizable, and asthenopia has become the common a kind of disease of present ophthalmology.Long-time people with eye such as student, IT personnel, literal worker, the crowd of office at excessive eye, persistent fixation, or close eye continuously, will occur that momentary visual function goes down or a series of ophthalmic uncomfortable, thereby cause asthenopia.Patient's symptom is varied, the common near work that has can not be lasting, go out to lose face and eye socket around pain, blurred vision, eyes dry and astringent, shed tears etc., severe patient headache, symptom such as nauseating, dizzy, and often with lethargy, hypomnesis, mental symptoms such as insomnia have a strong impact on patient's study, live and work.The quickening of modern life rhythm, the variation of environment, the increase with eye work all makes asthenopic sickness rate that the trend that increases is arranged, therefore researching and developing a kind of medicine or health food with asthenopia releasing function all has crucial meaning.

Summary of the invention

The object of the present invention is to provide a kind of pharmaceutical composition with asthenopia releasing function.

Another object of the present invention has provided this preparation of drug combination method.

The present invention is achieved by the following technical solutions:

The present invention is made by the following weight proportion raw material:

Radix Rehmanniae Preparata 1-10 part, Semen Cassiae 1-10 part, Fructus Lycii 5-20 part, Flos Chrysanthemi 1-10 part.

Be preferably:

Radix Rehmanniae Preparata 4-7 part, Semen Cassiae 4-7 part, Fructus Lycii 10-15 part, Flos Chrysanthemi 4-7 part.

Preparation of drug combination method of the present invention is as follows:

1. get Radix Rehmanniae Preparata, Semen Cassiae, Fructus Lycii extracting in water in proportion 3 times, each 1-3 hour;

2. merge extractive liquid, filters, and filtrate concentrates, and precipitate with ethanol leaves standstill, and filters, and filtrate decompression is recycled to does not have the alcohol flavor;

3. Flos Chrysanthemi distills under decompression state, collects volatile oil twice.

4. volatile oil mixes with 2. gained solution, adds an amount of distilled water, is heated to boiling, filter, and packing, sterilization promptly gets oral liquid.

The preferred for preparation method of pharmaceutical composition of the present invention is as follows:

1. get Radix Rehmanniae Preparata, Semen Cassiae, Fructus Lycii in proportion, add 10 times of water gagings for the first time and extracted 2 hours, add 8 times of water gagings for the second time and extracted 1 hour, add 6 times of water gagings for the third time and extracted 1 hour;

2. merge extractive liquid, filters, and it is 1.10-1.20 that filtrate is concentrated into relative density, adds ethanol and makes that to contain the alcohol amount be 60%, and precipitate with ethanol left standstill 24 hours, filtered, and filtrate decompression is recycled to does not have the alcohol flavor;

3. Flos Chrysanthemi distills being decompressed under 75 ℃ under 1 atmospheric pressure, collects volatile oil twice, the 1 time 1.5 hours, the 2nd time 1 hour.

4. volatile oil mixes with 2. gained solution, adds an amount of distilled water, is heated to boiling, filter, and packing, sterilization promptly gets oral liquid.

Each drug mechanism is as follows among the present invention:

Radix Rehmanniae Preparata: sweet, tepor is returned liver, kidney channel.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, blood deficiency and yellow complexion, severe palpitation etc.Modern study shows, many, the photophobias dry and astringent with eye of asthenopia, frequent nictation conjunctivitis, keratitis person arranged easily with symptoms such as soreness of the waist and knees, dizziness and tinnitus, dreaminess, mostly be deficiency of both the liver and kidney to cause, thus employing Radix Rehmanniae Preparata nourishing the blood and yin, the effect of vital essence replenishing and marrow benifiting.

Semen Cassiae: return liver, kidney, large intestine channel.Liver heat removing makes eye bright, relieving constipation.It is dizzy to be used to have a headache, and conjunctival congestion is dim-sighted, constipation.Cure mainly the wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation etc." herbal classic ": control optic atrohic blindness, the red tunica albuginea of the excessive skin of order, swelling ophthalmalgia, lacrimation, the clothes benefit is with nothing left for a long time.Shennong's Herbal is classified Semen Cassiae as top grade, calls it, and " main optic atrohic blindness, order is excessive, skin is red, tunica albuginea, swelling ophthalmalgia, tear.The clothes benefit is with nothing left, makes light of one's life by commiting suicide ".

Fructus Lycii: sweet in the mouth, property is flat.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for dizzy, dizzy, tinnitus, visual deterioration, cough due to consumptive disease, ache of the spinal column, seminal emission, diabetes etc.The Compendium of Material Medica record: " nourishing the liver makes eye bright for Fructus Lycii, kidney-tonifying sperm-generating, hard smart bone, and fatigue taking away, easily color bleaches, and makes eye bright and calms the nerves, and makes us long-lived." Fructus Lycii has nourishing the liver and kidney, makes eye bright beneficial complexion, longue meat, the effect of hard muscles and bones.Clothes have life lengthening, the effect of slow down aging for a long time.

Flos Chrysanthemi: acrid in the mouth, sweet, bitter, cold nature is returned lung, Liver Channel.Has diffusing wind heat clearing away, the effect that suppressing the hyperactive liver makes eye bright.Be used for conjunctival congestion and swelling pain, eyes is dim-sighted, and it is dizzy to have a headache etc.With the Semen Cassiae compatibility, the effect of liver heat removing and eyesight improving peace liver-yang is preferably arranged, can be used for the liver-heat conjunctival congestion, the many tears of photophobia etc.

In sum, the present composition can be used for preparing medicine or the health food with asthenopia releasing function.

Below example illustrates beneficial effect of the present invention by experiment:

Experimental example

1 material and method

1.1 given the test agent

This is tried thing and placebo is oral liquid, and being tried thing is by patent working example 1 prepared oral liquid of the present invention, every day 2 times, each 1.

1.2 experimenter

Participating in from entering one's name voluntarily and selecting the age the personnel of test is 18-25 year, and long-term with eye, vision fatiguability person is the experimenter.Experimenter's exclusion standard is with reference to the 2nd in the 6th part in " health food check and assessment technique standard " second portion " function assessment evaluation test method ".

1.3 EXPERIMENTAL DESIGN and grouping

Adopt two kinds of control design between self and group.According to symptom and examination of visual acuity situation, consider factors such as age, sex simultaneously, by at random, double-blind method is divided into test group and matched group, every group 50 people.

1.4 test-meal method

Test group is taken according to recommend method and recommended dose and is tried thing, every day 2 times, each 1; Matched group is taken placebo, and usage and dosage is identical with test group, takes continuously 30 days.

1.5 observation index

Observation index is divided into safety indexes and effect index, and each measures once every index when test-meal on-test and end.

1.6 effect index criterion

Be divided into doing well,improving, effective, invalid.Doing well,improving: ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, the dry and astringent arbitrary doing well,improving of eye are improvement more than 1 minute and 1 minute, and 5 kinds of arbitrary improvement of symptom and other symptoms do not have deterioration and promptly judge doing well,improving; Effectively: differ before and after doing well,improving and the duration of photopic vision 〉=0.1, and comparing difference has statistical significance by statistics; Invalid: as not reach effective standard.

1.7 date processing

The data input database that to collect by experimental period is analyzed and statistical procedures.Symptom integral and duration of photopic vision are measurement data, and improvement rate and total effective rate are enumeration data, adopt t check and X respectively ²Check compares.

2 results

2.1 physical data

100 routine asthenopia patients, test group, each 50 example of matched group.Test group male's 24 examples, women's 26 examples, age 21-25, year mean age (22 ± 1); Matched group male 21 examples, women's 29 examples, age 19-24 year, year mean age (21 ± 1).

2.2 situation relatively as two groups of test-meals were last

Age, sex, duration of photopic vision, left and right sides bore hole distant vision, the every index difference of symptom integral not statistically significant (P＞0.05) have comparability before two groups of test-meals.

2.3 safety indexes is observed

Test-meal before and after test group and matched group crowd's general physical examination, blood parameters and routine urianlysis result are all in normal range.Test group and matched group crowd Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection are all in normal range before the test-meal.

2.4 distant vision improves relatively

All than making moderate progress before the test-meal, difference has statistical significance (P＜0.05) to test group right and left eyes distant vision; Relatively do not have before right and left eyes distant vision and the test-meal after the matched group test-meal obviously and improve difference not statistically significant (P＞0.05) (table 1).

Table 1 given the test agent is to influence (X ± S) (n=50) of experimenter's distant vision

2.5 duration of photopic vision changes relatively

0.63 ± 0.32 before by the test-meal of test group duration of photopic vision rises to 0.79 ± 0.03 after the test-meal, improved 0.16 ± 0.24, and difference has statistical significance (P＜0.01); Test group duration of photopic vision (0.79 ± 0.03) has statistical significance (P＜0.01) with matched group (0.65 ± 0.17) comparing difference after the test-meal.

2.6 doing well,improving relatively

The test group eye symptom is than matched group all improve significantly (table 2).

Table 2 given the test agent is to the influence of experimenter's eye symptom

2.7 symptom integral statistical

The eye symptom integration of test group is tried 3.87 ± 1.52 before the thing and is reduced to 2.25 ± 1.27 after taking by taking, and the front and back comparing difference has statistical significance (P＜0.01); Test group and matched group (3.08 ± 1.41) comparing difference has statistical significance (P＜0.01) after the test-meal.

2.8 total effective rate relatively before and after the test-meal

The total effective routine number of test group is 28 examples, and total effective rate is 56%; The total effective routine number of matched group is 5 examples, and total effective rate is 10%; Two groups of total effective rate comparing differences have statistical significance (P＜0.01).

Human trial is the result show, the experimenter takes the present composition after 30 days continuously, compares after the test group test-meal with before the test-meal, and difference has statistical significance; Compare with matched group after the test group test-meal, difference has statistical significance.The prompting present composition has the effect of alleviating asthenopia.

The specific embodiment

Come further to set forth preparation of compositions method of the present invention by the following examples.

Embodiment 1:

Prescription:

5 parts of Radix Rehmanniae Preparata, 5 parts of Semen Cassiaes, 12 parts of Fructus Lycii, 5 parts of Flos Chrysanthemis.

Preparation technology:

1. get Radix Rehmanniae Preparata, Semen Cassiae, Fructus Lycii in proportion, add 10 times of water gagings for the first time and extracted 2 hours, add 8 times of water gagings for the second time and extracted 1 hour, add 6 times of water gagings for the third time and extracted 1 hour;

2. merge extractive liquid, filters, and it is 1.10-1.20 that filtrate is concentrated into relative density, adds ethanol and makes that to contain the alcohol amount be 60%, and precipitate with ethanol left standstill 24 hours, filtered, and filtrate decompression is recycled to does not have the alcohol flavor;

3. Flos Chrysanthemi distills being decompressed under 75 ℃ under 1 atmospheric pressure, collects volatile oil twice, the 1 time 1.5 hours, the 2nd time 1 hour.

4. volatile oil mixes with 2. gained solution, adds an amount of distilled water, is heated to boiling, filter, and packing, sterilization promptly gets oral liquid.

Embodiment 2:

Prescription:

5.5 parts of Radix Rehmanniae Preparata, 5.5 parts of Semen Cassiaes, 13.5 parts of Fructus Lycii, 5.5 parts of Flos Chrysanthemis.

Preparation technology:

With embodiment 1.

Embodiment 3:

Prescription:

4.5 parts of Radix Rehmanniae Preparata, 4.5 parts of Semen Cassiaes, 14.5 parts of Fructus Lycii, 4.5 parts of Flos Chrysanthemis.

Preparation technology:

With embodiment 1.

Claims (5)

1. one kind has pharmaceutical composition of asthenopia releasing function and preparation method thereof, it is characterized in that, this pharmaceutical composition is to be made by following bulk drugs:

Radix Rehmanniae Preparata 1-10 part, Semen Cassiae 1-10 part, Fructus Lycii 5-20 part, Flos Chrysanthemi 1-10 part.

2. pharmaceutical composition according to claim 1 is characterized in that, the best proportioning of said composition is:

Radix Rehmanniae Preparata 4-7 part, Semen Cassiae 4-7 part, Fructus Lycii 10-15 part, Flos Chrysanthemi 4-7 part.

3. claim 1 or 2 described preparation of drug combination methods is characterized in that this method is:

1. get Radix Rehmanniae Preparata, Semen Cassiae, Fructus Lycii extracting in water in proportion 3 times, each 1-3 hour;

2. merge extractive liquid, filters, and filtrate concentrates, and precipitate with ethanol leaves standstill, and filters, and filtrate decompression is recycled to does not have the alcohol flavor;

3. Flos Chrysanthemi distills under decompression state, collects volatile oil twice.

4. volatile oil mixes with 2. gained solution, adds an amount of distilled water, is heated to boiling, filter, and packing, sterilization promptly gets oral liquid.

4. according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:

1. get Radix Rehmanniae Preparata, Semen Cassiae, Fructus Lycii in proportion, add 10 times of water gagings for the first time and extracted 2 hours, add 8 times of water gagings for the second time and extracted 1 hour, add 6 times of water gagings for the third time and extracted 1 hour;

2. merge extractive liquid, filters, and it is 1.10-1.20 that filtrate is concentrated into relative density, adds ethanol and makes that to contain the alcohol amount be 60%, and precipitate with ethanol left standstill 24 hours, filtered, and filtrate decompression is recycled to does not have the alcohol flavor;

3. Flos Chrysanthemi distills being decompressed under 75 ℃ under 1 atmospheric pressure, collects volatile oil twice, the 1 time 1.5 hours, the 2nd time 1 hour.

4. volatile oil mixes with 2. gained solution, adds an amount of distilled water, is heated to boiling, filter, and packing, sterilization promptly gets oral liquid.

5. claim 1 or the 2 described pharmaceutical compositions application that is used to prepare asthenopia releasing function.