CN101869534A - Lubricant for root canal therapy - Google Patents
Lubricant for root canal therapy Download PDFInfo
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- CN101869534A CN101869534A CN200910031514A CN200910031514A CN101869534A CN 101869534 A CN101869534 A CN 101869534A CN 200910031514 A CN200910031514 A CN 200910031514A CN 200910031514 A CN200910031514 A CN 200910031514A CN 101869534 A CN101869534 A CN 101869534A
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- root canal
- lubricant
- tween
- methacryloxy
- canal therapy
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Abstract
The invention discloses a lubricant for root canal therapy, which comprises ethylenediamine tetraacetic acid sodium salt, phytic acid, dodecyldimethylbenzyl ammonium chloride, Tween, cellulose, glycerol, germicide and water. Because the phytic acid has strong metal ion complexing capability and pH value adaptive ability, the product is easy for reaming and filing operation in the process of the root canal therapy; because the phytic acid has effects of corrosion prevention and bacterium inhibition, the stability and quality guarantee period of the product are improved; by adopting non-peroxide germicide and a pasting agent complexed by the Tween, the dodecyldimethylbenzyl ammonium chloride, the cellulose and glycerol, the surface tension and the fluidity of the product are adjusted by adjusting the proportions of all components in the pasting agent while improving the stability of the product, and the product not only can be used for syringe injection but also can be used for needle stick guide operation; and the invention can effectively remove a staining layer, the germicide added into the lubricant can kill pathogenic bacteria in the root canal reaming and filing process, therefore, the success rate of the root canal therapy is effectively improved.
Description
Technical field
The present invention relates to a kind of lubricant that is used for root canal, especially a kind ofly not only can be used for the needle tubing injection but also can be used for sticking needle guide going into operation, thereby and can remove smear layer, kill the lubricant that antibacterial in the root pipe reduces the root canal risk of failure.
Background technology
Root canal is a kind of effective ways for the treatment of dental pulp disease, periapical disease, and its core is to remove to infect, and stops to infect again.Root canal preparation is the committed step of root canal therapy, and the quality of root canal preparation is depended in the root canal therapy success or not to a great extent.In the root canal preparation process, often the rheological properties that increases because of pulp necrosis and dentin-dental pulp complex changes, and dental pulp calcification change gradually makes the pulp cavity smaller volume, and the part or all of calcification of pulp cavity is blocked, root pipe caliber from large to small, even obturation of root canal.In this case, it is logical to use mechanical preparation method to be difficult to its expansion separately, and the risk that exists root canal appliance to fracture, and causes malpractice.At this moment, by the calcium ion in chelating agent EDTA (ethylenediaminetetraacetic acid) the chelating tooth body make in the root pipe dentine decalcification's deliquescing again Aided Machine method preparation root pipe can get good effect.
After the root canal at present, the report of root canal failure is a lot.In mouthful during two subintrusion, the root canal of antibacterial operation the pathogen of infection site to remove antibacterial reason such as not thorough be the main cause that causes the root canal failure.Therefore, in preparation root pipe process,, then can effectively improve the success rate of root canal if can thoroughly remove the pathogen and the smear layer of infection.
Existing in the market chelating agent EDTA generally adopts urea peroxide to increase Dentinal permeability as antibacterial, Polyethylene Glycol as becoming paste to have lubricant concurrently, is beneficial to instrument tool and stretches into the deep cutting, the root pipe is enlarged and sterilization.But the existence of urea peroxide makes the quality instability of EDTA oxpara own, therefore the EDTA oxpara that contains urea peroxide requires strict to the condition of storage of opening the back product, generally need in refrigerator, preserve the inconvenience that this has just caused product to use.In addition, present commercially available EDTA root pipe lubricant need be done and have different mobile products and satisfy clinically various operational requirements.And not special the interpolation at the antibacterial of removing pathogen in the root pipe causes the root canal failure with the superinfection of bacteriological protection.
Summary of the invention
In order to address the above problem, the invention provides a kind of lubricant for root canal therapy, this lubricant that is used for root canal has overcome the unstable product quality that prior art exists, condition of storage is strict and problem such as the mobile difference of product.
The present invention for the technical scheme that solves its technical problem and adopt is:
A kind of lubricant for root canal therapy is made up of disodium edta, phytic acid, dodecyl dimethyl benzyl ammonium chloride, tween, cellulose, glycerol, antibacterial and water, and in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Disodium edta: 10%～25%;
Phytic acid: 5%～10%;
Dodecyl dimethyl benzyl ammonium chloride: 1%～5%;
Tween: 1%～5%;
Cellulose: 2%～5%;
Glycerol: 15%～25%;
Antibacterial: 0.5%～5%;
Surplus is a water.
Described disodium edta is at least a in disodium EDTA, sodium versenate salt and the tetrasodium salt of EDTA.
Described tween is at least a in tween 20, Tween-40, Tween-60 and the tween 80.
Described cellulose is at least a in hydroxyethyl-cellulose and the carboxymethyl cellulose.
Described antibacterial is at least a in methacryloxy alkyl pyridinium chloride, trichlorohydroxyl phenylate and the biguanides antibacterial.
Described methacryloxy alkyl pyridinium chloride antibacterial is at least a in methacryloxy butyl pyridinium chloride, methacryloxy octyl group pyridinium chloride, methacryloxy ten alkyl pyridinium chlorides, methacryloxy dodecyl chlorination pyridine, methacryloxy tridecyl pyridinium chloride, methacryloxy hexadecylpyridinium chloride and the methacryloxy eicosyl pyridinium chloride.
Described biguanides antibacterial is at least a in chlorhexidine acetate, two chlorhexidine hydrochloride and the two chlorhexidine gluconate.
The invention has the beneficial effects as follows: the phytic acid that adds among the present invention has stronger complexing of metal ion ability and pH value adaptive capacity than EDTA, makes this product be easier to expand the file operation in endodontic procedure; Because phytic acid has anticorrosion, bacteriostasis, increase product stability simultaneously, increased shelf life of products.The present invention adopts non-peroxide antibacterial and becomes paste by what tween, dodecyl dimethyl benzyl ammonium chloride, cellulose and glycerol were re-dubbed, when improving product stability, by being adjusted to surface tension and the flowability that the ratio of each component is regulated product in the paste, make a product can satisfy the demand under the different occasions, not only can be used for the needle tubing injection but also can be used for sticking needle guide going into operation, the scope of application is wider, is more suitable for clinical manipulation.The present invention can effectively remove smear layer, and owing to added special antibacterial at pathogen in the root pipe among the present invention, can expand in the journey of after filing at the root pipe and kill pathogen, effectively improves the success rate of root canal.
The specific embodiment
Embodiment 1: a kind of lubricant for root canal therapy, form by disodium EDTA, phytic acid, dodecyl dimethyl benzyl ammonium chloride, Tween-40, hydroxyethyl-cellulose, glycerol, trichlorohydroxyl phenylate and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Disodium EDTA: 20%;
Phytic acid: 10%;
Dodecyl dimethyl benzyl ammonium chloride: 5%;
Tween-40: 5%;
Hydroxyethyl-cellulose: 3%;
Glycerol: 15%;
Trichlorohydroxyl phenylate: 1%;
Surplus is a water.
Embodiment 2: a kind of lubricant for root canal therapy, form by tetrasodium salt of EDTA, phytic acid, dodecyl dimethyl benzyl ammonium chloride, tween 20, hydroxyethyl-cellulose, glycerol, methacryloxy octyl group pyridinium chloride and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Tetrasodium salt of EDTA: 25%;
Phytic acid: 10%;
Dodecyl dimethyl benzyl ammonium chloride: 3%;
Tween 20: 3%;
Hydroxyethyl-cellulose: 5%;
Glycerol: 25%;
Methacryloxy octyl group pyridinium chloride: 3%;
Surplus is a water.
Embodiment 3: a kind of lubricant for root canal therapy, form by sodium versenate salt, phytic acid, dodecyl dimethyl benzyl ammonium chloride, Tween-60, hydroxyethyl-cellulose, glycerol, chlorhexidine acetate and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Sodium versenate salt: 15%;
Phytic acid: 8%;
Dodecyl dimethyl benzyl ammonium chloride: 1%;
Tween-60: 1%;
Hydroxyethyl-cellulose: 2%;
Glycerol: 20%;
Chlorhexidine acetate: 5%;
Surplus is a water.
Embodiment 4: a kind of lubricant for root canal therapy, form by disodium EDTA, phytic acid, dodecyl dimethyl benzyl ammonium chloride, tween 80, carboxymethyl cellulose, glycerol, two chlorhexidine hydrochloride and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Disodium EDTA: 10%;
Phytic acid: 5%;
Dodecyl dimethyl benzyl ammonium chloride: 3%;
Tween 80: 5%;
Carboxymethyl cellulose: 4%;
Glycerol: 15%;
Two chlorhexidine hydrochlorides: 3%;
Surplus is a water.
Embodiment 5: a kind of lubricant for root canal therapy, form by tetrasodium salt of EDTA, phytic acid, dodecyl dimethyl benzyl ammonium chloride, Tween-40, carboxymethyl cellulose, glycerol, methacryloxy hexadecylpyridinium chloride and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Tetrasodium salt of EDTA: 20%;
Phytic acid: 8%;
Dodecyl dimethyl benzyl ammonium chloride: 5%;
Tween-40: 1%;
Carboxymethyl cellulose: 2%;
Glycerol: 25%;
Methacryloxy hexadecylpyridinium chloride: 5%;
Surplus is a water.
Embodiment 6: a kind of lubricant for root canal therapy, form by sodium versenate salt, phytic acid, dodecyl dimethyl benzyl ammonium chloride, Tween-60, carboxymethyl cellulose, glycerol, methacryloxy eicosyl pyridinium chloride and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Sodium versenate salt: 20%;
Phytic acid: 10%;
Dodecyl dimethyl benzyl ammonium chloride: 5%;
Tween-60: 3%;
Carboxymethyl cellulose: 5%;
Glycerol: 20%;
Methacryloxy eicosyl pyridinium chloride: 0.5%;
Surplus is a water.
Phytic acid among the present invention is a kind of natural additive for foodstuff, outstanding feature is that metal ion is had stronger complexing and non-oxidizability, phytic acid has extremely strong complexing power to most metal ions, and its complexing power is stronger than EDTA, and wider than the pH value range of application of EDTA.The adding of phytic acid makes the present invention be easier to expand the file operation when Aided Machine method preparation root pipe.In addition,, thereby make phytic acid have anticorrosion, bacteriostasis, can increase product stability, increase shelf life of products because the electronics that each phytic acid molecule can provide six pairs of hydrogen atoms to make free radical forms rock-steady structure.
Tween among the present invention (non-ionic surface active agent), dodecyl dimethyl benzyl ammonium chloride (cationic surfactant 1227), cellulose (as thickening agent) are re-dubbed into paste with glycerol.In tween (polyoxyethylene the anhydrate Span) molecule more hydrophilic radical---polyoxyethylene groups being arranged, have than strongly hydrophilic, is a kind of oil-in-water emulsifiers, and other material is evenly disperseed in solution, increases the stability of Emulsion; Dodecyl dimethyl benzyl ammonium chloride produces the cation activity group at dissociation in water, has wide spectrum, sterilizing ability efficiently, can prolong shelf life of products, and it has good dispersion, infiltration, emulsification, helps the stable of product system; Cellulose is a kind of macromolecular chemistry material, can imbibition, in water, during swelling, can form transparent thickness glue, and neutrality, it is harmless to have thickening, emulsifying, figuration, water conservation, effect such as stable and physiology; Glycerol has the lubrication of preserving moisture.These four kinds of materials are composite according to a certain percentage, can improve product system stability.When guaranteeing that product system is stable, the composite scope of these four kinds of materials is wider in addition, and the mobile range of accommodation of product is bigger, and product can satisfy the demand under the different occasions, not only can be used for the needle tubing injection but also can be used for sticking needle guide going into operation.
Methacryloxy alkyl pyridinium chloride, trichlorohydroxyl phenylate and biguanides antibacterial among the present invention can be killed the pathogen in the root pipe in the endodontic procedure, improves the success rate of root canal.
Claims (7)
1. lubricant for root canal therapy, it is characterized in that: form by disodium edta, phytic acid, dodecyl dimethyl benzyl ammonium chloride, tween, cellulose, glycerol, antibacterial and water, in the gross mass percentage ratio of lubricant, each constituent content is as follows:
Disodium edta: 10%～25%;
Phytic acid: 5%～10%;
Dodecyl dimethyl benzyl ammonium chloride: 1%～5%;
Tween: 1%～5%;
Cellulose: 2%～5%;
Glycerol: 15%～25%;
Antibacterial: 0.5%～5%;
Surplus is a water.
2. a kind of lubricant for root canal therapy according to claim 1 is characterized in that: described disodium edta is at least a in disodium EDTA, sodium versenate salt and the tetrasodium salt of EDTA.
3. a kind of lubricant for root canal therapy according to claim 1 is characterized in that: described tween is at least a in tween 20, Tween-40, Tween-60 and the tween 80.
4. a kind of lubricant for root canal therapy according to claim 1 is characterized in that: described cellulose is at least a in hydroxyethyl-cellulose and the carboxymethyl cellulose.
5. a kind of lubricant for root canal therapy according to claim 1 is characterized in that: described antibacterial is at least a in methacryloxy alkyl pyridinium chloride, trichlorohydroxyl phenylate and the biguanides antibacterial.
6. a kind of lubricant for root canal therapy according to claim 5 is characterized in that: described methacryloxy alkyl pyridinium chloride antibacterial is at least a in methacryloxy butyl pyridinium chloride, methacryloxy octyl group pyridinium chloride, methacryloxy ten alkyl pyridinium chlorides, methacryloxy dodecyl chlorination pyridine, methacryloxy tridecyl pyridinium chloride, methacryloxy hexadecylpyridinium chloride and the methacryloxy eicosyl pyridinium chloride.
7. a kind of lubricant for root canal therapy according to claim 5 is characterized in that: described biguanides antibacterial is at least a in chlorhexidine acetate, two chlorhexidine hydrochloride and the two chlorhexidine gluconate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100315142A CN101869534B (en) | 2009-04-22 | 2009-04-22 | Lubricant for root canal therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100315142A CN101869534B (en) | 2009-04-22 | 2009-04-22 | Lubricant for root canal therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101869534A true CN101869534A (en) | 2010-10-27 |
| CN101869534B CN101869534B (en) | 2012-02-29 |
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| CN2009100315142A Active CN101869534B (en) | 2009-04-22 | 2009-04-22 | Lubricant for root canal therapy |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213200A (en) * | 2015-10-14 | 2016-01-06 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
| CN105616169A (en) * | 2016-02-22 | 2016-06-01 | 浙江浙北药业有限公司 | Water-soluble root canal lubricant and preparation method thereof |
| CN107997972A (en) * | 2017-12-04 | 2018-05-08 | 首都医科大学附属北京口腔医院 | A kind of material of in-situ preparation phytic acid calcium closing dentine tube chamber and its application |
| CN108721121A (en) * | 2018-05-31 | 2018-11-02 | 济南秦鲁药业科技有限公司 | A kind of lubricant for root canal therapy and preparation method thereof |
| CN110051541A (en) * | 2019-06-06 | 2019-07-26 | 四川涑爽医疗用品有限公司 | A kind of calcium hydroxide root canal disinfection paste and preparation method thereof |
| CN111281809A (en) * | 2020-03-17 | 2020-06-16 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
| CN116421475A (en) * | 2023-04-19 | 2023-07-14 | 桂林凯文彼德科技有限公司 | Anhydrous lubricant for root canal treatment and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149536A (en) * | 1991-12-06 | 1992-09-22 | Ratkus Victor L | Dental root canal bacterialcidal lubricant |
| JP3144102B2 (en) * | 1992-12-08 | 2001-03-12 | 三菱マテリアル株式会社 | Tooth root canal disinfectant |
| US5649825A (en) * | 1996-03-01 | 1997-07-22 | Ratkus; Victor L. | Dental root canal bacterialcidal lubricant |
| CN101244012A (en) * | 2007-02-14 | 2008-08-20 | 张郁 | Lubricant agent for root canal treatment |
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2009
- 2009-04-22 CN CN2009100315142A patent/CN101869534B/en active Active
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213200B (en) * | 2015-10-14 | 2018-04-03 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
| CN105213200A (en) * | 2015-10-14 | 2016-01-06 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
| CN105616169A (en) * | 2016-02-22 | 2016-06-01 | 浙江浙北药业有限公司 | Water-soluble root canal lubricant and preparation method thereof |
| CN107997972B (en) * | 2017-12-04 | 2021-02-05 | 首都医科大学附属北京口腔医院 | Material for in-situ generation of calcium phytate to seal dentinal lumen and application thereof |
| CN107997972A (en) * | 2017-12-04 | 2018-05-08 | 首都医科大学附属北京口腔医院 | A kind of material of in-situ preparation phytic acid calcium closing dentine tube chamber and its application |
| CN108721121A (en) * | 2018-05-31 | 2018-11-02 | 济南秦鲁药业科技有限公司 | A kind of lubricant for root canal therapy and preparation method thereof |
| CN110051541A (en) * | 2019-06-06 | 2019-07-26 | 四川涑爽医疗用品有限公司 | A kind of calcium hydroxide root canal disinfection paste and preparation method thereof |
| CN111281809A (en) * | 2020-03-17 | 2020-06-16 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN111281809B (en) * | 2020-03-17 | 2023-03-21 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
| WO2022052631A1 (en) * | 2020-09-10 | 2022-03-17 | 昆明蓝橙口腔医院有限责任公司 | Application of citrate metal salt in endodontic treatment, and formulation obtained by preparation |
| CN112022725B (en) * | 2020-09-10 | 2022-09-20 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
| CN116421475A (en) * | 2023-04-19 | 2023-07-14 | 桂林凯文彼德科技有限公司 | Anhydrous lubricant for root canal treatment and preparation method thereof |
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| CN101869534B (en) | 2012-02-29 |
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